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The Zhang Laboratory

Publications

Jiang X, Guan L, Zhou Y, Hong W-X, Zhang Q, Kaback HR. Evidence for an intermediate conformer of LacY. Proc. Natl. Acad. Sci. USA 2012, 109:E698-704.

Wilderman PR, Gay S, Jang H-H, Zhang Q, Stout CD, Halpert JR. Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme. FEBS J. 2011, 279:1607-20.

Zhang Q, Tao H, Hong W-X. New Amphiphiles for Membrane Protein Structural Biology. Methods 2011, 55:318-23.

Shah MB, Pascual J, Zhang Q, Stout CD, Halpert JR. Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine:  Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains. Mol. Pharmacol. 2011, 80:1047-55.

Gay SC, Zhang H, Wilderman PR, Roberts AG, Liu T, Li S, Lin H, Zhang Q, Woods Jr. VL, Stout CD, Hollenberg PF, Halpert JR. Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity. Biochemistry 2011, 50:4903-11.

Yu F, Weng Y, Hong W-X, Zhang Q. Efficient Synthesis of Unsaturated 1-Monoacyl Glycerols for in meso Crystallization of Membrane Proteins. Synlett 2011, 809-812.

Hou T, Weng Y, Zhuo R, Chang G, Urbatsch IL, Zhang Q. Design and Synthesis of Selenazole-Containing Peptides for Co-crystallization with P-glycoprotein. ChemBioChem 2011, 12:868-73.

Wilderman PR, Shah MB, Liu T, Li S, Hsu, S, Roberts AG, Goodlett DR, Zhang Q, Woods Jr. VL, Stout CD, Halpert JR. Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-Ray Crystallography. J. Biol. Chem. 2010, 285:38602-11.

Xiao H, Szewczyk P, Karyakin A, Evin R, Hong W-X, Zhang Q, Chang, G. Structure of a Cation-bound Multidrug and Toxic Compound Extrusion Transporter. Nature 2010, 467:991-4.

Gay SB, Roberts AG, Maekawa, K, Talakad, JC, Hong W-X, Zhang Q, Stout CD, Halpert JR. Cytochrome P450 2B4 Complexed with Antiplatelet Drugs Ticlopidine and Clopidogrel. Biochemistry 2010, 49:8709-20.

Hong W-X, Kent BA, Ma X, Stevens RC, Yeager M, Zhang Q. Design, Synthesis, and Properties of Branch-chained Maltoside Detergents for Stabilization and Crystallization of Integral Membrane Proteins: Human Connexin 26. Langmuir 2010, 26(11):8690-6.

Gay SB, Shah MB, Talakad JC, Maekawa K, Roberts AG, Wilderman PR, Sun L, Yang JY, Huelga SC, Hong W-X, Zhang Q, Stout CD, Halpert JR. Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0 Å Resolution. Mol. Pharmacol. 2010, 77:529-38.

Annalora A, Goodin DB, Hong W-X, Zhang Q, Johnson EF, Stout CD. The Crystal Structure of CYP24A1, A Mitochondrial Cytochrome P450 Involved in Vitamin D Metabolism. J. Mol. Biol. 2010, 396:441-451.

Aller SG., Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding. Science 2009, 323:1718-1722.

Zhang Q, Horst R, Geralt M, Ma X, Finn MG, Stevens RC, Wuthrich K. Microscale NMR Screening of New Detergents for Membrane Protein Structural Biology. J. Am. Chem. Soc. 2008, 130:7357-7363.

Zhang Q, Ma X, Ward A, Hong W-X, Jaakola V-P, Stevens RC, Finn MG, Chang G. Designing Facial Amphiphiles for the Stabilization of Integral Membrane Proteins. Angew. Chem. Int. Ed. 2007, 46:7023-7025.

Stewart CR,* Wilson LM,* Zhang Q,* Pham CLL, Waddington L, Stapleton D, Staples MK, Kelly JW, Howlett GJ. Oxidized Cholesterol Metabolites Found in Human Atherosclerotic Lesions Promote Apolipoprotein Amyloid Fibril Formation, Biochemistry 2007, 46:5552-5561. (* equal contribution)

Bieschke J, Zhang Q, Bosco DA, Lerner RA , Powers ET, Wentworth Jr. P, Kelly JW. Small Molecule Oxidation Products Trigger Disease-Associated Protein Misfolding. Acc. Chem. Res. 2006, 39:611-619.

Bosco DA, Fowler D, Zhang Q, Nieva J, Powers ET, Wentworth Jr. P, Lerner RA, Kelly JW. Elevated Levels of Oxidized Cholesterol Metabolites in Lewy Body Disease Brains Accelerate Alpha-Synuclein Fibrillization. Nat. Chem. Biol. 2006, 2:249-253.

Zhang Q, Kelly JW. Cys-10 Mixed Disulfide Modifications Exacerbate Transthyretin Familial Variant Amyloidogenicity: A Likely Explanation for Variable Clinical Expression of Amyloidosis and the Lack of Pathology in C10S/V30M Transgenic Mice? Biochemistry 2005, 44:9079-9085.

Bieschke J, Zhang Q, Powers ET, Lerner RA, Kelly JW. Oxidative Metabolites Accelerate Alzheimer’s Amyloidogenesis by a Two Step Mechanism, Eliminating the Requirement for Nucleation. Biochemistry 2005, 44:4977-4983.

Zhang Q, Xu W, Lu X. Cycloisomerization of 1,6-Enynes Using Acetate as Nucleophile under Palladium(II) Catalysis. J. Org. Chem. 2005, 70:1505-1507.

Zhang Q, Powers ET, Nieva J, Huff ME, Galve R, Dendle MA, Bieschke J, Glabe CG, Eschenmoser A, Wentworth Jr. P, Lerner RA, Kelly JW. Metabolite Initiated Protein Misfolding May Trigger Alzheimer’s Disease. Proc. Natl. Acad. Sci. USA 2004, 101:4752-4757.

Zhang Q, Kelly, JW. Cys10 Mixed Disulfides Make Transthyretin More Amyloidogenic under Mildly Acidic Conditions. Biochemistry 2003, 42:8756-8761.

Zhang Q, Lu X, Han X. Palladium(II)-Catalyzed Asymmetric Cyclization of (Z)-4'-Acetoxy-2'-butenyl 2-Alkynoates. Role of Nitrogen-Containing Ligands in Palladium(II)-Mediated Reactions. J. Org. Chem. 2001, 66:7676-7684.

Zhang Q, Lu X. Reactions of palladium enolate intermediate with electrophiles under divalent palladium catalysis. Huaxue Xuebao 2001, 59:1702-1706.

Zhang Z, Lu X, Xu Z, Zhang Q, Han, X. Role of Halide Ions in Divalent Palladium-Mediated Reactions: Competition between b-Heteroatom Elimination and b-Hydride Elimination of a Carbon-Palladium Bond. Organometallics 2001, 20:3724-3728.

Lu X, Zhang Q. Effect of ligands on the divalent palladium-catalyzed carbon-carbon coupling reactions. Highly enantioselective synthesis of optically active g-butyrolactones. Pure Appl. Chem. 2001, 73:247-250.

Zhang Q, Lu X. Highly enantioselective palladium(II)-catalyzed cyclization of (Z)-4'-acetoxy-2'-butenyl -2-alkynoates: an efficient synthesis of optically active g-butyrolactones. J. Am. Chem. Soc. 2000, 122:7604-7605.

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