The Zhang Laboratory
Overview
Membrane Protein Chemistry and Structural Biology
Source http://wapedia.mobi/nl/Afbeelding:Cell_membrane_detailed_diagram.svg
Membrane bound proteins are encoded by about one third of the human genome, performing essential functions as receptors, transporters and channels. Owing to their profound physiological significance in numerous human diseases, membrane proteins comprise more than 50% of human drug targets. Our laboratory is primarily interested in the development of innovative methodologies and chemical tools enabling the structural and functional characterization of membrane proteins. We are also interested in the development and discovery of small molecule ligands and therapeutics targeting membrane proteins that are of great biological and biomedical significance. We combine multidisciplinary approaches in our research involving chemical design and synthesis, biochemical and biophysical assays, structural determinations, and most importantly, collaborations with world leading experts in the field of membrane protein research.
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