Scripps Research Logo

Zorrilla Lab Publications

All     Highlights    Obesity    Addiction     Stress/Anxiety/Depression      Reviews     Patents/Chapters

Addiction (as of 7/16/2012)

Stress history increases alcohol intake in relapse: Relation to phosphodiesterase 10A
Addict Biol, Addict Biol, 2012 Jun doi: 10.1111/j.1369-1600.2012.00460.x
Logrip, M. L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats
Addict Biol 17, 300-308, (2012)
Zorrilla, E. P., Wee, S., Zhao, Y., Specio, S., Boutrel, B., Koob, G. F., Weiss, F.
[ABSTRACT]  [PUBLISHER LINK] [PUBMED CENTRAL]

Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats
J Neurosci 32, 7563-7571, (2012)
Vendruscolo, L. F., Barbier, E., Schlosburg, J. E., Misra, K. K., Whitfield, T. W., Jr., Logrip, M. L., Rivier, C., Repunte-Canonigo, V., Zorrilla, E. P., Sanna, P. P., Heilig, M., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder
Neuropharmacology 62, 552-564, (2012)
Logrip, M. L., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Update on corticotropin-releasing factor pharmacotherapy for psychiatric disorders: a revisionist view
Neuropsychopharmacology 37, 308-309, (2012)
Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Systemic kappa-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats
Addict Biol 16, 116-119, (2011)
Walker, B. M., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Activation of sigma-receptors induces binge-like drinking in Sardinian alcohol-preferring rats
Neuropsychopharmacology 36, 1207-1218, (2011)
Sabino, V., Cottone, P., Blasio, A., Iyer, M. R., Steardo, L., Rice, K. C., Conti, B., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

The dark side of food addiction
Physiol Behav 104, 149-156, (2011)
Parylak, S. L., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention
CNS Drugs 25, 271-287, (2011)
Logrip, M. L., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence
Biol Psychiatry 67, 831-839, (2010)
Roberto, M., Cruz, M. T., Gilpin, N. W., Sabino, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., Koob, G. F., Siggins, G. R., Parsons, L. H.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake
Brain Res 1339, 1-10, (2010)
Repunte-Canonigo, V., van der Stap, L. D., Chen, J., Sabino, V., Wagner, U., Zorrilla, E. P., Schumann, G., Roberts, A. J., Sanna, P. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin
Brain Res 1314, 145-161, (2010)
Martin-Fardon, R., Zorrilla, E. P., Ciccocioppo, R., Weiss, F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor
Curr Opin Investig Drugs 11, 63-71, (2010)
Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBMED CENTRAL]

Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist
Psychopharmacology (Berl) 205, 327-335, (2009)
Sabino, V., Cottone, P., Zhao, Y., Steardo, L., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking
Neuropsychopharmacology 34, 1482-1493, (2009)
Sabino, V., Cottone, P., Zhao, Y., Iyer, M. R., Steardo, L., Jr., Steardo, L., Rice, K. C., Conti, B., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala
ScientificWorldJournal 9, 68-85, (2009)
Nie, Z., Zorrilla, E. P., Madamba, S. G., Rice, K. C., Roberto, M., Siggins, G. R.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration
Pharmacol Biochem Behav 91, 295-302, (2009)
Greenwell, T. N., Walker, B. M., Cottone, P., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats
Addict Biol 14, 130-143, (2009)
Greenwell, T. N., Funk, C. K., Cottone, P., Richardson, H. N., Chen, S. A., Rice, K. C., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis
J Neurosci 29, 5389-5401, (2009)
Francesconi, W., Berton, F., Repunte-Canonigo, V., Hagihara, K., Thurbon, D., Lekic, D., Specio, S. E., Greenwell, T. N., Chen, S. A., Rice, K. C., Richardson, H. N., O'Dell, L. E., Zorrilla, E. P., Morales, M., Koob, G. F., Sanna, P. P.
[ABSTRACT] [PUBLISHER LINK]

Increased perioculomotor urocortin 1 immunoreactivity in genetically selected alcohol preferring rats
Alcohol Clin Exp Res 33, 1956-1965, (2009)
Fonareva, I., Spangler, E., Cannella, N., Sabino, V., Cottone, P., Ciccocioppo, R., Zorrilla, E. P., Ryabinin, A. E.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food
Psychoneuroendocrinology 34, 38-49, (2009)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

CRF system recruitment mediates dark side of compulsive eating
Proc Natl Acad Sci U S A 106, 20016-20020, (2009)
Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., Conti, B., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats
Psychopharmacology (Berl) 196, 473-482, (2008)
Specio, S. E., Wee, S., O'Dell, L. E., Boutrel, B., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist
Pharmacol Biochem Behav 88, 497-510, (2008)
Richardson, H. N., Zhao, Y., Fekete, E. M., Funk, C. K., Wirsching, P., Janda, K. D., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food
Neuropsychopharmacology 33, 524-535, (2008)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats
Am J Physiol Regul Integr Comp Physiol 295, R1066-1076, (2008)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats
Alcohol Clin Exp Res 31, 1505-1515, (2007)
Zhao, Y., Weiss, F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

14-Methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats
Psychopharmacology (Berl) 192, 537-546, (2007)
Sabino, V., Cottone, P., Steardo, L., Schmidhammer, H., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats
J Pharmacol Exp Ther 320, 180-193, (2007)
O'Dell, L. E., Chen, S. A., Smith, R. T., Specio, S. E., Balster, R. L., Paterson, N. E., Markou, A., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
Proc Natl Acad Sci U S A 104, 17198-17203, (2007)
George, O., Ghozland, S., Azar, M. R., Cottone, P., Zorrilla, E. P., Parsons, L. H., O'Dell, L. E., Richardson, H. N., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats
Biol Psychiatry 61, 78-86, (2007)
Funk, C. K., Zorrilla, E. P., Lee, M. J., Rice, K. C., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout
Pharmacol Biochem Behav 86, 813-821, (2007)
Chu, K., Koob, G. F., Cole, M., Zorrilla, E. P., Roberts, A. J.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats
Psychopharmacology (Berl) 189, 175-186, (2006)
Sabino, V., Cottone, P., Koob, G. F., Steardo, L., Lee, M. J., Rice, K. C., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Unlimited access to heroin self-administration: independent motivational markers of opiate dependence
Neuropsychopharmacology 31, 2692-2707, (2006)
Chen, S. A., O'Dell, L. E., Hoefer, M. E., Greenwell, T. N., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats
Neuropsychopharmacology 30, 90-98, (2005)
Stinus, L., Cador, M., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

 

Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence
Alcohol 29, 55-60, (2003)
Valdez, G. R., Zorrilla, E. P., Roberts, A. J., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

 

Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor
Alcohol Clin Exp Res 26, 1494-1501, (2002)
Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats
Psychopharmacology (Berl) 158, 374-381, (2001)
Zorrilla, E. P., Valdez, G. R., Weiss, F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors
Ann N Y Acad Sci 937, 1-26, (2001)
Weiss, F., Ciccocioppo, R., Parsons, L. H., Katner, S., Liu, X., Zorrilla, E. P., Valdez, G. R., Ben-Shahar, O., Angeletti, S., Richter, R. R.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Altered amygdalar CRF release and increased anxiety-like behavior in Sardinian alcohol-preferring rats: a microdialysis and behavioral study
Alcohol Clin Exp Res 24, 1765-1772, (2000)
Richter, R. M., Zorrilla, E. P., Basso, A. M., Koob, G. F., Weiss, F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]