The Wüthrich Laboratory

Ge, H., Yang, L., Chen, C., Xu, Y., Liu, D. and Wüthrich, K. (2025) J. Am. Chem. Soc. 147, 44114–44122. Human Substance P Interactions with G Protein-Coupled Receptor NK1R Observed by NMR in Solution.

Guo, C., Yang, L., Liu, J., Liu, D. and Wüthrich, K. (2025) Cell Chem. Biol. 32, 1140–1149. Structural basis of adenosine 2A receptor-balanced signaling activation relies on allosterically mediated structural dynamics.

Pan, B., Liu, D., Yang, L. and Wüthrich, K. (2022) Proc. Natl. Acad. Sci. USA 119, doi: 10.1073/pnas.2122682119. GPCR large-amplitude dynamics by ¹⁹F-NMR of aprepitant bound to the neurokinin 1 receptor.

Shimada, I., Ueda, T., Kofuku, Y., Eddy, M.T. and Wüthrich, K. (2019) Nat. Rev. Drug Disc. 18, 59–82.
GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures.
 
Eddy, M.T., Lee, M.-Y., Gao, Z.-G., White, K.L., Didenko, T., Horst, R., Audet, M., Stanczak, P., McClary, K.M., Han, G.W., Jacobson, K.A., Stevens, R. and Wüthrich, K. (2018) Cell 172, 68–80.
Allosteric coupling of drug binding and intracellular signaling in the A_2A adenosine receptor.
 
Liu, J.J., Horst, R., Katritch, V., Stevens, R.C. and Wüthrich, K. (2012) Science 335, 1106–1110.
Biased signaling pathways in β₂-adrenergic receptor characterized by ¹⁹F-NMR.
 
Wüthrich, K. (2003) Angew.Chem. Int. Ed. 42, 3340−3363.
NMR studies of structure and function of biological macromolecules (Nobel Lecture).
 
Fiaux, J., Bertelsen, E., Horwich, A. and Wüthrich, K. (2002) Nature 418, 207–211.
NMR analysis of a 900K GroEL–GroES complex.

Pervushin, K., Riek, R., Wider, G. and Wüthrich, K. (1997) Proc. Natl. Acad. Sci. USA 94, 12366–12371. Attenuated T₂ relaxation by mutual cancellation of dipole–dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution.

Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, Wiley, New York.

Wüthrich, K. (1969) Proc. Natl. Acad. Sci. USA 63, 1071–1078.
High resolution proton nuclear magnetic resonance spectroscopy of cytochrome c.