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The Kelly Group Research

Amyloid as a functional fold:

There appears to be a fine line between pathology and physiology. It is hard to imagine, given the spontaneity of amyloid fibril formation, that this structure was not selected as a functional fold at some point during evolution. We are amassing evidence that this structure is used commonly in organelle biogenesis, and have developed the reagents to identify new amyloid folds in mammalian cells and tissue.


Transthyretin amyloid diseases: understanding the mechanism of proteotoxicity and inhibition of amyloid fibril formation

Understanding Abeta aggregation and Alzheimer's disease

Gelsolin amyloid disease mechanism and therapeutics

β-Sheet folding

Parkinson's disease

Restoration of enzyme homeostasis in lysosomal storage diseases

Amyloid as a functional fold