April 28, 2016
Scripps Florida Scientists Predict Cell Changes that Affect Breast Cancer Growth, Opening Door to More Effective Therapies
Designing effective new drugs, especially drugs to fight cancer, demands that you know as much as you can about the molecular workings of cancer growth.
April 27, 2016
TSRI, Harvard, Stanford and Brandeis Collaborate to Study MicroRNA’s Role in Memory, Sleep and Synapse Function
A group including scientists from the Florida campus of The Scripps Research Institute (TSRI) has been awarded a grant from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health to study the role of microRNAs in a range of physiological activities, including memory, sleep, synapse function and movement.
April 26, 2016
TSRI Scientists Reveal Secrets of a Deadly Virus Family
For the first time, scientists at The Scripps Research Institute (TSRI) have solved the structure of the biological machinery used by a common virus to recognize and attack human host cells.
April 21, 2016
New Molecule-Building Method from TSRI Opens Up Vast Realm of Chemistry for Pharma and Other Industries
Scientists at The Scripps Research Institute (TSRI) have devised a new molecule-building method that is likely to have a major impact on the pharmaceutical industry and many other chemistry-based enterprises.
April 21, 2016
Wellderly Study Suggests Link Between Genes That Protect Against Cognitive Decline and Overall Healthy Aging
An eight-year-long accrual and analysis of the whole genome sequences of healthy elderly people, or “Wellderly,” has revealed a higher-than-normal presence of genetic variants offering protection from cognitive decline, researchers from the Scripps Translational Science Institute (STSI) reported today in the journal Cell.
April 20, 2016
New Method Enlists Electricity for Easier, Cheaper, Greener Chemistry
Scientists at The Scripps Research Institute (TSRI) have found a new and better way to achieve a chemical reaction that is used widely in the pharmaceutical as well as flavor and fragrance industries.
April 14, 2016
New TSRI Project Helps Researchers Build a Biomedical Knowledgebase
Imagine attempting to bake a cake—except you have to go to different stores for flour and milk, drive across town to get eggs and call a friend to borrow a cake pan.
April 14, 2016
Scripps Florida Study Identifies Memory Suppressor Gene That Could Hold Key to New Alzheimer’s Disease Treatments
While research has identified hundreds of genes required for normal memory formation, genes that suppress memory are of special interest because they offer insights into how the brain prioritizes and manages all of the information, including memories, that it takes in every day.
April 05, 2016
TSRI Scientists Get First-Ever Glimpse of ‘Teenage’ HIV-Neutralizing Antibody
Scientists at The Scripps Research Institute (TSRI) and collaborating institutions have described the first-ever immature or “teenage” antibody found in a powerful class of immune molecules effective against HIV.
April 04, 2016
TSRI Scientists: Immune Cell Transforms from ‘Clark Kent’ to 'Superman'
A new study led by scientists at The Scripps Research Institute (TSRI) reveals a previously unknown type of immune cell.
March 31, 2016
Scripps Florida Team Awarded $3.4M to Develop Treatments for Addiction, Mood Disorders
A team from the Florida campus of The Scripps Research Institute (TSRI) and the University of North Carolina (UNC) has been awarded $3.4 million from the National Institute on Drug Abuse of the National Institutes of Health (NIH) to develop novel therapeutics for the treatment of addiction and mood disorders.
March 31, 2016
TSRI-Calibr Team Creates Novel Platform for Generating Long-Acting Drug Candidates
To improve the effectiveness of peptide hormones as treatments for chronic diseases such as diabetes and obesity, scientists at The Scripps Research Institute (TSRI) and the California Institute for Biomedical
March 29, 2016
Perfecting a Viral Pack Mule
Viruses aren’t always bad. In fact, scientists can harness the capabilities of some viruses for good—modifying the viruses to carry drug molecules, for example.
March 28, 2016
TSRI, Salk Scientists Discover 'Outlier' Enzymes that Could Offer New Targets to Treat Diabetes, Inflammation
A team led by scientists at The Scripps Research Institute (TSRI) and the Salk Institute for Biological Studies has discovered two enzymes that appear to play a role in metabolism and inflammation—and might someday be targeted with drugs to treat type 2 diabetes and inflammatory disorders.
March 24, 2016
New Findings in Humans Provide Encouraging Foundation for Upcoming AIDS Vaccine Clinical Trial
Some people infected with HIV naturally produce antibodies that effectively neutralize many strains of the rapidly mutating virus, and scientists are working to develop a vaccine capable of inducing such “broadly neutralizing” antibodies that can prevent HIV infection.
March 23, 2016
TSRI Chemists Find a Way to Synthesize Complex Plant Molecule Phorbol and Its Derivatives
In a landmark feat of chemical synthesis, scientists at The Scripps Research Institute (TSRI) have developed a 19-step process for making the naturally occurring compound phorbol in the laboratory, in quantities that are useful for pharmaceutical research.
March 18, 2016
Scripps Florida Scientists Win $1.4 Million Grant to Develop New Ways to Block Breast Cancer
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have received a $1.4 million grant from the Department of Defense to develop a series of drug candidates that act against molecules closely linked with the growth of cancer cells.
March 15, 2016
TSRI Scientists Identify Molecular Markers of Kidney Transplant Rejection
Despite advances in organ transplant medicine in recent decades, about half of all kidney transplant patients still lose their organ to rejection within 10 years.
March 10, 2016
TSRI Study Identifies New Type of Protein Clump that May Be Implicated in ALS
A new study led by scientists at The Scripps Research Institute (TSRI) suggests that cells construct protein “clumps” to protect against neurodegenerative diseases such as amyotrophic lateral sclerosis, a.k.a. ALS or Lou Gehrig’s disease.
March 09, 2016
Scripps Florida Study Lays Groundwork for Potential Bipolar Disorder Therapies
Bipolar disorder, which affects nearly eight million Americans, takes a toll not only on patients, but also on their families and communities.
March 08, 2016
Scripps Florida Scientists Win $2.4 Million to Develop New Strategies to Fight Obesity
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded $2.4 million from the National Institutes of Health (NIH) to identify the brain circuits involved in weight control and to develop novel strategies to fight obsessive eating and obesity.
March 07, 2016
Team Finds New Approach to Curbing Cancer Cell Growth
Using a new approach, scientists at The Scripps Research Institute (TSRI) and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung cancer and melanoma.
March 03, 2016
By Cloning Mouse Neurons, TSRI Scientists Find Brain Cells with 100+ Unique Mutations
In a new study published today in the journal Neuron, scientists from The Scripps Research Institute (TSRI) are the first to sequence the complete genomes of individual neurons and to produce live mice carrying neuronal genomes in all of their cells.
March 03, 2016
New TSRI Study Shows HIV Structure in Unprecedented Detail
A new study from scientists at The Scripps Research Institute (TSRI) describes the high-resolution structure of the HIV protein responsible for recognition and infection of host cells.
March 02, 2016
TSRI Scientists Find Clues to Neutralizing Coronaviruses Such as MERS
When the respiratory illness SARS (Severe Acute Respiratory Syndrome) emerged in 2003, it killed at least 775 people before it was contained.
March 01, 2016
CELLebrate2016 at the Gardens Mall to Spotlight Scripps Florida Science
Cutting-edge science, a host of exciting interactive displays, plus dozens of Scripps Florida scientists will be on hand at the Gardens Mall on Saturday, March 5, 2016, from 10:00 a.m. to 3:00 p.m. for the seventh annual CELLebrate Scripps Florida Science Day.
February 29, 2016
Scripps Florida Scientists Find Way to Predict Activity of Stem Cells
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time developed a way to predict how a specific type of stem cell will act against different diseases.
February 24, 2016
Scripps Florida Scientists Awarded $2.25 Million to Study Key Mechanisms Behind Some Cancers
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded a pair of grants totaling more than $2.25 million to study the assembly mechanisms that lie at the root of various cancers.
February 22, 2016
TSRI Researchers Uncover Potential Target for Treating Autoimmune Disease
Scientists from The Scripps Research Institute (TSRI) have identified a molecule that appears to be a cause of autoimmune diseases such as lupus.
February 19, 2016
TSRI and JCVI Scientists Find Popular Stem Cell Techniques Safe
A new study led by scientists at The Scripps Research Institute (TSRI) and the J. Craig Venter Institute (JCVI) shows that the act of creating pluripotent stem cells for clinical use is unlikely to pass on cancer-causing mutations to patients.
February 18, 2016
Scripps Florida’s Courtney Miller Wins Presidential Early Career Award
Courtney Miller, associate professor on the Florida campus of The Scripps Research Institute (TSRI), has been selected to receive a Presidential Early Career Award for Scientists and Engineers, the highest honor bestowed by the United States government on young professionals at the outset of their independent research careers.
February 18, 2016
Researchers Discover New Ebola-Fighting Antibodies in Blood of Outbreak Survivor
A research team that included scientists from The Scripps Research Institute (TSRI) has identified a new group of powerful antibodies to fight Ebola virus.
February 16, 2016
TSRI Scientists Create Vaccine Against Dangerous Designer Opioids
With use of synthetic opioid “designer drugs” on the rise, scientists from The Scripps Research Institute (TSRI) have a new strategy to curb addiction and even prevent fatal overdoses.
February 12, 2016
Scripps Florida Scientists Win $1.7 Million Grant to Advance New Strategies to Treat Huntington’s Disease
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have won nearly $1.7 million from the National Institutes of Health’s (NIH) National Institute of Neurological Disorders and Stroke (NINDS) to investigate the mechanisms that contribute to Huntington’s disease, a fatal inherited disease that some have described as having ALS, Parkinson’s and Alzheimer’s—at the same time.
February 11, 2016
Scripps Florida Scientists Identify a Memory Suppressor that May Play a Role in Autism
Discovered only in the 1990s, microRNAs are short molecules that work within virtually all cells.
February 11, 2016
TSRI Study Reveals New Link Between Brain and Fat-Burning Circuit
A new study in animal models, led by scientists at The Scripps Research Institute (TSRI), is the first to show that oxygen sensing in the brain has a role in metabolism and sensing an organism’s internal state.
February 10, 2016
Scripps Florida Researchers Develop 'LIGHTSABR'—A Cheap, Portable Drug-Discovery System
Screening large “libraries” of compounds to find those with a desired biological activity is a powerful method for discovering new drugs, but requires a large, expensive and dedicated facility.
February 05, 2016
Local Neuroscientists Gather for Synapse 2016
More than 200 of the brightest scientific minds in the region gathered today at the Florida campus of The Scripps Research Institute (TSRI) to network and share their research findings.
February 03, 2016
Scripps Florida Scientists Win $1.2 Million to Study New Strategies for Treating Obesity, Diabetes, Cardiovascular Disease and Muscle Decline
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded nearly $1.2 million from the National Institutes of Health (NIH) to create a series of drug candidates that advance more effective treatments for a range of conditions, including obesity, type-2 diabetes, cardiovascular disease and muscle atrophy.
January 29, 2016
Remicade ® Developer Funds New Super-Resolution Microscope at Scripps Florida
The co-developer of Remicade ®, one of the three top-selling drugs in the world, has donated more than $500,000 to fund what will be known as the Iris and Junming Le Foundation Super-Resolution Microscopy Facility on the Florida campus of The Scripps Research Institute (TSRI).
January 28, 2016
TSRI Study Reveals Workings of Mysterious 'Relief Valve' that Protects Cells from Swelling
A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
January 27, 2016
Philanthropist Samuel Yin Provides $12.8 Million Gift for New Laboratories at The Scripps Research Institute
Philanthropist and businessman Samuel Yin of Taiwan has given $12.8 million to The Scripps Research Institute (TSRI) to help fund construction of a new building complex on the La Jolla campus.
January 25, 2016
Crouching Protein, Hidden Enzyme
A new study led by scientists at The Scripps Research Institute (TSRI) and the University of California (UC), Berkeley shows how a crucial molecular enzyme starts in a tucked-in somersault position and flips out when it encounters the right target.
January 19, 2016
New TSRI Study Shows Path to ‘Dial Down’ Autoimmunity without Compromising Immune Response
A new study led by scientists at The Scripps Research Institute (TSRI) shows how dangerous autoimmune responses, seen in diseases such as lupus and multiple sclerosis, might be “dialed down” without compromising the immune system’s ability to fight viruses and bacteria.
January 18, 2016
TSRI Scientists Solve 3D Structure of Protein that Guides the Immune System
Many cells have microscopic gates, called ion channels, which open to allow the flow of ions across the cell membrane.
January 14, 2016
TSRI Researchers Develop Versatile New Way to Build Molecules
Chemists at The Scripps Research Institute (TSRI) have devised a new and widely applicable technique for building potential drug molecules and other organic compounds.
January 14, 2016
TSRI Chemists Devise Powerful New Method for Modifying Drug Molecules
Chemists at The Scripps Research Institute (TSRI) have developed a versatile new technique for making modifications—especially one type of extremely difficult, but much-sought-after modification—to complex drug molecules.
January 13, 2016
New TSRI Study: Flipping Molecular 'Switch' May Reduce Nicotine's Effects in the Brain
Scientists at The Scripps Research Institute (TSRI) have discovered that a lipid (fat molecule) in brain cells may act as a “switch” to increase or decrease the motivation to consume nicotine.
January 12, 2016
TSRI Chemists Awarded $2.1 Million to Create Potential New Therapies with Click Chemistry
Scientists at The Scripps Research Institute (TSRI) have received a grant of more than $2.1 million from the National Institutes of Health’s National Institute of General Medical Sciences to create and screen a new library of drug candidates.