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Publications

2020
Li, S., Wu, X. (2020). Common fragile sites: protection and repair. Cell Biosci 10, 29. (Review)
 
2019
Wu, X. (2019). Replication Stress Response Links RAD52 to Protecting Common Fragile Sites. Cancer 11 (10): 1467. (Review)
Hu, Q.*, Lu, H.*, Wang, H.*, Li, S., Truong, L.N., Li, J., Liu, S., Xiang, R. and Wu, X. (2019). Break-induced replication plays a prominent role in long-range repeat-mediated deletion. EMBO J. 38e101751
Li, S.*, Lu, H.*, Wang, Z.*, Hu, Q., Wang, H., Xiang, R., Chiba, T., and Wu, X. (2019) XPF is important for repair of DNA double-strand breaks containing secondary structures. iScience 16, 63-78. 
Wang, Z.*, Song, Y.*, Li, S., Kurian, S., Xiang, R., Chiba, T., and Wu, X. (2019). DNA polymerase (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse. Journal of Biological Chemistry 294, 3909-3919. 

2018
Wang, H.*, Li, S.*, Zhang, H., Wang, Y., Hao, S., and Wu, X. (2018). BLM prevents instability of structure-forming DNA sequences at common fragile sites. Plos Genetics 14, e1007816. 
Wang, H.*, Li, S.*, Oaks, J., Ren, J., Li, L., and Wu, X. (2018). The concerted roles of FANCM and Rad52 in the protection of common fragile sites. Nature Communication 9, 2791. 

Selected publications for past years:
Wang, H., Li, Y., Truong, L.N., Shi,L.Z., Hwang, P.Y.H., He, J., Cho, M.J., Li, H., Negrete, A., Shiloach, J., Berns, M.W., Shen, B., Chen, L. and Wu, X. (2014) CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity. Mol Cell 54:1012-1021.  PMID: 24837675
Truong, L.N., Li, Y., Sun, E., Ang, K., Hwang, P.Y., and Wu, X. (2014) Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication. J. Biol. Chem. 289:28910-28923.  PMID: 25160628
Truong, L., Li, Y., Shi, L., Hwang, P., He, J., Wang, H., Razavian, N., Berns, M., and Wu, X. (2013) Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc Natl Acad Sci. 110:7720-7725.  PMID: 23610439 
Wang, H., Shi, L.Z., Wong, C.C., Han, X., Hwang, P.Y., Truong, L.N., Zhu, Q., Shao, Z., Chen, D.J., Berns, M.W., Yates JR 3rd, Chen L, Wu X. (2013) The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet. 9: e1003277.  PMID: 23468639
Lee, A.Y., Chiba, T., Truong, L.N., Cheng, A.N., Do, J., Cho, M.J., Chen, L. and Wu, X. (2012) Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. J. Biol. Chem. 287:2531-3543.  PMID: 22123827
Wang, H., Shao, Z., Shi, L.Z., Hwang, P.Y., Truong, L.N., Berns, M.W., Chen, D.J. and Wu, X. (2012) CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks. J. Biol. Chem. 287:21471-21480.  PMID: 22544744
He, J., Shi, L.Z., Truong, L.N., Lu, C.S., Razavian, N., Li, J., Negrete, A., Shiloach, J., Berns, M.W. and Wu, X. (2012) Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-strand breaks and initiate various DNA damage responses. J. Biol. Chem. 287:31747-31756.  PMID: 22833675
Truong, L.N. and Wu, X. (2011) Prevention of DNA re-replication in eukaryotic cells. J. Mol. Cell Biol. 3:13-22.  PMID: 21278447
Chen, L., Nievera, C., Lee A. and Wu, X. (2008) Cell cycle-dependent complex formation of BRCA1/CtIP/Mre11-Rad50-Nbs1 is important for DNA double-strand break repair. J. Biol Chem. 283: 7713-7720.  PMID: 18171670
Olson E., Nievera C.J., Lee A.Y., Chen L. and Wu X. (2007) The Mre11 complex acts both upstream and downstream of ATR to regulate the S-phase checkpoint following UV treatment. J. Biol Chem.282: 22939-22952.  PMID: 17526493 
Liu E., Lee A.Y., Chiba T., Olson E. Sun P. and Wu X. (2007) ATR-mediated S-phase checkpoint prevents DNA rereplication in mammalian cells when the licensing control is disrupted. Journal of Cell Biology 179: 643-657.  PMID: 18025301
Olson E., Nievera C.J., Liu E., Lee A.Y., Chen L. and Wu X. (2007) The Mre11 complex mediates the S-phase checkpoint through an interaction with RPA. Molecular and Cellular Biology 27: 6053-6067.  PMID: 17591703
Lee A.Y., Liu E. and Wu X. (2007) The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells. J. Biol Chem. 282: 32243-32255.  PMID: 17715134 
Olson E., Nievera C. J., Klimovich V., Fanning E. and Wu X. (2006) RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint. J. Biol Chem. 281: 39517-39533.  PMID: 17035231 
Liu, E., Li, X., Yan, F., Zhao Q. and Wu, X. (2004) Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. J. Biol Chem. 279: 17283-17288.  PMID: 15004027
Wu, X.*, Avni, D., Chiba, T., Yan, F., Zhao, Q., Lin, Y., Heng, H.H.Q. and Livingston, D.M.* (2004) SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.  Genes & Development 18:1305-1316.  *Corresponding authors.  PMID: 15175262
Li, X., Zhao, Q., Liao, R., Sun, P. and Wu, X. (2003) The SCFSkp2 ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J. Biol Chem. 278: 30854-30858.  PMID: 12840033
Wu, X., Rathbun, G., Lane, W.S., Weaver, D.T. and Livingston, D.M. (2000) Communication of the Nijmegen Breakage Syndrome Protein with ATM and BRCA1. Cold Spring Harbor Symposia on Quantitative Biology LXV: 535-545.  PMID: 12760071
Wu, X., Ranganathan, V., Weisman, D.S., Heine, W.F., Ciccone, D.N., O’Neill, T.B., Crick, K.E., Pierce, K.A., Lane, W.S., Rathbun, G., Livingston, D.M. and Weaver, D.T. (2000). ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature 405: 477-482.  PMID: 10839545
Wu, X., Heine, W.F., Petrini, J.H.J., Weaver, D.T., Livingston, D.M. and Chen, J. (2000). Independence of Nbs1/Mre11/Rad50 nuclear focus formation and the presence of intact BRCA1. Science 289: 11
Wu, X., Wu, C. and Haber, J.E. (1997). Rules of donor preference in yeast mating-type gene switching revealed by a competition assay involving two types of recombination. Genetics 147: 399-407.  PMID: 9335581 
Wu, X., Haber, J.E. (1996) A 700 bp cis-acting region controls mating-type dependent recombination along the entire left arm of yeast chromosome III. Cell 87: 277-285.  PMID: 8861911
Wu, X., Moore, J.K. and Haber, J.E. (1996). Mechanism of MATa donor preference during mating-type switching of Saccharomyces cerevisiae.  Molecular and Cellular Biology 16: 657-668.  PMID: 8552094 
Wu, X. and Haber, J.E. (1995).  MATa donor preference in yeast mating-type switching: activation of a large chromosomal region for recombination.  Genes & Development 9:1922-1932.  PMID: 7649475