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The Nemazee Lab

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Publications

2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 1989-2000

2011

Duong, B.H., Ota, T., Aoki-Ota, M., Cooper, A.B., Aït-Azzouzene, D., Vela, J.L., Gavin, A.L., Nemazee, D. 2011. Negative Selection by IgM Superantigen Defines a B Cell Central Tolerance Compartment and Reveals Mutations Allowing Escape. J Immunol. 187:5596-5605.  PMID: 22043016 [PubMed Link]

Ota, T., Ota, M., Duong, B.H., Gavin, A.L., Nemazee, D. 2011. Liver-expressed Igk superantigen induces tolerance of polyclonal B cells by clonal deletion, not k-to-l receptor editing. J.Exp.Med. 208:617-629. PMCID: PMC3058582. PMID: 21357741 [PubMed Link]  

Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B. 2011. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol. 12:434-440. PMCID: PMC3079768. [PubMed Link]

2010

Ota, M., Duong, B.H., Torkamani, A., Doyle, C., Gavin, A., Ota, T., Nemazee, D. 2010. Regulation of the B cell receptor repertoire and self reactivity by BAFF. J. Immunol., 185:4128-4136.

Aït-Azzouzene, D., Kono, D.H., Gonzalez-Quintial, R., McHeyzer-Williams, L.J., Lim, M., Wickramarachchi, D., Gerdes, T., Gavin, A.L., Skog, P., McHeyzer-Williams, M.G., *Nemazee, D., *Theofilopoulos, A.N.  2010.  Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice. J. Immunol. 185:1015-1027. *co-PI

Siggs, O.M., Berger, M., Krebs, P., Arnold, C.N., Eidenschenk, C., Huber. C,, Pirie. E,, Smart, N.G., Khovananth, K., Xia, Y., McInerney, G., Karlsson-Hedestam, G.B., Nemazee, D., Beutler, B. 2010. A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha. Proc. Natl. Acad. Sci. U S A. 107:3046-3051. PMCID: PMC2840324.

Duong, B.H., Ota, T., Aït-Azzouzene, D., Ota, M., Vela, J.L., Huber, C., Walsh, K., Gavin, A. L., Nemazee, D. 2010. Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen. J. Immunol. 184:4143-4158. PMCID: PMC2874719. PMID: 20231687 [PubMed Link]

Duong, B.H., Tian, H., Ota, T, Completo, G., Han, S., Vela, J.L., Ota, M., Kubitz, M., Bovin, N. Paulson, J., Nemazee, D. 2010. Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo. J.Exp.Med. 207:173-187. PMCID: PMC2812539.  PMID: 20038598 [PubMed Link]

2009

Ota, T., Aoki-Ota, M., Duong, B.H., Nemazee, D. 2009. Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE. J. Immunol. 182:8110-8117. PMCID: PMC2874974.

Beck, K., Peak, M.M., Ota, T., Nemazee, D., Murre, C. 2009. Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci. J Exp Med. 206:2271-2284. PMCID: PMC2757879.

2008

Huber, C., Mårtensson, A., Bokoch, G.M., Nemazee, D., Gavin, A.L. 2008. FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J. Biol. Chem. 283:34002-34012. PMCID: PMC2590680.

Vela, J.L., Aït-Azzouzene, D., Duong, B.H., Ota, T. and Nemazee, D. 2008. Recombination by the mouse immunoglobulin kdeleting element RS promotes immune tolerance and Igl B cell production. Immunity, 28:161. PMCID: PMC2351955.

2007

Verkoczy, L., Duong, B., Skog, P., Aït-Azzouzene, D., Puri, K., Vela, J.L., Nemazee, D. 2007. Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. J Immunol. 178:6332.

Lamoureux, J.L., Watson, L.C., Cherrier, M., Skog, P., Nemazee, D., Feeney, A.J. 2007. Reduced receptor editing in lupus-prone MRL/lpr mice. J Exp Med. 204:2853.

Vela, J.L. and Nemazee, D. Role of RS/kappaDE in B cell receptor editing. 2007. Adv Exp Med Biol. 596:169.

2006

Ait-Azzouzene, D., Verkoczy, L., Duong, B., Skog, P., Gavin, A., and Nemazee, D. 2006. Split tolerance in peripheral B cell subsets in mice expressing a low level of Igk-reactive ligand. J. Immunol. 176:939-948.

Ait-Azzouzene, D., Gavin, A., Skog, P., Duong, B., and Nemazee, D. 2006. Effect of cell:cell competition and BAFF expression on peripheral B cell tolerance and B-1 cell survival in transgenic mice expressing a low level of Igkappa-reactive macroself antigen. Eur. J. Immunol. 36:985-996.

Watson LC, Moffatt-Blue CS, McDonald RZ, Kompfner E, Ait-Azzouzene D, Nemazee D, Theofilopoulos AN, Kono DH, Feeney AJ. 2006. Paucity of V-D-D-J Rearrangements and VH Replacement Events in Lupus Prone and Nonautoimmune TdT-/- and TdT+/+ Mice. J Immunol. 15;177(2):1120-8.

Nemazee, D., Gavin, A., Hoebe, K., and Beutler, B. 2006.  Immunology: Toll-like receptors and antibody responses. Nature.  441:7091.

Gavin, A., Hoebe, K., Duong, B., Ota, T., Martin, C., Beutler, B., Nemazee, D. 2006. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science. 314-:1936-1938.

Nemazee, D. Receptor editing in lymphocyte development and central tolerance. 2006. Nat Rev Immunol. 6:728.

2005

Gavin, A., Duong, B., Skog, P., Aït-Azzouzene, D., Martensson, Greaves, D.R., Scott, M. and Nemazee, D. 2005. ?delta]BAFF, a splice isoform of BAFF, opposes full length BAFF activity in vivo in transgenic mouse models. J. Immunol. 175:319-328.

Ait-Azzouzene, D., Verkoczy, L., Peters, J., Gavin, A., Skog, P., Vela, J.L., and Nemazee, D. 2005. An immunoglobulin Ck-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. J. Exp. Med. 201:817-828.

Collins, C.E., Gavin, A.L., Migone, T.S., Hilbert, D.M., Nemazee, D., Stohl, W. 2005. B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels. Arthritis Res Ther. 8(1):R6. 

Verkoczy, L., Ait-Azzouzene, D., Skog, P., Martensson, A., Lang, J., Duong B., and Nemazee, D. 2005. A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. Immunity 22:519-531.

2004

Quong, M.W., Martensson, A., Langerak, A.W., Rivera, R.R., Nemazee, D. and Murre, C. 2004. Receptor Editing and Marginal Zone B Cell Development are Regulated by the Helix-Loop-Helix Protein, E2A. J.Exp.Med.  199(8): 1101-12.

Ait-Azzouzene, D., Skog, P., Retter, M., Kouskoff, V., Hertz, M., Lang, J., Kench, J., Chumley, M., Melamed, D., Sudaria, J., Gavin, A., Martensson, A., Verkoczy, L., Duong, B., Vela, J, Nemazee, D. 2004. Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection. Immunol. Rev. 197:219-230.

Gavin, A., Verkoczy, L., Aït-Azzouzene, D., Martensson, A., Skog, P., Vela, J., Duong, B. and Nemazee, D. 2004. Peripheral B Lymphocyte Tolerance. Keio J. Med., 53:151-158.
Verkoczy, L.K., Martensson, A.S., Nemazee, D. 2004. The scope of receptor editing and its association with autoimmunity. Curr. Opin. Immunol. 16:808-814.

2003

Nemazee, D., Gavin, A. 2003. Do B cells take advantage of "missing self" recognition? Curr. Dir. Autoimmun. 6:245-264.

Gavin, A.L., Ait-Azzouzene, D., Ware, C.F., and Nemazee, D. 2003. delta BAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF. J. Biol. Chem. 278:38220-38228.

1989 - 2000

Kouskoff, V., Lacaud, G., Nemazee, D. 2000. T-cell independent rescue of B lymphocytes from peripheral immune tolerance. Science 287, 2501-2503.

Nemazee, D. 2000. Receptor selection in B and T lymphocytes. Annu. Rev. Immunol., 18, 19-51.

Chumley, M.J., Dal Porto, J. M., Kawaguchi, S., Cambier, J.C., Nemazee, D., and Hardy, R.R. 2000. A VH11Vk9 BCR drives generation of CD5+ B cells both in vivo and in vitro. J. Immunol., 164:4586-4593.
Kouskoff, V., Lacaud, G., Retter, M., and Nemazee, D. 2000. B cell receptor expression level determines the fate of developing B lymphocytes: Receptor editing versus selection. Proc. Natl. Acad. Sci. USA, 97: 7435-7439.

Kouskoff, V., Lacaud, G., Nemazee, D. 2000. T-cell independent rescue of B lymphocytes from peripheral immune tolerance. Science 287: 2501-2503.

Melamed, D., Miri, E., Leider, N., Nemazee, D. 2000. Unexpected autoantibody production in membrane Ig-mu-deficient/lpr mice. J Immunol. 165: 4353-4358.

Nemazee, D. (1998). Theoretical limits to massive receptor editing in immature B-cells. Curr. Top. Immunol. Microbiol. 229, 163-171.

Melamed, D., Benschop, R. J., Cambier, J. C., and Nemazee, D. (1998). Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell 92, 173-182.

Hertz, M., Kouskoff, V., Nakamura, T., and Nemazee, D. (1998). V(D)J recombinase induction in splenic B cells is inhibited by antigen receptor ligation. Nature 394, 292-295.

Kench, J.A., Russell, D. M. and Nemazee, D. (1998). Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes. J. Exp. Med., 188, 909-917.

Retter, M.W. and Nemazee, D. (1998). Receptor editing occurs frequently during normal B cell development. J. Exp. Med., 188, 1231-1238.

Kouskoff, V., Kaye, B, Lang, P., Cambier, J., and Nemazee, D. (1998). Partial agonist ligands of the B cell receptor induce differential lymphokine production and partial tyrosine phosphorylation. J. Exp. Med., 188, 1453-1464.

Hertz, M. and Nemazee, D. (1997). BCR ligation induces receptor editing in IgM+D- bone marrow B-cells in vitro. Immunity 6, 429-436.

Melamed, D., Kench, J.A., Rolink, A., and Nemazee, D. (1997). Functional B cell receptor transgene allows IL-7 independent maturation of B cell precursors. J. Immunol. 159, 1233-1239.

Melamed, D. and Nemazee, D. (1997). Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developemental arrest. Proc. Natl. Acad. Sci. USA 94, 9267-9272.

Lang, J.L., Strasser, A., Korsmeyer, S., Harris, A., and Nemazee, D. (1997). Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B-cells in an antigen dose-dependent manner, and promotes receptor editing in immature B-cells. J. Exp. Med., 186, 1513-1522.

Rubio, C.F., Kench, J., Russell, D.M., Yawger, R., and Nemazee, D. (1996). Analysis of central B-cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes. J. Immunol. 157, 65-71.

Lang, J.L., Brunmark, A., Jackson, M., Russell, D.M., Yawger, R., and Nemazee, D. (1996). Efficient deletion of immature, but not mature, autoreactive B-cells by ultra-low affinity, membrane-bound self antigens. J. Exp. Med. 184, 1685-1697.

Nemazee, D. (1995) Antigen receptor "capacity" and the sensitivity of self tolerance. Immunol. Today 17, 25-29.

Spanopoulou, E., Roman, C.A.J., Corcoran, L., Schissel, M., Silver, D.P., Storb, U., Nemazee, D., Nussenzweig, M., Shinton, S.A., Hardy, R.R. and Baltimore, D. (1994) Expression of functional immunoglobulin transgenes allows ordered B-cell differentiation to progress in Rag-1 deficient mice. Genes & Devel. 8, 1030-1042.

Tiegs, S.L., Russell, D.M. and Nemazee, D. (1993) Receptor editing in self-reactive bone marrow B-cells. J. Exp. Med. 177, 1009-1020.

Russell, D.M., Dembic, Z., Morahan, G., Miller, JFAP, Bürki, K. and Nemazee, D. (1991) Peripheral deletion of self-reactive B-cells. Nature 354, 308-311.

Nemazee, D.A., and K. Bürki. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature. 337:562-566.

Nemazee, D.A. and K. Bürki. 1989. Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras. Proc. Natl. Acad. Sci. USA 86, 8039-8043.

 

 

 

 

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