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Life-Changing Medicines.

Groundbreaking Science.

Life-Changing Medicines.

At Scripps Research, we believe science can transform human health worldwide. We combine the best of nonprofit fundamental research and drug discovery to accelerate the impact of scientific advances on patients.

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Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
News

Scientists discover a new way that a disease-linked protein comes apart

Chi-Huey Wong.
News

Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dyna-1 predicted millisecond-scale movements in regions of KRAS (pictured), a cancer-associated protein that has been notoriously difficult to target. “Switch I” and “Switch II” indicate the protein’s movements in this timescale. The thickness of the circular dashed lines indicates Dyna-1’s predictions compared to the experimentally measured us-ms exchange in color.
News

Where milliseconds matter: Scripps Research scientists build new ML model to predict protein movements essential for biological function

From left: Michael Ko and Giorgio Quer
News

New AI algorithm could improve detection and prediction of heart diseases

Event background

The Front Row lecture series: Christian Diercks, PhD

Wednesday, October 14, 2026

4:00 - 6:00 PM PT

Enter curious, leave informed.

Celebrate the journey: Graduation Day 2026
Video

Celebrate the journey: Graduation Day 2026

Hear from 3 of our newest PhD recipients as they reflect on their experience as students in Scripps Research’s Skaggs Graduate School. The students are among the 49 who were awarded doctoral degrees at the institute’s May 15th Commencement.

Graduate Program
scripps research science changing life podcast episode 58
Podcast

2025 Year in Review: Five insights we’re still thinking about

In a special year-end episode of Science Changing Life, we’re revisiting five moments from 2025 that continue to shape how we think about science. Featuring insights from Scripps Research experts across genetics, infectious disease, public health surveillance and chronic illness, this episode features some of this year’s most memorable soundbites.

Alcohol Use Disorder Long COVID
amy lightner lab
Magazine

The new guidelines for ulcerative colitis mean fewer surgeries—and fewer colonoscopies

Dr. Amy Lightner has spent her career moving between the operating room and the research lab, treating ulcerative colitis (UC) and other inflammatory bowel disease (IBD) patients as a surgeon while also searching for better treatments as a scientist.

Groundbreaking Science.
Life-changing Medicine.