Un nuevo estudio descarta que la reacción de formosa haya generado ribosa en la Tierra primitiva, replanteando el origen del ARN y ofreciendo una vía inesperada para producir biocombustibles sostenibles.
Scripps Research and Georgia Institute of Technology scientists’ discovery could help understand how life evolved on Earth and lead to better biofuel production.
A recent study by Scripps Research proposes a credible pathway for the early formation and evolution of protocells, suggesting that phosphorylation might have been crucial in developing complex, functional precursors to life on Earth about 4 billion years ago. This discovery enhances our understanding of the origins of life and the early Earth’s chemical environment. Credit: SciTechDaily.com
Study demonstrates a closely related set of chemical reactions that could have supported the development of early life forms.
May 2021
And the reaction to chimeric RNA-DNA research from our lab continues, this time with an in-depth and thoughtful discussion by a Russian Science News Magazine called ELEMENTS.asking the question
On the early Earth, a forerunner of the complex cycle of reactions that underpins metabolism in today’s cells might have originated from interactions between just two simple, versatile molecules in water, according to new research. Read more by John Rennie in Quantamagazine
Origin-of-life chemists discover plausible ancestor of essential metabolic process used by most plants and animals
Prebiotic synthesis reveals that DNA nucleosides may form just as readily as RNA in the absence of enzymes, and therefore could have existed alongside RNA before the origin of life. Behind the paper By Nick Green
Read the ENGLISH translation: New puzzle piece found in the primordial soup -Chemists find a new route where RNA and DNA originate from the same building block (provided by Google) HERE.
Interview with Paul Ross (talkRADIO)
April, 11, 2019 03:00-03:30 time slot
Interview begins around 13 minutes into this audio clip
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NASA's new Prebiotic Chemistry and Early Earth Environments (PCE3) Consortium will identify planetary conditions that might give rise to life's chemistry. Credit Rensselaer
NASA is uniting experts across multiple disciplines to investigate life's beginnings on our planet -- and to explore if and how life sprung up elsewhere in the universe
Latest chemistry lands on the cover of The Journal of Organic Chemistry
Georgia Tech researchers have expanded the synthetic value of the common building block dihydroxyfumaric acid (DHF). The diester derivative of DHF has been used exclusively as an electron-seeking (electrophilic) reagent in organic synthesis. Read More....
Normally when we think of metabolism, we think of weight loss fads like the Keto diet, the Paleo diet or intermittent fasting. Metabolism, however, is way more interesting than weight loss trends. It is the process used by your body to transform Cap'n Crunch into brain cells, and some scientists believe it his has huge implication for the origin of life!
Experiments in 'primordial' conditions (maybe) found chemical reactions that ape a key biological cycle and could exist under the extreme conditions of billions of years ago BY RUTH SCHUSTER
LA JOLLA, Calif. – Nov. 6, 2017 – Chemists at The Scripps Research Institute (TSRI) have found a compound that may have been a crucial factor in the origins of life on Earth.More here .....
Minkorrekt Folge 108 “Erklima was Thema war”Methodisch inkorrekt. Thema 1: “Wer hat in die Suppe gespuckt?” – Was war alles nötig damit aus der Ursuppe zufällig leben entsteht? Ehrlich gesagt erstaunlich viel…aber ging das eventuell auch mit weniger? Dieser Frage versucht das erste Paper auf den Grund zu gehen.
As to how the depsipeptide idea came about and progressed within the Center for Chemical Evolution ...read the background here
Cleaning Up the Clutter
How proto-biology arose from the prebiotic clutter.
Written byKeith Cooper
Just like the mythical creation stories that depict the formation of the world as the story of order from chaos, the early Earth was home to a chaotic ‘clutter’ of organic molecules from which, somehow, more complex biological structures such as RNA and DNA emerged.
There was no guiding hand to dictate how the molecules within that prebiotic clutter should interact to form life. Yet had those molecules just interacted randomly then the likelihood is that they would never have chanced upon the right interactions to ultimately lead to life.
LA JOLLA, CA – September 28, 2016 – A new study led by scientists at The Scripps Research Institute (TSRI) offers a twist on a popular theory for how life on Earth began about four billion years ago.
The crucibles that bore out early building blocks of life may have been, in many cases, modest puddles.
Now, researchers working with that hypothesis have achieved a significant advancement toward unlocking a longstanding evolutionary mystery -- how components of RNA and DNA formed from chemicals present on early Earth before life existed. It could also have implications on how astrobiologists view the probability of live elsewhere in the universe.
Have you ever wondered how life first got started on Earth?
So do scientists! Though the question has not yet been fully answered, a careful study of Chemical Evolution is beginning to shed light on this mystery.
Credit: Scripps Institution of Oceanography, UC San Diego. Vials contain samples of prebiotic materials created by
Stanley Miller in 1958, labeled by Miller himself. Miller added a potential prebiotic condensation agent, cyanamide,
during the course of the experiment. Cyanamide has been suggested to induce polymerization of amino acid into
simple peptides which is an important set in chemical evolution and possibly the origin of life. For unknown reasons,
Miller had never analyzed the samples. In a paper published in 2014, researchers at Georgia Tech and Scripps
Institution of Oceanography at UC San Diego analyzed the samples and established the potential importance of
reagents - substances that cause chemical reactions such as cyanamide -- in the origin of life on Earth.
Stanley Miller, the chemist whose landmark experiment published in 1953 showed how some of the molecules of life could have formed on a young Earth, left behind boxes of experimental samples that he never analyzed. The first-ever analysis of some of Miller's old samples has revealed another way that important molecules could have formed on early Earth.
Prebiotic Chemistry: Researchers discover a potential prebiotic reaction that can form tartrates, providing another possible entry point to an early citric acid cycle
Researchers have struggled to uncover the chemical mechanisms that could have converted an abiotic “primordial soup” into building blocks of biopolymers. In examining the formation of carbohydrates from fundamental components such as water and carbon dioxide, researchers initially proposed the formose reaction that converts formaldehyde to a mixture of aldoses and ketoses in a series of steps.
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JACS Image Challenge
Challenge #184
The article reported experimental investigations on the reactions of dihydroxyfumarate with small molecule aldehydes (glyoxylate, glycolaldehyde, and glyceraldehyde). Which pathway actually accounts for the formation of a mixture of diastereomers of pentulosonic acid 3a+3b from glyoxylate?
Exploratory Experiments on the Chemistry of the "Glyoxylate Scenario": Formation of Ketosugars from Dihydroxyfumarate. Sagi, V.N.; Punna, V.; Hu, F.; Meher, G.; Krishnamurthy, R. J. Am. Chem. Soc. 2012, 134, pp 3577–3589
DNA is the building block for life on Earth. But it is a highly complex molecule, and could not have arranged itself spontaneously. What did it develop from? Astrobiologists examine possible ancestors of DNA: nucleic acids called PNA, p-RNA, and TNA.