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2026 | 2024 |2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 Moss JA, Srinivasan P, Butkyavichene I, Gunawardana M, Castonguay AE, Cortez JM Jr, Galvan P, Rivera S, Zhang J, Dinh C, Holder A, Little D, Bachman S, Kelley K, Ramirez CM, Gallay PA, Vincent KL, Smith JM, Baum MM. Preclinical Pharmacokinetics of a Triple-Combination Intravaginal Ring for HIV Prevention. Pharmaceutics. 2026 Jul 7;18(7):829. doi: 10.3390/pharmaceutics18070829. PMID: 42514907 Free PMC article.
Paull JRA, Luscombe CA, Seta A, Heery GP, Bobardt MD, Gallay PA, Constant S, Castellarnau A. Astrodimer sodium nasal spray forms a barrier to SARS-CoV-2 in vitro and preserves normal mucociliary function in human nasal epithelium. Sci Rep.2024 Sept 11;14(1);14:21259. doi: 10.1038/s41598-024-72262-w. PMID 39261670 Free PMC article.
Stauffer W, Goodman, AZ, Gallay P. Cyclophilin inhibition as a strategy for the treatment of human disease. Font. Pharmacol., 07 July 2024 Sec. Experimental Pharmacology and Drug Discovery Volume 15 - 2024 https://doi.org/10.3389/fphar.2024.1417945
Stauffer W, Bobardt M., Ure D, Forster R, Gallay P. Cyclophilin D knockout significantly prevents HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH PLoS One. 2024 Apr 4;19(4):e0301711. doi: 10.1371/journal.pone.0301711. eCollection 2024. PMID: 38573968 Free PMC article.
Stauffer W, Goodman AZ, Bobardt M., Ure D, Forster R, Gallay P. Mice lacking Cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model PLoS 2024 Mar 1;19(3):e0298211. Doi: 10.1371/ournal.pone.0298211. eCollection 2024
Stauffer W, Bobardt M, Ure D, Foster R, Gallay P. The Cyclophilin Inhibitor Rencofilstat Decreases HCV-Induced Hepatocellular Carcinoma Independently of its Antiviral Activity Viruses 2023 Oct 17;15(10):2099. doi: 10.3390/v15102099.
Gallay PA, Ramirez CM, Baum MM Acute antagonism in three-drug combinations for vaginal HIV prevention in humanized mice. Sci Rep. 2023 Mar 21;13(1):4594. doi: 10.1038/s41598-023-31695-5. PMID: 36944714 Free PMC article.
Gunawardana M, Remedios-Chan M, Sanchez D, Fanter R, Webster S, Webster P, Moss JA, Trinh M, Beliveau M, Ramirez CM, Marzinke MA, Kuo J, Gallay PA, Baum MM. Preclinical Considerations for Long-acting Delivery of Tenofovir Alafenamide from Subdermal Implants for HIV Pre-exposure Prophylaxis Pharm Res. 2023 Jul;40(7):1657-1672. doi: 10.1007/s11095-022-03440-6. Epub 2022 Nov 23. PMID: 36418671
Ewart G, Bobardt M, Bentzen BH, Yan Y, Thomson A, Klumpp K, Becker S, Rosenkilde MM, Miller M, Gallay P. Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2. PLoS Pathog. 2023 Aug 7;19(8):e1011328. doi: 10.1371/journal.ppat.1011328. Online ahead of print. PMID: 37549173 Free article. 2022 Gunawardana M, Remedios-Chan M, Sanchez D, Webster S, Castonguay AE, Webster P, Buser C, Moss JA, Trinh M, Beliveau M, Hendrix CW, Marzinke MA, Tuck M, Caprioli RM, Reyzer ML, Kuo J, Gallay PA, Baum MM. Fundamental aspects of long-acting tenofovir alafenamide delivery from subdermal implants for HIV prophylaxis. Sci Rep. 2022 May 17;12(1):8224. doi: 10.1038/s41598-022-11020-2.
Simón Serrano S, Tavecchio M, Grönberg A, Elmér E, Kifagi C, Gallay P, Hansson MJ, Massoumi R. Synergistic Effects of Sanglifehrin-Based Cyclophilin Inhibitor NV651 with Cisplatin in Hepatocellular Carcinoma. Cancers (Basel). 2022 Sep 20;14(19):4553. Doi: 10.3390/cancers14194553.
Gunawardana M, Webster S, Rivera S, Cortez JM Jr, Breslin J, Pinales C, Buser C, Ibarrondo FJ, Yang OO, Bobardt M, Gallay PA, Adler AP, Ramirez CM, Anton PA, Baum MM. Early SARS-CoV-2 dynamics and immune responses in unvaccinated participants of an intensely sampled longitudinal surveillance study. Commun Med (Lond). 2022 Oct 11;2:129. doi: 10.1038/s43856-022-00195-4. eCollection 2022.
Paull JRA, Luscombe CA, Castellarnau A, Heery GP, Bobardt MD, Gallay PA. Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 Mice. Viruses. 2021 Aug 20;13(8):1656. doi: 10.3390/v13081656.
Do TND, Donckers K, Vangeel L, Chatterjee AK, Gallay PA, Bobardt MD, Bilello JP, Cihlar T, De Jonghe S, Neyts J, Jochmans D. A Robust SARS-CoV-2 Replication Model in Primary Human Epithelial Cells at the Air Liquid Interface to Assess Antiviral Agents. Antiviral Res. 2021 June 26,192:105122. doi: 10.1016/j.antiviral.2021. 105122. Online ahead of print. PMID: 34186107.
Bobardt M, Ramirez CM, Baum MM, Ure D, Foster R, Gallay PA. The Combination of the NS5A and Cyclophilin Inhibitors Results in an Additive Anti-HCV Inhibition in Humanized Mice without Development of Resistance. PLoS One. 2021 May 20;16(5):e0251934. doi: 10.1371/journal.pone.0251934. eCollection 2021. PMID: 34014993.
Serrano SS, Tavecchio M, Gronberg A, Sime W, Jemaa M, Moss S, Gregory MA, Gallay P, Elmer E, Hansson MJ, Massoui R. Novel Cyclophilin Inhibitor Decreases Cell Proliferation and Tumor Growth in Models of Hepatocellular Carcinoma. Cancers 2021, 13(12), 3041 (This article belongs to the Special Issue Curative Strategies for the Management of Hepatocellular Cancer). doi: 10.3390. cancers13123041.
Paull JRA, Heery GP, Bobardt MD, Castellarnau A, Luscombe CA, Fairley JK, Gallay PA. Virucidal and Antiviral Activity of Astodrimer Sodium against SARS-CoV-2 in vitro. Antiviral Res. 2021 Jul;191:105089. doi: 10.1016/j.antiviral.2021.105089. Epub 2021 May 16. PMID: 34010661.
Gundawardana M, Remedios-Chan M, Sanchez D, Webster S, Galvan P, Fanter R, Castonguay A, Webster P, Moss JA, Kuo, J, Gallay PA, Vincent KL, Motamedi M, Weinberger D, Marzinke MA, Hendrix CW, Baum MM. Multispecies Evaluation of a Long-Acting Tenofovir Alafenamide Subdermal Implant for HIV Prophylaxis. Front. Pharmacol., 2020 Nov 25; 11:569373. doi: 10.3389. eCollection 2020. PMID: 33536904
Bobardt M, Hansson MJ, Mayo P, Ure D, Foster R, Gallay P. Structurally distinct cyclosporin and sanglifehrin analogs CRV431 and NV556 suppress established HCV infection in humanized-liver mice. PLoS One. 2020 Aug 7;15(8):e0237236. doi: 10.1371/journal.pone.0237236. eCollection 2020. PMID: 32764799
Baum MM, Ramirez CM, Moss JA, Gunawardana M, Bobardt M, Gallay PA. Highly synergistic drug combination prevents vaginal HIV infection in humanized mice. Sci Rep. 2020 Aug 3;10(1):12995. doi: 10.1038/s41598-020-69937-5. PMID: 32747682 Free PMC article.
Bobardt M, Kuo J, Chatterji U, Wiedemann N, Vuagniaux G, Gallay P. The Inhibitor of Apoptosis Proteins Antagonist Debio 1143 Promotes the PD-1 Blockade-Mediated HIV Load Reduction in Blood and Tissues of Humanized Mice. PLoS One. 2020 Jan 24; 15(1).
Kuo J, Bobardt M, Chatterji U, Mayo PR, Trepanier DJ, Foster RT, Gallay P, Ure DR. A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models. J Pharmacol Exp Ther. 2019 Nov;371(2):231-241.
Kuo J, Serrano SS, Grönberg A, Massoumi R, Hansson MJ, Gallay P. Cyclophilin Inhibitor NV556 Reduces Fibrosis and Hepatocellular Carcinoma Development in Mice With Non-Alcoholic Steatohepatitis. Front Pharmacol. 2019 Sep 26;10:1129.
Gallay P, Ure D, Bobardt M, Chatterji U, Ou J, Trepanier D, Foster R. The cyclophilin inhibitor CRV431 inhibits liver HBV DNA and HBsAg in transgenic mice. PLoS One. 2019 Jun 10;14(6):e0217433. Bobardt M, Kuo J, Chatterji U, Chanda S, Little SJ, Wiedemann N, Vuagniaux G, Gallay PA. The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate. PLoS One. 2019 Feb 4;14(2):e0211746.
de Wilde AH, Zevenhoven-Dobbe JC, Beugeling C, Chatterji U, de Jong D, Gallay P, Szuhai K, Posthuma CC, Snijder EJ. Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture. Virology. 2018 Apr;517:148-156. Gallay PA, Chatterji U, Kirchhoff A, Gandarilla A, Pyles RB, Baum MM, Moss JA. 2018. Protection Efficacy of C5A Against Vaginal and Rectal HIV Challenges in Humanized Mice. Open Virol J. Feb 28;12:1-13.
Gallay PA, Chatterji U, Kirchhoff A, Gandarilla A, Gunawardana M, Pyles RB, Marzinke MA, Moss JA, Baum MM. 2017. Prevention of vaginal and rectal HIV transmission by antiretroviral combinations in humanized mice. PLoS One. Sep 7;12(9):e0184303. Vidotto A, Morais AT, Ribeiro MR, Pacca CC, Terzian AC, Gil LH, Mohana-Borges R, Gallay P, Nogueira ML. Systems Biology Reveals NS4B-Cyclophilin A Interaction: A New Target to Inhibit YFV Replication. J Proteome Res. 2017 Apr 7;16(4):1542-1555.
Chatterji U, Bobardt M, Schaffer L, Wood M, Gallay PA. 2016. Cyclophilin Inhibitors Remodel the Endoplasmic Reticulum of HCV-Infected Cells in a Unique Pattern Rendering Cells Impervious to a Reinfection. PLoS One. 11(7):e0159511.
Chatterji U, Bobardt M, Tai A, Wood M, & Gallay PA. 2015. Cyclophilin and NS5A inhibitors, but not other anti-hepatitis C virus (HCV) agents, preclude HCV-mediated formation of double-membrane-vesicle viral factories. Antimicrob Agents Chemother. 59(5):2496-2507. Gallay PA, Bobardt MD, Chatterji U, Trepanier DJ, Ure D, Ordonez C, & Foster R. 2015. The Novel Cyclophilin Inhibitor CPI-431-32 Concurrently Blocks HCV and HIV-1 Infections via a Similar Mechanism of Action. PLoS One. 10(8): e0134707.
Lim PJ, Gallay PA. 2014. Hepatitis C NS5A protein: two drug targets within the same protein with different mechanisms of resistance. Curr Opin Virol. 8C:30-37.
Baugh JM, Garcia-Rivera JA, Gallay PA. 2013. Host-targeting agents in the treatment of hepatitis C: a beginning and an end? Antiviral Res. 100(2):555-561.
Hopkins, S., DiMassimo, B, Rusnak, P., Heuman, D., Lalezari, J., Sluder, A., Scorneaux, B., Mosier, S., Kowalczyk, P., Ribeill, Y., Baugh, J., and Gallay, P.A. 2012. The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection. J. Hepatol. 56(7):3888-3897. |