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Scripps Laboratories for tRNA Synthetase Research

Sajish Mathew, Ph.D.

Photo of Sajish Mathew, Ph.D.

Education:

Ph. D: Indian Institute of Technology (IIT) Kanpur. (2009)

M.Sc : Department of Life Sciences, University of Calicut, Kerala, India (2003)

Current Research:

I am interested in understanding the molecular and structural mechanism underlying the anti-angiogenic activity of human Tryptophanyl tRNA Synthetase (hTrpRS) and pro-angiogenic activity of human Tyrosyl tRNA Synthetase (TyrRS), members of the large AminoAcyl tRNA Synthetase (AARS) superfamily. My focus is to get the co-crystal structures of TrpRS with some of its nuclear partners that would bring out a structural insight into the anti-angiogenic activity of TrpRS.

Publications:

  1. Mathew Sajish, Divya Tiwari, Dimple Rananaware, Vinay Kumar Nadicoori and Balaji Prakash (2007) “A Charge Reversal Differentiates(p)ppGpp Synthesis by Monofunctional and Bifunctional Rel Proteins” J. Biol. Chem., 282 (48); 34977-34983.
  2. Mathew Sajish,Sissy Kalayil, Sunil Kumar Verma, Vinay Kumar Nandicoori, and Balaji Prakash (2009) “The Significance of EXDD and RXKD Motif Conservation in Rel Proteins” J. Biol. Chem., 284 (14); 9115-9123

Awards/Fellowships

  • National Doctoral Fellowship (NDF) by All India Council of Technical Education (AICTE) 2004.
  • Joint Council of Scientific and Industrial Research (CSIR) and University Grants Commission (UGC) – National Eligibility Test (NET) for lectureship and Junior Research Fellowship (JRF) - June 2002.
  • Graduate Aptitude Test in Engineering (GATE) - 2002 with 97 percentile and All India Rank 72
  • Joint Council of Scientific and Industrial Research (CSIR) and University Grants Commission (UGC) – National Eligibility Test (NET) for lectureship and Junior Research Fellowship (JRF) - December 2001.

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