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The Russell Laboratory


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  1. Jensen, K.L., Russell, P. (2016) Ctp1-dependent clipping and resection of DNA double-strand breaks by Mre11 endonuclease complex are not genetically separable. Nucleic Acids Res. 44, 8241-8249.
  2. Guo, L., Ganguly, A., Sun, L., Suo, F., Du, L.L., Russell, P.  (2016) Global fitness profiling identifies arsenic and cadmium tolerance mechanisms in fission yeast.  G3, 6, 3317-3333.
  3. Mejia-Ramirez, E., Limbo, O., Langerak, P., Russell, P. (2015) Critical Function of γH2A in S-Phase. PLoS Genet. Sept 14;11(9):e1005517.
  4. Sanchez, A., Russell, P. (2015) Ku stabalizes replication forks in the absence of Brc1. PLoS One. May 12;10(5):e0126598.
  5. Caetano, C., Limbo, O., Farmer, S., Klier, S., Dovey, C., Russell, P., de Bruin, RA. (2014) Tolerance of deregulated G1/S transcription depends on critical G1/S reulon genes to prevent catastrophic genome instability. Cell Rep. Dec 24;9(6):2279-89.
  6. Wang, L., Limbo, O., et al. (2014) Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. Proc Natl Acad Sci USA. Dec 30;111(52):18566-71.
  7. Wei, Y., Wang, HT., Zhai, Y., Russell, P., Du, LL. (2014) Mdb1, a fission yeast homolog of human MDC1, modulates DNA damage response and mitotic spindle function. PLoS One. May 7;9(5):e97028.
  8. Dodson, GE., Russell, P. (2011) Enhanced Tel1(ATM) checkpoint signaling at protein-bound double-strand breaks. Mol Cell Biol. May;31(10):1936-7.
  9. Sánchez, A., Roguev, A., Krogan, N.J., Russell, P.  (2015) Genetic interaction landscape reveals critical requirements for Schizosaccharomyces pombe Brc1 in DNA damage response mutants.  G3 in press.
  10. Deshpande, R., Williams, G.J., Limbo, O., Williams, R.S., Kuhnlein, J., Lee, J.-H., Classen, S., Guenther, G., Russell, P., Tainer, J.A., Paull, T.T. (2014) ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling EMBO J33, 482-500.
  11. Lee, S.Y., Russell, P.  (2013)  Brc1 links replication stress response and centromere function.  Cell Cycle  12, 1665-1671.
  12. Dehé, P.M., Coulon, S., Scaglione, S., Shanahan, P., Takedachi, A., Wohlschlegel, J.A., Yates 3rd, J.R., Llorente, B., Russell, P., Gaillard, P.H.  (2013) Regulation of Mus81-Eme1 Holliday Junction Resolvase in Response to DNA Damage.  Nature Struct. Mol. Biol.  20, 598-603.
  13. Lee, S.Y., Rozenzhak, S., Russell, P.  (2013)  γH2A-Binding Protein Brc1 Affects Centromere Function in Fission Yeast.  Mol. Cell. Biol.  33, 1410-1416.
  14. Rhind, N., Russell, P.  (2012) Signaling pathways that regulate cell division.  Cold Spring Harb. Perspect. Biol.  4, p. 1-15.
  15. Limbo, O., Moiani, D., Kertokalio, A., Wyman, C., Tainer, J.A., Russell, P. (2012) Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair. Nucleic Acids Res40, 11435-11449.
  16. Sánchez, A., Sharma, S., Rozenzhak, S., Roguev, A., Krogan, N.J., Chabes, A., Russell, P. (2012) Replication fork collapse and genome instability in dCMP deaminase mutant. Mol. Cell. Biol. 32 (21):4445-54.
  17. Qu, M., Yang, B.,Tao, L., Yates, J., Russell, P., Dong, M.-Q., Du, L.-L. (2012) Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint. PLoS Genet. 8, e1002817.
  18. Guo L, Ghassemian M, Komives E, Russell P. (2012) Cadmium-induced proteome remodeling regulated by Spc1/Sty1 and Zip1 in fission yeast. Toxicol Sci. 129 (1):200-12.
  19. Langerak, P., Mejia-Ramirez, E., Limbo, O., Russell, P. (2011) Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks. PLoS Genet. 7, e1002271.
  20. Langerak, P., Russell, P. (2011) Regulatory Networks Integrating Cell Cycle Control with DNA Damage Checkpoints and Double-Strand Break Repair. Phil. Trans. R. Soc. B. 366, 3562-3571.
  21. Williams, G.J., Williams, R.S., Williams, J.S., Moncalian, G., Arvai, A., Limbo, O., Guenther, G., SilDas, S., Hammel, M., Russell, P., Tainer, J.A. (2011) ABC ATPase signature helices in Rad50 link its nucleotide state to the Mre11 interface for DNA repair Nature Struct. Mol. Biol. 18, 423-431.
  22. Limbo, O., Porter-Goff, M.E., Rhind, N., Russell, P. (2011) Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks. Mol. Cell. Biol. 31, 573-583.
  23. Matsumoto, S., Shimmoto, M., Kakusho, N., Yokoyama, M. Kanoh, Y., Hayano, M., Russell, P., Masai, H. (2010) Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast. Cell Cycle, 9, 4627-4637.
  24. Tougan, T., Kasama, T., Ohtaka, A., Okusaki, D., Saito, T.T., Russell, P., Nojima, H. (2010) The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe. Cell Cycle, 9, 4688-4702.
  25. Mendoza-Cozatl, D., Zhai, Z., Jobe, T., G.Z., A., Song, W. Y., Limbo, O., Russell, M., Kozlovskyy, V., Martinoia, E., Vatamaniuk, O. K., Russell, P. & Schroeder, J. I. (2010) Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. J. Biol. Chem. 285, 40416-40426.
  26. Cavero, S., Limbo, O., Russell, P. (2010) Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast. PLoS Genetics, 6(9): e1001138.doi:10.1371/journal.pgen.1001138.
  27. Sofueva, S., Du, L.-L., Limbo, O., Williams, J.S., Russell, P. (2010) BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint. Mol. Cell. Biol. 30, 4732-4743.  
  28. Rozenzhak, S., Mejía-Ramírez, E., Williams, J.S., Schaffer, L., Hammond, J.A., Head, S.R., Russell, P. (2010) Rad3ATR decorates critical chromosomal domains with γH2A to protect genome integrity during S-phase in fission yeast. PLoS Genetics, 6: e1001032. doi:10.1371/journal.pgen.1001032.  
  29. Khair, L., Chang, Y., Subramanian,  L., Russell, P., Nakamura,T. M. (2010) Roles of the Checkpoint Sensor Clamp Rad9-Rad1-Hus1 (911)-Complex and the Clamp Loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe Telomere Maintenance. Cell Cycle, 9: 2237-2248.
  30. Dodson, G.E., Limbo, O., Nieto, D., Russell, P. (2010) Phosphorylation regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks. Cell Cycle, 9:1516 - 1522.
  31. Williams, J.S., Williams, R.S., Dovey, C.L., Guenther, G., Tainer, J.A., Russell, P. (2010) γH2A binds Brc1 to maintain genome integrity during S-phase. EMBO J, 29:1136-1148.
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  32. Dovey, C.L., Aslanian, A., Sofueva, S., Yates III, J.R., Russell, P. (2009) Mms1-Mms22 complex protects genomic integrity in Schizosaccharomyces pombe. DNA Repair, 8, 1390-1399.
  33. Williams, R.S., Dodson, G.E., Limbo, O.L., Yamada, Y., Williams, J.S., Grant, G.,  Classen, S., Glover, J.N. M., Iwasaki, H., Russell, P., Tainer, J.A.T. (2009) Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate double-strand break processing and repair. Cell, 139, 87-99.
  34. Shimmoto M, Matsumoto S, Odagiri Y, Noguchi E, Russell P, Masai H. (2009) Interactions between Swi1-Swi3, Mrc1 and S phase kinase, Hsk1 may regulate cellular responses to stalled replication forks in fission yeast. Genes Cells, 14, 669-682.
  35. Fekairi, S., Scaglione, S., Chahwan, C., Taylor, E.R., Tissier, A., Coulon, S., Dong, M.-Q., Ruse, C., Yates III, J.R., Russell, P., Fuchs, R.P., McGowan, C.H., Gaillard. P.-H.L. (2009) Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell, 138, 78-89.
  36. Noguchi, E., Ansbach, A.B., Noguchi, C., Russell, P. (2009) Assays used to study the DNA replication checkpoint in fission yeast. Methods Mol. Biol., 521, 493-507.
  37. Williams, J.S., Hayashi, T., Yanagida, M. Russell, P. (2009) Fission yeast Scm3 mediates stable assembly of Cnp1 (CENP-A) into centromeric chromatin. Molecular Cell, 33:287-299.
  38. Vashisht, A.A., Kennedy, P.J., Russell, P. (2009) Centaurin-Like Protein Cnt5 Contributes Arsenic and Cadmium Resistance in Fission Yeast. FEMS Yeast Res. 9:257-269.
  39. Williams, R.S., Moncalian, G., Williams, J.S., Yamada, Y., Limbo, O., Shin, D.S., Groocock, L.M., Cahill, D., Hitomi, C., Guenther, G., Moiani, D., Carney, J.P., Russell, P., Tainer, J.A. (2008) Mre11 dimers coordinate DNA end bridging and nuclease processing in double strand break repair. Cell, 135, 97-109.
  40. Kennedy, P.J., Vashisht, A.A., Hoe, K.L., Kim, D.U., Park, H.O., Hayles, J., Russell, P. (2008). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe. Toxic. Sci. 6,124-139.
  41. de Bruin, R. A. M., Kalashnikova,T.I., Aslanian, A., Wohlschlegel, J., Chahwan, C., Yates III, J. R., Russell, P., Wittenberg, C. (2008) The DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1. Proc. Natl. Acad. Sci. U.S.A. 105, 11230-11235.
  42. Roseaulin, L., Yamada, Y., Tsutsui, Y., Russell, P., Iwasaki, H., Arcangioli, B. (2008) Mus81 is essential for sister chromatid recombination at broken replication forks. EMBO J. 27, 1378-1387.  
  43. Rodriguez-Gabriel, M.A., Russell, P. (2008) Control of mRNA stability by SAPKs. Topics Curr. Genet. 20, 159-166.
  44. Limbo, O., Chahwan, C., Yamada, Y., de Bruin, R.A.M., Wittenberg, C., Russell, P. (2007) Ctp1 is a cell cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Molecular Cell 28, 134-146.
  45. Martin, V., Du, L.-L., Rozenzhak, S., Russell, P. (2007) Protection of telomeres by a conserved Stn1-Ten1 complex. Proc. Natl. Acad. Sci. U. S. A. 104, 14038-14043.
  46. Dovey, C.L., Russell, P. (2007) Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe. Genetics 177, 47-61.
  47. Cavero, S., Chahwan, C., Russell, P. (2007). Xlf1 is required for DNA repair by nonhomologous end-joining in Schizosaccharomyces pombe. Genetics 175, 963-967.
  48. de Bruin, R.A.M., Kalashnikova, T.I., Chahwan, C., McDonald, W.H., Wohlschlegel, J., Yates III, J.R., Russell, P., Wittenberg, C. (2006). Constraining G1-specific transcription to late G1-phase: The MBF-associated corepressor Nrm1 acts via negative feedback. Molecular Cell 23, 483-496.
  49. Rodríguez-Gabriel, M.A., Watt, S., Bähler, J., Russell, P. (2006). Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast. Mol. Cell. Biol. 26, 6347-6356.  
  50. Du, L.-L., Nakamura, T.M., Russell, P. (2006) Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. Genes Dev. 20, 1583-1596.
  51. Martin, V., Chahwan, C., Gao, H., Blais, V., Wohlschlegel, J., Yates 3rd, J.R., McGowan, C.H., Russell, P. (2006) Sws1 is a conserved regulator of homologous recombination in eukaryotic cells. EMBO J. 25, 2564-2574.
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  52. Coulon, S., Noguchi, E., Du, L.-L., Nakamura, T.M., Russell, P. (2006) Rad22Rad52-dependent repair of ribosomal DNA repeats cleaved by Slx1-Slx4 endonuclease. Mol. Biol. Cell. 17, 2081-2090.
  53. Martín, V., Rodríguez-Gabriel, M.A., McDonald, W. H., Watt, S., Yates 3rd , J.R. Bähler, J., Russell, P. (2006). Cip1 and Cip2 are novel RNA-Recognition-Motif proteins that counteract Csx1 function during oxidative stress. Mol. Biol. Cell. 17, 1176-1183.
  54. Matsumoto, S., Ogino, K., Noguchi, E., Russell, P. Masai, H. (2005) Hsk1-Dfp1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex. J. Biol. Chem. 280, 42536-42542.
  55. Nakamura, T.M., Moser, B. A., Du, L. L., Russell, P. (2005) Cooperative control of Crb2 by ATM-family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast. Mol. Cell. Biol. 25, 10721-10730.
  56. Rodriguez-Gabriel, M.A., Russell, P. (2005) Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe. Eukaryotic Cell. 4, 1396-1402.
  57. You, Z., Chahwan, C., Bailis, J., Hunter, T. Russell, P. (2005) ATM activation and its recruitment to damaged DNA require binding to the C-terminus of Nbs1. Mol. Cell. Biol. 13, 5363-5379.
  58. Kai, M., Boddy, M.N., Russell, P., Wang, T.S.F. (2005) Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress. Genes Dev. 19, 919-932.
  59. Zhao, H. and Russell, P. (2004) DNA binding domain in the replication checkpoint protein Mrc1 of Schizosaccharomyces pombe. J. Biol. Chem. 279, 53023-53027.
  60. McGowan, C.H. and Russell, P. (2004) The DNA damage response: sensing and signaling. Curr. Opin. Cell Biol. 16, 629-633.
  61. Noguchi, E., Noguchi, C., McDonald, W. H., Yates, J. R. 3rd, and Russell, P. (2004) Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol. Cell. Biol. 24, 8342-8355.
  62. Du, L.-L., Moser, Bettina A. and Russell, P. (2004) Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2. J. Biol. Chem. 279, 38409-38414.
  63. Tanaka, K. and Russell, P. (2004) Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1. J. Biol. Chem. 279, 32079-32086.
  64. Nakamura, T.M., Du, L.L., Redon, C. and Russell, P. (2004) Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast. Mol. Cell. Biol. 24, 6215-6230.
  65. Blais, V., Gao, H., Elwell, C.A. Boddy, M.N., Gaillard, P.-H.L., Russell, P. and McGowan, C.H. (2004) RNA interference inhibition of Mus81 reduces mitotic recombination in human cells. Mol. Biol. Cell 15, 552-562.
  66. Coulon, S., Gaillard, P,-H., Chahwan, C., McDonald, W. H., Yates, J. R. 3rd, and Russell, P. (2004) Slx1-Slx4 are subunits of a structure-specific endonuclease that maintains ribosomal DNA in fission yeast. Mol. Biol. Cell 15, 71-80.
  67. Smith, G.R., Boddy, M.N., Shanahan, P., and Russell, P. (2003). Fission yeast Mus81-Eme1 Holliday junction resolvase is required for meiotic crossing over but not for gene conversion. Genetics 165, 2289-2293.
  68. Rodriguez-Gabriel, M.A., Burns, G., McDonald, W.H., Martin, V., Yates, J. Y. 3rd, Bahler, J. and Russell, P. (2003) RNA binding protein Csx1 mediates global control of gene expression in response to oxidative stress. EMBO J. 22, 6256-6266.
  69. Zhao, H., Tanaka, K., Noguchi, E., Noguchi, C., and Russell, P. (2003) Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast. Mol. Cell. Biol. 23, 8395-8403.
  70. Noguchi, E., Noguchi, C., Du, L.L., and Russell, P. (2003) Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1. Mol. Cell. Biol. 23, 7861-7874.
  71. Gaillard, P,-H., Noguchi, E., Shanahan, P., and Russell, P. (2003). The endogenous Mus81-Eme1 complex resolves Holliday Junctions by a nick and counternick mechanism. Molecular Cell 12, 747-759.
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  72. Chahwan, C., Nakamura, T.M., Sivakumar, S., Russell, P., and Rhind, N. (2003) The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint. Mol. Cell. Biol. 23, 6564-6573.
  73. Du, L.L., Nakamura, T.M.,  Moser, B.A. and Russell, P. (2003) Retention but not recruitment of Crb2 at double-strand breaks requires Rad1 and Rad3 complexes. Mol. Cell. Biol. 23, 6150-6158.
  74. Boddy, M. N., Shanahan, P., McDonald, W. H., Lopez-Girona, A., Noguchi, E., Yates, J. Y. 3rd, and Russell, P. (2003) Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Mol. Cell. Biol. 23, 5939-5946.
  75. Nakamura, T., Moser, B. and Russell, P. (2002) Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics, 161, 1437-1452.
  76. Saitoh, S., Chabes, A., McDonald, W. H., Thelander, L., Yates, J. Y. 3rd, and Russell, P. (2002). Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Cell 109, 563-573.
  77. Noguchi, E., Shanahan, P. Noguchi, C., and Russell, P. (2002) CDK phosphorylation of Drc1 regulates DNA replication in fission yeast. Curr. Biol. 12, 599-605.
  78. Boddy, M. N., and Russell, P. (2001). DNA replication checkpoint. Curr. Biol. 11, R953-R956.
  79. Chen, X. B., Melchionna, R., Denis, C. M., Gaillard, P.-H. L., Blasina, A., Van de Meyer, I., Boddy, M. N., Russell, P., Vialard, J., and McGowan, C. H. (2001). Human Mus81 associated endonuclease activity cleaves Holliday junctions in vitro. Molecular Cell 8, 1117-1127.
  80. Boddy, M. N., Gaillard, P.-H. L., McDonald, W. H., Shanahan, P., Yates, J. Y. 3rd, and Russell, P. (2001). Mus81-Eme1 are essential components of a Holliday junction resolvase. Cell 107, 537-548.
  81. Tanaka, K., and Russell, P. (2001). Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1. Nature Cell Biol. 3, 966-972.
  82. Lopez-Girona, A., Tanaka, K., Chen, X. B., Baber-Furnari, B. A., McGowan, C., and Russell, P. (2001). Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast, Proc. Natl. Acad. Sci. U. S. A. 98, 11289-11294.
  83. Tanaka, K., Boddy, M. N., Chen, X. B., McGowan, C., and Russell, P. (2001). Threonine-11, phosphorylated by Rad3 and ATM in vitro, is required for activation of fission yeast checkpoint kinase Cds1. Mol. Cell. Biol. 21, 3398-3404.
  84. Rhind, N. & Russell, P. (2001). The roles of the mitotic inhibitors Wee1 and Mik1 in the G2 DNA damage and replication checkpoints. Mol. Cell. Biol. 21, 1499-1508.
  85. Lopez-Girona, A., Kanoh, J. and Russell, P. (2001). Nuclear exclusion of Cdc25 is not required for DNA damage checkpoint in fission yeast. Curr. Biol. 11, 50-54.
  86. Rhind, N., Baber-Furnari, B. A., Lopez-Girona, A., Boddy, M. N., Brondello, J.-M., Moser, B. A., Shanahan, P., Blasina, A., McGowan, C., and Russell, P. (2000). DNA damage checkpoint control of mitosis in fission yeast. Cold Spring Harbor Symp Quant. Biol. 65, 353-359.
  87. Rhind N, and Russell P. (2000) Checkpoints: It takes more than time to heal some wounds. Curr. Biol. 10, R908-R911.
  88. Moser, B. A., and Russell, P. (2000). Cell cycle regulation in Schizosaccharomyces pombe. Curr. Opin. Microbiol. 3, 631-636.
  89. Boddy, M. N., Lopez-Girona, A., Shanahan, P., Heyer, W.-D., Interthal, H., and Russell, P. (2000). Damage tolerance protein Mus81 associates with FHA1 Domain of checkpoint kinase Cds1. Mol. Cell. Biol. 20, 8758-8766.
  90. Rhind, N., and Russell, P. (2000). Chk1 and Cds1: Linchpins of the DNA damage and replication checkpoint pathways. J. Cell Sci113,3889-3896.
  91. Kanoh, J., and Russell, P. (2000). Slm9, a novel nuclear protein involved in mitotic control in fission yeast. Genetics 155, 623-631.
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  92. Moser, B. A., Brondello, J.-M., Baber-Furnari, B., and Russell, P. (2000). Mechanism of caffeine-induced checkpoint override in fission yeast. Mol. Cell. Biol. 20, 4288-4294.
  93. Kiely, J., Haase, S. B., Russell, P., and Leatherwood, J. (2000). Functions of fission yeast Orp2 in DNA replication and checkpoint control. Genetics 154, 599-607.
  94. Baber-Furnari, B. A., Rhind, N., Boddy, M. N., Shanahan, P., Lopez-Girona, A. and Paul Russell. (2000) Regulation of mitotic inhibitor Mik1 helps to enforce the DNA damage checkpoint. Mol. Biol. Cell 11, 1-11.
  95. Boddy, M. N., and Russell, P. (1999). DNA replication checkpoint control. Front. Biosci. 4, 841-848.
  96. Gaits, F. & Russell, P. (1999). Vacuole fusion regulated by Protein Phosphatase 2C in fission yeast. Mol. Biol. Cell 10, 2647-2654.
  97. Gaits, F., and Russell, P. (1999). Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/Sty1 in fission yeast. Mol. Biol. Cell 10, 1395-1407.
  98. Iacavoni, J., Russell, P., and Gaits, F. (1999). A new inducible protein expression system in fission yeast based on the glucose-repressed inv1 promoter. Gene 232, 53-58.
  99. Brondello, J.-M., Boddy, M. N., Furnari, B., and Russell, P. (1999). Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases. Mol. Cell. Biol. 19, 4262–4269.
  100. Furnari, B., Blasina, A., Boddy, M. N., McGowan, C. H., and Russell, P. (1999). Cdc25 inhibited in vitro and in vivo by checkpoint kinases Cds1 and Chk1. Mol. Biol. Cell 10, 833-845.
  101. Lopez-Girona, A., Furnari, B., Mondesert, O., and Russell, P. (1999) Nuclear localization of Cdc25 regulated by DNA damage and 14-3-3 protein. Nature, 397, 172-175.
  102. Shiozaki, K., Shiozaki, M. and Russell, P. (1998). Heat stress activates fission yeast Spc1/Sty1 MAPK by a MEKK-independent mechanism. Mol. Biol. Cell 9, 1339-1349.
  103. Russell, P. (1998). Checkpoints on the road to mitosis. Trends Biochem. Sci. 24, 309-402.
  104. Rhind, N., and Russell, P. (1998). The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage. Genetics 149, 1729-1737.
  105. Rhind, N., and Russell, P. (1998). Mitotic DNA damage and replication checkpoints in yeast. Curr. Opin. Cell Biol. 10, 749-758.
  106. Rhind, N. and Russell, P. (1998). Cdc2 activation is inhibited by tyrosine phosphorylation during a replication checkpoint in Schizosaccharomyces pombe. Mol. Cell. Biol. 18, 3782-3787.
  107. Lopez-Girona, A., Mondesert, O., Leatherwood, J. and Russell, P. (1998). Negative regulation of Cdc18 DNA replication protein by Cdc2 kinase. Mol. Biol. Cell 9, 63-73.
  108. Kanoh, J., and Russell, P. (1998). The protein kinase Cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast. Mol. Biol. Cell 9, 3321-3334.
  109. Gaits, F., Degols, G., Shiozaki, K. and Russell, P. (1998). Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1 stress-activated kinase in fission yeast. Genes Dev. 12, 1464-1473.
  110. Boddy, M., Furnari, B., Mondesert, O. and Russell, P. (1998). Replication checkpoint enforced by kinases Cds1 and Chk1. Science 280, 909-912.
  111. Wu, L. and Russell, P. (1997). Roles of Wee1 and Nim1 protein kinases in regulating the switch from mitotic division to sexual development in Schizosaccharomyces pombe. Mol. Cell. Biol. 17, 10-17.
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  112. Wu, L. and Russell, P. (1997). Nif1, a novel mitotic inhibitor in Schizosaccharomyces pombe. EMBO J. 16, 1342-1350.
  113. Shiozaki, K., Shiozaki, M. and Russell, P. (1997). Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade. Mol. Biol. Cell 8, 409-419.
  114. Shiozaki, K. and Russell, P. (1997). Stress-activated protein kinase pathway in  cell cycle control of fission yeast. Meth. Enz. 283, 506-520.
  115. Shiozaki, K. and Russell, P. (1997). Expression, purification and analyses of cell-cycle regulatory proteins in S. pombe. In Foreign Gene Expression in Fission Yeast Schizosaccharomyces pombe, Y. Giga-Hama and H. Kumagai, ed. (Austin: Landes Bioscience), 133-148.
  116. Furnari, B., Rhind, N. and Russell, P. (1997). Cdc25 phosphatase targeted by Chk1 checkpoint kinase. Science 277, 1495-1497.
  117. Gaits, F., Shiozaki, K. and Russell, P. (1997). Protein phosphatase 2C acts independently of stress-activated kinase cascade to regulate the stress response in fission yeast. J. Biol. Chem. 272, 17873-17879.
  118. Furnari, B. A., Russell, P. and Leatherwood, J. (1997). pch1, a second essential C-type cyclin in Schizosaccharomyces pombe. J. Biol. Chem. 272, 12100-12106.
  119. Rhind, N., Furnari, B. and Russell, P. (1997). Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast. Genes Dev. 11, 504-511.
  120. Degols, G. and Russell, P. (1997). Discrete roles of Spc1 kinase and Atf1 transcription factor in the UV response of Schizosaccharomyces pombe. Mol. Cell. Biol. 17, 3356-3363.
  121. Aligue, R., Wu, L. and Russell, P. (1997). Regulation of Schizosaccharomyces pombe Wee1 tyrosine kinase. J. Biol. Chem. 272, 13320-13325.
  122. Wu, L., Shiozaki, K., Aligue, R. and Russell, P. (1996). Spatial organization of the Nim1-Wee1-Cdc2 mitotic control network in Schizosaccharomyces pombe. Mol. Biol. Cell 7, 1749-1758.
  123. Shiozaki, K. and Russell, P. (1996). Conjugation, meiosis and the osmotic stress response are regulated by Spc1 kinase via Atf1 transcription factor in fission yeast. Genes Dev. 10, 2276-2288.
  124. Mondesert, O., McGowan, C. H. and Russell, P. (1996). Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe. Mol. Cell. Biol. 16, 1527-1533.
  125. Leatherwood, J., Lopez-Girona, A. and Russell, P. (1996). Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein. Nature 379, 360-364.
  126. Kovelman, R. and Russell, P. (1996). Stockpiling of Cdc25 during a DNA replication checkpoint arrest in Schizosaccharomyces pombe. Mol. Cell. Biol. 16, 86-93.
  127. Degols, G., Shiozaki, K. and Russell, P. (1996). Activation and regulation of Spc1 stress-activated protein kinase in Schiozosaccharomyces pombe. Mol. Cell. Biol. 16, 2870-2877.
  128. Zhang, Z.-Y., Zhou, G., Denu, D. M., Wu, L., Tang, X., Mondesert, O., Russell, P., Butch, E. and Guan, K.-L. (1995). Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from the fission yeast Schizosaccharomyces pombe. Biochem. 34, 10560-10568.
  129. Shiozaki, K. and Russell, P. (1995). Multiple type 2C protein phosphatase genes functioning in fission yeast signal transduction cascades. Adv. Prot. Phosphatases 9, 249-262.
  130. Shiozaki, K. and Russell, P. (1995). Counteractive roles of protein phosphatase 2C and a MAP kinase kinase homolog in the osmoregulation of fission yeast. EMBO J. 14, 492-502.
  131. Shiozaki, K. and Russell, P. (1995). Cell-cycle control linked to the extracellular environment by MAP kinase pathway in fission yeast. Nature 378, 739-743.
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  132. McGowan, C. H. and Russell, P. (1995). Cell cycle regulation of human WEE1. EMBO J. 14, 2166-2175.
  133. Buck, V., Russell, P. and Millar, J. B. A. (1995). Identification of a cdk-activating kinase in fission yeast. EMBO J. 14, 6173-6183.
  134. Tang, C. S. L., Bueno, A. and Russell, P. (1994). ntf1 encodes a Cys6 zinc finger transcription factor that regulates the nmt1 promoter in fission yeast. J. Biol. Chem. 269, 11921-11926.
  135. Tainer, J. and Russell, P. (1994). Cracking tyrosine phosphatases (News and Views). Nature 370, 506-507.
  136. Shiozaki, K. and Russell, P. (1994). Cellular function of protein phosphatase 2C in yeast. Cell Mol. Biol. Res. 40, 241-243.
  137. Shiozaki, K., Akhavan-Niaki, H., McGowan, C. H. and Russell, P. (1994). Protein phosphatase 2C encoded by ptc1+ is important in the heat shock response of fission yeast. Mol. Cell. Biol. 14, 3743-3751.
  138. Mondesert, O., Moreno, S. and Russell, P. (1994). Low Mr protein-tyrosine phosphatases are highly conserved between fission yeast and man. J. Biol. Chem. 269, 27966-27999.
  139. Aligue, R., Akhavan-Niaki, H. and Russell, P. (1994). A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90. EMBO J. 13, 6099-6106.
  140. Wu, L. and Russell, P. (1993). Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase. Nature 363, 738-741.
  141. McGowan, C. H. and Russell, P. (1993). Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. EMBO J. 12, 75-85.
  142. Bueno, A. and Russell, P. (1993). Two fission yeast B-type cyclins, Cig2 and Cdc13, have different functions in mitosis. Mol. Cell. Biol. 13, 2286-2297.
  143. Seki, T., Yamashita, K., Nishitani, H., Russell, P., Takagi, T. and Nishimoto, T. (1992). Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm. Mol. Biol. Cell 3, 1373-1388.
  144. Millar, J. B. A., Russell, P., Dixon, J. E. and Guan, K. L. (1992). Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast. EMBO J. 11, 4943-4952.
  145. Millar, J. B. A. and Russell, P. (1992). The cdc25 M-phase inducer: An unconventional protein phosphatase. Cell 68, 407-410.
  146. Millar, J. B. A., Lenaers, G. and Russell, P. (1992). Pyp3 PTPase acts as a mitotic inducer in fission yeast. EMBO J. 11, 4933-4941.
  147. Millar, J. B. A., Lenaers, G., McGowan, C. H. and Russell, P. (1992). MPF activation in fission yeast. Regulation of the Eukaryotic Cell Cycle, London, England, The Ciba Foundation.
  148. Girard, F., Strausfeld, U., Cavadore, J.-C., Russell, P., Fernandez, A. and Lamb, N. J. C. (1992). cdc25 is a nuclear protein expressed constitutively throughout the cell cycle in nontransformed mammalian cells. J. Cell. Biol. 118, 785-794.
  149. Bueno, A. and Russell, P. (1992). Dual functions of CDC6, a yeast protein required for DNA replication also inhibits nuclear division. EMBO J. 11, 2167-2176.
  150. Millar, J. B. A., McGowan, C. H., Lenaers, G., Jones, R. and Russell, P. (1991). p80cdc25 mitotic inducer is the tyrosine phosphatase that activates G2-phase p34cdc2 kinase in fission yeast. EMBO J. 10, 4301-4309.
  151. Strausfeld, U., Labbe, J. C., Fesquet, D., Cavadore, J. C., Picard, A., Sadhu, K., Russell, P. and Doree, M. (1991). Dephosphorylation and activation of a p34cdc2 /cyclin B complex in vitro by human CDC25 protein. Nature 351, 242-245.
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  152. Millar, J. B. A., McGowan, C., Bueno, A., Sadhu, K., Jones, R., Richardson, H. and Russell, P. (1991). cdc25 M-phase inducer. Cold Spring Harbor Symp. Quant. Biol. 56, 577-584.
  153. Millar, J. B. A., Blevitt, J., Gerace, L., Sadhu, K., Featherstone, C. and Russell, P. (1991). p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells. Proc. Natl. Acad. Sci. USA 88, 10500-10504.
  154. Milarski, K. L., Dunphy, W. G., Russell, P., Gould, S. J. and Newport, J. W. (1991). Cloning and characterization of Xenopus cdc2, a component of MPF. Cold Spring Harbor Symp. Quant. Biol. 56, 377-384.
  155. Featherstone, C. and Russell, P. (1991). Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase. Nature 349, 808-811.
  156. Bueno, A., Richardson, H., Reed, S. I. and Russell, P. (1991). A fission yeast B-type cyclin functioning early in the cell cycle. Cell 66, 149-159.
  157. Sadhu, K., Reed, S. I., Richardson, H. and Russell, P. (1990). Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Proc. Natl. Acad. Sci. U. S. A. 87, 5139-5143.
  158. Richardson, H. E., Stueland, C. S., Thomas, J., Russell, P. and Reed, S. I. (1990). Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. Genes Dev 4, 1332-44.
  159. Moreno, S., Nurse, P. and Russell, P. (1990). Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast. Nature 344, 549-552.
  160. McGowan, C., Russell, P. and Reed, S. I. (1990). Periodic biosynthesis of the human M-phase promoting factor catalytic subunit p34 during the cell cycle. Mol. Cell. Biol. 10, 3847-3851.
  161. Russell, P. (1989). Gene cloning and expression in fission yeast. in Molecular Biology of the Fission Yeast. Nasim, A., Young, P., and Johnson, B. F., eds. Academic Press, San Diego, pp. 243-271.
  162. Russell, P., Moreno, S. and Reed, S. I. (1989). Conservation of mitotic controls in fission and budding yeasts. Cell 57, 295-303.
  163. Russell, P. and Nurse, P. (1987). The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. Cell 49, 569-576.
  164. Russell, P. and Nurse, P. (1987). Negative regulation of mitosis by wee1, a gene encoding a protein kinase homolog. Cell 49, 559-567.
  165. Russell, P. and Nurse, P. (1986). Schizosaccharomyces pombe and Saccharomyces cerevisiae: A look at yeasts divided. Cell 45, 781-782.
  166. Russell, P. and Nurse, P. (1986). cdc25 functions as an inducer in the mitotic control of fission yeast. Cell 45, 145-153.
  167. Russell, P. (1985). Transcription of the triose-phosphate-isomerase gene of Schizosaccharomyces pombe initiates from a start point different from that in Saccharomyces cerevisiae. Gene 40, 125-130.
  168. Russell, P. (1983). Evolutionary divergence of the mRNA transcription initiation mechanism in yeast. Nature 301, 167-169.
  169. Russell, P. and Hall, B. D. (1983). The primary structure of the alcohol dehydrogenase gene from the fission yeast Schizosaccharomyces pombe. J. Biol. Chem. 258, 143-149.
  170. Russell, P. and Hall, B. D. (1982). Structure of the Schizosaccharomyces pombe cytochrome c gene. Mol. Cell. Biol. 2, 106-116.


Underlined authors contributed equally.


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