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The Ruf Laboratory


The Ruf laboratory is focused on vascular and cancer biology, in particular on protease pathways in thrombosis, inflammation, angiogenesis and tumor progression. Recent focus is on non-coagulant, signaling roles of the coagulation cascade, on signaling specificity of protease activated receptors and on the application of genomic approaches and animal models to study those pathways.

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Recent overview articles:

Ruf, W., Dorfleutner, A., Riewald, M. Specificity of coagulation factor signaling. J. Thromb. Haemost. 1:1495-1503, 2003. (Link to full text article.)

Ruf, W. Emerging roles of tissue factor in viral hemorrhagic fever. Trends Immunol 25:461-464, 2004. (Link to PubMed Abstract.)

Belting, M., Ahamed, J., Ruf, W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arteriocler. Thromb. Vasc. Biol. 25:1545-1550, 2005. (Link to full text article.)