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The Wüthrich Laboratory

Selected List of Publications 

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Sušac, L., Eddy, M.T., Didenko, T., Stevens, R.C. and Wüthrich, K. (2019) Proc. Natl. Acad. Sci. USA 115, 12733–12738.
A2A adenosine receptor functional states characterized by 19F-NMR.
Shimada, I., Ueda, T., Kofuku, Y., Eddy, M.T. and Wüthrich, K. (2019) Nat. Rev. Drug Disc. 18, 59–82.
GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures.
Eddy, M.T., Lee, M.-Y., Gao, Z.-G., White, K.L., Didenko, T., Horst, R., Audet, M., Stanczak, P., McClary, K.M., Han, G.W., Jacobson, K.A., Stevens, R. and Wüthrich, K. (2018) Cell 172, 68–80.
Allosteric coupling of drug binding and intracellular signaling in the A2A adenosine receptor.
Liu, J.J., Horst, R., Katritch, V., Stevens, R.C. and Wüthrich, K. (2012) Science 335, 1106–1110.
Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.
Wüthrich, K. (2003) Angew.Chem. Int. Ed. 42, 3340−3363.
NMR studies of structure and function of biological macromolecules (Nobel Lecture).
Fiaux, J., Bertelsen, E., Horwich, A. and Wüthrich, K. (2002) Nature 418, 207–211.
NMR analysis of a 900K GroEL–GroES complex.

Pervushin, K., Riek, R., Wider, G. and Wüthrich, K. (1997) Proc. Natl. Acad. Sci. USA 94, 12366–12371.
Riek, R., Hornemann, S., Wider, G., Billeter, M., Glockshuber, R. and Wüthrich, K. (1996) Nature
382, 180–182.
NMR structure of the mouse prion protein domain PrP(121–231).

Otting, G., Liepinsh, E. and Wüthrich, K. (1991) Science 254, 974–980.
Protein hydration in aqueous solution.

Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, Wiley, New York.

Wüthrich, K. (1969) Proc. Natl. Acad. Sci. USA 63, 1071–1078.
High resolution proton nuclear magnetic resonance spectroscopy of cytochrome c.