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Publications

  1. Aarde, S. M.; Huang, P.-K.; Creehan, K. M.; Dickerson, T. J.; Taffe, M. A. The novel recreational drug 3,4-methylenedioxypyrovalerone (MDPV) is a potent psychomotor stimulant: self-administration and locomotor activity in rats. Neuropsychopharmacology, submitted.
  2. Aarde, S. M.; Angrish, D.; Barlow, D. J.; Wright, M. J.; Vanderwater, S. A.; Creehan, K. M.; Houseknecht, K. L.; Dickerson, T. J.; Taffe, M. A. Mephedrone (4-methylmethcathinone) supports intravenous self-administration in Sprague-Dawley and Wistar rats. Addict. Biol., submitted.
  3. Sakamuri, R. M.; Čapek, P.; Dickerson, T. J.; Barry, C. E. III; Mukundan, H.; Swanson, B. I. Detection of stealthy small amphiphilic biomarkers. Tuberculosis, submitted.
  4. Čapek, P.; McBride, N.; Dona, V.; Angrish, D.; Saccavini, C.; Tahlan, K.; Jiang, B. G.; Boschoff, H. I.; Barry, C. E. III; Dickerson, T. J. Revisiting the total synthesis of mycobactins: Synthetic revision and biological validation. ACS Chem. Biol., submitted. 
  5. Miller, M. L.; Creehan. K. M.; Angrish, D.; Barlow, D. J.; Houseknecht, K. L.; Dickerson, T. J.; Taffe, M. A. Changes in ambient temperature differentially alter the thermoregulatory, cardiac and locomotor stimulant effects of 4-methylmethcathinone (mephedrone). Drug Alcohol Depend. 2012, in press.
  6. Wright, M. J.; Vandewater, S. A.; Angrish, D.; Dickerson, T. J.; Taffe, M. A. Mephedrone (4-methylmethcathinone) and d-methamphetamine improve visuo-spatial associative memory, but not spatial working memory, in rhesus macaques. Brit. J. Pharmacol., 2012, in press.
  7. Huang, P.-K.; Aarde, S. A.; Angrish, D.; Houseknecht, K. L.; Dickerson, T. J.; Taffe, M. A. Contrasting effects of d-methamphetamine, 3,4-methylenedioxymethamphetamine, 3,4- methylenedioxypyrovalerone, and 4-methylmethcathinone on wheel activity in rats. Drug Alcohol Depend. 2012, in press.
  8. Wright, M. J.; Angrish, D.; Aarde, S. A.; Creehan, K. M.; Vandewater, S. A.; Dickerson, T. J.; Taffe, M. A. Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone (mephedrone) in Wistar and Sprague-Dawley rats. PLOS ONE 2012, 7, e44652.
  9. Smith, G. R.; Caglič, D.; Čapek, P.; Zhang, Y.; Godbole, S.; Reitz, A. B.; Dickerson, T. J. Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: Extending towards the b-exosite. Bioorg. Med. Chem. Lett. 2012, 11, 3754-3757.
  10. Caglič, D.; Dickerson, T. J. A coincidence detector triggers botulinum neurotoxin translocation. Future Microbiol. 2012, 7, 185-188.
  11. Čapek, P.; Zhang, Y.; Barlow, D. J.; Houseknecht, K. L.; Smith, G. R.; Dickerson, T. J. Enhancing the pharmacokinetic properties of botulinum neurotoxin serotype A protease inhibitors through rational design. ACS Chem. Neurosci. 2011, 2, 288-293.
  12. Denery, J. R.; Nunes, A. A. K.; Dickerson, T. J. Characterization of differences between blood sample matrices in untargeted metabolomics. Anal. Chem. 2011, 83, 1040-1047.
  13. Čapek, P.; Kirkconnell, K. S.; Dickerson, T. J. A bacteriophage-based platform for rapid trace detection of proteases. J. Am. Chem. Soc. 2010, 132, 13126-13128.
  14. Denery, J. R.; Nunes, A. A. K.; Hixon, M.; Dickerson, T. J.; Janda, K. D. Mass spectrometry based metabolomics: Discovery of diagnostic biomarkers for onchocerciasis. PLoS Negl. Trop. Dis. 2010, 4, e834.
  15. Moreno, A. Y.; Azar, M. R.; Warren, N. A.; Dickerson, T. J.; Koob, G. F.; Janda, K. D. A critical evaluation of a nicotine vaccine within a self-administration behavioral model. Mol. Pharmaceutics 2010, 7, 431-441.
  16. Čapek, P.; Dickerson, T. J. Sensing the deadliest toxin: Technologies for botulinum neurotoxin detection. Toxins, 2010, 2, 24-53. (for “Neurotoxins of Biological Origin” special issue)
  17. Frederick, M. O.; De Lamo Marin, S.; Janda, K. D.; Nicolaou, K. C.; Dickerson, T. J. Monoclonal antibodies with orthogonal azaspiracid epitopes. ChemBioChem 2009, 10, 1625-1629.
  18. Treweek, J. T.; Dickerson, T. J.; Janda, K. D. Drugs of abuse that mediate advanced glycation endproduct formation: A chemical link to disease pathology. Acc. Chem. Res. 2009, 42, 659-696.
  19. Fischer A.; Nakai, Y.; Eubanks, L. M.; Clancy, C. M.; Tepp, W. H.; Pellett, S.; Dickerson, T. J.; Johnson, E. A.; Janda, K. D.; Montal, M. Bimodal modulation of the botulinum neurotoxin protein-conducting channel. Proc. Natl. Acad. Sci. USA 2009, 106, 1330-1335.
    Featured as an Editor’s Choice in Science 2009, 323, 689.
  20. Nakai, Y.; Tepp, W. H.; Dickerson, T. J.; Johnson, E. A.; Janda, K. D. Function-oriented synthesis applied to the anti-botulinum natural product toosendanin. Bioorg. Med. Chem. 2009, 17, 1152-1157.
  21. Rohrbach, A. S.; Dickerson, T. J. Predicting protein evolution in vitro by phage escape technology. Mol. BioSyst. 2009, 5, 128-133.
  22. Treweek, J. B.; Sun, C.; Mayorov, A. V.; Qi, L.; Levy, C. L.; Roberts, A. J.; Dickerson, T. J.; Janda, K. D. Prevention of drug-induced memory impairment by immunopharmacotherapy. J. Med. Chem. 2008, 51, 6866-6875.
  23. Willis, B.; Eubanks, L. M.; Dickerson, T. J.; Janda, K. D. The strange case of botulinum neurotoxin:  Using chemistry and biology to modulate the most deadly poison. Angew. Chem. Intl. Ed. 2008, 47, 8360-8379.
  24. Park, J.; Dickerson, T. J.; Janda, K. D. Major sperm protein as a diagnostic antigen for onchocerciasis. Bioorg. Med. Chem. 2008, 16, 7206-7209.
  25. Lowery, C. A.; Dickerson, T. J.; Janda, K. D. Interspecies and interkingdom communication mediated by bacterial quorum sensing. Chem. Soc. Rev. 2008, 37, 1337-1346.
  26. Willis, B.; Eubanks, L. M.; Wood, M. R.; Janda, K. D.; Dickerson, T. J.; Lerner, R. A. Biologically templated organic polymers with nanoscale order. Proc. Natl. Acad. Sci. USA 2008, 105, 1416-1419.
  27. Eubanks, L. M.; Dickerson, T. J. Investigating novel therapeutic targets and molecular mechanisms to treat botulinum neurotoxin A intoxication. Future Microbiol. 2007, 2, 677-687.
  28. Brogan, A. P.; Dickerson, T. J.; Janda, K. D. Nornicotine-organocatalyzed aqueous reduction of a,b-unsaturated aldehydes. Chem. Commun. 2007, 4952-4954.
  29. Čapková, K.; Yoneda, Y.; Dickerson, T. J.; Janda, K. D. Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors. Bioorg. Med. Chem. Lett. 2007, 17, 6463-6466.
  30. Yao, Y.; Dickerson, T. J.; Hixon, M. S.; Dyson, H. J. NMR detection of adventitious binding of xylose to the quorum-sensing protein SdiA of Escherichia coli. Bioorg. Med. Chem. Lett. 2007, 17, 6202-6205.
  31. Dickerson, T. J.; McKenzie, K. M.; Hoyt, A. S.; Wood, M. R.; Janda, K. D.; Brenner, S.; Lerner, R. A. Phage escape libraries for checkmate analysis. Proc. Natl. Acad. Sci. USA 2007, 104, 12703-12708.
    Featured as a Research Highlight in Nature, 2007, 448, 390.
    Featured as a Research Highlight in Nature Methods 2007, 4, 686.
  32. Treweek, J. B.; Wee, S.; Koob, G. F.; Dickerson, T. J.; Janda, K. D. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease. Proc. Natl. Acad. Sci. USA, 2007, 104, 11580-11584.
  33. Ino, A.; Dickerson, T. J.; Janda, K. D. Positional linker effects in haptens for cocaine immunopharmacotherapy. Bioorg. Med. Chem. Lett. 2007, 17, 4280-4283.
  34. Brogan, A. P.; Eubanks, L. M.; Koob, G. F.; Dickerson, T. J.; Janda, K. D. Antibody-catalyzed oxidation of D9-tetrahydrocannabinol. J. Am. Chem. Soc. 2007, 129, 3698-3702.
  35. Eubanks, L. M.; Hixon, M. S.; Jin, W.; Hong, S.; Clancy, C. M.; Tepp, W. H.; Baldwin, M. R.; Malizio, C. J.; Goodnough, M. C.; Barbieri, J. T.; Johnson, E. A.; Boger, D. L.; Dickerson, T. J.; Janda, K. D. An in vitro and in vivo disconnect uncovered through high throughput identification of botulinum neurotoxin A antagonists. Proc. Natl. Acad. Sci. USA 2007, 104, 2602-2607.
    Featured as a Science Concentrate in Chemical & Engineering News, 2007, 85, 69.
  36. Eubanks, L. M.; Dickerson, T. J.; Janda, K. D. Technological advancements for the detection of and protection against biological and chemical warfare agents. Chem. Soc. Rev. 2007, 36, 458-470.
    Graphic selected for the cover of Chem. Soc. Rev.
  37. Brogan, A. P.; Dickerson, T. J.; Janda, K. D. Catalytic antibodies:  Past, present, and future. In:  Wiley Encyclopedia of Chemical Biology; Wiley: New York, 2009, pp 236-253.
  38. Brogan, A. P.; Dickerson, T. J.; Janda, K. D. Enamine-based aldol organocatalysis in water:  Are they really “all wet”? Angew. Chem. Intl. Ed. 2006, 45, 8100-8102.
  39. Eubanks, L. M.; Rogers, C. J.; Beuscher, A. E. IV; Koob, G. F.; Olson, A. J.; Dickerson, T. J.; Janda, K. D. A molecular link between the active component of marijuana and Alzheimer’s disease pathology. Mol. Pharmaceutics 2006, 3, 773-777.
    Most accessed article in Mol. Pharmaceutics July 2006-December 2007
    Selected for press release by American Chemical Society (“Marijuana's active ingredient may slow progression of Alzheimer's disease”)
  40. Rogers, C. J.; Eubanks, L. M.; Dickerson, T. J.; Janda, K. D. Unexpected acetylcholinesterase activity of cocaine esterases. J. Am. Chem. Soc. 2006, 128, 15364-15365.
  41. Kaufmann, G. F.; Sartorio, R.; Lee, S.-H.; Rogers, C. J.; Moss, J. A.; Meijler, M. M.; Clapham, B.; Brogan, A. P.; Dickerson, T. J.; Janda, K. D. Discovering additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. In: Understanding Biology Using Peptides. Proceedings of the 19th American Peptide Symposium, Blondelle, S. E., Ed.; Springer: New York, 2006, pp. 252-254.
  42. Dickerson, T. J.; Janda, K. D. The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication. ACS Chem. Biol. 2006, 1, 359-369.
  43. Dickerson, T. J. Combinatorial Chemistry and Technologies: Methods and Applications, 2nd Edition Edited by Giorgio Fassina (XEPTAGEN S.p.A., Pozzuoli, Italy) and Stanislav Miertus (University of Trieste, Italy). CRC Press (an imprint of Taylor and Francis). J. Am. Chem. Soc. 2006, 128, 8365-8366. (Book Review)
  44. McAllister, L. A.; Hixon, M. S.; Kennedy, J. P.; Dickerson, T. J.; Janda, K. D. Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease:  A new wrinkle in botulinum neurotoxin. J. Am. Chem. Soc. 2006, 128, 4176-4177.
    Selected for press release by American Chemical Society (“New ‘wrinkle’ in Botox treatment could lead to lower doses, better safety”)
  45. Boldt, G. E.; Dickerson, T. J.; Janda, K. D. Emerging chemical and biological approaches for the preparation of discovery libraries. Drug Discov. Today 2006, 11, 143-148.
  46. Zhu, X.; Dickerson, T. J.; Rogers, C. J.; Kaufmann, G. F.; Mee, J. M.; Janda, K. D.; Wilson, I. A. Complete reaction cycle of a cocaine catalytic antibody at atomic resolution. Structure 2006, 14, 205-216.
    Featured in NIH NIGMS Biomedical Beat
  47. Rogers, C. J.; Dickerson, T. J.; Janda, K. D. Kinetic isotope and thermodynamic analysis of the nornicotine catalyzed aqueous aldol reaction. Tetrahedron 2006, 2-3, 352-356. (for Organocatalysis Symposium-in-Print)
  48. Yao, Y.; Martinez-Yamout, M.; Dickerson, T. J.; Brogan, A. P.; Wright, P. E.; Dyson, H. J. Homoserine lactone “folding switches” for the Escherichia coli quorum sensing protein SdiA. J. Mol. Biol. 2006, 355, 262-273.
  49. Rogers, C. J.; Dickerson, T. J.; Wentworth, P., Jr.; Janda, K. D. A high-swelling reagent scaffold suitable for use in aqueous and organic media. Tetrahedron 2005, 61, 12140-12144 (for Polymeric Reagents and Catalysts Symposium-in-Print)
  50. Shute, T. S.; Matsushita, M.; Dickerson, T. J.; La Clair, J. J.; Janda, K. D.; Burkart, M. D. A site-specific bifunctional protein labeling system for affinity and fluorescent analysis. Bioconjug. Chem. 2005, 16, 1352-1355.
  51. Eubanks, L. M.; Dickerson, T. J.; Janda, K. D. Vitamin B2-mediated cellular photoinhibition of botulinum neurotoxin A. FEBS Lett. 2005, 579, 5361-5364.
  52. Dickerson, T. J.; Beuscher, A. E. IV; Rogers, C. J.; Hixon, M. S.; Yamamoto, N.; Xu, Y.; Olson, A. J.; Janda, K. D. Discovery of acetylcholinesterase ligands through computational refinement of a directed library. Biochemistry 2005, 44, 14845-14853.
  53. Brogan, A. P.; Dickerson, T. J.; Boldt, G. E.; Janda, K. D. Altered retinoid homeostasis catalyzed by a nicotine metabolite:  Implications in macular degeneration and normal development. Proc. Natl. Acad. Sci. USA 2005, 102, 10433-10438.
  54. Rogers, C. J.; Mee, J. M.; Kaufmann, G. F.; Dickerson, T. J.; Janda, K. D. Towards cocaine esterase therapeutics. J. Am. Chem. Soc. 2005, 127, 10016-10017.
  55. Dickerson, T. J.; Kaufmann, G. F.; Janda, K. D. Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy. Expert Opin. Biol. Ther. 2005, 5, 773-791.
  56. Rogers, C. J.; Dickerson, T. J.; Brogan, A. P.; Janda, K. D. Hammett correlation of nornicotine analogs in the aqueous aldol reaction: Implications for green organocatalysis. J. Org. Chem. 2005, 70, 3705-3708.
  57. Reed, N. N.; Dickerson, T. J.; Boldt, G. E.; Janda, K. D. Enantioreversal in the Sharpless asymmetric epoxidation reaction controlled by the molecular weight of a covalently appended achiral polymer. J. Org. Chem. 2005, 70, 1728-1731.
  58. Kaufmann, G. F.; Sartorio, R.; Lee, S.-H.; Rogers, C. J.; Moss, J. A.; Meijler, M. M.; Clapham, B.; Brogan, A. P.; Dickerson, T. J.; Janda, K. D. Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. Proc. Natl. Acad. Sci. USA 2005, 102, 309-314.
    Featured in Chemical & Engineering News, 2005, 83, 38.
    Featured in Nature Rev. Microbiology 2005, 3, 192.
  59. Dickerson, T. J.; Reed, N. N.; La Clair, J. J.; Janda, K. D. A precipitator for the detection of thiophilic metals in aqua. J. Am. Chem. Soc. 2004, 126, 16582-16586.
  60. Dickerson, T. J.; Lovell, T.; Meijler, M. M.; Noodleman, L.; Janda, K. D. Nornicotine aqueous aldol reactions:  Synthetic and theoretical investigations into the origins of catalysis. J. Org. Chem. 2004, 69, 6603-6609.
  61. Dickerson, T. J.; Yamamoto, N.; Ruiz, D.; Janda, K. D. Immunological consequences of methamphetamine protein glycation. J. Am. Chem. Soc. 2004, 126, 11446-11447.
    Selected for press release by American Chemical Society (“Chemists identify immune system mechanism for methamphetamine binges”)
  62. Dickerson, T. J.; Yamamoto, N.; Janda, K. D. Antibody-catalyzed oxidative degradation of nicotine by riboflavin. Bioorg. Med. Chem. 2004, 12, 4981-4987.
  63. McDunn, J. E.; Dickerson, T. J.; Janda, K. D. Antibody catalysis of disfavored chemical reactions. Chapter 7 in: Catalytic Antibodies, Keinan, E., Ed.; Wiley: New York, 2004, pp. 184-216.
  64. Dickerson, T. J.; Tremblay, M. R.; Hoffman, T. Z.; Ruiz, D. I.; Janda, K. D. Catalysis of the photo-Fries reaction:  Antibody-mediated stabilization of high energy states. J. Am. Chem. Soc. 2003, 125, 15395-15401.
  65. Dickerson, T. J.; Janda, K. D. Glycation of the amyloid b-protein by a nicotine metabolite:  A fortuitous chemical dynamic between smoking and Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 2003, 100, 8182-8187.
    Featured on Scientific American.com, June 17, 2003.
    Featured in Chemical & Engineering News, 2003, 81, 38.
    Featured in The Economist, June 19, 2003.
    Featured in Nature Rev. Drug Disc. 2003, 2, 690.
  66. Gambs, C.; Dickerson, T. J.; Mahajan, S.; Pasternack, L. B.; Janda, K. D. High resolution diffusion ordered spectroscopy to probe the microenvironment of JandaJelTM and Merrifield resins. J. Org. Chem. 2003, 68, 3673-3678.
  67. Dickerson, T. J.; Reed, N. N.; Janda, K. D. Soluble polymers as catalyst & reagent platforms:  Liquid-phase methodologies. Chapter 5 in: Polymeric Materials in Organic Synthesis and Catalysis, Buchmeiser, M. R., Ed.; Wiley: New York, 2003, pp. 241-276.
  68. Dickerson, T. J.; Cordova, A.; Chen, D.-W.; Janda, K. D. The use of enzymes and catalytic antibodies in the asymmetric aldol reaction. In: Encyclopedia of Catalysis, ed. I. T. Horvath, Wiley, N.Y., 2003.
  69. Dickerson, T. J.; Janda, K. D. A previously undescribed chemical link between smoking and metabolic disease. Proc. Natl. Acad. Sci. USA 2002, 99, 15084-15088.
    Featured on BBC News, October 29, 2002.
    Featured on Scientific American.com, October 30, 2002.
    Featured in U.S. News and World Reports, November 11, 2002.
    Featured in Environmental Health Perspectives, 2003, 111 (NIH Publication)
  70. Dickerson, T. J.; Reed, N. N.; Janda, K. D. Soluble polymers as scaffolds for recoverable reagents and catalysts. Chem. Rev. 2002, 102, 3325-3344.
  71. Dickerson, T. J.; Janda, K. D. Aqueous aldol catalysis by a nicotine metabolite. J. Am. Chem. Soc. 2002, 124, 3220-3221.
    Featured as a Science Concentrate in Chemical & Engineering News, 2002, 80, 52.
    Featured as an Editor’s Choice in Science 2002, 296, 15.
  72. Moss, J. A.; Dickerson T. J.; Janda, K. D. Solid phase peptide synthesis on JandaJel™ resin. Tetrahedron Lett. 2002, 43, 37-40.
  73. Tremblay, M. R.; Dickerson, T. J.; Janda, K. D. Advances in antibody catalysis of cycloaddition reactions. Adv. Synth. Catal. 2001, 6/7, 577-585.
  74. Dickerson, T. J.; Reed, N. N.; Janda, K. D. Regio-reactive resin: A platform for orthogonal loading on the polymer backbone and cross-linker. Bioorg. Med. Chem. Lett. 2001, 11, 1507-1509.

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