Hiroshi Asahara, MD, PhD
Professor of MCB
Department of Molecular and Cellular Biology
Research Focus
As a molecular biologist and orthopedic surgeon, Dr. Asahara's research focuses on examining the precise mechanism of chromatin-dependent gene regulation related to limb development. Combining these new findings in molecular and developmental biology, with clinical research in the field of locomotive science, our aim is to develop innovative new therapies that will benefit patients with arthritis, bone tumor and spinal cord injuries.
Select Publications
-
Asahara, Hiroshi; Chiba, Tomoki; D’Lima, Darryl; Fuku, Noriyuki; Kurimoto, Ryota; Lotz, Martin; Ma, Shang; Morrison, Errol; Nakamichi, Ryo; Nonoyama, Takayuki; Ohzono, Hiroki; Olmer, Merissa; Ozaki, Toshifumi; Patapoutian, Ardem; Pitsiladis, Yannis P.; Shukunami, Chisa; Wang, Guan The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance. Science Translational Medicine 2022, 14.
View -
Tsutsumi, Hiroki; Tanaka, Yoko; Tabata, Yusuke; Shinohara, Masahiro; Nishida, Keiichiro; Nakamichi, Ryo; Mokuda, Sho; Matsuzaki, Tokio; Matsushima, Takahide; Lotz, Martin K.; Liu, Lin; Kurimoto, Ryota; Ito, Yoshiaki; Inotsume, Maiko; Ayabe, Fumiaki; Asahara, Hiroshi Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2a expression and coordinately regulate cartilage homeostasis.. Nature communications 2021, 4148.
-
Asahara, Hiroshi; Chiba, Tomoki; Ito, Yoshiaki; Kurimoto, Ryota; Matsushima, Takahide; Miyata, Kohei; Suzuki, Tsutomu; Tomita, Kozo; Yano, Yuki; Yashiro, Yuka The tRNA pseudouridine synthase TruB1 regulates the maturation of let-7 miRNA.. EMBO Journal 2020, 39, e104708.
-
Mochizuki, Y.; Chiba, T.; Kataoka, K.; Yamashita, S.; Sato, T.; Kato, T.; Takahashi, K.; Miyamoto, T.; Kitazawa, M.; Hatta, T.; Natsume, T.; Takai, S.; Asahara, Hiroshi Combinatorial CRISPR/Cas9 approach to elucidate a far-upstream enhancer complex for tissue-specific Sox9 expression. Developmental Cell 2018, 46, 794-806.
View -
Inui, M.; Mokuda, S.; Sato, T.; Tamano, M.; Takada, S.; Asahara, Hiroshi Dissecting the roles of miR-140 and its host gene. Nature Cell Biology 2018, 20, 516-518.
View -
Ito, Y.; Inoue, A.; Seers, T.; Hato, Y.; Igarashi, A.; Toyama, T.; Taganov, K. D.; Boldin, M. P.; Asahara, Hiroshi Identification of targets of tumor suppressor microRNA-34a using a reporter library system. Proceedings of the National Academy of Sciences of the United States of America 2017, 114, 3927-3932.
View
