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The Nemazee Lab

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Publications

2013 | 20122011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 1989-2000

2015

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen. Jardine JG, Ota T, Sok D, Pauthner M, Kulp DW, Kalyuzhniy O, Skog PD, Thinnes TC, Bhullar D, Briney B, Menis S, Jones M, Kubitz M, Spencer S, Adachi Y, Burton DR, Schief WR, Nemazee D. Science 2015 June 18. pii: aac5894. [Epub ahead of print]

2013

Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10. Doyle-Cooper C, Hudson KE, Cooper AB, Ota T, Skog P, Dawson PE, Zwick MB, Schief WR, Burton DR, Nemazee D. J Immunol. 2013 Sep 15;191(6):3186-91.

B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates. Ota T, Doyle-Cooper C, Cooper AB, Doores KJ, Aoki-Ota M, Le K, Schief WR, Wyatt RT, Burton DR, Nemazee D. J Immunol. 2013 Sep 15;191(6):3179-85.

2012

Anti-HIV B Cell lines as candidate vaccine biosensors. Ota, T., C. Doyle-Cooper, A. B. Cooper, M. Huber, E. Falkowska, K. J. Doores, L. Hangartner, K. Le, D. Sok, J. Jardine, J. Lifson, X. Wu, J. R. Mascola, P. Poignard, J. M. Binley, B. K. Chakrabarti, W. R. Schief, R. T. Wyatt, D. R. Burton, and D. Nemazee. 2012. J Immunol 189:4816-4824.

Skewed primary Igkappa repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing. Aoki-Ota, M., A. Torkamani, T. Ota, N. Schork, and D. Nemazee. 2012. J Immunol 188:2305-2315.

2011

Negative Selection by IgM Superantigen Defines a B Cell Central Tolerance Compartment and Reveals Mutations Allowing Escape. Duong, B.H., Ota, T., Aoki-Ota, M., Cooper, A.B., Aït-Azzouzene, D., Vela, J.L., Gavin, A.L., Nemazee, D. 2011. J Immunol. 187:5596-5605.  PMID: 22043016 [PubMed Link]

Liver-expressed Igk superantigen induces tolerance of polyclonal B cells by clonal deletion, not k-to-l receptor editing. Ota, T., Ota, M., Duong, B.H., Gavin, A.L., Nemazee, D. 2011.  J.Exp.Med. 208:617-629. PMCID: PMC3058582. PMID: 21357741 [PubMed Link]  

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B. 2011.  Nat Immunol. 12:434-440. PMCID: PMC3079768. [PubMed Link]

2010

Regulation of the B cell receptor repertoire and self reactivity by BAFF. Ota, M., Duong, B.H., Torkamani, A., Doyle, C., Gavin, A., Ota, T., Nemazee, D. 2010.  J. Immunol., 185:4128-4136.

Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice. Aït-Azzouzene, D., Kono, D.H., Gonzalez-Quintial, R., McHeyzer-Williams, L.J., Lim, M., Wickramarachchi, D., Gerdes, T., Gavin, A.L., Skog, P., McHeyzer-Williams, M.G., *Nemazee, D., *Theofilopoulos, A.N.  2010.   J. Immunol. 185:1015-1027. *co-PI

A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha. Siggs, O.M., Berger, M., Krebs, P., Arnold, C.N., Eidenschenk, C., Huber. C,, Pirie. E,, Smart, N.G., Khovananth, K., Xia, Y., McInerney, G., Karlsson-Hedestam, G.B., Nemazee, D., Beutler, B. 2010.  Proc. Natl. Acad. Sci. U S A. 107:3046-3051. PMCID: PMC2840324.

Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen. Duong, B.H., Ota, T., Aït-Azzouzene, D., Ota, M., Vela, J.L., Huber, C., Walsh, K., Gavin, A. L., Nemazee, D. 2010.  J. Immunol. 184:4143-4158. PMCID: PMC2874719. PMID: 20231687 [PubMed Link]

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo. Duong, B.H., Tian, H., Ota, T, Completo, G., Han, S., Vela, J.L., Ota, M., Kubitz, M., Bovin, N. Paulson, J., Nemazee, D. 2010.  J.Exp.Med. 207:173-187. PMCID: PMC2812539.  PMID: 20038598 [PubMed Link]

2009

Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE. Ota, T., Aoki-Ota, M., Duong, B.H., Nemazee, D. 2009. J. Immunol. 182:8110-8117. PMCID: PMC2874974.

Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci. Beck, K., Peak, M.M., Ota, T., Nemazee, D., Murre, C. 2009. J Exp Med. 206:2271-2284. PMCID: PMC2757879.

2008

FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. Huber, C., Mårtensson, A., Bokoch, G.M., Nemazee, D., Gavin, A.L. 2008. J. Biol. Chem. 283:34002-34012. PMCID: PMC2590680.

Recombination by the mouse immunoglobulin kdeleting element RS promotes immune tolerance and Igl B cell production. Vela, J.L., Aït-Azzouzene, D., Duong, B.H., Ota, T. and Nemazee, D. 2008. Immunity, 28:161. PMCID: PMC2351955.

2007

Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. Verkoczy, L., Duong, B., Skog, P., Aït-Azzouzene, D., Puri, K., Vela, J.L., Nemazee, D. 2007. J Immunol. 178:6332.

Reduced receptor editing in lupus-prone MRL/lpr mice. Lamoureux, J.L., Watson, L.C., Cherrier, M., Skog, P., Nemazee, D., Feeney, A.J. 2007. J Exp Med. 204:2853.

Role of RS/kappaDE in B cell receptor editing. Vela, J.L. and Nemazee, D. 2007. Adv Exp Med Biol. 596:169.

2006

Split tolerance in peripheral B cell subsets in mice expressing a low level of Igk-reactive ligand. Ait-Azzouzene, D., Verkoczy, L., Duong, B., Skog, P., Gavin, A., and Nemazee, D. 2006. J. Immunol. 176:939-948.

Effect of cell:cell competition and BAFF expression on peripheral B cell tolerance and B-1 cell survival in transgenic mice expressing a low level of Igkappa-reactive macroself antigen. Ait-Azzouzene, D., Gavin, A., Skog, P., Duong, B., and Nemazee, D. 2006. Eur. J. Immunol. 36:985-996.

Paucity of V-D-D-J Rearrangements and VH Replacement Events in Lupus Prone and Nonautoimmune TdT-/- and TdT+/+ Mice. Watson LC, Moffatt-Blue CS, McDonald RZ, Kompfner E, Ait-Azzouzene D, Nemazee D, Theofilopoulos AN, Kono DH, Feeney AJ. 2006. J Immunol. 15;177(2):1120-8.

Immunology: Toll-like receptors and antibody responses. Nemazee, D., Gavin, A., Hoebe, K., and Beutler, B. 2006.  Nature.  441:7091.

Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Gavin, A., Hoebe, K., Duong, B., Ota, T., Martin, C., Beutler, B., Nemazee, D. 2006. Science. 314-:1936-1938.

Receptor editing in lymphocyte development and central tolerance. Nemazee, D. 2006. Nat Rev Immunol. 6:728.

2005

deltaBAFF, a splice isoform of BAFF, opposes full length BAFF activity in vivo in transgenic mouse models. Gavin, A., Duong, B., Skog, P., Aït-Azzouzene, D., Martensson, Greaves, D.R., Scott, M. and Nemazee, D. 2005.  J. Immunol. 175:319-328.

An immunoglobulin Ck-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. Ait-Azzouzene, D., Verkoczy, L., Peters, J., Gavin, A., Skog, P., Vela, J.L., and Nemazee, D. 2005. J. Exp. Med. 201:817-828.

B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels.Collins, C.E., Gavin, A.L., Migone, T.S., Hilbert, D.M., Nemazee, D., Stohl, W. 2005. Arthritis Res Ther. 8(1):R6. 

A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. Verkoczy, L., Ait-Azzouzene, D., Skog, P., Martensson, A., Lang, J., Duong B., and Nemazee, D. 2005. Immunity 22:519-531.

2004

Receptor Editing and Marginal Zone B Cell Development are Regulated by the Helix-Loop-Helix Protein, E2A. Quong, M.W., Martensson, A., Langerak, A.W., Rivera, R.R., Nemazee, D. and Murre, C. 2004. J.Exp.Med.  199(8): 1101-12.

Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection. Ait-Azzouzene, D., Skog, P., Retter, M., Kouskoff, V., Hertz, M., Lang, J., Kench, J., Chumley, M., Melamed, D., Sudaria, J., Gavin, A., Martensson, A., Verkoczy, L., Duong, B., Vela, J, Nemazee, D. 2004. Immunol. Rev. 197:219-230.

Peripheral B Lymphocyte Tolerance. Gavin, A., Verkoczy, L., Aït-Azzouzene, D., Martensson, A., Skog, P., Vela, J., Duong, B. and Nemazee, D. 2004. Keio J. Med., 53:151-158.
The scope of receptor editing and its association with autoimmunity. Verkoczy, L.K., Martensson, A.S., Nemazee, D. 2004. Curr. Opin. Immunol. 16:808-814.

2003

Do B cells take advantage of "missing self" recognition? Nemazee, D., Gavin, A. 2003. Curr. Dir. Autoimmun. 6:245-264.

delta BAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF. Gavin, A.L., Ait-Azzouzene, D., Ware, C.F., and Nemazee, D. 2003. J. Biol. Chem. 278:38220-38228.

1989 - 2000

T-cell independent rescue of B lymphocytes from peripheral immune tolerance. Kouskoff, V., Lacaud, G., Nemazee, D. 2000. Science 287, 2501-2503.

Receptor selection in B and T lymphocytes. Nemazee, D. 2000. Annu. Rev. Immunol., 18, 19-51.

A VH11Vk9 BCR drives generation of CD5+ B cells both in vivo and in vitro. Chumley, M.J., Dal Porto, J. M., Kawaguchi, S., Cambier, J.C., Nemazee, D., and Hardy, R.R. 2000. J. Immunol., 164:4586-4593.


B cell receptor expression level determines the fate of developing B lymphocytes: Receptor editing versus selection. Kouskoff, V., Lacaud, G., Retter, M., and Nemazee, D. 2000.  Proc. Natl. Acad. Sci. USA, 97: 7435-7439.

T-cell independent rescue of B lymphocytes from peripheral immune tolerance. Kouskoff, V., Lacaud, G., Nemazee, D. 2000. Science 287: 2501-2503.

Unexpected autoantibody production in membrane Ig-mu-deficient/lpr mice. Melamed, D., Miri, E., Leider, N., Nemazee, D. 2000.  J Immunol. 165: 4353-4358.

Theoretical limits to massive receptor editing in immature B-cells. Nemazee, D. (1998). Curr. Top. Immunol. Microbiol. 229, 163-171.

Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Melamed, D., Benschop, R. J., Cambier, J. C., and Nemazee, D. (1998). Cell 92, 173-182.

V(D)J recombinase induction in splenic B cells is inhibited by antigen receptor ligation. Hertz, M., Kouskoff, V., Nakamura, T., and Nemazee, D. (1998). Nature 394, 292-295.

Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes. Kench, J.A., Russell, D. M. and Nemazee, D. (1998). J. Exp. Med., 188, 909-917.

Receptor editing occurs frequently during normal B cell development. Retter, M.W. and Nemazee, D. (1998). J. Exp. Med., 188, 1231-1238.

Partial agonist ligands of the B cell receptor induce differential lymphokine production and partial tyrosine phosphorylation. Kouskoff, V., Kaye, B, Lang, P., Cambier, J., and Nemazee, D. (1998).  J. Exp. Med., 188, 1453-1464.

BCR ligation induces receptor editing in IgM+D- bone marrow B-cells in vitro. Hertz, M. and Nemazee, D. (1997). Immunity 6, 429-436.

Functional B cell receptor transgene allows IL-7 independent maturation of B cell precursors.Melamed, D., Kench, J.A., Rolink, A., and Nemazee, D. (1997). J. Immunol. 159, 1233-1239.

Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developemental arrest. Melamed, D. and Nemazee, D. (1997). Proc. Natl. Acad. Sci. USA 94, 9267-9272.

Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B-cells in an antigen dose-dependent manner, and promotes receptor editing in immature B-cells. Lang, J.L., Strasser, A., Korsmeyer, S., Harris, A., and Nemazee, D. (1997). J. Exp. Med., 186, 1513-1522.

Analysis of central B-cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes. Rubio, C.F., Kench, J., Russell, D.M., Yawger, R., and Nemazee, D. (1996). J. Immunol. 157, 65-71.

Efficient deletion of immature, but not mature, autoreactive B-cells by ultra-low affinity, membrane-bound self antigens. Lang, J.L., Brunmark, A., Jackson, M., Russell, D.M., Yawger, R., and Nemazee, D. (1996). J. Exp. Med. 184, 1685-1697.

Antigen receptor "capacity" and the sensitivity of self tolerance. Nemazee, D. (1995) Immunol. Today 17, 25-29.

Expression of functional immunoglobulin transgenes allows ordered B-cell differentiation to progress in Rag-1 deficient mice. Spanopoulou, E., Roman, C.A.J., Corcoran, L., Schissel, M., Silver, D.P., Storb, U., Nemazee, D., Nussenzweig, M., Shinton, S.A., Hardy, R.R. and Baltimore, D. (1994) Genes & Devel. 8, 1030-1042.

Receptor editing in self-reactive bone marrow B-cells. Tiegs, S.L., Russell, D.M. and Nemazee, D. (1993) J. Exp. Med. 177, 1009-1020.

Peripheral deletion of self-reactive B-cells. Russell, D.M., Dembic, Z., Morahan, G., Miller, JFAP, Bürki, K. and Nemazee, D. (1991) Nature 354, 308-311.

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nemazee, D.A., and K. Bürki. 1989.  Nature. 337:562-566.

Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras. Nemazee, D.A. and K. Bürki. 1989. Proc. Natl. Acad. Sci. USA 86, 8039-8043.