The Zhang Laboratory

Overview

Source http://wapedia.mobi/nl/Afbeelding:Cell_membrane_detailed_diagram.svg

Interactions of Membrane Proteins with Drugs and Lipids

We are a multidisciplinary group working on chemical and structural biology of membrane proteins. Membrane Proteins account for about one third of human genes and comprise more than 50% of human drug targets. Our laboratory develops novel methodologies and chemical tools enabling their structural and functional characterizations. A major interest is to study the interactions between membrane proteins and lipids that govern the protein stability and function. We are also interested in the development and discovery of small molecule therapeutics targeting membrane proteins of great biological and biomedical significance including transporters, GPCRs and channels. Towards this end, we have devoted efforts to solve membrane protein structures for drug binding and mechanistic studies. Developing synthetic methodologies to make biologically relevant molecules is another component of our laboratory.

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