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Publications

64. Ho PT, Reddy VS. Rapid increase of near atomic resolution virus capsid structures determined by cryo-electron microscopy. Journal of structural biology, doi: 10.1016/j.jsb.2017.10.007. PubMed PMID: 29080674 (2017).

63. Wagner C, Reddy V, Asturias F, Khoshouei M, Johnson JE, Manrique P, Munson-McGee J, Baumeister W, Lawrence CM, Young MJ. Isolation and Characterization of Metallosphaera turreted icosahedral virus (MTIV), a founding member of a new family of archaeal viruses. J Virol, doi:10.1128/JVI.00925-17 (2017).

62. V. S. Reddy, The Role of Hexon Protein as a Molecular Mold in Patterning the Protein IX Organization in Human Adenoviruses. J Mol Biol 429, 2747-2751 (2017).

61. Yu, X., Veesler, D., Campbell, M., Barry, M.E., Asturias, F., Barry, M.A. and Reddy, V.S. Cryo-EM structure of human adenovirus D26 reveals the conservation of structural organization among human adenoviruses. Sci. Adv. 3, e1602670 (2017).

60. Snijder J, Borst AJ, Dosey A, Walls AC, Burrell A, Reddy VS, Kollman JM, Veesler D. Vitrification after multiple rounds of sample application and blotting improves particle density on cryo-electron microscopy grids. Journal of structural biology 198, 38-42 (2017).

59. D. J. Montiel-Garcia, R. V. Mannige, V. S. Reddy, M. Carrillo-Tripp, Structure based sequence analysis of viral and cellular protein assemblies. Journal of structural biology 196, 299-308 (2016).

58. Huynh, N.T., Hesketh, E.L., Saxena, P., Meshcheriakova, Y., Ku, Y.C., Hoang, L.T., Johnson, J.E., Ranson, N.A., Lomonossoff, G.P., Reddy, V.S., 2016. Crystal Structure and Proteomics Analysis of Empty Virus-like Particles of Cowpea Mosaic Virus. Structure 24, 567-575.

57. Reddy. V.S. Application of the phase extension method in virus crystallography. Crystallogr Rev 22, 128-140 (2016).

56. M. Carrillo-Tripp, D. J. Montiel-Garcia, C. L. Brooks, 3rd, V. S. Reddy, CapsidMaps: protein-protein interaction pattern discovery platform for the structural analysis of virus capsids using Google Maps. Journal of structural biology 190, 47-55 (2015); published online EpubApr (10.1016/j.jsb.2015.02.003).

55. H. M. Berman, M. J. Gabanyi, C. R. Groom, J. E. Johnson, G. N. Murshudov, R. A. Nicholls, V. Reddy, T. Schwede, M. D. Zimmerman, J. Westbrook, W. Minor, Data to knowledge: how to get meaning from your result. IUCrJ 2, 45-58 (2015); published online EpubJan 1 (10.1107/S2052252514023306).

54.Reddy, V. S. & Nemerow, G. R. Reply to Campos: Revised structures of adenovirus cement proteins represent a consensus model for understanding virus assembly and disassembly. Proc Natl Acad Sci U S A 111, E4544-4545, doi:10.1073/pnas.1417014111 (2014).

53.Reddy, V. S. & Nemerow, G. R. Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection. Proc Natl Acad Sci U S A 111, 11715-11720, doi:10.1073/pnas.1408462111 (2014).

52.Benevento, M. et al. Adenovirus composition, proteolysis, and disassembly studied by in-depth qualitative and quantitative proteomics. J Biol Chem 289, 11421-11430, doi:10.1074/jbc.M113.537498 (2014).

51.Snijder, J. et al. The cleaved N-terminus of pVI binds peripentonal hexons in mature adenovirus. J Mol Biol 426, 1971-1979, doi:10.1016/j.jmb.2014.02.022 (2014).

50.Snijder, J., Reddy, V.S., May, E.R., Roos, W.H., Nemerow, G.R., Wuite, G.J., 2013. Integrin and defensin modulate the mechanical properties of adenovirus. J Virol 87, 2756-2766.

49.Nemerow, G.R., Stewart, P.L., Reddy, V.S., 2012. Structure of human adenovirus. Current opinion in virology 2, 115-121.

48. Khare R, Reddy VS, Nemerow GR, Barry MA. Identification of adenovirus serotype 5 hexon regions that interact with scavenger receptors. J Virol. 2012;86(4):2293-301.

47.  Reddy, V. S., Natchiar, S. K., Stewart, P. L., and Nemerow, G. R. (2010). Crystal structure of human adenovirus at 3.5 A resolution. Science 329(5995), 1071-5. PMCID: PMC2929978

46.  Reddy, V. S., Natchiar, S. K., Gritton, L., Mullen, T. M., Stewart, P. L., and Nemerow, G. R. (2010). Crystallization and preliminary X-ray diffraction analysis of human adenovirus. Virology 402(1), 209-14.PMCID: PMC2871957

45. Carrillo-Tripp, M., Brooks, C. L., 3rd, and Reddy, V. S. (2008). A novel method to map and compare protein-protein interactions in spherical viral capsids. Proteins 73(3), 644-655. NIHMS138422

44. Pache, L., Venkataraman, S., Nemerow, G. R., and Reddy, V. S. (2008a). Conservation of fiber structure and CD46 usage by subgroup B2 adenoviruses. Virology 375(2), 573-9.

43. Pache, L., Venkataraman, S., Reddy, V. S., and Nemerow, G. R. (2008b). Structural variations in species B adenovirus fibers impact CD46 association. J Virol 82(16), 7923-31. PMC2519554

42. Venkataraman, S., Reddy, S. P., Loo, J., Idamakanti, N., Hallenbeck, P. L., and Reddy, V. S. (2008a). Crystallization and preliminary X-ray diffraction studies of Seneca Valley Virus-001, a new member of the Picornaviridae family. Acta Crystallogr Sect F Struct Biol Cryst Commun 64(Pt 4), 293-6. PMC2374260

41. Venkataraman, S., Reddy, S. P., Loo, J., Idamakanti, N., Hallenbeck, P. L., and Reddy, V. S. (2008b). Structure of Seneca Valley Virus-001: an oncolytic picornavirus representing a new genus. Structure16(10), 1555-61. PMC2572565

40. Carrillo-Tripp, M., Shepherd, C. M., Borelli, I. A., Venkataraman, S., Lander, G., Natarajan, P., Johnson, J. E., Brooks, C. L., 3rd, and Reddy, V. S. (2009). VIPERdb2: an enhanced and web API enabled relational database for structural virology. Nucleic Acids Res 37(Database issue), D436-42. PMC2686430

39. Kumar, S., Ochoa, W., Singh, P., Hsu, C., Schneemann, A., Manchester, M., Olson, M., and Reddy, V. (2009). Tomato bushy stunt virus (TBSV), a versatile platform for polyvalent display of antigenic epitopes and vaccine design. Virology 388(1), 185-90. PMC in process

38. Nemerow, G. R., Pache, L., Reddy, V., and Stewart, P. L. (2009). Insights into adenovirus host cell interactions from structural studies. Virology 384(2), 380-8. PMC2666334

37. Nguyen, H. D., Reddy, V. S., and Brooks, C. L., 3rd (2009). Invariant polymorphism in virus capsid assembly. J Am Chem Soc 131(7), 2606-14. NIHMS138431

36. Lad, S. P., G. Yang, D. A. Scott, G. Wang, P. Nair, J. Mathison, V. S. Reddy, and E. Li. 2007. Chlamydial CT441 Is a PDZ Domain-Containing Tail-Specific Protease That Interferes with the NF-{kappa}B Pathway of Immune Response. J Bacteriol 189:6619-25.

35. Manayani, D. J., D. Thomas, K. A. Dryden, V. Reddy, M. E. Siladi, J. M. Marlett, G. J. Rainey, M. E. Pique, H. M. Scobie, M. Yeager, J. A. Young, M. Manchester, and A. Schneemann. 2007. A viral nanoparticle with dual function as an anthrax antitoxin and vaccine. PLoS Pathog 3:1422-31.

34. Nguyen, H. D., Reddy, V.S. and C. L. Brooks, III. 2007. Deciphering the kinetic mechanism of spontaneous self-assembly of icosahedral capsids. Nano Lett 7:338-44.

33. Kumar, S., W. Ochoa, S. Kobayashi, and Reddy, V.S. 2007. Presence of a surface-exposed loop facilitates trypsinization of particles of Sinsiro virus, a genogroup II.3 norovirus. J Virol 81:1119-28.

32. Hsu, C., Singh, P., Ochoa, W., Manayani, D. J., Manchester, M., Schneemann, A., and Reddy, V. S. (2006). Characterization of polymorphism displayed by the coat protein mutants of tomato bushy stunt virus. Virology 349(1), 222-9.

31. Shepherd, C. M., Borelli, I. A., Lander, G., Natarajan, P., Siddavanahalli, V., Bajaj, C., Johnson, J. E., Brooks, C. L., III, and Reddy, V. S. (2006). VIPERdb: a relational database for structural virology.Nucleic Acids Res 34 (Database issue), D386-9.

30. Taylor, D. J., Speir, J. A., Reddy, V.S., Cingolani, G., Pringle, F. M., Ball, L. A., and Johnson, J. E. (2006). Preliminary x-ray characterization of authentic providence virus and attempts to express its coat protein gene in recombinant baculovirus. Arch Virol 151(1), 155-65.

29. Shepherd, C. M., and Reddy, V. S. (2005). Extent of protein-protein interactions and quasi-equivalence in viral capsids. Proteins 58(2), 472-7.

28. Reddy, V. S., and Johnson, J. E. (2005). Structure-derived insights into virus assembly. Adv Virus Res 64, 45-68.

27. Natarajan, P., Lander, G. C., Shepherd, C. M., Reddy, V. S., Brooks, C. L., III, and Johnson, J. E. (2005). Exploring icosahedral virus structures with VIPER. Nat Rev Microbiol 3(10), 809-17.

26. Damodaran K.V., Reddy, V.S., Johnson, J.E. and Brooks, C.L., III (2002). A general method to quantify quasi-equivalence in Icosahedral viruses. J. Mol. Biol. 324, 723-737.

25. Reddy, V.S., Schneemann, A. and Johnson, J.E. (2002). Nodavirus endopeptidase. In Handbook of Proteolytic Enzymes, (In press) Ed. A. Barret, N. Rawlings, J. Woessnet, Academic Press limited, London.

24. Mitra, A.K., Ren, G., Reddy, V.S., Cheng, A and Froger, A (2002). The architecture of a water-selective pore in the lipid bilayer visualized by electron crystallography in vitreous ice. In Ion Channels – from atomic resolution physiology to functional genomics, P 33-50. (Novartis Foundation Symposium 245), Wiley, Chichester, New York.

23. Reddy, V.S., Natarajan, N., Okerberg, B., Li, K., Damodaran, K.V., Morton, R.T., Brooks, C.L., III and Johnson, J.E. (2001). Virus Particle Explorer (VIPER), a website for virus capsid structures and their computational analyses. J. Virol., 75, 11943-11947.

22. Ren, G., Reddy, V.S., Cheng, A., Melnyk, P. and Mitra, A.K. (2001). Visualization of a water-selective pore by electron crystallography in vitreous ice. Proc. Natl. Acad. Sci., 98, 1398-1403.

21. Sousa, M.C., Trame, C.B., Tsuruta, H., Wilbanks, M., Reddy, V.S., McKay, D.B. (2000). Crystal and solution structures of an HslUV Protease-Chaperone Complex. Cell., 103, 633-643.

20. Ren, G., Cheng, A., Reddy, V.S., Melnyk, P. and Mitra, A.K. (2000). Three-dimensional fold of the human AQP1 water channel determined at 4 resolution by electron crystallography of 2-dimensional crystals embedded in ice. J. Mol. Biol., 301, 369-387

19. Oliveira, A.C., Gomes, A.M., Almeida, F.C., Mohana-Borges, R., Valente, A.P, Reddy, V.S. and Johnson, J.E. and Silva, J.L. (2000). Virus maturation targets the protein capsid to concerted disassembly and unfolding, J. Biol. Chem., 275, 16037-16043.

18. Schneemann, A., Krishna, N.K., Reddy, V.S. and Johnson, J.E. (1999). New perspectives on the importance of RNA-protein interactions in nodavirus structure and function. Recent Res. Devel. Virol.,1, 295-315.

17. Huang, S., Reddy, V.S., Dasgupta, N., Nemerow, G.R. (1999). A single amino acid in Adenovirus type 37 fiber confers binding to human conjunctival cells. J. Viol., 73, 2798-2802.

16. Padidam, M., Reddy, V.S., Beachy, R.N. and Fauquet, C.M. (1999). Molecular characterization of a plant mitochondrial chaperone GrpE. Plant Mol. Biol., 39, 871-881.

15. Bothner, B., Schneemann, A., Marshall, D., Reddy, V., Johnson, J.E. and Siuzdak, G. (1999). Crystallographically identical capsids display different properties in solution. Nature Struc. Biol., 6, 114-116.

14. Tsuruta, H., Reddy, V.S., Wikoff, W.R. and Johnson, J.E. (1998). Imaging RNA and dynamic protein segments with low-resolution virus crystallography: Experimental design, data processing and implications of electron density mapsJ. Mol. Biol., 284, 1439-1452.

13. Johnson, J.E. and Reddy, V.S. (1998). Biggest virus molecular structure yet. Nature Struc. Biol., 5, 849-854.

12. Johnson, J.E. and Reddy, V.S. (1998). Structural studies of Nodaviruses and Tetraviruses. In The insect viruses, pp. 171-223, (Miller, L.K. and Ball, L.A. eds), Plenum publishing, New York.

11. Reddy, V.S., Giesing, H.A., Morton, R.T., Kumar, A., Post, C.B., Brooks, C.L., III and Johnson, J.E. (1998). Energetics of quasi-equivalence: Computational analysis of protein-protein interactions in icosahedral viruses. Biophys. J., 74, 546-558.

10. Schnemann, A., Reddy, V.S. and Johnson, J.E. (1998). Structure and Function of nodaviruses: A paradigm for understanding chemical Biology. Adv. Virus. Res., 50, 381-446.

9. Kumar, A., Reddy, V.S., Yusibov, V., Chipman, P., Hatta, Y., Fita, I., Fukiyama, K., Rossmann, M., Loesch-Fries, S., Baker, T. and Johnson, J.E. (1997). The structure of Alfaalfa mosaic virus assembled as T=1 icosahedral particle at 4.0 resolution. J. Virol., 71, 7911-7916.

8. Munshi, S., Liljas, L., Cavarelli, J., Bomu, W., Mckinney, B., Reddy, V. and Johnson, J.E. (1996). Membrane translocation of RNA : deductions from the 2.8 structure of a T=4 animal virus. J. Mol. Biol.,261, 1-10.

7. Zlotnick, A., Reddy, V.S., Schneemann, A., Dasgupta, R., Rueckert, R. and Johnson, J.E. (1994). Capsid assembly in a family of animal viruses primes an autoproteolytic maturation that depends on a single aspartic residue. J. Biol. Chem. ., 269, 13680-13684.

6. Cheng, R.H., Reddy, V.S., Olson, N.H., Fisher, A.J., Baker, T.S. and Johnson, J.E. (1994). Functional implications of quasi-equivalence in a T=3 icosahedral animal virus established by cryo-electron microscopy and X-ray crystallography. Structure , 2, 271-282.

5. Wery, J.P., Reddy, V.S., Hosur, M.V. and Johnson, J.E. (1994). The refined three-dimensional structure of an insect virus at 2.8 resolution. J. Mol. Biol., 235, 565-586.

4. Johnson, J.E., Munshi, S., Liljas, L., Agrawal, D., Olson, N.H., Reddy, V., Fisher, A., McKinney, B., Schmidt, T., Baker, T.S. (1992). Comparative studies of T=3 and T=4 icosahedral RNA insect viruses. In Proc. 3rd Intl. Positive strand RNA virus conf. (Dr. C. Calishu, ed.).

3. Reddy, V.S. and Rao, V.S.R. (1992). Modes of binding of a(1-2) linked manno-oligosaccharides to Concanavalin AInt. J. Biol. Macromol., 14, 185-192.

2. Rao, V.S.R., Reddy, V.S., Mukhopadhyay, C. and Biswas, M. (1990). Computer simulation of protein-carbohydrate complexes: Application to Concanavalin A and L-arabinose binding protein. InComputer Modeling of Carbohydrate Molecules (French, A.D. and Brady, J.W. ed.), pp. 361-376. ACS symposium series 430.

1. Sen, K.D. and Reddy, V.S. (1984). Approximate upper bounds to average radial electron density expectation value <r> within an isoelectronic series of atoms. J. Chem. Phys.81, 5213-5214.

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