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Class of '16

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Class of '16

Doctorate of Philosophy


amador

Ariadna Amador


The regulation of sleep and wakefulness by the Rev-Erbs


Advisor: Thomas P. Burris, PhD, Professor and Chair, Saint Louis University, Department of Pharmacology and Physiology


barrios

Danielle Barrios-Steed


Part I. Origins of Y. pestis Sensitivity to the Arylomycin Antibiotics and the Inhibition of Type I Signal Peptidase


Part II. Investigations into the Synergistic Effect of Signal Peptidase Inhibitor and β-lactam co-therapy in MRSA


Advisor: Floyd E. Romesberg, PhD, Professor, Department of Chemistry


blanchard

Joel William Blanchard


Deprogramming Reprogramming: Development and Application of Technology for Altering Cellular Identity


Advisor: Kristin Baldwin, PhD, Associate Professor, Department of Molecular and Cellular Neuroscience


bollong

Michael Bollong


Chemical Modulation of Cell Fate


Advisor: Peter G. Schultz, PhD, Chief Executive Officer; Vice Chair, Board of Trustees; Professor, Department of Chemistry


bruhn

Jessica Bruhn


Insights into the structural assemblies governing RNA virus transcription and genomic replication


Advisor: Erica Ollmann Saphire, PhD, Professor of Immunology, Department of Immunology and Microbial Science


campbell

Melody Campbell


High-Throughput and High-Resolution Electron Microscopy


Advisor: Bridget Carragher, PhD, Co-Director, New York Structural Biology Center


chatterje

Sandip Chatterjee


Development of Proteomic Methods for the Functional Characterization of the Human Gut Microbiota


Advisor: Dennis W. Wolan, PhD, Assistant Professor, Department of Molecular and Experimental Medicine


john chen

John Chen


Modulating the Quality and Secretion of Secreted Proteins using the ER Proteostasis Network


Advisor: R. Luke Wiseman, PhD, Assistant Professor, Department of Molecular and Experimental Medicine


wentao chen

Wentao Chen


Enhanced Aromatic Sequons and Sulfur (VI) Fluoride Functional Groups in Biological Systems


Advisor: Jeffery W. Kelly, PhD, Professor and Chair, Department of Molecular and Experimental Medicine


dao

Hai Dao


Steroid Synthesis Inspired Methodologies for Selective Olefin Functionalization


Advisor: Phil Baran, PhD, Professor, Department of Chemistry


dreyton

Christina Dreyton


Small Molecule Probes to Study Protein Folding in the Cell


Advisor: Paul R. Thompson, PhD, Professor, University of Massachusetts, Department of Biochemistry and Molecular Pharmacology


Introduction: William R. Roush, PhD, Associate Dean of Graduate Studies, Florida; Professor, Department of Chemistry


garcia

Francisco Garcia


Expanding the Chemical Tool Kit for the Detection of Redox Regulated Protein Tyrosine Phosphatases


Advisor: Kate Carroll, PhD, Associate Professor, Department of Chemistry


gianatassio

Ryan Gianatassio


Enabling Tools for Medicinal Chemistry Through C-H Functionalization and Strain Release Amination


Advisor: Phil Baran, PhD, Professor, Department of Chemistry


hartfield

Kimberly Hartfield


Functional Insights from Structural Analyses of Light- or Redox-Active Flavo- and Metalloproteins


Advisor: C. David Stout, PhD, Associate Professor, Department of Integrative Structural and Computational Biology


Introduction: Elizabeth Getzoff, PhD, Professor, Department of Integrative Structural and Computational Biology


higginson

Cody James Higginson


Functional Materials Based on Oxanorbornadiene Cleavable Linkers


Advisor: M.G. Finn, PhD, Professor and Chair, Department of Chemistry and Biochemistry, Georgia Institute of Technology


hulce

Jonathan Hulce


Chemical Probes of Lipid Binding and Metabolizing Proteins


Advisor: Benjamin Cravatt, PhD, Professor and Chair, Department of Chemical Physiology


jansen

Daniel Jansen


Potent Cytotoxins and HAT Hydrogenation through the Exploration of Asmarine Alkaloids


Advisor: Ryan A. Shenvi, PhD, Associate Professor, Department of Chemistry


jin

Hyun-Yong Jin


Function and Mechanism of MicroRNA-17~92 in B cells


Advisor: Changchun Xiao, PhD, Associate Professor, Department of Immunology and Microbial Science


lai

Jiun-I Lai


Transcriptional Profiling in Isogenic iPSC-Derived Friedreich’s Ataxia Neurons


Advisor: Joel Gottesfeld, PhD, Professor, Department of Cell and Molecular Biology


lebeouf

Sarah E. Leboeuf


Sirtuin 5 Regulates Glucose and Glutamine Metabolism and Tumor Progression in Breast Cancer


Advisor: Brunhilde Felding, PhD, Associate Professor, Department of Chemical Physiology


lee

Jeong Hyun Lee


Structural Characterization of Broadly Neutralizing Quaternary Epitopes on the HIV-1 Envelope Glycoprotein


Advisors: Andrew Ward, PhD, Associate Professor, Department of Integrative Structural and Computational Biology; Ian Wilson, PhD, Professor and Chair, Department of Integrative Structural and Computational Biology


lin

Xiaotian Lin


‘Self’ vs. ‘Non-Self’ Discrimination by the Immune System in Type 1 Diabetes


Advisor: Linda A. Sherman, PhD, Professor, Department of Immunology and Microbial Science

Introduction: Bruce Torbett, PhD, Professor, Department of Molecular and Experimental Medicine


Liu

Yu Liu


Small Molecule Probes to Study Protein Folding in the Cell


Advisor: Jeffery W. Kelly, PhD, Professor and Chair, Department of Molecular and Experimental Medicine


Luo

Xiaozhou Luo


Chemical Biology Approaches to Novel Antibiotics and Vaccines


Advisor: Peter G. Schultz, PhD, Chief Executive Officer; Vice Chair, Board of Trustees; Professor, Department of Chemistry


murin

Charles Daniel Murin


Of Mice and Men: Investigating Antibody-mediated Immune Responses to Filoviruses by Electron Microscopy


Advisors: Andrew Ward, PhD, Associate Professor, Department of Integrative Structural and Computational Biology; Erica Ollmann Saphire, PhD, Professor of Immunology, Department of Immunology and Microbial Science


Pedzisa

Lee Pedzisa


Interrogating the Molecular Importance of the Protein Arginine Deiminase Family


Advisor: William R. Roush, PhD, Associate Dean of Graduate Studies, Florida; Professor, Department of Chemistry


rainbolt

Thomas Kelly Rainbolt


The Activity and Regulation of Proteolysis in Mitochondrial Quality Control


Advisor: R. Luke Wiseman, PhD, Assistant Professor, Department of Molecular and Experimental Medicine


rosen

Brandon R. Rosen


I. C–H Functionalization Logic Enables a Synthesis of (+)-Hongoquercin A

II. Total Synthesis of Dixiamycin B by Electrochemical Oxidation

III. Electrochemical Allylic C–H Oxidation


Advisor: Phil S. Baran, PhD, Professor, Department of Chemistry


rupniewski

Igor Rupniewski


The Evolution of an Intein Domain for the Ephemeral Expression of a Peptide Sequence


Advisor: M.G. Finn, PhD, Professor and Chair, Department of Chemistry and Biochemistry, Georgia Institute of Technology


sears

Justin Edward Sears


I. New Insights into the Mechanism of the Fe(III)-Promoted Vinblastine Coupling

II. Next Generation Synthesis of Vindoline via the [4 + 2]/[3 + 2] Cycloaddition Reaction Cascade of an Allene Dienophile


Advisor: Dale L. Boger, PhD, Professor and Chair, Department of Chemistry


silverman

Joshua Max Silverman


Economics of the Bacterial Proteome


Advisor: James R. Williamson, PhD, Vice President of Academic Affairs; Dean of Graduate and Postdoctoral Studies; Professor, Department of Integrative Structural and Computational Biology


sitaula

Sadichha Sitaula


Regulation of Cholesterol Biosynthesis, Inflammation and Atherosclerosis by Nuclear Receptor REV-ERB


Advisor: Thomas P. Burris, PhD, Professor and Chair, Saint Louis University, Department of Pharmacology and Physiology


stein

Benjamin Stein


Development and Application of Proteomic Platforms to Annotate Protein Interaction and Signaling Dynamics


Advisor: John Yates III, PhD, Professor, Department of Integrative Structural and Computational Biology


Introduction: Reuben Shaw, PhD, Professor, Salk Institute, Molecular and Cell Biology Laboratory


susac

Lukas Susac


NMR Studies of GPCR Structure and Function


Advisor: Kurt Wüthrich, PhD, Professor, Department of Integrative Structural and Computational Biology


tabor

Martin Gregory Tabor


Development of a Practical Hydroamination Transform for use in Complex Synthesis


Advisor: Ryan A. Shenvi, PhD, Associate Professor, Department of Chemistry


wan

Kanny Ka Kei Wan


Potent cytotoxins and HAT hydrogenation through the Exploration of Asmarine Alkaloids


Advisor: Ryan A. Shenvi, PhD, Associate Professor, Department of Chemistry


wilde

Nathan C. Wilde


The Two-Phase Synthesis of Taxane Natural Products: Developing the Tools for the Oxidase Phase


Advisor: Phil S. Baran, PhD, Professor, Department of Chemistry


ying

Maben Ying


Pursuing Reidispongiolide A: Studies on the Total Synthesis and Design and Synthesis of Natural Product Mimics


Advisor: William R. Roush, PhD, Associate Dean of Graduate Studies, Florida; Professor, Department of Chemistry






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