MOST RECENT PUBLICATIONS (SINCE 2019)
2024
Lee JC, Shirey RJ, Turner LD, Park H, Lairson LL, Janda KD. Discovery of PLD4 modulators by high-throughput screening and kinetic analysis. Results Chem. 2024; DOI: 10.1016/j.rechem.2024.101349:101349.
2023
Eubanks LM, Pholcharee T, Oyen D, Natori Y, Zhou B, Wilson IA, Janda KD. An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression. ACS Chem Neurosci. 2023;14(16):2849-56. PMID: 37534714.
Park H, Lin M, Zhou J, Eubanks LM, Zhou B, Janda KD. Development of a Vaccine against the Synthetic Opioid U-47700. Front Pharmacol. 2023;14:1219985. PMID: 37492086.
Richardson RS, Sulima A, Rice KC, Kucharczk JA, Janda KD, Nisbett KE, Koob GF, Vendruscolo LF, Leggio L. Pharmacological GHSR (ghrelin receptor) blockade reduces alcohol binge-like drinking in male and female mice. Neuropharmacology. 2023;238:109643. PMID: 37369277.
Lin M, Eubanks LM, Karadkhelkar NM, Blake S, Janda KD. Catalytic Antibody Blunts Carfentanil-Induced Respiratory Depression. ACS Pharmacol Transl Sci. 2023;6(5):802-11. PMID: 37200811.
Lin L, Patel EN, Nielsen AL, Turner LD, Tepp WH, Nguyen K, Pellett S, Janda K. Transformation of a metal chelate into a “catch and anchor” inhibitor of Botulinum A protease. Int J Mol Sci. 2023;24(5). PMID: 36901734.
Karadkhelkar NM, Lin M, Eubanks LM, Janda KD. Demystifying the Druggability of the MYC Family of Oncogenes. J Am Chem Soc. 2023;145(6):3259-69. PMID: 36734615.
2022
Lee JC, Eubanks LM, Zhou B, Janda KD. Development of an effective monoclonal antibody against heroin and its metabolites reveals therapies have mistargeted 6-monoacetylmorphine and morphine over heroin. ACS Cent Sci. 2022;8(10):1464-70. PMID: 36313156.
Lin M, Marin A, Ellis B, Eubanks LM, Andrianov AK, Janda KD. Polyphosphazene: A new adjuvant platform for cocaine vaccine development. Mol Pharm. 2022;19(9):3358-66. PMID: 35984034.
Patel EN, Lin L, Sneller MM, Eubanks LM, Tepp WH, Pellett S, Janda KD. Investigation of salicylanilides as botulinum toxin antagonists. ACS Infect Dis. 2022;8(8):1637-45. PMID: 35877209.
Patel EN, Turner LD, Hixon MS, Janda KD. Identification of slow-binding inhibitors of the BoNT/A protease. ACS Med Chem Lett. 2022;13(4):742-7. PMID: 35450355.
Lee JC, Park H, Eubanks LM, Ellis B, Zhou B, Janda KD. A vaccine against benzimidazole-derived new psychoactive substances that are more potent than fentanyl. J Med Chem. 2022;65(3):2522-31. PMID: 34994550.
Lee JC, Janda KD. Development of effective therapeutics for polysubstance use disorders. Curr Opin Chem Biol. 2022;66:102105. PMID: 34936944.
2021
Staples MC, Herman MA, Lockner JW, Avchalumov Y, Kharidia KM, Janda KD, Roberto M, Mandyam CD. Isoxazole-9 reduces enhanced fear responses and retrieval in ethanol-dependent male rats. J Neurosci Res. 2021;99(11):3047-65. PMID: 34496069.
Shirey RJ, Turner LD, Lairson LL, Janda KD. Modulators of immunoregulatory exonucleases PLD3 and PLD4 identified by high-throughput screen. Bioorg Med Chem Lett. 2021;49:128293. PMID: 34332037.
Blake S, Shaabani N, Eubanks LM, Maruyama J, Manning JT, Beutler N, Paessler S, Ji H, Teijaro JR, Janda KD. Salicylanilides reduce SARS-CoV-2 replication and suppress induction of inflammatory cytokines in a rodent model. ACS Infect Dis. 2021;7(8):2229-37. PMID: 34339171.
Turner LD, Nielsen AL, Lin L, Campedelli AJ, Silvaggi NR, Chen JS, Wakefield AE, Allen KN, Janda KD. Use of crystallography and molecular modeling for the inhibition of the botulinum neurotoxin A protease. ACS Med Chem Lett. 2021;12(8):1318-24. PMID: 34413962.
Lin M, Ellis B, Eubanks LM, Janda KD. Pharmacokinetic approach to combat the synthetic cannabinoid PB-22. ACS Chem Neurosci. 2021;12(14):2573-9. PMID: 34254505.
Shirey RJ, Hart JR, Sridharan B, Novick SJ, Turner LD, Zhou B, Nielsen AL, Eubanks LM, Ueno L, Hixon MS, Lairson LL, Spicer TP, Scampavia LD, Griffin PR, Vogt PK, Janda KD. Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay. Bioorg Med Chem. 2021;42:116246. PMID: 34130216.
Park H, Lee JC, Eubanks LM, Ellis B, Zhou B, Janda KD. Improvements on a chemically contiguous hapten for a vaccine to address fentanyl-contaminated heroin. Bioorg Med Chem. 2021;41:116225. PMID: 34034147.
Turner LD, Nielsen AL, Lin L, Pellett S, Sugane T, Olson ME, Johnson EA, Janda KD. Irreversible inhibition of BoNT/A protease: Proximity-driven reactivity contingent upon a bifunctional approach. RSC Med Chem. 2021;12(6):960-9. PMID: 34223161.
Belz TF, Lin M, Eubanks LM, Ellis B, Janda KD. Vaccine design through transition state mimicry of heroin hydrolysis. Tetrahedron Lett. 2021;71:153045.
Rayo J, Gregor R, Jacob NT, Dandela R, Dubinsky L, Yashkin A, Aranovich A, Thangaraj M, Ernst O, Barash E, Malitsky S, Florea BI, Krom BP, Wiemer EAC, Kickhoefer VA, Rome LH, Mathison JC, Kaufmann GF, Overkleeft HS, Cravatt BF, Zor T, Janda KD, Ulevitch RJ, Kravchenko VV, Meijler MM. Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones. Proc Natl Acad Sci U S A. 2021;118(12). PMID: 33723037.
Eubanks LM, Blake S, Natori Y, Ellis B, Bremer PT, Janda KD. A highly efficacious carfentanil vaccine that blunts opioid-induced antinociception and respiratory depression. ACS Chem Biol. 2021;16(2):277-82. PMID: 33533592.
Tararina MA, Dam KK, Dhingra M, Janda KD, Palfey BA, Allen KN. Fast kinetics reveals rate-limiting oxidation and the role of the aromatic cage in the mechanism of the nicotine-degrading enzyme NicA2. Biochemistry. 2021;60(4):259-73. PMID: 33464876.
Lee JC, Janda KD. Immunopharmacotherapeutic advancements in addressing methamphetamine abuse. RSC Chem Biol. 2021;2(1):77-93. PMID: 34458776.
Lin M, Lee JC, Blake S, Ellis B, Eubanks LM, Janda KD. Broadly neutralizing synthetic cannabinoid vaccines. JACS Au. 2021;1(1):31-40. PMID: 34467269.
Blake S, Bremer PT, Zhou B, Petrovsky N, Smith LC, Hwang CS, Janda KD. Developing translational vaccines against heroin and fentanyl through investigation of adjuvants and stability. Mol Pharm. 2021;18(1):228-35. PMID: 33301675.
Lin L, Turner LD, Silhar P, Pellett S, Johnson EA, Janda KD. Identification of 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione as a metal-binding motif for the inhibition of botulinum neurotoxin A. RSC Med Chem. 2021;12(1):137-43. PMID: 34046606.
Townsend EA, Bremer PT, Jacob NT, Negus SS, Janda KD, Banks ML. A synthetic opioid vaccine attenuates fentanyl-vs-food choice in male and female rhesus monkeys. Drug Alcohol Depend. 2021;218:108348. PMID: 33268227.
2020
Belz TF, Olson ME, Giang E, Law M, Janda KD. Evaluation of a series of lipidated tucaresol adjuvants in a hepatitis C virus vaccine model. ACS Med Chem Lett. 2020;11(12):2428-32. PMID: 33335664.
Kyzer JL, McGuire M, Park H, Belz TF, Bonakdar R, Janda KD, Wenthur CJ. Anti-opioid antibodies in individuals using chronic opioid therapy for lower back pain. ACS Pharmacol Transl Sci. 2020;3(5):896-906. PMID: 33073189.
Lin L, Olson ME, Sugane T, Turner LD, Tararina MA, Nielsen AL, Kurbanov EK, Pellett S, Johnson EA, Cohen SM, Allen KN, Janda KD. Catch and anchor approach to combat both toxicity and longevity of botulinum toxin A. J Med Chem. 2020;63(19):11100-20. PMID: 32886509.
Belz TF, Bremer PT, Zhou B, Blake S, Ellis B, Eubanks LM, Janda KD. Sulfonate-isosteric replacement examined within heroin-hapten vaccine design. Bioorg Med Chem Lett. 2020;30(17):127388. PMID: 32738981.
Natori Y, Kim D J. Synthesis of drug vaccine against heroin contaminated with fentanyl and their biological evaluation. J Synth Org Chem Jpn. 2020;78(9):875-85.
Belz TF, Bremer PT, Zhou B, Ellis B, Eubanks LM, Janda KD. Enhancement of a heroin vaccine through hapten deuteration. J Am Chem Soc. 2020;142(31):13294-8. PMID: 32700530.
Blake S, Thanissery R, Rivera AJ, Hixon MS, Lin M, Theriot CM, Janda KD. Salicylanilide analog minimizes relapse of Clostridioides difficile infection in mice. J Med Chem. 2020;63(13):6898-908. PMID: 32482070.
Lee JC, Kim HY, Lee S, Shin J, Kim HV, Kim K, Baek S, Lee D, Jeon H, Kim D, Yang SH, Han G, Park K, Choi J, Park J, Moss JA, Janda KD, Kim Y. Discovery of chemicals to either clear or indicate amyloid aggregates by targeting memory-impairing anti-parallel abeta dimers. Angew Chem Int Ed Engl. 2020;59(28):11491-500. PMID: 32233096.
Wang J, Ellis B, Zhou B, Eubanks LM, Blake S, Janda KD. A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galalpha1-3Gal epitope. Chem Commun (Camb). 2020;56(48):6551-4. PMID: 32396160.
Janda KD, Iadarola MJ. Standing out from the crowd in treating COVID-19. Med Drug Discov. 2020;6:100034. PMID: 32292907.
Townsend EA, Bremer PT, Faunce KE, Negus SS, Jaster AM, Robinson HL, Janda KD, Banks ML. Evaluation of a dual fentanyl/heroin vaccine on the antinociceptive and reinforcing effects of a fentanyl/heroin mixture in male and female rats. ACS Chem Neurosci. 2020;11(9):1300-10. PMID: 32271538.
2019
Tenney RD, Blake S, Bremer PT, Zhou B, Hwang CS, Poklis JL, Janda KD, Banks ML. Vaccine blunts fentanyl potency in male rhesus monkeys. Neuropharmacology. 2019;158:107730. PMID: 31369740.
Olson ME, Sugane T, Zhou B, Janda KD. Consequence of hapten stereochemistry: An efficacious methamphetamine vaccine. J Am Chem Soc. 2019;141(36):14089-92. PMID: 31479256.
Townsend EA, Blake S, Faunce KE, Hwang CS, Natori Y, Zhou B, Bremer PT, Janda KD, Banks ML. Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats. Neuropsychopharmacology. 2019;44(10):1681-9. PMID: 31043682.
Lin L, Olson ME, Eubanks LM, Janda KD. Strategies to counteract botulinum neurotoxin A: Nature's deadliest biomolecule. Acc Chem Res. 2019;52(8):2322-31. PMID: 31322847.
Hwang CS, Smith LC, Wenthur CJ, Ellis B, Zhou B, Janda KD. Heroin vaccine: Using titer, affinity, and antinociception as metrics when examining sex and strain differences. Vaccine. 2019;37(30):4155-63. PMID: 31176539.
Smith LC, Bremer PT, Hwang CS, Zhou B, Ellis B, Hixon MS, Janda KD. Monoclonal antibodies for combating synthetic opioid intoxication. J Am Chem Soc. 2019;141(26):10489-503. PMID: 31187995.
Natori Y, Hwang CS, Lin L, Smith LC, Zhou B, Janda KD. A chemically contiguous hapten approach for a heroin-fentanyl vaccine. Beilstein J Org Chem. 2019;15:1020-31. PMID: 31164940.
Nguyen JD, Grant Y, Creehan KM, Hwang CS, Vandewater SA, Janda KD, Cole M, Taffe MA. △9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions. Neuropharmacology. 2019;151:127-35. PMID: 30980837.
Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, Malkin D, Ellison DW, VandenBerg SR, Eberhart CG, Sears RC, Roussel MF, Gilbertson RJ, Wechsler-Reya RJ. Myc and loss of p53 cooperate to drive formation of choroid plexus carcinoma. Cancer Res. 2019;79(9):2208-19. PMID: 30885981.
Wenthur CJ, Gautam R, Zhou B, Vendruscolo LF, Leggio L, Janda KD. Ghrelin receptor influence on cocaine reward is not directly dependent on peripheral acyl-ghrelin. Sci Rep. 2019;9(1):1841. PMID: 30755699.
Olson ME, Eubanks LM, Janda KD. Chemical interventions for the opioid crisis: Key advances and remaining challenges. J Am Chem Soc. 2019;141(5):1798-806. PMID: 30532973.
Smith LC, Lin L, Hwang CS, Zhou B, Kubitz DM, Wang H, Janda KD. Lateral flow assessment and unanticipated toxicity of Kratom. Chem Res Toxicol. 2019;32(1):113-21. PMID: 30380840.
Hwang CS, Ellis B, Zhou B, Janda KD. Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin. Bioorg Med Chem. 2019;27(1):125-32. PMID: 30497790.
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