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Wong CV

Chi-Huey Wong Headshot

Dr. Chi-Huey Wong
Scripps Family Chair Professor 
Department of Chemistry
10550 North Torrey Pines Road
Mail Drop: BCC338
Tel: (858) 784-2487

Ella Blanc
Lab Administrative Coordinator
Tel: (858) 784-8377

Chi-Huey Wong Publications


B.S. (1966-1970) and M.S. (1975-1977) in Biochemical Sciences, National Taiwan University

Ph.D. in Chemistry (1979-1982), Department of Chemistry, MIT

Postdoctoral Fellow (1982-1983), Department of Chemistry, Harvard University


Academic Appointments

1983-1989: Assistant Professor (1983–1986), Associate Professor (1986–1987), and Professor (1987–1989) of Chemistry, Texas A&M University.

1989-2006: Professor and Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute.

1991-1999: Head, Frontier Research Program on Glycotechnology, RIKEN, Japan.

1996-2006: Member, the Skaggs Institute for Chemical Biology, The Scripps Research Institute.

2003-2006: Director and Distinguished Research Fellow, Genomics Research Center, Academia Sinica, Taipei, Taiwan.

2006-2016: President, Academia Sinica, Taipei, Taiwan.

2016-2019: Distinguished Research Fellow, Genomics Research Center, Academia Sinica, Taipei, Taiwan.

2006-2019: Professor of Chemistry, The Scripps Research Institute.

2019-Present: Scripps Family Chair Professor, Department of Chemistry, The Scripps Research Institute (with joint appointment at Academia Sinica as Distinguished Research Fellow).



  • Searle Scholar Award in Biomedical Sciences, USA (1985–1988).
  • Presidential Young Investigator Award in Chemistry, USA (1986–1991).
  • American Chemical Society Arthur C. Cope Scholar Award (1993).
  • The Roy Whistler Award of International Carbohydrate Organization (1994).
  • The ACS Division of Carbohydrate Chemistry Melville L. Wolfrom Award (1995).
  • The Taiwanese American Foundation Prize in Science and Engineering (1997).
  • The American Chemical Society Harrison Howe Award in Chemistry (1998).
  • The American Chemical Society Claude S. Hudson Award in Carbohydrate Chemistry (1999).
  • The International Enzyme Engineering Award (1999).
  • The American Chemical Society San Diego Section Outstanding Scientist Award (1999).
  • The Presidential Green Chemistry Challenge Award, USA (2000).
  • NIH Merit Award, USA (2001).
  • The American Chemical Society Award for Creative Work in Synthetic Organic Chemistry (2005).
  • The Georges Smets Chair Award for Organic or Polymer Chemistry, Louvain-la-Neuve, Belgium (2006).
  • Humboldt Research Award for Senior Scientists, Germany (2006).
  • The F. A. Cotton Medal for Excellence in Chemical Research, USA (2008).
  • National Science Council Science Professional Gold Medal, Taiwan (2009).
  • The American Chemical Society Arthur C. Cope Award (2012).
  • The Nikkei Asia Prize for Science, Technology and Innovation, Japan (2012).
  • The Wolf Prize in Chemistry (2014).
  • The Royal Society of Chemistry Robert Robinson Award, UK (2015).
  • Elected Member of Academia Sinica, Taiwan (1994).
  • Elected Member of The American Academy of Arts and Sciences (1996).
  • Elected Member of the US National Academy of Sciences (2002).
  • Elected Fellow of the American Association for the Advancement of Science (2005).
  • Elected Member of the World Academy of Sciences (2007).
  • Elected Associate Member of the European Molecular Biology Organization (EMBO) (2010).
  • Elected Fellow of the U.S. National Academy of Inventors (2014).
  • Elected Laureate of ITRI (Industrial Technology Research Institute, Taiwan) (2020).
  • The Robert A. Welch Award in Chemistry (2021).


Professional Honors and Activities

  • The Chinese American Chemical Society Distinguished Research Achievement Award (1994).
  • Member, NIH Biomedical Sciences Study Section (1993–1995), NIH Bioorganic and Natural Products Chemistry Study Section, USA (1995–1999).
  • Visiting Professor, Chemical Center, University of Lund, Sweden (1995–1998).
  • Distinguished Visiting Scholar, Institute of Chemistry (1999–2002) and Corresponding Research Fellow, Institute of Biological Chemistry, Academia Sinica, Taipei (1996–2002).
  • Honorary Professor, Shanghai Institute of Organic Chemistry, The Chinese Academy of Sciences, (1999).
  • Selected by ISI as one of the 100 most cited chemists in the world for the period (1981–1999), current H-Index: 138.
  • Doctor, Scientiarum Honoris Causa, Technion – Israel Institute of Technology, Israel (2007).
  • Honorary Doctorate, National Yang-Ming University, Taipei, Taiwan (2007).
  • Honorary Fellow, the Chemical Research Society of India (CRSI), India (2007).
  • Honorary Doctorate, National Sun Yat-sen University, Taiwan (2008).
  • Honorary Doctorate, City University of Hong Kong, Hong Kong (2009).
  • Honorary Doctorate, National Chung Hsing University, Taiwan (2010).
  • Honorary Doctorate, Kaohsiung Medical University, Taiwan (2011).
  • Honorary Doctorate, National Chiao Tung University, Taiwan (2011).
  • Honorary Doctorate, National Tsing-Hua University, Taiwan (2011).
  • Distinguished Fellow, University of Malaya (2012-present).


Advisory Activity

  • Advisory Board Member:  Journal of Organic Chemistry (1993–1997);  Journal of Chemical Society, Perkin Transaction 1 (1993–2002);  ChemBioChem (2005-2015);  The  Journal of the American Chemical Society (2005–2011);  Chemistry–An Asian Journal (2006–2017);  Angewandte Chemie (2010–2017),  Advanced Synthesis and Catalysis (2011-2013).
  • Editorial Board Member:  Drug  Discovery Today (1996–1999);  Current Opinion in Chemical Biology (1998–present);  Advanced Synthesis and Catalysis (2000–2010).
  • Founder, Combichem, Inc., San Diego, CA (1994); Founder, Board Member, and Chairman of the Scientific Advisory Board, Optimer Pharmaceuticals, Inc., San Diego (1999–2006).
  • Consultant for Dow Chemical (1983–1988), W.R. Grace (1984–1987), Amgen (1991–1993), Dow Corning (1992–1994), Abbott Laboratories (1991–1994), Lilly Research Laboratories (1991–1993), Mitsubishi Chemical Group Science and Technology Research Center, Japan (2005–2006).
  • Scientific Advisor for Amylin (1989–1993), Oncogene Science (1993–1998), Cytel (1991–1997), Affymax (1992–1995), ArQule (1994–1995), Kosan Biosciences (1997–2002), Pharmanex (1997–2006), Advanced Medicine (now Theravance) (1997–2000), Combichem (1994–1998), Momenta (2001–2003), Diversa (2001–2006), Institute of Chemistry (1992–2000; Chairman of the Board, 1994–2000) and Institute of Biological Chemistry (1994–2002), Academia Sinica, Taipei; Institute of Molecular and Cell Biology, National University of Singapore (1994–1997), Industrial Technology Research Institute (ITRI), Taiwan (2004–2006), Development Center for Biotechnology (DCB), Taiwan (2004–2006 & 2009-present); OBI Pharma, Taiwan (2017-present); CHO Pharma, Taiwan (2016-present); Delos Capital (2021-).
  • Member, Scripps/Novartis Joint Scientific Council (1993–2006).
  • Editor-in-Chief,  Bioorganic & Medicinal Chemistry (1993–2010).
  • Member of Executive Board of Editors for the Tetrahedron Publications (1993–2010), Chairman of the Board (2006–2008).
  • Scientific Advisor for Max-Planck Institute at Dortmund, Germany (2000–2008).
  • Board member of the National Research Council on Chemical Sciences & Technology, USA (2000–2004).
  • Member, 8 th and 9 th RIKEN Advisory Council (RAC) (2011 & 2014).
  • Chief Science Advisor (2006-2011), Member, Board of Science and Technology (2012-2016), Executive Yuan, Taiwan.
  • Member, Steering Committee of the Lily TB Drug Discovery Initiative (2009 – 2017).
  • Member, Board of Scientific Governors, The Scripps Research Institute (2009 – 2016).
  • Member, Committee on Assessing the Importance of Glycoscience and Glycomics, National Research Council USA (2011-12). A report  published in 2012 on “Transforming Glycoscience: A Roadmap for the Future”
  • Member, High Impact Research (HIR) Advisory Council, University of Malaya (2012-present).


Plenary and Named Lectures

1984: 188th ACS National Meeting
1985: NATO Advanced Research Workshop
1986: US/Japan Biotechnology Conference, Japan. International Symposium on “Biocatalysis in Organic Media,” Wageningen, the Netherlands; 5 th International Symposium on Life Science: Prospects for Enzyme Technology, Kyoto
1987: The Pittsburg–Cleveland Catalysis Society Meeting: Frontiers in Catalysis. Gordon Research Conference on Organic Reactions and Processes; The 18 th Annual NSF Workshop on Organic Synthesis and Natural Products Chemistry; The 87 th American Society of Microbiology Meeting, Atlanta. 194 th ACS National Meeting, New Orleans. Biotechnica ‘87, Hannover
1988: Symposium on Biotransformation, The Society of General Microbiology, University of Southampton, UK (2/2); Symposium on Bioorganic Synthesis, Swedish Academy of Sciences (2/3). ACS Regional Meeting, 22 nd MARM Symposium on Organic Synthesis (5/24); ACS central regional meeting, Symposium on New Synthetic Strategy, West Virginia (6/2); Gordon Research Conference on Stereochemistry, New Port (7/4); Conference on Biocatalytic Synthesis of Organic Compounds, New York (8/8); Symposium on Molecular Recognition Phenomena, Royal Society of Chemistry and Swiss Chemical Society (9/11)
1989: French–American Chemical Society 1st Meeting, Paris (6/5–6/8)
1990: University of Illinois, Frontier in Enzyme Chemistry (3/17); Texas A&M IUCCP Program (3/19); ACS National Meeting, Boston, Division of Carbohydrate Chemistry (4/25); Gordon Conference on Natural Products (7/22); IUMS Congress, Osaka (9/16); Society for Complex Carbohydrates, La Jolla (10/12)
1991: US–Japan Conference on Biotechnology, Hawaii (1/6); The 13 th Annual Conference on Clinical Laboratory Molecular Analysis (2/14); Frontiers in Biomedical Research, Annenberg Center, Palm Springs (2/18); Merck lecturer, University of Alberta, Chemistry (3/18); US–Japan Conference on Selectivity in Synthetic and Bioorganic Chemistry, Tokyo (6/3); ASM Biotechnology Conference, New York (6/27); ACS National Meeting/Fourth North American Congress (8/28); European Peptide Society, Enzymes in Peptide Synthesis, IEC-Bogensee, Germany (9/2); Enzyme Engineering, Hawaii (9/25); International Biotechnology Conference, San Francisco (10/27); Rhone-Poulenc’s 14 th Scientific Sessions, Frontiers in Chemistry and Biology, Paris (11/19); International Symposium on Bioorganic Chemistry, University of Chicago (11/22)
1992: Symposium on Enzymes in organic synthesis, IUPAC meeting in New Delhi, India (1/6); NATO Meeting on Microbial Reagents in Organic Synthesis (3/23); Symposium on Enzymes in organic chemistry: Synthetic and mechanistic aspects, The Organic Chemistry Division, The Royal Netherlands Chemical Society (4/9); Monsanto lecturer, Purdue University (5/4); International Workshop on New Aspects of Biocatalysis, Kyoto University (6/12); 4 th International SCBA Symposium, Singapore (6/14); IUPAC International Carbohydrate Symposium, Paris (7/5–7/10); Syntex lecturer, Colorado State University (11/19–11/20); Symposium on the Preparation of Enantiomerically Pure Compounds, Societe Royale de Chimie, Belgium (10/22–10/23); International Symposium on Gangliosides, Tokyo (11/5)
1993: Merck-Frosst lecturer, University of Victoria (1/21); International Symposium on Bioorganic Chemistry, Interlaken, Switzerland (3/31–4/2); the 28 th ESF/EUCHEM Conference on Stereochemistry-Burgenstock (5/2–5/8); Harvard University Mini-Symposium in Organic Chemistry (5/17); Complex Carbohydrate for Drug Research, Denmark (6/6–6/10); Carbohydrate Gordon Research Conference (7/5–7/8); Chiron lecturer, UC-Berkeley (9/7)
1994: Bristol-Myers Squibb Distinguished Lecturer, Syracuse University, New York (4/5); Sino-American Symposium on Asymmetric Synthesis, Taiwan (4/8); New Perspective in drug design, Thurnberry, Scotland (4/11); CHI’s Glycotechnology Conference, San Diego (5/16);  Organizer and Plenary Lecturer, Table Ronde on Biomolecular Recognition and Catalysis, Paris (7/8–7/9); International Carbohydrate Award lecturer, International Carbohydrate Symposium, Ottawa (7/18); IASOC Conference, Ischia, Italy (9/25); W. S. Johnson Symposium in Organic Chemistry, Stanford University (10/7); 6 th Annual Glaxo-UNC Frontiers in Chemistry and Medicine Symposium (11/7)
1995: International Symposium on Protein Structure and Function, U. Exeter, UK (4/19); Contemporary Challenges in Carbohydrate Chemistry, 1995 UM/PD Symposium, Ann Arbor (4/28); Merck lecturer, University of Cambridge, England (5/10); Tetrahedron Symposium, Kyoto (5/26); The 10 th Nozaki Conference, Nagoya (6/15); International Heterocycle Chemistry, Taipei (8/7); Nobel Symposium on Catalytic Asymmetric Synthesis, Stockholm (9/3); The 7 th International Symposium on Chiral Discrimination (ISCD), Jerusalem (11/12)
1996: Swiss Chemical Society (5/23); IUPAC Conference on Organic Synthesis, Amsterdam (6/30); Keynote speaker, the 4 th International Symposium for Chinese Organic Chemists, Hong Kong (4/5); Wyeth-Ayerst lecturer, Columbia University (4/19); Keynote speaker, the Royal Society of Chemistry Annual Meeting, Perthshire, Scotland (9/12); ACS Princeton Organic Chemistry Symposium (9/27)
1997: Israel Chemical Society (2/3); Distinguished Visiting Professor, Department of Chemistry, University of Florida (2/12); the Royal Society of Chemistry Carbohydrate Division (3/24); ACS William Johnson Symposium (4/14); Keynote lecturer, 2 nd Carbohydrate Bioengineering, La Rochelle, France (4/15); C. H. Li Memorial lecturer, Academia Sinica, Taipei (5/2); 9 th European Carbohydrate Symposium (6/11); 35 th ACS National Organic Chemistry Symposium (6/22); Sponsored lecturer, 6 th International Symposium on the synthesis and application of isotopes and isotopically labeled compounds, Philadelphia (9/14); Frontier in Chemical Research Program, Texas A&M University (10/13)
1998: Allelix lecturer, Department of Chemistry, University of Toronto, (5/7); 26 th National Medicinal Chemistry Symposium, Richmond, Virginia, (6/15); 20 th Japanese Carbohydrate Symposium (7/15); ACS Symposium on Asymmetric synthesis of Fluoroorganic Compounds, Boston (8/23); Tetrahedron Prize Symposium, Boston (8/26); The 17 th International Symposium on the Life Sciences, Kyoto (11/4)
1999: Paul Gassman lecturer, Department of Chemistry, University of Minnesota, Minneapolis (6/1); The 37 th IUPAC Congress, Berlin (8/14); The 1999 Naff Symposium on Carbohydrates and Cell Recognition (4/16); Enzyme Engineering XV (10/10). Frontiers in Bioorganic Chemistry 2000, Taipei (10/29)
2000: The Knud Lind Larsen Symposium on Chirality, Danish Academy of Technical Sciences (1/27); The Eighth International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-8), Kyoto (7/11); the Gordon Conference on Green Chemistry, Connecticut (7/18); International Carbohydrate Conference, Hamburg (8/22); The Novartis lecturer, Budapest (10/22); International Chemical Congress of Pacific Basin Societies, Honolulu (12/18)
2001: the Royal Society of Chemistry Carbohydrate Group, Dublin, Ireland (4/4); the International Conference on Green Chemistry, Wales Swansea, UK (4/6); Gordon Research Conference on Bioorganic Chemistry, New Hampshire (6/17); Enzyme Engineering XVI Conference, Potsdam, Germany (10/7); Robert A. Welch Foundation Conference on Chemistry for the 21 st Century, Houston (10/29); Merck lecturer, Wayne State University (11/4)
2002: International Conference on Industrial Applications of Biocatalysis, San Diego (3/21); Health Care Ventures Scientific Advisory Board Retreat, Palm Beach (4/10); First ICI Conference on Contemporary Asymmetric Catalysis (9/12); The Merck lecturer, University of Cambridge, UK (9/22). IUPAC Conference on Natural Products, Florence, Italy (7/29)
2003: Treat B. Johnson Lecture, Yale University (2/19); International Bioinspiring Conference, Haifa, Israel (12/8); International Enzyme Engineering Conference, Santa Fe, New Mexico (11/9)
2004: 3 rd International Proteomics Conference, Taipei, Taiwan (5/17); Ralph and Helen Oesper Symposium, University of Cincinnati (10/15); The 4 th Tateshima Conference in Organic Chemistry, Tokyo, Japan (11/12); Yousei University lectureship, Seoul, Korea (11/16); International Symposium on Current Therapeutics Development for Infectious Diseases, Taipei, Taiwan (12/16)
2005: Keynote lecturer, 3 rd Annual Conference on Glycomics–Carbohydrates in Drug Development, San Diego (3/21); American Society for Biochemistry and Molecular Biology (ASBMS), San Diego (4/2); Wyeth Ayerst lecturer, University of Pennsylvania (4/12); Arnold O. Beckman lecturer, California Institute of Technology (5/18); Commissariat a L’energie Atomique u Centre de Sacly, Paris, France (6/27); Tetrahedron Symposium, Bordeaux, France (6/28); Tetrahedron Prize Symposium, 2005 American Chemical Society Meeting, Washington D.C. (8/29); Royal Society of Chemistry-Fluroine Group, Oxford, UK (9/1–9/2); Harry Day lecturer, Indiana University (9/14)
2006: Smets Chair Award, Louvain-la-Neuve, Belgium (3/13-3/14); Keynote speaker, CHI’s 4 th Annual Glycomics and Carbohydrates in Drug Development, San Diego (3/23–3/24); Keynote lecturer, CACS 25 th Anniversary Symposium, Atlanta (3/27);  Trends in Organic Chemistry: Enzymatic Synthesis, Stockholm (9/4); Keynote speaker, Joint third AOHUPO and Fourth International Structural Biology and Functional Genomics Conference, Singapore (12/4-12/7)
2007: Novartis Lecturer, Columbia University (1/29); Claude S. Hudson Award Symposium, 233 th ACS National Meeting, Chicago (3/25); Organic Chemistry—Present & Future, International Symposium Organized in Honor of Prof. Léon Ghosez, Louvain-la-Neuve, Belgium (4/10-4/13); 24 th Herbert C. Brown Lecture, Purdue University (4/19); Gordon Research Conferences—Carbohydrates, Tilton School, New Hampshire (6/17); Tetrahedron Symposium, Berlin (6/28); International Symposium on Molecular Immunology of Complex Carbohydrates, Academia Sinica, Taipei (7/9); Eli Lilly Lecture, Yale University (9/19); The 4 th Takeda Science Foundation Symposium on Pharma Sciences, Tokyo (12/3)
2008: The 10th CRSI (Chemical Research Society of India) National Symposium—Honorary Fellow Award & Lecture, Bangalore, India (2/1~2/3); Monte Jade Annual Conference—Dinner Keynote Speech, Santa Clara Convention Center, CA (3/8); The 4 th Symposium: Innovation COE Program for Future Drug Discovery and Medical Care, Hokkaido University, Japan (3/14); Cotton Medal Symposium, Texas A & M University (3/24~3/26); Joint 7 th Human Genome Organization-Pacific Meeting and the 8 th Asia Pacific Conference on Human Genetics, Cebu, the Philippines (4/2~4/5); ASBMB Meeting, San Diego (4/5~4/9); International Congress on Bioactive Molecules and the 3 rd International Symposium on Medicinal and Aromatic Plants, Oujda, Morocco (5/28~5/29); IUPAC ICOS-17, the 17 th IUPAC International Conference on Organic Synthesis, Daejeon, Korea (6/24~6/26); Tetrahedron Symposium, Berkeley, California (7/22~7/26); Howard Lectures, University of Sydney, Sydney, Australia (8/6~8/8); Tetrahedron Prize Symposium and the 236 th ACS Meeting, Philadelphia (8/17~8/22); NRC-NSC Eminent Researchers Program (9/2~9/6); EMBL Conference on Chemical Biology 2008, Heidelberg, Germany (10/8~10/11); 50th Anniversary of Microbial Chemistry Research Foundation, Tokyo (10/30); ISOR-2008, International Symposium on Organic Reactions, Taiwan (11/23)
2009: Harvard Business School Asia Business Conference, Boston (2/14~2/15); Scripps Scientific Governors Inaugural Symposium, Florida (2/26~2/27); The 237 th ACS Meeting and Claude Hudson Award in Carbohydrate Chemistry Symposium, Salt Lake City (3/22~3/26); SAPA-Monte Jade Annual Conference, New England and 11th SAPA-NE (Sino-American Pharmaceutical Professionals Association) Annual Conference, Philadelphia, (5/16); TAITA 2009 Annual Conference, San Francisco (5/23); Merck KGaA, Darmstadt, Germany (5/26~5/27); Final Symposium of the SFB 470: From Glycobiology to Glycochemistry, University of Hamburg (5/28~5/29); The 238th ACS Meeting, Washington D.C. (8/16~8/20); 11th Conference on Chitin and Chitosan, Taiwan (9/7); The 1st Hokkaido University-Academia Sinica Joint Symposium and The 7th Symposium for Future Drug Discovery and Medical Care, Hokkaido, Japan (10/7~10/8); The 3 rd International Symposium on Bio-Inspired Engineering, Taiwan (10/21~10/23), Peiking University (10/22~10/26); City University of Hong Kong and Chinese University of Hong Kong (11/9~11/11)
2010: 7th International Symposium for Chinese Medicinal Chemists (ISCMC-2010), Kaohsiung, Taiwan (2/1~2/5); XII International Symposium on Respiratory Viral Infections, Taipei (3/11~3/14); Conference of Presidents of Academies and Scholarly Societies: in celebration of the 50 th anniversary of The Israel Academy of Sciences and Humanities, Israel (3/14~3/20); EMBL Conference, Hamburg (5/5~5/7); The 21st Banyu Life Science International Sendai Symposium, Sendai, Japan (6/5); Konstanz Symposium Chemical Biology, Konstanz, Germany (6/16~6/18); Humboldt University, Germany (6/24); The Inaugural (1st) International Conference on Molecular and Functional Catalysis, Singapore (7/11~7/15); 25th International Carbohydrate Symposium(ICS 2010), Tokyo, Japan (8/1~8/6); the 240th ACS National Meeting, Boston (8/22~8/26); Taiwan Swiss Biomedical Symposium, Taiwan (8/31~9/2); Univ. of Notre Dame Reilly Lectureship (9/13~9/15); UCSD/Taiwan Symposium on Frontiers in Biosciences, San Diego (9/16~9/17); 11th Int'l Symposium for Chinese Organic Chemists, Taiwan (10/24~10/26); RIKEN Chemical Biology Symposium (10/26~10/28); UC Berkeley Green Chemistry Seminar (12/6)
2011: The 76th ICS (Israel Chemical Society) Meeting, Israel (2/9~2/10); Frontiers in Biomedical Research Symposium, Palm Spring (2/20~2/23); Infectious Disease Research Institute, Seattle (3/1); 2011 R. Bryan Miller Symposium, University of California at Davis (3/3~3/4); The 241 st ACS Meeting and the Claude S. Hudson Award Symposium, Anaheim (3/27~3/31); University of Namur, Belgium (4/8); European Young Investigator Workshop on Carbohydrate Chemistry: From Synthesis to Applications, Lyon, France (4/11~4/15); The 9th Carbohydrate Bioengineering Meeting (CBM9), Lisbon, Portugal (5/15~5/18); 2011 Keystone Symposium on Pathogenesis of Influenza: Virus-Host Interactions, Hong Kong (5/23~5/28); The 21st International Symposium on Glycoconjugates, Vienna, Austria (8/21-8/26); The 31st Naito Conference on Glycan Expression and Regulation, Sapporo, Japan (9/13~9/16); International Symposium on Cancer Translational Research, Taipei (11/19~11/20); The 8th AFMC International Medicinal Chemistry Symposium, Tokyo, Japan (11/29~12/2)
2012: The 243 rd ACS Meeting, San Diego (3/25~3/29); The 244 th ACS Meeting, Philadelphia (8/19~8/23); Taiwan-UK Conference on Life Sciences, Oxford, England (9/1~9/2); Sialoglyco 2012 International Symposium, Taipei (9/9); 13th FAOBMB Congress, Bangkok (11/25~11/26)
2013: 7th Glycan Forum, Berlin, Germany (3/20~3/22); 2013 Boston Taiwanese Biotechnology Symposium, Boston, USA (6/15); The 17th European Carbohydrate Symposium (EuroCarb 17), Tel Aviv, Israel (7/7~7/11); The Solvay Conference, Brussels, Belgium (10/16~10/19); 4th Asian-Oceanian Conference on Green and Sustainable Chemistry (AOC-4 GSC), Taipei, Taiwan (11/4); From Molecules to Medicine, the first Israel – Taiwan Life Science Conference, Taipei, Taiwan (12/9~12/11)
2014: 27th International Carbohydrate Symposium, Bangalore, India (1/12~1/17); 7th General Assembly and International Conference of Asian Pacific Organization for Cancer Prevention, Taipei (3/21); Sialoglyco 2014 Meeting, Australia (9/7~9/10); 15th IUBMB-24th FAOBMB-TSBMB International Conference, Taipei (10/21~10/26); 2014 Joint Meeting of Society for Glycobiology and Japanese Society of Carbohydrate Research, Honolulu, Hawaii (11/16~11/19)
2015: The 249 th ACS Meeting, Denver, Colorado, USA (3/22~3/26); SCBA Symposium, Taipei , Taiwan (6/26~6/29); The 250 th ACS Meeting, Boston, USA (8/16~8/20); Glyco23 Congress, Croatia (9/15~9/20); 2nd Shanghai Tech-SIAIS Bioforum, Shanghai (11/10~11/12); ASCB  (American Society for Cell Biology) Annual Meeting ,San Diego (12/12)
2016: The Einstein Lecturer, Israel Academy of Sciences (3/14); The 251 st ACS Meeting, San Diego (3/16~3/17); The 251 st ACS Meeting, San Diego, USA (3/16~3/17); AAI (American Association of Immunologists) Satellite Meeting, Seattle (5/14); ASCO Annual Meeting, Chicago, USA (6/3~6/7);  23rd Pacific Science Congress, Taipei, Taiwan (6/13~6/17). ACBC (4th Asian Chemical Biology Conference), Kaohsiung, Taiwan (11/28). Special IUBMB Meeting: Frontiers in Glycoscience: Host-Pathogen Interactions (12/12)
2017: Academia Sinica-Osaka Bilateral Symposium, Taipei, Taiwan (10/12). EMBO Event, Taipei, Taiwan (11/20); IUBMB Special Meeting on “Frontiers in Glycoscience: Oncology”, Taipei, Taiwan (12/4)
2018: Bowei Science Conference (BSC): From Chemistry to Material Design, Hsin-Chu, Taiwan (1/5~1/7). Israel-Taiwan Life Science Conference, Taipei, Taiwan (11/14~11/15). 10th ACGG Conference, Tainan, Taiwan (11/18~11/21)
2019: 2019 Gordon Research Conference (GRC) on Carbohydrates (6/23~6/28), Hong Kong
2020: Asia-Pacific Federation of Pharmacology (APFP) Meeting (5/3~5/6) (Canceled). PacifiChem, Hawaii (Dec 15-20) (Cancelled).
2021: Carbohydrates Gordon Research Conference (6/20-6/25), New Hampshire, USA; International Glycoconjugate Symposium, Taipei (Aug 29-Sept 3) (Canceled). The 14th Meeting of the Asia-Pacific Federation of Pharmacologists (APFP) (11/26-11/29). Andrew University (Sept 23). Stanford University, Chemistry (Oct 6). Welch Chemical Conference (Oct 26).
2022: 30th International Carbohydrate Symposium (July12).

Principal areas of research interest

Chemical Biology and Synthetic Chemistry: development of new tools and methods for understanding the role of glycosylation in biology and disease progression; chemo-enzymatic synthesis of complex carbohydrates and glycoproteins; design of small-molecule probes for the study of carbohydrate-mediated biological recognition; programmable one-pot oligosaccharide synthesis and glycan microarray development; vaccine design and drug discovery against infectious diseases and cancers. H-index 150.


Published Papers  (

The following 12 publications are earlier work in the area of peptide and protein chemistry:

J. Chin. Biochem. Soc., 2, 64–69, (1973); 4, 24, (1975); 5, 1–6, (1976); 9, 25, (1980);  J. Chin. Chem. Soc., 23, 155, (1976); 24, 129–133, (1977); 25, 209–214, (1978); 26, 75–78, (1979); 25, 215, (1978); 26, 11, (1979);  Toxicon, 14, 420, (1976);  Proc. Natl. Acad. Council R.O.C., 2, 346–351, (1978).

  1. C.-H. Wong, S.W. Chen, C. L. Ho,K. T. Wang, “Synthesis of cobra neurotoxin”, Proc. Natl. Sci. Council R.O.C., 2, 149–153 (1978).
  2. C.-H. Wong, Y. H. Chen, M.C.Hung, K. T. Wang, C. L. Ho, T. B. Lo, “Regeneration of a reduced cobra cardiotoxin”, Biochim. Biophys. Acta, 533, 105–111 (1978).
  3. C.-H. Wong, C. L. Ho, K. T.Wang, “Purification of synthetic cardiotoxin by affinity chromatography”, J.Chromatogr., 154, 25–32 (1978).
  4. C.-H. Wong, K. T. Wang, “Electrochemistryin organic synthesis: large-scale preparation of cysteine from cystine”, J.Chin. Chem. Soc., 25, 149–152 (1978).
  5. C.-H. Wong, S.-T. Chen, C.-L.Ho, K.-T. Wang, “Synthesis of a fully active snake venom cardiotoxin by fragmentcondensation on a solid polymer”, Biochim. Biophys. Acta, 536, 376–389(1978).
  6. C.-H. Wong, M. F. Ho, K. T.Wang, “Preparation of optically pure N- tert-butyloxycarbonyl- O-benzyl-l-serine and its antipode”, J. Org. Chem., 43, 3604(1978).
  7. C.-H. Wong, K. T. Wang, “Mutual resolutionof (±)-ephedrine and Z-dl-amino acid induced by seeding chiralsalt”, Tetrahedron Lett., 40, 3813–3816 (1978).
  8. C.-H. Wong, S.T. Chen, K. T.Wang, “Enzymic synthesis of opioid peptides”, Biochim. Biophys. Acta, 576, 247–249 (1979).
  9. C.-H. Wong, S.D. McCurry, G. M.Whitesides, “Practical enzymatic synthesis of ribulose-1,5-bisphosphate and ribose-5-phosphate”, J. Am. Chem. Soc., 102, 7938–7939 (1980).
  10. C.-H. Wong, G. M. Whitesides, “Enzyme-catalyzedorganic synthesis: NAD(P)H cofactor regeneration using glucose-6-phosphate andthe glucose-6-phosphate dehydrogenase from Leuconostocmesenteroides”, J. Am. Chem. Soc., 103, 4890–4899 (1981).
  11. C.-H. Wong, L. Daniels, W. H.Orme-Johnson, G. M. Whitesides, “Enzyme-catalyzed organic synthesis: NAD(P)H cofactorregeneration using dihydrogen and the hydrogenase from Methanobacterium thermoautotrophicum”, J. Am. Chem. Soc., 103, 6227–6228 (1981).
  12. C.-H. Wong, J. Gordon, C. L. Cooney, G. M.Whitesides, “Regeneration of NAD(P)H using glucose-6-sulfate and glucose-6-phosphatedehydrogenase”, J. Org. Chem., 46, 4676–4679 (1981).
  13. R.DiCosimo, C.-H. Wong, L. Daniels, G. M. Whitesides, “Enzyme-catalyzed organicsynthesis: electrochemical regeneration of NAD(P)H from (NAD(P) using methylviologen and flavoenzymes”, J. Org. Chem., 46, 4622–4623 (1981).
  14. C.-H. Wong, A. Pollak, S. McCurry, J. Sue, J.R. Knowles, G. M. Whitesides, “Ribulose-1,5-bisphosphate: routes from glucose-6-phosphate(via 6-phosphogluconate and ribose-5-phosphate) and from adenosine monophosphate(via ribose-5-phosphate and ribulose-5-phosphate)”, Method. Enzymol.,89, 108–121 (1982).
  15. C.-H. Wong, G. M. Whitesides, “Enzyme-catalyzedtranshydrogenation between nicotinamide cofactors and its application in organicsynthesis”, J. Am. Chem. Soc., 104, 3542–3544 (1982).
  16. C.-H. Wong, G. M. Whitesides, “Enzyme-catalyzedorganic synthesis: NAD(P)H cofactor regeneration using ethanol/alcohol dehydrogenase/aldehydedehydrogenase and methanol/alcohol dehydrogenase/aldehyde dehydrogenase/formatedehydrogenase”, J. Org. Chem., 47, 2816–2818 (1982).
  17. C.-H. Wong, S. L. Haynie, G. M.Whitesides, “Enzyme-catalyzed synthesis of N-acetyllactosaminewith in situ regeneration of uridine5¢-diphosphate glucose and uridine5¢-diphosphate galactose”, J.Org. Chem., 47, 5416–5418 (1982).
  18. C.-H. Wong, S. L. Haynie, G. M.Whitesides, “Preparation of a mixture of nucleoside triphosphates from yeastRNA: use in enzymatic synthesis requiring nucleoside triphosphate regeneration,and conversion to nucleoside diphosphate sugars”, J. Am. Chem. Soc., 105, 115–117 (1983).
  19. C.-H. Wong, G. M. Whitesides, “Enzyme-catalyzedorganic synthesis: regeneration of deuterated nicotinamide cofactors for use inlarge-scale enzymatic synthesis of deuterated substances”, J. Am. Chem. Soc., 105, 5012–5014 (1983).
  20. C.-H. Wong, G. M. Whitesides, “Synthesisof sugars by aldolase-catalyzed condensation reactions”, J. Org. Chem., 48, 3199–3205 (1983).
  21. C.-H. Wong, F. P. Mazenod, G. M.Whitesides, “Chemical and enzymatic synthesis of 6-deoxyhexoses; conversion to2,5-dimethyl-4-hydroxy-2,3-dihydrofuran-3-one (furaneol) and analogs”, J.Org. Chem., 48, 3493–3497 (1983).
  22. G. M. Whitesides, C.-H. Wong, “Enzymesas catalysts in organic synthesis”, Aldrichimica, 16, 27–34 (1983).
  23. J. R. Matos, M. B. Smith, C.-H. Wong,“Enantioselectivityof alcohol dehydrogenase-catalyzed oxidation of 1,2-diols and aminoalcohols”, Bioorg.Chem., 13, 121–130 (1985).
  24. C.-H. Wong, D. G. Drueckhammer,H. M. Sweers, “Enzymatic versus fermentative synthesis: thermostable glucose dehydrogenasecatalyzed regeneration of NAD(P)H for use in enzymatic synthesis”, J. Am.Chem. Soc., 107, 4028–4031 (1985).
  25. R. L. Root, J. R. Durrwachter,C.-H. Wong, “Enzymatic synthesis of unusual sugars: galactose oxidase-catalyzedstereospecific oxidation of polyols”, J. Am. Chem. Soc., 107, 2997–2999(1985).
  26. C.-H. Wong, J. R. Matos, “Enantioselectiveoxidation of 1,2-diols to l-a-hydroxy acids using co-immobilizedalcohol dehydrogenase/aldehyde dehydrogenase as catalysts”, J. Org. Chem., 50, 1992–1994 (1985).
  27. C.-H. Wong, D. G. Drueckhammer, “Enzymaticsynthesis of chiral hydroxy compounds using immobilized glucose dehydrogenasefrom Bacillus cereus for NAD(P)H regeneration”, Bio/Technology, 3, 649–651 (1985).
  28. G. M. Whitesides, C.-H. Wong, “Enzymesas catalysts in synthetic organic chemistry”, Angew. Chem. Int. Ed. Engl.,24, 617–638 (1985).
  29. C.-H. Wong “Enzymes in organic synthesis:aldol condensation”, Industrial Chemical News, 6(12), 24–25 (1985).
  30. D. G. Drueckhammer, C.-H. Wong, “FMNReductase-catalyzed regeneration of NAD(P) for use in enzymatic synthesis”, J.Org. Chem., 50, 5387–5389 (1985).
  31. D. G. Drueckhammer, C.-H. Wong, “Chemoenzymaticsyntheses of fluoro sugar phosphates and analogues”, J. Org. Chem., 50,5912–5913 (1985).
  32. J. R. Durrwachter, H. M. Sweers,K. Nozaki, C.-H. Wong, “Enzymatic aldol reaction/isomerization as a route to unusualsugars”, Tetrahedron Lett., 27, 1261–1264 (1986).
  33. J. B. West, C.-H. Wong, “Enzyme-catalyzedsynthesis of peptides containing d-aminoacids”, J. Chem. Soc. Chem. Comm., 417–418 (1986).
  34. J. R. Matos, C.-H. Wong, “Biphasicone-pot synthesis of two useful and separable compounds using cofactor-requiringenzymatic reactions: glutamate dehydrogenase-catalyzed synthesis of l-2-aminoadipate coupled with alcohol dehydrogenase-catalyzedsynthesis of a chiral lactone”, J. Org. Chem., 51, 2388 (1986).
  35. J. B. West, C.-H. Wong, “Enzyme-catalyzedirreversible formation of peptides containing d-aminoacids”, J. Org. Chem., 51, 2728–2735 (1986).
  36. C.-H. Wong, J. B. West “Enzymaticsynthesis of peptides containing d-aminoacids”, Fed. Proc., 45, 1789 (1986).
  37. H. M. Sweers, C.-H. Wong, “Enzyme-catalyzedregioselective deacylation of protected sugars in carbohydrate synthesis”, J.Am. Chem. Soc., 108, 6421–6422 (1986).
  38. S.-T. Chen, K.-T. Wang and C.-H.Wong, “Chirally selective hydrolysis of d,l-aminoacid esters catalyzed by alkaline protease”, J.C.S. Chem. Comm., 1514–1516(1986)
  39. C.-H. Wong, “Enzyme-catalyzed synthesisof unusual carbohydrates and peptides”, Proceeding of 5th InternationalSymposium on Life Science: Prospects for Enzyme Technology (H. Yamada,ed.), Kyoto, Japan. 1986, pp 86–89.
  40. J. R. Durrwachter, D. G.Drueckhammer, K. Nozaki, H.M. Sweers, C.-H. Wong, “Enzymatic aldol condensation/isomerizationas a route to unusual sugar derivatives”, J. Am. Chem. Soc., 108, 7812–7818(1986).
  41. D. C. Crans, R. J. Kazlauskas,B. L. Hirschbein, C.-H. Wong, O. Abril, G. M. Whitesides, “Enzymatic regenerationof ATP: acetyl phosphate, phosphoenolpyruvate, methoxycarbonyl phosphate, dihydroxyacetonephosphate, 5-phospho-d-ribosyl-1-pyrophosphate,uridine-5¢-diphosphoglucose”, MethodEnzymol., 136, 263–280 (1987).
  42. J. R. Matos, F. M. Raushel,C.-H. Wong, “ S-Adenosylmethionine: studieson chemical and enzymatic synthesis”, Biotech. Appl. Biochem., 9, 39–52(1987).
  43. J. R. Matos, C.-H. Wong, “ S-Adenosylmethionine: stability and stabilization”, Bioorg. Chem., 15, 71–80 (1987).
  44. C. F. Barbas, C.-H. Wong, “Papaincatalyzed peptide synthesis: control of amidase activity and the introductionof unusual amino acids”, J.C.S. Chem. Comm., 533–534 (1987).
  45. J. B. West, C.-H. Wong, “Use of non-proteasesin peptide synthesis”, Tetrahedron Lett., 28, 1629–1632 (1987).
  46. D. G. Drueckhammer, S. K.Sadozai, S. M. Roberts, C.-H. Wong, “Biphasic one-pot synthesis of two usefuland separable compounds using cofactor-requiring enzymes as catalysts”, EnzymeMicrob. Tech., 9, 564–569 (1987).
  47. J. R. Matos, J. B. West, C.-H.Wong, “Lipase catalyzed synthesis of peptides: preparation of a penicillin G precursorand other peptides”, Biotech. Lett., 9, 233–236 (1987).
  48. J. J. Lalonde, D. E.Bergbreiter, C.-H. Wong, “Enzymatic kinetic resolution of a-nitro a-methyl carboxylic acids”, J.Org. Chem., 53, 2323–2327 (1988).
  49. D. G. Drueckhammer, C. F.Barbas, III, K. Nozaki, C. Y. Wood, M. Cinfolini, “Chemoenzymatic synthesis of chiralfuran derivatives: useful building blocks for optically active structures”, J.Org. Chem., 53, 1607–1611 (1988).
  50. C. F. Barbas, J. R. Matos, J. B.West, C.-H. Wong, “A search for peptide ligase: cosolvent mediated conversionof proteases to esterases for peptide synthesis”, J. Am. Chem. Soc., 110, 5162–5166 (1988).
  51. J. B. West, J. Scholten, W. J.Stolowich, J. L. Hogg, A. I. Scott, C.-H. Wong, “Modification of proteases toesterases for peptide synthesis: methylchymotrypsin”, J. Am. Chem. Soc., 110, 3709–3710 (1988).
  52. Y.-F. Wang, J. J. Lalonde, M. Momogan, D. E.Bergbreiter, C.-H. Wong, “Lipase catalyzed irreversible transesterification usingenol esters as acylating reagents: preparative enantio- and regioselective synthesisof alcohols, glycerol derivatives, sugars and organometallics”, J. Am. Chem.Soc., 110, 7200–7205 (1988).
  53. C. F. Barbas, C.-H. Wong, “One-pottripeptide synthesis catalyzed by papain”, Tetrahedron Lett., 29, 2907–2910(1988).
  54. M. J. Kim, W. J. Hennen, H. M.Sweers, C.-H. Wong “Enzymes in carbohydrate synthesis: N-acetylneuraminic acid aldolase catalyzed reactions and preparationof N-acetyl-2-deoxy- d-neuraminic acid derivatives”, J.Am. Chem. Soc., 110, 6481–6486 (1988).
  55. Y. F. Wang, C.-H. Wong “Lipase-catalyzedirreversible transesterification for preparative synthesis of chiral glycerol derivatives”, J. Org. Chem., 53, 3127–3129 (1988).
  56. J. R. Durrwachter, C.-H. Wong “Fructose-1,6-diphosphatealdolase catalyzed stereoselective synthesis of C-alkyl and N-containing sugars: thermodynamically controlled C–C bondformations”, J. Org. Chem., 53, 4175–4181(1988).
  57. W. J. Hennen, H. M. Sweers, Y. F.Wang, C.-H. Wong “Enzymes in carbohydrate synthesis: lipase-catalyzed selectiveacylation and deacylation of furanose and pyranose derivatives”, J. Org.Chem., 53, 4939–4945 (1988).
  58. R. L. Pederson, M. J. Kim, C.-H.Wong “A combined chemical and enzymatic procedure for the synthesis of 1-deoxynojirimycinand 1-deoxymannojirimycin”, Tetrahedron Lett., 29, 4645–4648 (1988).
  59. C.-H. Wong, J. R. Matos, J. B.West, and C. F. Barbas “Practical enzymatic approaches to unusual peptides”, J. Indust. Microbiol. Supp., 3, 171–177 (1988).
  60. D. G. Drueckhammer, J. R.Durrwachter, R. L. Pederson, D. C. Crans, C.-H. Wong, “Reversible and in situ formation of organic arsenatesand vanadates as organic phosphate mimics in enzymatic reactions: investigationof aldol reactions and synthetic applications”, J. Org. Chem., 54, 70–77(1989).
  61. Y.-F Wang, C.-H. Wong “Lipasecatalyzed irreversible transesterification using enol esters: resolution of cyanohydrinsand syntheses of ethyl ( R)-2-hydroxy-4-phenylbutyrateand ( S)-propanolol”, TetrahedronLett., 30, 1917–1920 (1989).
  62. R. L. Pederson, C.-H. Wong, “Enzymaticaldol reactions as a route to heterocycles: synthesis of 1,4-dideoxy-1,4-imino-d-arabinitol, fagomine,1-deoxynojirimycin and 1-deoxymannojirimycin”, Heterocycles, 28, 477–480(1989).
  63. C. H. von der Osten, A. J.Sinskey, C.F. Barbas, R. L. Pederson, Y.-F. Wang, C.-H. Wong “Use of recombinant bacterial fructose-1,6-diphosphatealdolase in aldol reactions: preparative synthesis of 1-deoxynojirimycin, 1-deoxymannojirimycin,1,4-dideoxy-1,4-imino-d-arabinitoland fagomine”, J. Am. Chem. Soc., 111, 3924–3927 (1989).
  64. C.-H. Wong “Enzymatic catalystsin organic synthesis”, Science, 244, 1145–1152 (1989).
  65. C. H. Von der Osten, C. F.Barbas, C.-H. Wong, A. J. Sinskey, “Molecular cloning, nucleotide sequence andfine structural analysis of the Corynebacteriumglutamicum fda gene: structural comparison of C. glutamicum fructose-1,6-diphosphate aldolase to class I andclass II aldolases”, Mol. Microbiol., 3, 1625–1637 (1989).
  66. W. J. Hennen, C.-H. Wong, “A newmethod for the enzymatic synthesis of nucleosides using purine nucleosidephosphorylase”, J. Org. Chem., 54, 4692–4699 (1989).
  67. S.-T. Chen, C.-H. Wong, “Studieson angiotensin-converting enzyme inhibitors: protease catalyzed resolution ofaryl 3-mercapto-2-methylpropionic ester”, J. Chin. Chem. Soc., 36, 451–458(1989).
  68. Y.-F. Wang, C.-H. Wong, “Enantioselectivesynthesis of platelet-activating factor and a phospholipase A2inhibitor from chiral synthons prepared enzymatically”, J. Chin. Chem. Soc.,36, 463–468 (1989).
  69. C. F. Barbas, Y.-F. Wang, C.-H.Wong, “Deoxyribose-5-phosphate aldolase as a synthetic catalyst”, J. Am.Chem. Soc., 112, 2013–2014 (1990).
  70. J. B. West, W. J. Hennen, J. A.Bibbs, J. L. Lalonde, Z. Zhong, E. F. Meyer, C.-H. Wong, “Enzymes as syntheticcatalysts: mechanistic and active site considerations of natural and modifiedchymotrypsin”, J. Am. Chem. Soc., 112, 5313–5320 (1990).
  71. C.-H. Wong, “Enzymes in organicsynthesis”, Chemtracts-Organic Chemistry, 3, 91–111 (1990).
  72. K. K.-C. Liu, K. Nozaki, C.-H.Wong, “Problems of acyl migration in lipase-catalyzed enantioselectivetransformation of meso-1,3-diol systems”, Biocatalysis, 3, 169–177(1990).
  73. C.-H. Wong, S.-T. Chen, W. J.Hennen, J.A. Bibbs, Y.-F. Wang, J. L.-C. Liu, M.W. Pantoliano, M. Whitlow, P.N.Bryan, “Enzymes in organic synthesis: use of subtilisin and a highly stablemutant derived from multiple site-specific mutations”, J. Am. Chem. Soc., 112, 945–953 (1990).
  74. R. L. Pederson, K. K.-C. Liu, J.F. Rutan, L. Chen, C.-H. Wong, “Enzymes in organic synthesis: Synthesis ofhighly enantiomerically pure 1,2-epoxy aldehyde, epoxyalcohols, thiirane,aziridine and glyceraldehyde 3-phosphate”, J. Org. Chem., 55, 4897–4901(1990).
  75. Y.-F. Wang, C.-H. Wong, John S.Ngo, K. A. Babiak, J. H. Dygos, “Lipase-catalyzed transesterifications usingenol esters: resolution of prostaglandin synthons4-hydroxy-2-alkyl-2-cyclopentenones and inversion of the 4 S enantiomer to the 4 R Enantiomer”, J. Org. Chem., 55 3377–3381, (1990).
  76. G.-J. Shen, Y.-F. Wang, C.Bradshaw, C.-H. Wong, “A new NAD-dependent alcohol dehydrogenase with oppositefacial selectivity useful for asymmetric reduction and cofactor regeneration”, J.Chem. Soc., Chem. Commun., 677–679 (1990).
  77. S.-H. Hsu, S.-S. Wu, Y.-F. Wang,C.-H. Wong, “Lipase-catalyzed irreversible transesterification using enolesters: XAD-8 immobilized lipoprotein lipase-catalyzed resolution of secondaryalcohols”, Tetrahedron Lett., 31, 6403–6406 (1990).
  78. C.-H. Wong, “Design anddevelopment of enzymatic organic synthesis”, Chem. Aspects Enzyme Biotech.,Scott, A. I., Baldwin, T., Raushel, F. (eds.), Plenum, 1990, pp 165–178.
  79. S.-H. Hsu, S.-S. Wu, Y.-F. Wang,C.-H. Wong, “Lipase catalyzed irreversible transesterification using enolesters: XAD-8 immobilized lipoprotein lipase-catalyzed resolution of secondaryalcohols”, Tetrahedron Lett., 31, 6403–6406 (1990).
  80. Z. Zhong, J. L.-C. Liu, L. M.Dinterman, M. A. J. Finkelman, W. Thomas Mueller, M. L. Rollence, M. Whitlow,C.-H. Wong, “Engineering subtilisin for reaction in dimethylformamide”, J.Am. Chem. Soc., 113, 683–684 (1991).
  81. Z. Zhong, J. A. Bibbs, W. Yuan,C.-H. Wong “Active-site directed modification of subtilisin”, J. Am. Chem.Soc., 113, 2259–2263 (1991).
  82. D. G. Drueckhammer, W. J.Hennen, R. L. Pederson, C. F. Barbas III, C. M. Gautheron, T. Krach, C.-H.Wong, “Enzyme catalysis in synthetic carbohydrate chemistry”, Synthesis, 7, 499–525 (1991).
  83. C.-H. Wong, K.-T. Wang, “Newdevelopment in enzymatic peptide synthesis”, Experientia, 47, 1123–1129(1991).
  84. C. F. Barbas, C.-H. Wong, “Overexpressionand substrate specificity studies of phosphodeoxyribomutase and thymidinephosphorylase”, Bioorg. Chem., 19, 261–269 (1991).
  85. C. Bradshaw, C.-H. Wong, W.Hummel, M.-R. Kula, “Enzyme-catalyzed asymmetric synthesis of ( S)-2-hydroxy-4-phenylbutyric acid and ( R)-2-amino-4-phenylbutyric acid”, Bioorg.Chem., 19, 29–39 (1991).
  86. C.-H. Wong, G.-J. Shen, R. L.Pederson, Y.-F. Wang, W. J. Hennen, “Concepts and applications of enzymaticcatalysis in organic synthesis”, Method. Enzymol., 202, 591–602 (1991).
  87. H. Fu, G.-J. Shen, C.-H. Wong, “Asymmetricepoxidation of allyl alcohol derivatives by w-hydroxylase from Pseudomonas oleovorans”, Recueil (Journalof the Royal Netherlands Chemical Society), 110, 167–170 (1991).
  88. R. L. Pederson, J. Esker, C.-H.Wong, “An improved synthesis of dihydroxyacetone phosphate”, Tetrahedron, 47, 2643–2648 (1991).
  89. T. Kajimoto, L. Chen, K. K.-C.Liu, C.-H. Wong “Palladium-mediated stereocontrolled reductive amination ofazasugars prepared from enzymatic aldol condensation: a general approach to thesynthesis of azasugars”, J. Am. Chem. Soc., 113, 6678–6680 (1991).
  90. T. Kajimoto, K. K.-C. Liu, R. L.Pederson, Z. Zhong, Y. Ichikawa, J. A. Porco, C.-H. Wong, “Enzyme-catalyzedaldol condensation for asymmetric synthesis of azasugars: synthesis,evaluation, and modeling of glycosidase inhibitors”, J. Am. Chem. Soc., 113, 6187–6196 (1991).
  91. H. Fu, M. Newcomb, C.-H. Wong, “ Pseudomonas oleovorans monooxygenase-catalyzed asymmetric epoxidation of allyl alcohol derivatives andhydroxylation of a hypersensitive radical probe with the radical ring openingrate exceeding rebound rate”, J. Am. Chem. Soc., 113, 5878–5880 (1991).
  92. Y. Ichikawa, G.-J. Shen, C.-H.Wong, “Enzyme-catalyzed synthesis of sialyl oligosaccharide with in situ regeneration of CMP-sialic acid”, J. Am. Chem. Soc., 113, 4698–4700 (1991).
  93. C.-H. Wong, C. Gautheron, T.Krach, Y. Ichikawa, G. C. Look, F. Gaeta, D. Thomson, K. C. Nicolaou, “Synthesisof novel disaccharides using glycosyltransferases: b1,4-galactosyltransferase”, Tetrahedron Lett., 32, 4867–4870 (1991).
  94. C. Gautheron, Y. Ichikawa, C.-H.Wong, “A complete change of stereoselectivity in sialic acid aldolase reactions:a novel synthetic route to the KDO type of nine carbon l-sugars”, J. Am. Chem. Soc., 113, 7816–7818 (1991).
  95. C. Bradshaw, G.-J. Shen, C.-H.Wong, “A new alcohol dehydrogenase with unique stereospecificity from Pseudomonas sp.”, Bioorg. Chem.,19, 398–417 (1991).
  96. K. C. Nicolaou, C. W. Hummel, N.J. Bockovich, C.-H. Wong, “Stereocontrolled synthesis of sialyl Lex,the oligosaccharide binding ligand to ELAM-1”, J. Chem. Soc., Chem. Commun.,870–871 (1991).
  97. C. Gautheron, C.-H. Wong, “Glycosyltransferase-catalyzedstereoselective glycosylation of monosaccharide-based glycosidase inhibitors: anew approach to the synthesis of sequence-specific glycosidase inhibitors”, J.Chem. Soc., Chem. Commun., 1130–1131 (1991).
  98. C.-H. Wong, Y. Ichikawa, T.Krach, C. Gautheron, D. Dumas, G. Look, “Probing the acceptor specificity of b-1,4-galactosyltransferase for the development ofenzymatic synthesis of novel oligosaccharides”, J. Am. Chem. Soc., 113,8137–8145 (1991).
  99. K. K.-C. Liu, T. Kajimoto, L.Chen, Y. Ichikawa, C.-H. Wong, “Use of dihydroxyacetone phosphate dependentaldolases in the synthesis of deoxyazasugars”, J. Org. Chem., 56, 6280–6289(1991).
  100. Y. Ichikawa, J. L.-C. Liu, G.-J.Shen, C.-H. Wong, “A highly efficient multienzyme system for the one-stepsynthesis of a sialyl trisaccharide: insitu generation of sialic acid and N-acetyllactosaminecoupled with regeneration of UDP-glucose, UDP-galactose and CMP-sialic acid”, J.Am. Chem. Soc., 113, 6300–6302 (1991).
  101. D. P. Dumas, Y. Ichikawa, C.-H.Wong, J. B. Lowe, R. P. Nair, “Enzymatic synthesis of sialyl Lex andderivatives based on a recombinant fucosyltransferase”, Bioorg. Med. Chem.Lett., 1, 425–428 (1991).
  102. W. Yuan, Z. Zhong, C.-H. Wong,J. Z. Haeggstrom, A. Witterholm, B. Samuelsson, “Probing the inhibition ofleukotriene A4 hydrolase based on its aminopeptidase activity”, Bioorg.Med. Chem. Lett., 10, 551–556 (1991).
  103. K. K.-C. Liu, R. L. Pederson,C.-H. Wong, “Fructose-1,6-diphosphate aldolase catalyzed stereoselective C–Cbond formation”, J. Chem. Soc. Perkin, 1, 2669 (1991).
  104. H. Fu, G .C. Look, W. Zhang, E. N.Jacobsen, C.-H. Wong, “Mechanistic study of a synthetically usefulmono-oxygenase model using the hypersensitive probe trans-2-phenyl-1-vinylcyclopropane”, J. Org. Chem., 56, 6497–6500(1991).
  105. Z. Zhong, C.-H. Wong, “Developmentof new enzymatic catalysts for peptide synthesis in aqueous and organicsolvents”, Biomed. Biochim. Acta, 50, S9–S14 (1991).
  106. G.-J. Shen,C.-H. Wong, “Construction of a diverse Fab expression library fromautoimmunized mice based on an improved preparation of cloning arms frombacteriophage vectors: a new library with potential for screening ofbiocatalysts”, Biocatalysis, 6, 101–114 (1992).
  107. G.-J. Shen, J. L.-C. Liu, C.-H.Wong, “Cloning and overexpression of CMP-N-acetylneuraminic acid synthetasefrom E. coli using a lambda phagesystem”, Biocatalysis, 6, 31–42 (1992).
  108. L. Chen, D. P. Dumas, C.-H.Wong, “Deoxyribose 5-phosphate aldolase as a catalyst in asymmetric aldolcondensation”, J. Am. Chem. Soc., 114, 741–748 (1992).
  109. C. W. Bradshaw, H. Fu, G.-J.Shen, C.-H. Wong, “A pseudomonas sp. alcohol dehydrogenase with broad substratespecificity and unusual stereospecificity for organic synthesis”, J. Org.Chem., 57, 1526–1532 (1992).
  110. D. P. Dumas, T. Kajimoto, K.K.-C. Liu, C.-H. Wong, D. B. Berkowitz, S. J. Danishefsky, “Azasugar and glycalinhibitors of a-l-fucosidase”, Bioorg. Med. Chem. Lett., 2, 33–36(1992).
  111. C. W. Bradshaw, W. Hummel, C.-H.Wong, “Lactobacillus kefir alcohol dehydrogenase: A useful catalyst forsynthesis”, J. Org. Chem., 57, 1532–1536 (1992).
  112. J. L.-C. Liu, G.-J. Shen, Y.Ichikawa, J. R. Rutan, C. Zapata, W.F. Vann, C.-H. Wong, “Overproduction ofCMP-sialic acid synthetase for organic synthesis”, J. Am. Chem. Soc., 114, 3901–3910 (1992).
  113. Y. Ichikawa, M. M. Sim, C.-H.Wong, “Efficient chemical synthesis of GDP-Fucose”, J. Org. Chem., 57,2943–2946 (1992).
  114. C. W. Bradshaw, J. J. Lalonde,C.-H. Wong, “Enzymatic synthesis of ( R)-and ( S)-1-deuterohexanol”, Appl.Biochem. Biotech., 33, 15–24 (1992).
  115. C.-H. Wong, K. K.-C. Liu, T.Kajimoto, L. Chen, Z. Zhong, D. P. Dumas, J. L.-C. Liu, Y. Ichikawa, G.-J.Shen, “Enzymes for carbohydrate and peptide syntheses”, Pure Appl. Chem., 64, 1197–1202 (1992).
  116. Y. Ichikawa, G. C. Look, C.-H.Wong, “Enzymatic oligosaccharide synthesis,” Anal. Biochem., 202,215–238 (1992).
  117. Y.-C. Lin, C. W. Hummel, D.-H.Huang, Y. Ichikawa, K. C. Nicolaou, C.-H. Wong, “Conformational studies ofsialyl LeX in aqueous solution”, J. Am. Chem. Soc., 114, 5452–5454(1992).
  118. E. Fernholz, D. Schloeder, K. K.-C.Liu, C. W. Bradshaw, H. Huang, K. Janda, R. A. Lerner, C.-H. Wong, “Specificityof antibody catalyzed transesterifications using enol esters: a comparison withlipase reactions”, J. Org. Chem., 57, 4756–4761 (1992).
  119. K. K.-C. Liu, C.-H. Wong, “Enzymatichalohydration of glycals”, J. Org. Chem., 57, 3748–3750 (1992).
  120. C.-H. Wong,R. Wang, Y. Ichikawa, “Regeneration of sugar nucleotides for enzymaticoligosaccharide synthesis: use of galactose 1-phosphate uridyltransferase inthe regeneration of UDP-galactose, UDP-2-deoxygalactose and UDP-galactosamine”, J. Org. Chem., 57, 4343–4344 (1992).
  121. G. C. Look, C.-H. Wong, “Afacile enzymatic synthesis of Gal b1,3glucal: a key intermediatefor the synthesis of Lea and sialyl Lea”, Tetrahedron Lett., 33, 4253–4256(1992).
  122. W. Yuan, J. Z. Haeggstrom, A.Wetterholm, B. Samuelsson, C.-H. Wong, “Novel tight-binding inhibitors ofleukotriene A4 hydrolase”, J. Am. Chem. Soc., 114, 6552–6553(1992).
  123. C.-H. Wong, D. P. Dumas, Y.Ichikawa, K. Koseki, S. J. Danishefsky, B. W. Weston, J. B. Lowe, “Specificity,inhibition, and synthetic utility of a recombinant human a1,3-fucosyltransferase”, J. Am. Chem. Soc. 114,7321–7322 (1992).
  124. Y. Ichikawa, Y.-C. Lin, D. P. Dumas, G.-J. Shen, E.Garcia-Junceda, M. A. Williams, R. Bayer, C. Ketcham, L. Walker, J. C. Paulson, C.-H. Wong, “Chemical-enzymaticsynthesis and conformational study of sialyl lewis x and derivatives”, J.Am. Chem. Soc., 114, 9283–9297 (1992).
  125. K. K.-C. Liu, C.-H. Wong, “A newstrategy for the enzymatic synthesis of nucleoside analogs using fructose-1,6-diphosphatealdolase”, J. Org. Chem., 57, 4789–4791 (1992).
  126. S. J. Danishefsky, J. Geruay, J.M. Peterson, F. E. McDonald, K. Koseki, T. Oriyama, D. A. Griffith, C.-H. Wong,D. P. Dumas, “Remarkable regioselectivity in the chemical glycosylation of glycalacceptors: a concise solution to the synthesis of sialyl-Lewis x glycal, a fucosyltransferaseinhibitor”, J. Am. Chem. Soc., 114, 8329–8331 (1992).
  127. R. L. Pederson, C.-H. Wong, “Lipoproteinlipase catalyzed kinetic resolution of 2-acetoxy-3-azidopropanal diethyl acetal”,in Preparative Biotransformations, S. M. Roberts, K. Wiggins, G. Casy,eds. 1992, 1:6.14.
  128. H. Kondo, Y. Ichikawa, C.-H.Wong, “b-Sialyl phosphite andphosphoramidite: Synthesis and application to the chemo-enzymatic synthesis ofCMP-sialic acid and sialyl Lewis X”, J. Am. Chem. Soc., 114, 8748–8750(1992).
  129. H. Fu, H. Kondo, Y. Ichikawa, G.C. Look, C.-H. Wong, “Chloroperoxidase catalyzed asymmetric synthesis:Enantioselective reactions of chiral hydroperoxides with sulfides, and bromohydrationof glycals”, J. Org. Chem., 57, 7265–7270 (1992).
  130. W. J. Hennen, H. M. Sweers,Y.-F. Wang, C.-H. Wong, “Enzymatic regioselective hydrolysis of a peracetylatedfuranose derivative”, in Preparative Biotransformations, S. M. Roberts,K. Wiggins, G. Casy, eds. 1992, 1:7.1.
  131. C.-H. Lin, T. Sugai, R. L.Halcomb, Y. Ichikawa, C.-H. Wong, “Unusual stereoselectivity in sialic acidaldolase catalyzed aldol condensations: Synthesis of both enantiomers ofhigh-carbon monosaccharides”, J. Am. Chem. Soc., 114, 10138–10145(1992).
  132. C.-H. Wong, “Engineering enzymesfor chemoenzymatic synthesis Part I: Practical routes to aza-sugars and complexcarbohydrates”, TIBTECH, 10, 337–341 (1992).
  133. C.-H. Wong, “Engineering enzymesfor chemoenzymatic synthesis Part II:Modifying proteases for peptide synthesis”, TIBTECH, 10, 378 (1992).
  134. K. K.-C. Liu, R. L. Pederson,C.-H. Wong, “Rabbit muscle aldolase catalyzed preparation of 6-deoxy-6-chloro-d-fructose and 6-deoxy-6-chloro-l-sorbose from3-chloro-2-hydroxypropanal and DHAP”, in Preparative Biotransformations,S. M. Roberts, K. Wiggins, G. Casy, eds. 1992, 4:1.1.
  135. C.-H. Wong, K. K.-C. Liu, T.Kajimoto, L. Chen, Z. Zhong, Y. Ichikawa, G.-J. Shen, “Developing betterenzymes for organic synthesis”, Enzyme Engineering XI, Ann. N.Y. Acad.Sci. 672, 343–351 (1992).
  136. W. Yuan, B. Munoz, J.Haeggstrom, A. Wetterholm, B. Samuelsson, C.-H. Wong, “Synthesis of selectivetight-binding inhibitors of leukotriene A4 hydrolase”, J. Med.Chem., 36, 211–220 (1993).
  137. M. Schuster, B. Munoz, W. Yuan,C.-H. Wong, “Papain catalyzed synthesis of peptide isosteres”, TetrahedronLett., 34, 1247–1250 (1993).
  138. Y.-F. Wang, D. Dumas, C.-H.Wong, “Chemo-enzymatic synthesis of five-membered aza sugars as inhibitors offucosidase and fucosyltransferase: An issue of stereochemistry discriminationat transition state”, Tetrahedron Lett., 34, 403–406 (1993).
  139. T. Sugai, G.-J. Shen, Y.Ichikawa, C.-H. Wong, “Synthesis of 3-deoxy-d-manno-2-octulosonicacid (KDO) and its analogs based on KDO aldolase-catalyzed reactions”, J.Am. Chem. Soc., 115, 413–421 (1993).
  140. P. Wang, G.-J. Shen, Y.-F. Wang,C.-H. Wong, “Enzymes in oligosaccharide synthesis: Active-domainoverproduction, specificity study, and synthetic use of an a1,2-mannosyltransferase with regeneration of GDP-mannose”, J. Org. Chem., 58, 3985–3990 (1993).
  141. M. M. Sim, H. Kondo, C.-H. Wong,“Synthesis of dibenzyl glycosyl phosphites using dibenzyl N, N-diethylphosphoramiditeas phosphitylating reagent: An effective route to glycosyl phosphates, sugarnucleotides, and glycosides”, J. Am. Chem. Soc., 115, 2260–2267 (1993).
  142. G. C. Look, C. H. Fotsch, C.-H.Wong, “Enzyme-catalyzed organic synthesis: Practical routes to aza-sugars andtheir analogs for use as glycoprocessing inhibitors”, Acc. Chem. Res.,26, 182–190 (1993).
  143. C.-H. Wong, Y. Ichikawa, T.Kajimoto, K. K.-C. Liu, G.-J. Shen, C.-H. Lin, Y.-F. Wang, D. P. Dumas, Y.-C.Lin, R. Wang, G. C. Look, “Practical synthesis of carbohydrates based onaldolases and glycosyltransferases”, Pure Appl. Chem., 65, 803–808(1993).
  144. G. Siuzdak, Y. Ichikawa, T. J.Caulfield, B. Munoz, C.-H. Wong, K. C. Nicolaou, “Evidence of Ca++dependent carbohydrate association through ion spray mass spectrometry”, J.Am. Chem. Soc., 115, 2877–2881 (1993).
  145. G. F. Herrmann, Y. Ichikawa, C.Wandrey, F. C. A. Gaeta, J.C. Paulson, C.-H. Wong, “A new multi-enzyme systemfor a one-pot synthesis of sialyl-oligosaccharides: combined use of b-galactosidase and a(2,6)-sialyltransferase coupledwith regeneration in situ ofCMP-sialic acid”, Tetrahedron Lett., 19, 3091–3094 (1993).
  146. C.-H. Wong, M. Schuster, P.Wang, P. Sears, “Enzymatic synthesis of N- and O-linked glycopeptides”, J.Am. Chem. Soc., 115, 5893–5901 (1993).
  147. G. C. Look, Y. Ichikawa, G.-J.Shen, P.-W. Cheng, C.-H. Wong, “A combined chemical and enzymatic strategy for theconstruction of carbohydrate-containing antigen core units”, J. Org. Chem.,58, 4326–4330 (1993).
  148. C.-H. Wong, “Development ofenzymes for chemo-enzymatic synthesis”, Chimia, 47, 127–132 (1993).
  149. Y. Takaoka, T. Kajimoto, C.-H.Wong, “Inhibition of N-acetylglucosaminyltransferenzymes: Chemical-enzymatic synthesis of new five-membered acetamido azasugars”, J. Org. Chem., 58, 4809–4812 (1993).
  150. S. A. DeFrees, F. C. A. Gaeta,Y.-C. Lin, Y. Ichikawa, C.-H. Wong, “Ligand recognition by E-selectin: Analysisof conformation and activity of synthetic monomeric and bivalent sialyl Lewis xanalogs”, J. Am. Chem. Soc., 115, 7549–7550 (1993).
  151. T. Sugai, H. Ritzen, C.-H. Wong,“Towards the chemoenzymatic synthesis of lipid A”, Tetrahedron Asymmetry, 4, 1051–1058 (1993).
  152. T. Kajimoto, T. Sugai, C.-H.Wong, “Aldolase catalyzed reaction for carbohydrate synthesis”, TrendsGlycosci. Glycotechnol., 5, 193–207 (1993).
  153. R. L. Halcomb, C.-H. Wong, “Synthesisof oligosaccharides, glycopeptides, and glycolipids”, Curr. Opin. Struct. Biol., 3, 694–700 (1993).
  154. P. Wang, M. Schuster, Y.-F.Wang, C.-H. Wong, “Synthesis of phospholipid-inhibitor conjugates by enzymatictransphosphatidylation with phospholipase D”, J. Am. Chem. Soc., 115,10487–10491 (1993).
  155. I. Henderson, K. B. Sharpless,C.-H. Wong, “Synthesis of carbohydrates via tandem use of the osmium-catalyzedasymmetric dihydroxylation and enzyme-catalyzed aldol addition reactions”, J.Am. Chem. Soc., 116, 558–561 (1994).
  156. I. Henderson, K. Laslo, C.-H.Wong, “Chemoenzymatic synthesis of homoazasugars”, Tetrahedron Lett., 35, 359–362 (1994).
  157. H. J. M. Gijsen, C.-H. Wong, “Unprecedentedasymmetric aldol reactions with three aldehyde substrates catalyzed by2-deoxyribose-5-phosphate aldolase”, J. Am. Chem. Soc., 116, 8422–8423(1994).
  158. L. Provencher, D. Steensma,C.-H. Wong, “Five-membered ring azasugars as potent inhibitors of l-a-rhamnosidase from Penicillium decumbens”, Bioorg. Med.Chem., 2, 1179–1188 (1994).
  159. J.-M. Fang, C.-H. Wong, “Enzymesin organic synthesis: Alteration of reversible reactions to irreversibleprocesses”, Synlett, 6, 393–402 (1994).
  160. C. H. Fotsch, C.-H. Wong, “Synthesisof a guanidino-sugar as a glycosyl cation mimic”, Tetrahedron Lett., 35,3481–3484 (1994).
  161. Y.-F. Wang, Y. Takaoka, C.-H.Wong, “Remarkable stereoselectivity in the inhibition of a-galactosidase from coffee bean by a newpolyhydroxypyrrolidine inhibitor”, Angew. Chem. Int. Ed. Engl., 33, 1242–1244(1994).
  162. W.-C. Chou, L. Chen, J.-M. Fang,C.-H. Wong, “A new route to deoxythiosugars based on aldolases”, J. Am.Chem. Soc., 116, 6191–6194 (1994).
  163. G. F. Herrmann, P. Wang, G.-J.Shen, C.-H. Wong, “Recombinant whole cells as catalysts for the enzymaticsynthesis of oligosaccharides and glycopeptides”, Angew. Chem. Int. Ed. Engl.,33, 1241–1242 (1994).
  164. B. Munoz, C.-Z. Giam, C.-H.Wong, “a-Ketoamide Phe-Pro isostere as anew core structure for the inhibition of HIV protease”, Bioorg. Med. Chem., 2, 1085–1090 (1994).
  165. G. F. Herrmann, P. Wang, G.-J.Shen, E. Garcia-Junceda, S. Chen, S. H. Khan, K. L. Matta, C.-H. Wong, “Large scaleproduction of recombinant a-1,2-mannosyltransferase from E. coli for the study of acceptor specificityand use of the recombinant whole cells in synthesis”, J. Org. Chem., 59,6356–6362 (1994).
  166. Y. Ichikawa, R. L. Halcomb,C.-H. Wong, “Sticky solutions”, Chemistry in Britain, 30, 117–121(1994).
  167. H. Kondo, S. Aoki, Y. Ichikawa,R. L. Halcomb, H. Ritzen, C.-H. Wong, “Glycosylphosphites as glycosylationreagents: Scope and mechanism”, J. Org. Chem., 59, 864–877 (1994).
  168. P. Sears, P. Wang, K. Witte, M.Schuster, C.-H. Wong, “Engineering subtilisin for peptide coupling: studies onthe effects of counterions and site-specific modifications on the stability andspecificity of the enzyme in aqueous and organic solvents”, J. Am. Chem.Soc., 116, 6521–6530 (1994).
  169. I. Henderson, E. Garcia-Junceda,G.-J. Shen, C.-H. Wong, “Cloning, overexpression and isolation of the Type IIFDP aldolase from E. coli forspecificity study and synthetic application”, Bioorg. Med. Chem., 2, 837–843(1994).
  170. M. Schuster, P. Wang, J. C.Paulson, C.-H. Wong, “Solid-phase chemical-enzymatic synthesis of glycopeptidesand oligosaccharides”, J. Am. Chem. Soc., 116, 1135–1136 (1994).
  171. Y. Ichikawa, R. Wang, C.-H.Wong, “Regeneration of sugar nucleotides in glycosyltransferase-catalyzed oligosaccharidesynthesis”, Method. Enzymol., 247, 107–127 (1994).
  172. H. Kondo, M. M. Sim, R. Halcomb,Y. Ichikawa, S. Aoki, C.-H. Wong, “Dibenzyl glycosyl phosphites: preparationand use in glycosylation”, Method. Enzymol., 247, 193–211 (1994).
  173. J. L. Marquardt, E.D. Brown, W. S.Lane, T. M. Haley, Y. Ichikawa, C.-H. Wong, C. T. Walsh, “Kinetics,stoichiometry and identification of the reactive thiolate in the inactivationof UDP-GlcNAc enolypyruvyl transferase by the antibiotic fosfomycin”, Biochemistry, 33, 10646–10651 (1994).
  174. S. Hiranuma, T. Kajimoto, C.-H.Wong, “A facile synthesis of 1-thiopentofuranosides”, Tetrahedron Lett., 35, 5257–5260 (1994).
  175. H. Yuasa, T. Kajimoto, C.-H.Wong, “Synthesis of iminothiasugar as a potential transition-state analoginhibitor of glycosyltransfer reactions”, Tetrahedron Lett., 35, 8243–8246(1994).
  176. R. L. Halcomb, H. Huang, C.-H.Wong, “Solution- and solid-phase synthesis of inhibitors of H. pylori attachment andE-selectin-mediated leukocyte adhesion”, J. Am. Chem. Soc., 116, 11315–11322(1994).
  177. S.-H. Jung, J.-H. Jeong, P.Miller, C.-H. Wong, “An efficient multigram scale preparation ofdihydroxyacetone phosphate”, J. Org. Chem., 59, 7182–7184 (1994).
  178. R. L. Halcomb, W. Fitz, C.-H.Wong, “Enzymatic synthesis of 7-deoxy- N-acetylneuraminicacid and 7-0-methyl- N-acetylneuraminicacid”, Tetrahedron: Asymmetry, 5, 2437–2442 (1994).
  179. W. Fitz, C.-H. Wong, “Combineduse of subtilisin and N-acetylneuraminicacid aldolase for the synthesis of a fluorescent sialic acid”, J. Org. Chem.,59, 8279–8280 (1994).
  180. G. Siuzdak, Z.-L. Zheng, J. R.Ramphal, Y. Ichikawa, K. C. Nicolaou, F. C. A. Gaeta, K.S. Chatman, C.-H. Wong,“Examination of the sialyl Lewis X - calcium complex by electrospray massspectrometry”, Bioorg. Med. Chem Lett., 4, 2863–2866 (1994).
  181. T. Sugai, C.-H. Lin, G.-J. Shen,C.-H. Wong, “CMP-KDO synthetase: overproduction and application to thesynthesis of CMP-KDO and analogs”, Bioorg. Med. Chem, 3, 313–320 (1995).
  182. S. A. DeFrees, W. Kosch, W. Way,J. C. Paulson, S. Sabesan, R. Halcomb, D.-H. Huang, Y. Ichikawa, C.-H. Wong, “Ligandrecognition by E-selectin: synthesis, inhibitory activity, and conformational analysisof bivalent sialyl Lewis x analogs”, J. Am. Chem. Soc., 117, 66–79(1995).
  183. C.-H. Wong, E. Garcia-Junceda,L. Chen, O. Blanco, D. H. Steensma, “Recombinant 2-deoxyribose-5-phosphate aldolasein organic synthesis: use of sequential two-substrate and three-substrate aldolReactions”, J. Am. Chem. Soc., 117, 3333–3339 (1995).
  184. C.-M. Fang, C.-H. Wong, “Enzymesin organic synthesis: oxidoreductions”, J. Chem. Soc., Perkin Trans I.,967–978 (1995).
  185. C.-H. Wong, R. Halcomb, Y.Ichikawa, T. Kajimoto, “Enzymes in organic synthesis: application to theproblems of carbohydrate recognition (Part I)”, Angew. Chem. Int. Ed. Engl.,34, 412–432 (1995).
  186. C.-H. Wong, R. Halcomb, Y.Ichikawa, T. Kajimoto, “Enzymes in organic synthesis: application to theproblems of carbohydrate recognition (Part II)”, Angew. Chem. Int. Ed. Engl.,34, 521–546 (1995).
  187. P. Wang, W. Fitz, C.-H. Wong, “Makingcomplex carbohydrates via enzymatic routes”, Chemtech, 22–32 (1995).
  188. C.-H. Wong, “Enzymatic andchemo-enzymatic synthesis of carbohydrates”, Pure Appl. Chem., 67, 1609–1616(1995).
  189. C.-H. Wong, R. Alajarin, F.Moris-Varas, O. Blanco, E. Garcia-Junceda, “Enzymatic synthesis of l-fucose and analogs”, J. Org. Chem., 60, 7360–7363 (1995).
  190. H. Huang, C.-H. Wong, “Synthesisof biologically active sialyl Lewis X mimetics”, J. Org. Chem., 60, 3100–3106(1995).
  191. V. P. Vassilev, T. Uchiyama, T. Kajimoto,C.-H. Wong, “An efficient chemo-enzymatic synthesis of a-amino-b-hydroxy g-butyrolactone”, Tetrahedron Lett., 36, 5063 (1995).
  192. C.-H. Lin, G.-J. Shen, C.-H.Wong, “Enzymatic synthesis and regeneration of 3¢-phosphoadenosine-5¢-phosphosulfate (PAPS) for use in regiospecificenzymatic sulfation”, J. Am. Chem. Soc., 117, 8031–8032 (1995).
  193. C.-H. Wong, L. Provencher, J.Porco, S.-H. Jung, Y.-F. Wang, L. Chen, R. Wang, D. Steensma, “Synthesis andevaluation of homoazasugars as glycosidase inhibitors”, J. Org. Chem., 60, 1492–1502 (1995).
  194. E. A. Stura, S. Gosh, E.Garcia-Junceda, L. Chen, C.-H. Wong, I. A. Wilson, “Crystallization andpreliminary crystallographic data for class I deoxyribose-5-phosphate aldolasefrom E. coli: An application ofreverse screening”, Proteins: Struct., Funct., Genet., 22, 67–72 (1995).
  195. T. Ikeda, T. Kajimoto, T.Nohara, J.-E. Kinjo, C.-H. Wong, “Preparation of a neoglycolipid carrying theoligosaccharide component of saponin from Albizziajulibrissin”, Tetrahedron Lett., 36, 1509–1510 (1995).
  196. A. Wetterholm, J. Z. Haeggstrom,B. Samuelsson, W. Yuan, B. Munoz, C.-H. Wong, “Potent and selective inhibitorsof leukotriene A4 hydrolase: effects on purified enzyme and humanpolymorphonuclear leukocytes”, J. Pharmacol. Exp. Ther., 275, 31–37(1995).
  197. R. Ollmann, J. H. Hogg, B. Munoz,C.-H. Wong, J. Z. Haeggstrom, B. Samuelsson, “Investigation of the inhibitionof leukotriene A4 hydrolase”, Bioorg. Med. Chem., 3, 969–995(1995).
  198. J. H. Hogg, I. R. Ollmann, C.-H.Wong, J. Z. Haeggstrom, B. Samuelsson, “Amino hydroxamic acids as potentinhibitors of leukotriene A4 hydrolase”, Bioorg. Med. Chem., 3, 1405–1415 (1995).
  199. W. Fitz, J.-R. Schwark, C.-H.Wong, “Aldotetroses and C(3)-modified aldohexoses as substrates for N-acetylneuraminic acid aldolase:comments on the lack of stereospecificity displayed by the enzyme”, J. Org.Chem., 60, 3663–3670 (1995).
  200. W.-C. Chou, C. Fotsch, C.-H.Wong, “Synthesis of nitrocyclitols based on enzymatic aldol reaction andintramolecular nitroaldol reaction”, J. Org. Chem., 60, 2916–2917(1995).
  201. H. J. M. Gijsen, C.-H. Wong, “Sequentialone-pot aldol reactions catalyzed by 2-deoxyribose-5-phosphate aldolase andfructose-1,6-diphosphate aldolase”, J. Am. Chem. Soc., 117, 2947–2948(1995).
  202. E. Garcia-Junceda, G.-J. Shen,T. Sugai, C.-H. Wong, “A new strategy for the cloning, overexpression and onestep purification of three DHAP-dependent aldolases: rhamnulose-1-phosphatealdolase, fuculose-1-phosphate aldolase and tagatose-1,6-diphosphate aldolase”, Bioorg. Med. Chem., 3, 945–953 (1995).
  203. T. Uchiyama, V.P. Vassilev, T.Kajimoto, W. Wong, H. Huang, C.-C. Lin, C.-H. Wong, “Design and synthesis of sialylLewis X mimetics”, J. Am. Chem. Soc., 117, 5395–5396 (1995).
  204. V. P. Vassilev, T. Uchiyama, T. Kajimoto,C.-H. Wong, “l-Threonine aldolasein organic synthesis: preparation of novel b-hydroxy-a-amino acids based on threonine aldolase”, TetrahedronLett., 36, 4081–4084 (1995).
  205. C. De Luca, M. Lansing, I.Martin, F. Crescenzi, G.-J. Shen, M. O’Regan, C.-H. Wong, “Enzymatic synthesisof hyaluronic acid with regeneration of sugar nucleotides”, J. Am. Chem.Soc., 117, 5869–5870 (1995).
  206. M. Hendrix, C.-H. Wong, “Enzymesin organic synthesis: Application to the study of carbohydrate recognition”, Proceedingsof the Chiral ‘95 USA Symposium, Spring Innovation Ltd., 1995, pp 27–34.
  207. H. J. M. Gijsen, C.-H. Wong, “Sequentialthree- and four-substrate aldol reactions catalyzed by aldolases”, J. Am.Chem. Soc., 117, 7585–7591 (1995).
  208. R. Alajarin, E. Garcia-Junceda,C.-H. Wong, “A short enzymatic synthesis of l-glucosefrom dihydroxyacetone phosphate and l-glyceraldehyde”, J. Org. Chem., 60, 4294–4295 (1995).
  209. C.-H. Wong, “Intervention ofcarbohydrate-mediated biological recognitions”, RIKEN Rev., 8, 3–4(1995).
  210. T. Kajimoto, C.-H. Wong, “Transition-stateanalog inhibitors for N-acetylglucosaminyltransferenzymes”, RIKEN Rev., 8, 13–14 (1995).
  211. S. Hiranuma, V. P. Vassilev, T.Kajimoto, C.-H. Wong, “Design of oligosaccharide mimetics with higher stabilityand simpler structures than parent oligosaccharides”, RIKEN Rev., 8, 19–20(1995).
  212. T. Ikeda, T. Kajimoto, C.-H.Wong, “Oligosaccharides components in traditional Chinese medicines and theliposomes carrying oligosaccharides”, RIKEN Rev., 8, 21–22 (1995).
  213. V. P. Vassilev, T. Kajimoto,C.-H. Wong, “Application of l-allo-threoninealdolase in the synthesis of glycoconjugate precursors”, RIKEN Rev., 8,25–26 (1995).
  214. E. Garcia-Junceda, G.-J. Shen,R. Alajarin, C.-H. Wong, “Cloning and overexpression of rhamnose isomerase andfucose isomerase”, Bioorg. Med. Chem., 3, 1349–1355 (1995).
  215. D. H. Slee, K. L. Laslo, J. H.Elder, I. R. Ollmann, A. Gustchina, J. Kervinen, A. Zdanov, A. Wlodawer, C.-H.Wong, “Selectivity in the inhibition of HIV and FIV protease: Inhibitory andmechanistic studies of pyrrolidine-containing a-keto amide andhydroxyethylamine core structures”, J. Am. Chem. Soc., 117, 11867–11878(1995).
  216. H. J. M. Gijsen, C.-H. Wong, “Synthesisof a cyclitol via a tandem enzymatic aldol-intramolecularHorner-Wadsworth-Emmons reaction”, Tetrahedron Lett., 36, 7057–7060(1995).
  217. C.-H. Lin, M. Shimazaki, C.-H.Wong, M. Koketsu, L. R. Juneja, M. Kim, “Enzymatic synthesis of a sialyl LewisX dimer from egg yolk as an inhibitor of E-selectin”, Bioorg. Med. Chem.,3, 1625–1630 (1995).
  218. J.-H. Jeong, B. W. Murray, S.Takayama, C.-H. Wong, “Cyclic guanidino-sugars with low pKa as transition-stateanalog inhibitors of galactosidases: neutral instead of charged species are theactive forms”, J. Am. Chem. Soc., 118, 4227–4234 (1996).
  219. H. M. Gijsen, L. Qiao, W. Fitz,C.-H. Wong, “Recent advances in the chemo-enzymatic synthesis of carbohydratesand carbohydrate mimetics”, Chem. Rev., 96, 443–473, (1996).
  220. W. Fitz, C.-H. Wong, “Synthesisof a thiomethylmercuric sialic acid to be used in the X-ray structuredetermination of an influenza virus esterase”, Bioorg. Med. Chem., 4, 1349–1353(1996).
  221. B. Orsat, P. Alper, W. Moree, C.P. Mak, C.-H. Wong, “Homocarbonates as substrates for the enantioselectiveenzymatic protection of amines”, J. Am. Chem. Soc., 118, 712–713 (1996).
  222. P. Sears, C.-H. Wong, “Engineeringenzymes for bioorganic synthesis: peptide bond formation”, Biotech. Prog.,12, 423–433 (1996).
  223. S.-H. Wu, M. Shimazaki, C.-C.Lin, L. Qiao, W.J. Moree, C.-H. Wong, “Synthesis of fucopeptides as sialylLewis X mimetics”, Angew. Chem. Int. Ed. Engl., 35, 88–89 (1996).
  224. C.-C. Lin, M. Shimazaki, M-P.Heck, S. Aoki, R. Wang, T. Kimura, H. Ritzen, S. Takayama, S.-H. Wu, G.Weitz-Schmidt, C.-H. Wong, “Synthesis of sialyl Lewis X mimetics and relatedstructures using the glycosyl phosphite methodology and evaluation ofE-selectin inhibition”, J. Am. Chem. Soc., 118, 6826–6840 (1996).
  225. S. Takayama, M. Shimazaki, C.-H.Wong, “Efficient synthesis of lactosamine derivatives using b-d-galactosidasefrom B. circulans”, Bioorg. Med.Chem Lett., 6, 1123–1126 (1996).
  226. J. E. Patterson, I. R. Ollmann,B. F. Cravatt, D. L. Boger, C.-H. Wong, R. A. Lerner, “Inhibition of oleamidehydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide”, J. Am. Chem.Soc., 118, 5938–5945 (1996).
  227. C.-H. Wong, “Chemoenzymaticsynthesis: application to the study of carbohydrate recognition”, Acta Chem.Scan., 50, 211–218 (1996) (Nobel Symposium on Catalytic AsymmetricSynthesis).
  228. M. Hendrix, C.-H. Wong, “Achemoenzymatic approach to carbohydrate-mediated cell adhesion”, Pure Appl.Chem., 68, 2081–2087 (1996).
  229. L. Qiao, B. W. Murray, M. Shimazaki, J.Schultz, C.-H. Wong, “Synergistic inhibition of human a-1,3-fucosyltransferase V”, J. Am. Chem. Soc., 118, 7653–7662,(1996).
  230. W. K. C. Park, M. Auer, C.-H.Wong, “Rapid combinatorial synthesis of aminoglycoside mimetics using amultiple component condensation strategy: Use of a polyethylene glycol-linkedamine and a neamine-derived aldehyde as key components”, J. Am. Chem. Soc.,118, 10150–10155 (1996).
  231. K. Hiruma, I. R. Ollmann, T.Kajimoto, G. Weitz-Schmidt, C.-H. Wong, “Rational design and synthesis of a1,1-linked disaccharide that is five times as active as sialyl Lewis X inbinding to E-selectin”, J. Am. Chem. Soc., 118, 9265–9270 (1996).
  232. C. De Luca, M. Lansing, F.Crescenzi, I. Martini, G.-J. Shen, M. O’Regan, C.-H. Wong, “Overexpression,one-step purification and characterization of UDP-glucose dehydrogenase andUDP- N-acetylglucosaminepyrophosphorylase”, Bioorg. Med. Chem., 4, 131–142 (1996).
  233. R. D. Kidd, H. P. Yennawar, P.Sears, C.-H. Wong, G. K. Farber, “A weak calcium binding site in subtilisin BPN’has a dramatic effect on protein stability”, J. Am. Chem. Soc., 118,1645–1650 (1996).
  234. R. Wang, C.-H. Wong, “Synthesisof sialyl Lewis X mimetics: use of O-a-fucosyl-(1 R,2 R)-2-aminocyclohexanol as core structure”, Tetrahedron Lett., 37, 5427–5430 (1996).
  235. F. Moris-Varas, X. H. Qian andC.-H. Wong, “Enzymatic and chemical synthesis of seven-membered iminocyclitolsas inhibitors of glycosidases”, J. Am. Chem. Soc., 118, 7647–7652(1996).
  236. C.-C. Lin, T. Kimura, S.-H. Wu,G. Weitz-Schmidt, C.-H. Wong, “Liposome-like fucopeptides as sialyl Lewis Xmimetics”, Bioorg. Med. Chem Lett., 6, 2755–2760 (1996).
  237. X. Qian, F. Moris-Varas, C.-H.Wong, “Synthesis of C2-symmetrical polyhydroxyazepanes as inhibitorsof glycosidases”, Bioorg. Med. Chem Lett., 6, 1117–1122 (1996).
  238. M. W. Cappi, W. J. Moree, L.Qiao, T. G. Marron, G. Weitz-Schmidt, C.-H. Wong, “The synthesis of novel6-amino-6-deoxy-l-galactoseglycopeptides as potent sialyl Lewis X mimetics”, Angew. Chem. Int. Ed. Engl.,35, 2346–2347 (1996).
  239. S.-C. Hung, C.-H. Wong, “Samariumdiiodide-mediated coupling of glycosyl phosphates with carbon radical or carbonanion acceptors for the synthesis of C-glycosides”, Angew. Chem. Int. Ed. Engl., 35, 2671–2674 (1996).
  240. P. B. Alper, S.-C. Hung C.-H.Wong, “Metal catalyzed diazo transfer for the synthesis of azides from amines”, Tetrahedron Lett., 37, 6029–6032 (1996).
  241. T. Uchiyama, T. J. Woltering, W.Wong, T. Kajimoto, M. Takebayashi, G. Weitz-Schmidt, C.-H. Wong, “Design and synthesisof C-linked fucopeptides as inhibitors of E-selectin”, Bioorg. Med. Chem.,4, 1149–1165 (1996).
  242. B. W. Murray, S. Takayama, C.-H.Wong, “Mechanism and specificity of human a-1,3-fucosyltransferase V” Biochemistry,35, 11183–11195 (1996).
  243. K. Shibata, K. Shingu, V. P.Vassilev, K. Nishide, T. Fujita, M. Node, T. Kajimoto, C.-H. Wong, “Kinetic andthermodynamic control of l-threoninealdolase catalyzed reaction and its application to the synthesis ofMycestericin D”, Tetrahedron Lett., 37, 2791–2794 (1996).
  244. S.-C. Hung, C.-H. Wong, “Synthesisof glycosyl chlorides with acid-labile protecting group”, Tetrahedron Lett.,37, 4903–4906 (1996).
  245. T. Kimura, S. Takayama, H.Huang, C.-H. Wong, “A practical method for the synthesis of N-acetyl-d-lactosamine derivatives by the tandem use of galactoseoxidase and b-galactosidase”, Angew. Chem.Int. Ed. Engl., 35, 2348–2349 (1996).
  246. S. Takayama, W. J. Moree, C.-H.Wong, “Enzymatic resolution of amines and amino alcohols using pent-4-enoylderivatives”, Tetrahedron Lett., 37, 6287–6290 (1996).
  247. T. J. Woltering, G.Weitz-Schmidt, C.-H. Wong, “C-Fucopeptides as selectin antagonists: Attachmentof lipid moieties enhances the activity”, Tetrahedron Lett., 37, 9033–9036(1996).
  248. T. G. Marron, T. J. Woltering,G. Weitz-Schmidt, C.-H. Wong, “C-Mannose derivatives as potent mimics of sialylLewis X”, Tetrahedron Lett., 37, 9037–9040 (1996).
  249. S. Takayama, P. O. Livingston,C.-H. Wong, “Synthesis of the melanoma-associated ganglioside 9-0-acetyl GD3through regioselective enzymatic acetylation of GD3 using subtilisin”, Tetrahedron Lett., 37, 9271–9274 (1996).
  250. P. Sears, C.-H. Wong, “Interventionof carbohydrate recognition by proteins and nucleic acids”, Proc. Natl.Acad. Sci. U.S.A., 93, 12086–12093 (1996).
  251. X. Qian, F. Moris-Varas, M. C.Fitzgerald, C.-H. Wong, “ C2-Symmetricaltetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases”, Bioorg.Med. Chem., 4, 2055–2069 (1996).
  252. M. Hendrix, C.-H. Wong, “Achemo-enzymatic approach to the study of carbohydrate recognition in biologicalsystems”, Enantiomer, 1, 305–310 (1996).
  253. J. Wu, S. Takayama, C.-H. Wong,G. Siuzdak, “Quantitative electrospray mass spectrometry for the rapid assay ofenzyme inhibitors”, Chem. Biol., 4, 653–657 (1997).
  254. T. Hayashi, B. W. Murray, R.Wang, C.-H. Wong, “A chemo-enzymatic synthesis ofUDP-(2-deoxy-2-fluoro)galactose and evaluation of its interaction withgalactosyltransferase”, Bioorg. Med. Chem., 5, 497–500 (1997).
  255. R. Wang, D. H. Steensma, Y.Takaoka, C.-H. Wong, “A search of pyrophosphate mimetics for the development ofsubstrates and inhibitors of glycosyltransferases”, Bioorg. Med. Chem.,5, 641–644 (1997).
  256. M. Hendrix, P. B. Alper, E. S.Priestley, C.-H. Wong, “Hydroxyamines as a new motif for the molecularrecognition of phosphodiesters: implications for aminoglycoside RNAinteractions”, Angew. Chem. Int. Ed. Engl., 36, 95–96 (1997).
  257. B. W. Murray, V. Wittmann, M. D.Burkart, S. -C. Hung, C.-H. Wong, “Mechanism of human a-1,3-fucosyltransferase V: Glycosidic cleavage occursprior to nucleophilic attack”, Biochemistry, 36, 823-831 (1997).
  258. C.-H. Lin, B. W. Murray, I. R.Ollmann, C.-H. Wong, “Why is CMP-KDO highly unstable?”, Biochemistry,36, 780–785 (1997).
  259. W. Fitz, C.-H. Wong, “Oligosaccharidesynthesis by enzymatic glycosidation”, in Preparative Carbohydrate Chemistry,S. Hanessian ed., M. Dekker Publication Inc., New York 1997, pp 485–504.
  260. S. Takayama, C.-H. Wong, “Chemo-enzymaticapproach to carbohydrate recognition”, Curr. Org. Chem., 1, 109–126(1997).
  261. V. Wittmann, C.-H. Wong, “1 H-Tetrazole as catalyst inphosphoromorpholidate coupling reactions: efficient synthesis of GDP-fucose,GDP-mannose and UDP-galactose”, J. Org. Chem., 62, 2144–2147 (1997).
  262. M. Hendrix, E. S. Priestley, G.Joyce, C.-H. Wong, “Direct observation of aminoglycoside–RNA interactions bysurface plasmon resonance”, J. Am. Chem. Soc., 119, 3641–3646 (1997).
  263. W. J. Moree, P. Sears, K.Kawashiro, K. Witte, C.-H. Wong, “Exploitation of subtilisin BPN’ as catalystsfor the synthesis of peptides containing noncoded amino acids, peptide mimeticsand peptide conjugates”, J. Am. Chem. Soc., 119, 3942–3947 (1997).
  264. K. D. Janda, L.-C. Lo, C.-H. Lo,M.-M. Sim, R. Wang, C.-H. Wong, R.A. Lerner, “Chemical selection for catalysisin combinatorial antibody libraries”, Science, 275, 945–948 (1997).
  265. C.-H. Wong, F. Moris-Varas,S.-C. Hung, T. G. Marron, C.-C. Lin, K. W. Gong, G. Weitz-Schmidt, “Smallmolecules as structural and functional mimics of the tetrasaccharide sialylLewis X in selectin inhibition: A remarkable enhancement of inhibition by additionalnegative charge and/or hydrophobic group”, J. Am. Chem. Soc., 119, 8152–8158(1997).
  266. S.-C. Hung, C.-C. Lin, C.-H.Wong, “One-pot synthesis of 1-allyl and 1-allenyl-6- O-benzyl-a-d-glycosides from methyl tetra- O-benzyl-a-d-glycosides”, Tetrahedron Lett., 38, 5419–5422(1997).
  267. M. W. Cappi, W. J. Moree, L.Qiao, T. G. Marron, G. Weitz-Schmidt, C.-H. Wong, “Synthesis of novel6-amino-6-deoxy-l-galactosederivatives as potent sialyl Lewis x mimetics”, Bioorg. Med. Chem., 5,283–296 (1997).
  268. G. J. McGarvey, C.-H. Wong, “Chemical,enzymatic and structural studies in molecular glycobiology”, Liebigs Annal.,6, 1059–1074 (1997).
  269. S. Takayama, G. J. McGarvey,C.-H. Wong, “Microbial aldolases and transketolases: New biocatalyticapproaches to simple and complex sugars”, Annu. Rev. Microbiol., 51, 285–310(1997).
  270. C.-C. Lin, C.-H. Lin, C.-H.Wong, “Sialic acid aldolase-catalyzed condensation of pyruvate and N-substituted mannosamine: A usefulmethod for the synthesis of N-substitutedsialic acids”, Tetrahedron Lett., 38, 2649–2652 (1997).
  271. K. Witte, P. Sears, R. Martin,C.-H. Wong, “Enzymatic glycoprotein synthesis: Preparation of ribonucleaseglycoforms via enzymatic glycopeptide condensation and glycosylation”, J.Am. Chem. Soc., 119, 2114–2118 (1997).
  272. M. J. Kim, I. T. Lim, H.-J. Kim,C.-H. Wong, “Enzymatic single aldol reactions of remote dialdehydes”, TetrahedronAsymmetry, 8, 1507–1509 (1997).
  273. C.-H. Wong, “A chemo-enzymaticapproach to the study of carbohydrate-based biological recognitions,” Pure Appl.Chem., 69, 419–422 (1997).
  274. T. Kimura, V. P. Vassilev, G.-J.Shen, C.-H. Wong, “Enzymatic synthesis of b-hydroxy-a-amino acids based on d-and l-threonine aldolases”, J.Am. Chem. Soc., 119, 11734–11742 (1997).
  275. O. Seitz, C.-H. Wong, “Chemoenzymaticsolution- and solid-phase synthesis of an O-glycopeptidesof the mucin domain of MAdCAM-1. a general route to O-LacNAc, O-sialyl-LacNAc,and O-sialyl-Lewis-X peptides”, J.Am. Chem. Soc., 119, 8766–8776 (1997).
  276. S. Takayama, G. J. McGarvey,C.-H. Wong, “Enzymes in organic synthesis: Recent development in aldolreactions and glycosylations”, Chem. Soc. Rev., 26, 407–415 (1997).
  277. S. Takayama, R. Martin, J. Wu,K. Laslo, G. Siuzdak, C.-H. Wong, “Chemoenzymatic preparation of novel cyclic iminesugars and rapid biological activity evaluation using electrospray mass spectrometryand kinetic analysis”, J. Am. Chem. Soc., 119, 8146–8151 (1997).
  278. M. D. Burkart, S.-C. Hung, Z.Zhang, C.-H. Wong, “A new method for the synthesis of fluoro-carbohydrates andglycosides using SelectfluorTM”, J. Am. Chem. Soc., 119,11743–11746 (1997).
  279. M. Koketsu, T. Nitoda, H.Sugino, L. R. Juneja, M. Kim, T. Yamamoto, N. Abe, T. Kajimoto, C.-H. Wong, “Synthesisof a novel sialic acid derivative (sialylphospholipid) as an antirotaviralagent”, J. Med. Chem., 40, 3332–3335 (1997).
  280. T. Ikeda, T. Kajimoto, H. Kondo,C.-H. Wong, “Design and synthesis of an a-mannosyl terpenoid as aselective inhibitor of p-selectin”, Bioorg. Med. Chem. Lett., 7, 2485–2490(1997).
  281. M. Kanebo, O. Kanie, T.Kajimoto, C.-H. Wong, “Toward a transition state analog inhibitor of N-acetylglucosaminyl transferase V”, Bioorg.Med. Chem. Lett., 7, 2809–2812 (1997).
  282. J. B. Jones, C.-H. Wong, “Biocatalysisand biotransformation exploiting nature’s magic”, Curr. Opin. Chem. Biol.,2, 67–69 (1998).
  283. E. Simanek, G. J. McGarvey,C.-H. Wong, “Selectin-carbohydrate interaction: From natural ligands todesigned mimics”, Chem. Rev., 98, 838–862 (1998).
  284. P. Sears, C.-H. Wong, “Enzymeaction in glycoprotein synthesis”, Cell. Mol. Life Sci., 54, 223-252(1998).
  285. P. B. Alper, M. Hendrix, C.-H.Wong, “Probing the specificity of aminoglycoside–RNA interactions with designedsynthetic analogs”, J. Am .Chem. Soc., 120, 1965–1978 (1998).
  286. T. F. J. Lampe, G.Weitz-Schmidt, C.-H. Wong, “Parallel synthesis of sialyl Lewis x mimetics onsolid phase, a library approach toward fucopeptides”, Angew. Chem. Int Ed.Engl., 37, 1707–1711 (1998).
  287. K. Hiruma, O, Kanie, C.-H. Wong,“Synthesis of analogs of 1,1-linked galactosyl mannoside as mimetics of sialylLewis x tetrasaccharide”, Tetrahedron, 54, 15781–15792 (1998).
  288. T. Lee, G. S. Laco, B. E.Torbett, H. S. Fox, D. L. Lerner, J. H. Elder, C.-H. Wong, “Analysis of the S3and S3¢ subsite specificity of FIVprotease: Development of a broad-based protease inhibitor efficacious againstFIV, SIV and HIV in vitro and ex vivo”, Proc. Natl. Acad. Sci. U.S.A.,95, 939–944 (1998).
  289. C. Y. Tsai, W. K. C. Park, G.Weitz-Schmidt, B. Ernst, C.-H. Wong, “Synthesis of sialyl Lewis x mimeticsusing the Ugi four-component reaction”, Bioorg. Med. Chem Lett., 8, 2333–2338(1998).
  290. E. E. Simanek, D.-H. Huang, L. Pasternack, T. D. Machajewski, O. Seitz, D. S. Millar, H. J. Dyson and C.-H. Wong, “ Glycosylationof Threonine of the Repeating Unit of RNA Polymerase II with β-Linked  N-AcetylglucosameLeads to a Turnlike Structure ”, J. Am. Chem. Soc., 120 (45), 11567–11575 (1998).
  291. P. Sears, C.-H. Wong, “Mechanism-basedinhibition of carbohydrate-mediated biological recognitions”, Chem. Comm.,11, 1161–1170 (1998).
  292. R. Martin, K. L. Witte, C.-HWong, “The synthesis and enzymatic incorporation of sialic acid derivatives foruse as tools to study the structure, activity and inhibition of glycoproteinsand other glycoconjugates”, Bioorg. Med. Chem., 6, 1283–1292 (1998).
  293. Y. Kanie, A. Kirsch, O. Kanie,C.-H. Wong, “Enzymatic assay of galactosyltransferase by capillaryelectrophoresis”, Anal. Biochem., 263, 240–245 (1998).
  294. H. Kamitakahara, T. Suzuki, N.Nishigori, Y. Suzuki, O. Kanie, C.-H. Wong, “Lyso GM3 ganglioside-poly-l-glutamic acid conjugate as picomolarinhibitor of influenza hemagglutinin”, Angew. Chem. Int. Ed. Engl., 37,1524–1528 (1998).
  295. V. Wittmann, S. Takayama, K. W.Kong, G. Weitz-Schmidt, C.-H. Wong, “Ligand recognition by E- and P-selectin:chemoenzymatic synthesis and inhibitory activity of bivalent sialyl Lewis x derivativesand sialyl Lewis x carboxylic acids”, J. Org. Chem., 63, 5137–5143(1998).
  296. J. H. Hogg, I. R. Ollmann, A.Wetterhold, M.B. Andberg, J. Haeggstrom, B. Samuelsson, C.-H. Wong, “Probingthe activities and mechanisms of leukotriene A4 hydrolase withsynthetic inhibitors”, Chem. Eur. J., 4, 1698–1713 (1998).
  297. K. Witte, O. Seitz, C.-H. Wong, “Solutionand solid-phase synthesis of N-protectedpeptide esters of the benzyl type as substrates for subtilisin-catalyzedglycopeptide coupling”, J. Am. Chem. Soc., 120, 1979–1989 (1998).
  298. V. P. Vassilev, E. E. Simanek,M. R. Wood, C.-H. Wong, “Enzymatic synthesis of a chiral gelator withremarkably low molecular weight”, Chem. Comm., 1865–1866 (1998).
  299. C.-H. Wong, M. Hendrix, D. D.Manning, C. Rosenbohm, W. A. Greenberg, “A library approach to the discovery ofsmall molecules that recognize RNA: use of a 1,3-hydroxyamine motif as core”, J.Am. Chem. Soc., 120, 8319–8327 (1998).
  300. C.-H. Wong, M. Hendrix, E. S.Priestley, W. A. Greenberg, “Specificity of aminoglycoside antibiotics for theribosomal decoding region A-site RNA”, Chem. Biol., 5, 397–406 (1998).
  301. C.-H. Wong, X.-S. Ye, Z. Zhang, “Assemblyof oligosaccharide libraries using a designed building block and an efficientorthogonal protection-deprotection strategy”, J. Am. Chem. Soc., 120,7137–7138 (1998).
  302. R. Wischnat, R. Martin, C.-H.Wong, “Synthesis of a new class of N-linkedLewis x and LacnAc analogs as potential inhibitors of human fucosyltransferases:A general method for the incorporation of an iminocyclitol as transition-statemimic of the donor sugar to the acceptor”, J. Org. Chem., 63, 8361–8365(1998).
  303. T. Miura, T. Kajimoto, M. Jimbo,K. Yamagishi, J.-C. Inokuchi, C.-H. Wong, “Synthesis and evaluation ofmorpholino- and pyrrolidinosphingolipids as inhibitors of glycosylceramidesynthase”, Bioorg. Med. Chem., 6, 1481–1489 (1998).
  304. T. Kanemitsu, O. Kanie, C.-H.Wong, “Quantitative monitoring of solid-phase synthesis using gated decoupling 13C-NMRwith 13C-enriched protecting group and internal standard in thesynthesis of sialyl Lewis x tetrasaccharide”, Angew. Chem. Int. Ed. Engl.,37, 3415–3418 (1998).
  305. K. Witte, J. Skolnick, C.-H.Wong, “A synthetic retrotransition (backwards reading) sequence of the righthanded three-helix bundle domain B (10-53) of protein A shows similarity inconformation as predicted by computation”, J. Am. Chem. Soc., 120, 13042–13045(1998).
  306. R. Wischnat, R. Martin, S.Takayama, C.-H. Wong, “Chemoenzymatic synthesis of iminocyclitol derivatives: Auseful library strategy for the development of selective fucosyltransferenzymes inhibitors”, Bioorg. Med. Chem. Lett., 8, 3353–3358 (1998).
  307. P. B. Rosenthal, X. Zhang, F.Formanowski, W. Fitz, C.-H. Wong, H. Meier-Ewert, J. Skehel, D.C. Wiley, “Threedimensional structure of the haemagglutinin-esterase-function glycoprotein ofinfluenza C virus”, Nature, 396, 92–96 (1998).
  308. S. J. Chung, S. Takayama, C.-H.Wong, “Acceptor substrate-based selective inhibition of galactosyltransferases”, Bioorg. Med. Chem. Lett., 8, 3359–3364 (1998).
  309. C.-T. Guo, C.-H. Wong, T.Kajimoto, T. Miura, Y. Ida, L. R. Juneja, M.-J. Kim, H. Masuda, T. Suzuki, Y,Suzuki, “Synthetic sialylphosphatidylethanolamine binds to human influenza Aviruses and inhibits the viral infection”, Glycoconjugates, 15, 1099–1108(1998).
  310. X. Zhang, P. B. Rosenthal, W.Fitz, C.-H. Wong, H. Meier-Ewert, J. J. Skehel, D. C. Wiley, “X-raycrystallographic determination of the structure of the influenza C virushaemagglutinin-esterase-function glycoprotein”, ACTA Cryst., D55, 945–961(1999).
  311. P. Sears, K. Witte, C.-H. Wong, “Theeffect of counterion, water concentration, and stirring on the stability ofsubtilisin BPN’ in organic solvents”, J. Mol. Catalysis, 6, 297–304(1999).
  312. H. Yuasa, H. Hashimoto, Y. Abe,T. Kajimoto, C.-H. Wong, “Studies on the unusual stability ofcis-2,5-diethoxy-1,4-dioxane-2,5-dimethanol”, Tetrahedron 55, 2193–2204(1999).
  313. C.-C. Lin, F. Moris-Varas, G.Weitz-Schmidt, C.-H. Wong, “Synthesis of sialyl Lewis x mimetics as selectininhibitors by enzymatic aldol condensation reactions”, Bioorg. Med. Chem.,7, 425–434 (1999).
  314. G.-J. Shen, A. K. Datta, C.-C.Lin, K. Koeller, R.-F. Huang, C.-H. Wong, “Expression of(2,8/2,9-polysialyltransferase from E.coli K92: Characterization of the enzyme and its reaction products”, J. Biol.Chem., 274, 35139–35146 (1999).
  315. C.-H. Wong, “Mimics of complexcarbohydrates recognized by receptors”, Acc. Chem. Res., 32, 376–385(1999).
  316. S. Takayama, S. J. Chung, Y.Igarashi, Y. Ichikawa, A. Sepp, R. I. Lechler, J. Wu, T. Hayashi, G. Siuzdak,C.-H. Wong, “Selective inhibition of b-1,4- and a-1,3-galactosyltransferases: donor sugar-nucleotidebased approach”, Bioorg. Med. Chem., 7, 401–409 (1999).
  317. S. Takayama, S. T. Lee, S.-C.Hung, C.-H. Wong, “Designing acylating reagents for enzymatic resolution ofamines”, Chem. Comm., 127–128 (1999).
  318. Z. Zhang, I. R. Ollmann, X.-S. Ye, R.Wischnat, T. Baasov, C.-H. Wong, “Programmable one-pot oligosaccharide synthesis”, J. Am. Chem. Soc., 121, 734–753 (1999).
  319. M. Takebayashi, S. Hiranuma, Y.Kanie, T. Kajimoto, O. Kanie, C.-H. Wong, “A versatile synthetic strategy forthe preparation and discovery of new iminocyclitols as inhibitors ofglycosidases”, J. Org. Chem., 64, 5280–5291 (1999).
  320. C. M. Huwe, T. J. Woltering, J.Jiricek, G. Weitz-Schmidt, C.-H. Wong, “Design, synthesis and biologicalevaluation of aryl-substituted sialyl Lewis X mimetics prepared viacross-metathesis of C-fucopeptides”, Bioorg.Med. Chem., 7, 773–788 (1999).
  321. T. Lee, V.-D. Le, Y.-C. Lin, A. L.Wong, G. M Morris, A. J. Olson, J. H. Elder, C.-H. Wong, “Development of a newtype of protease inhibitors efficacious against FIV and HIV variants”, J.Am. Chem. Soc., 121, 1145–1155 (1999).
  322. G. Weitz-Schmidt, K. W. Gong,C,-H. Wong, “Selectin/glycoconjugate binding assays for the identification andoptimization of selectin antagonists”, Anal. Biochem., 273, 81–88(1999).
  323. W.-G. Wu, L. Pasternak, D.-H.Huang, K. M. Koeller, C.-C. Lin, O. Seitz, C.-H. Wong, “Structural study on O-glycopeptides: glycosylation-inducedconformational changes of O-GlcNAc, O-LacNAc, O-Sialyl-LacNAc and O-sialylLewis x peptides of the mucin domain of MadCAM-1”, J. Am. Chem. Soc.,121, 2409–2417 (1999).
  324. S. Mao, C. Gao, L. Lo, P.Wirsching, C.-H. Wong, K. D. Janda, “Phage-display library selection ofhigh-affinity human single-chain antibodies to tumor-associated carbohydrateantigens sialyl Lewis x and Lewis x”, Proc. Natl. Acad. Sci. U.S.A., 96,6953–6958 (1999).
  325. S. Vincent, M.D. Burkart, Z.Zhang, C.-Y. Tsai, C.-H. Wong, “Electrophilic fluorination-nucleophilicaddition reaction mediated by Selectfluor: mechanistic studies and newapplications”, J. Org. Chem., 64, 5264–5279 (1999).
  326. W. A. Greenberg, E. S.Priestley, P.S. Sears, P. B. Alper, C. Rosenbohm, S.-C. Hung, C.-H. Wong, “Designand synthesis of new aminoglycoside antibiotics using neamine as a corestructure: correlation of antibiotic activity with in vitro inhibition of translation”, J. Am. Chem. Soc., 121,6527–6541 (1999).
  327. R. D. Kidd, P. Sears, D.-H.Huang, K. Witte, C.-H. Wong, G. K. Farber, “Breaking the low barrier hydrogenbond in a serine protease”, Protein Sci., 8, 410–417 (1999).
  328. S. Hiranuma, O. Kanie, C.-H.Wong, “Formation of the 1,2,6-orthoester of mannose and its utilization in theglycosylation reaction”, Tetrahedron Lett., 40, 6423–6426 (1999).
  329. P. Sears, C.-H. Wong, “Carbohydratemimetics: A new strategy for tackling the problem of carbohydrate-mediatedbiological recognition”, Angew. Chem. Int. Ed. Engl., 38, 2300-2324(1999).
  330. M. D. Burkart, M. Izumi, C.-H.Wong, “Enzymatic regeneration of 3¢-phosphoadenosine-5¢-phosphosulfate (PAPS) using aryl sulfotransferase:Synthesis of sulfated carbohydrates and spectrophotometric assay ofsulfotransferases”, Angew. Chem. Int. Ed. Engl., 38, 2747–2750 (1999).
  331. T. D. Machajewski, C.-H. Wong, “Chemoenzymaticsynthesis of key epothilone fragments”, Synthesis, S1, 1469–1472 (1999).
  332. M. D. Burkart, S. P. Vincent,C.-H. Wong, “An efficient synthesis of CMP-3-fluoro-neuraminic acid”, Chem.Comm., 1525–1526 (1999).
  333. M.D. Burkart, C.-H. Wong, “A continuous assay for the spectrophotometric analysisof sulfotransferases using aryl sulfotransferase IV”, Anal. Biochem.,274, 131–137 (1999).
  334. D. Depre, A. Duffels, L. G.Green, R. Lenz, S. V. Ley, C.-H. Wong “Synthesis of glycans from the glycodelins:two undeca-, two deca-, three nona-, an octa- and a heptasaccharide”, Chem.Eur. J., 5, 3326–3340 (1999).
  335. M. Li, G. M. Morris, T. Lee, G.S. Laco, C.-H. Wong, A. J. Olson, J. H. Elder, A. Wlodawer, A. Gustchina, “Structuralstudies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIVprotease”, Proteins: Struct. Funct. Genet., 38, 29–40 (1999).
  336. V. Wittmann, A. K. Datta, K. M.Koeller, C.-H. Wong, “Chemoenzymatic synthesis and fluorescent visualization ofcell-surface selectin-bound sialyl Lewis X derivatives”, Chem. Eur. J.,6, 162–171 (2000).
  337. V.-D. Le, C.-H. Wong, “Synthesisof 2-substituted polyhydroxyhexahydropyrimidines ( N-hydroxy cyclic guanidino-sugars): transition-state mimics ofenzymatic glycosidic cleavage”, J. Org. Chem., 65, 2399–2409 (2000).
  338. S. J. Sucheck, W. A. Greenberg,T. J. Tolbert, C.-H. Wong, “Design of small molecules that recognize RNA: developmentof aminoglycosides as potential antitumor agents targeting oncogenic RNAsequences”, Angew. Chem. Int. Ed. Engl., 39, 1080–1084, (2000). Angew.Chem., 112, 1122–1126 (2000).
  339. K. M. Koeller, C.-H. Wong, “Chemoenzymaticsynthesis of sialyl-trimeric-Lewis X”, Chem. Eur. J., 6, 1243–1251(2000).
  340. K. M. Koeller, M. E. B. Smith,C.-H. Wong, “Tyrosine sulfation on a PSGL-1 glycopeptide influences thereactivity of glycosyltransferases responsible for synthesis of the attached O-glycan”, J. Am. Chem. Soc.,122, 742–743 (2000).
  341. T. D. Machajewski, C.-H. Wong, “Thecatalytic asymmetric aldol reaction”, Angew. Chem. Int. Ed. Engl., 39,1352–1374, (2000). Angew. Chem., 112, 1406–1430 (2000).
  342. K. M. Koeller, M. E. B. Smith,R.-F. Huang, C.-H. Wong, “Chemoenzymatic synthesis of a PSGL-1 N-terminal glycopeptide containingtyrosine sulfate and a- O-linked sialyl Lewis X”, J. Am. Chem. Soc., 122, 4241–4242(2000).
  343. X.-L. Sun, Y. Kanie, C.-T. Guo,O. Kanie, Y. Suzuki, C.-H. Wong, “Syntheses of C-3 modified sialylglycosides asselective inhibitors of influenza hemagglutinin and neuraminidase”, Eur. J.Org. Chem., 14:2643–2653 (2000).
  344. X.-S. Ye, C.-H. Wong, “Anomericreactivity-based one-pot oligosaccharide synthesis: A rapid route tooligosaccharide libraries”, J. Org. Chem., 65, 2410–2431 (2000).
  345. T. J. Tolbert, C.-H. Wong, “Intein-mediatedsynthesis of proteins containing carbohydrates and other molecular probes”, J.Am. Chem. Soc., 122, 5421–5428 (2000).
  346. S. Fong, T. D. Machajewski, C. C.Mak, C.-H. Wong, “Directed evolution of d-2-keto-3-deoxy-6-phosphogluconates to new aldolases capable of making d-and l-sugars”, Chem. Biol.,7, 873–883 (2000).
  347. M. D. Burkart, M. Izumi, E.Chapman, C.-H. Lin, C.-H. Wong, “Regeneration of PAPS for the enzymaticsynthesis of sulfated oligosaccharides”, J. Org. Chem., 65, 5565–5574(2000).
  348. C. Saotome, Y. Kanie, O. Kanie,C.-H. Wong, “Synthesis and enzymatic evaluation of five-membered iminocyclitolsand a pseudodisaccharide”, Bioorg. Med. Chem., 8, 2249–2261 (2000).
  349. M. Takayanagi and C.-H. Wong, “Astrategy for the solution-phase parallel synthesis of N-(pyrrolidinylmethyl)hydroxamic acids”, J. Org. Chem., 65,3811–3815 (2000).
  350. S. P. Vincent, A. Schleyer,C.-H. Wong, “Asymmetric strecker synthesis of C-glycosides”, J. Org. Chem., 651, 4440–4443 (2000).
  351. K. M. Koeller, C.-H. Wong, “Synthesisof complex carbohydrates and glycoconjugates: enzyme-based and programmable one-potstrategies”, Chem. Rev., 100, 4465–4493 (2000).
  352. K. M. Koeller, M. E. B. SmithC.-H. Wong, “Chemoenzymatic synthesis of PSGL-1 glycopeptides: Sulfation ontyrosine affects glycosyltransferase-catalyzed synthesis of the O-glycan”, Bioorg. Med. Chem., 8,1017–1025 (2000).
  353. S. J. Sucheck, A. L. Wong, K. M.Koeller, D. D. Boehr, K.-A. Draker, P. Sears, G. D. Wright, C.-H. Wong, “Designof bifunctional antibiotics that target bacterial rRNA and inhibitresistance-causing enzymes”, J. Am. Chem. Soc., 122, 5230–5231 (2000).
  354. K. Shibata, K. Hiruma, O. Kanie,C.-H. Wong, “Synthesis of 1,1-linked galactosyl mannosides carrying a thiazinering as mimetics of sialyl Lewis x antigen: Investigation of the effect ofcarboxyl group orientation on P-selectin inhibition”, J. Org. Chem., 65,2393–2398 (2000).
  355. A. Romero, C.-H. Wong, “Chemo-enzymatictotal synthesis of 3-epiaustraline, australine and 7-epialexine”, J. Org.Chem., 65, 8264–8268 (2000).
  356. O. Kanie, G. Grotenberg, C.-H.Wong, “Removal of benzyl protecting group from solid supported compounds byhydrogenolysis using palladium nanoparticles”, Angew. Chem. Int. Ed., 39, 4545–4546, (2000). Angew.Chem., 112, 4719–4721 (2000).
  357. K. M. Koeller, C.-H. Wong, “Emergingthemes in medicinal glycoscience”, Nature Biotech., 18, 835–844 (2000).
  358. M. D. Burkart, S. P. Vincent, A.Düffels, B. W. Murray, S. V. Ley, C.-H. Wong, “Chemo-enzymatic synthesis offluorinated sugar nucleotide; useful mechanistic probes for glycosyltransferases”, Bioorg. Med. Chem., 8, 1937–1946 (2000).
  359. S. J. Sucheck, C.-H. Wong, “RNAas a target for small molecules”, Curr. Opin. Chem. Biol., 4, 678–686(2000).
  360. K. M. Koeller, C.-H. Wong, “Complexcarbohydrate synthesis tools for glycobiologists: enzyme-based approach andprogrammable one-pot strategies”, Glycobiology, 10, 1157–1169 (2000).
  361. T. Flessner, C.-H. Wong, “Efficientsynthesis of triazoles from d-arabinoseand l-fucose”, TetrahedronLett., 41, 7805–7808 (2000).
  362. T. L. Sheppard, C.-H. Wong, G. F.Joyce, “Nucleoglycoconjugates: design and synthesis of a new class of DNA–carbohydrateconjugates”, Angew. Chem. Int. Ed., 39, 3660–3663, (2000); Angew.Chem., 112, 3806–3809 (2000).
  363. C.-Y. Tsai, X. Huang, C.-H.Wong, “Design and synthesis of cyclic sialyl Lewis x mimetics: A remarkableenhancement of inhibition by pre-organizing all essential functional groups”, TetrahedronLett., 41, 9299–9503 (2000).
  364. A. Düffels, L. G. Green, R.Lenz, S. V. Ley, S. P. Vincent, C.-H. Wong, “Chemoenzymatic synthesis of l-galactosylated dimeric sialyl Lewis Xstructures employing a-1,3-fucosyltransferase V”, Bioorg.Med. Chem., 8, 2519–2525 (2000).
  365. Y.-C. Lin, Z. Beck, T. Lee,V.-D. Le, B. M. Morris, A. J. Olson, C.-H. Wong, J. H. Elder, “Alteration ofsubstrate and inhibitor specificity of feline immunodeficiency virus protease”, J. Virol., 74, 4710–4718 (2000).
  366. X.-S. Ye, X. Huang, C.-H. Wong, “Anew glycosyl donor for efficient sialylation with unusual stereoselectivity: conversionof the carboxyl group to a protected hydroxymethyl increases the reactivity andyield dramatically with no elimination”, Chem. Comm., 11, 974–975(2001).
  367. F. Burkhart, Z. Zhang, S.Wacowich-Sgarbi, C.-H. Wong, “Synthesis of Globo H using the programmablereactivity-based one-pot strategy”, Angew. Chem. Int. Ed., 40, 1274–1276(2001).
  368. M. G. Silvestri, C.-H. Wong, “Openingof thiiranes: Preparation of orthogonal protected 2-thioglyceraldehyde”, J.Org. Chem., 66, 910–914 (2001).
  369. C. C. Mak, V.-D. Le, Y.-C. Lin,J. H. Elder, C.-H. Wong, “Design, synthesis and biological evaluation ofHIV/FIV protease inhibitors incorporating conformational-constrained macrocyclewith a small P3’ residue”, Bioorg. Med. Chem. Lett., 11, 219–222 (2001).
  370. T. K. Ritter, C.-H. Wong, “Synthesisof N-acetyl glucosaminethiazoline/lipid II hybrids”, Tetrahedron Lett., 42, 615–618 (2001).
  371. V.-D. Le, C. C. Mak, Y.-C. Lin,J. H. Elder, C.-H. Wong, “Structure–activity studies of FIV and HIV proteasesinhibitors containing allophenylnorstatine”, Bioorg. Med. Chem., 9, 1185–1195(2001).
  372. I. A. Kozlov, S. Mao, Y. Xu, X.Huang, L. Lee, P. S. Sears, C. Gao, A. R. Coyle, K.D. Janda, C.-H. Wong, “Synthesisof solid-supported mirror-image sugars: a novel method for selecting receptorsfor cellular-surface carbohydrates”, ChemBioChem, 2, 741–746 (2001).
  373. K. M. Koeller, C.-H. Wong, “Enzymesfor chemical synthesis”, Nature, 409, 232–240 (2001).
  374. P. Sears, C.-H. Wong, “Towardautomated synthesis of oligosaccharides and glycoproteins”, Science, 291,2344–2350 (2001).
  375. J. Liu, A. R. Shikhaman, M. K.Lotz, C.-H. Wong, “Hexosaminidase inhibitors as new drug candidates for thetherapy of osteoarthritis”, Chem. Biol., 8, 701–711 (2001).
  376. T. K. Ritter, C.-H. Wong, “Carbohydrate-basedantibiotics: a new approach to tackling the problem of resistance”, Angew.Chem. Int. Ed., 40, 3508–3533. Angew. Chem., 113, 3616–3641 (2001).
  377. X. Huang, K. L. Witte, D. E.Bergbreiter, C.-H. Wong, “Homogeneous enzymatic synthesis using athermoresponsive water-soluble polymer support”, Adv. Synth. Cat., 343,675–681 (2001).
  378. C.-S. Yu, K. Niikura, C.-C. Lin,C.-H. Wong, “The thioglycoside and glycosyl phosphite of 5 azido sialic acid: excellentdonors for a-glycosylation of primaryhydroxyls”, Angew. Chem. Int. Ed., 40, 2900–2903 (2001); Angew. Chem.,113, 2984–2987 (2001).
  379. C. Saotome, C.-H. Wong, O.Kanie, “Combinatorial library of five-membered iminocyclitol and the inhibitoryactivities against glyco-enzymes”, Chem. Biol., 8, 1061–1070 (2001).
  380. H. Liu, R. Sadamoto, P. S.Sears, C.-H. Wong, “An efficient chemo-enzymatic strategy for the synthesis ofwild-type and vancomycin-resistant bacterial cell-wall precursors: UDP- N-acetylmuramyl-peptides”, J. Am.Chem. Soc., 123, 9916–9917 (2001).
  381. M. Izumi, G.-J. Shen, S.Wacowich-Sgarbi, T. Nakatani, O. Plettenburg, C.-H. Wong, “Microbialglycosyltransferases for carbohydrate synthesis: a-2,3-sialyltrasferase from Neisseria gonorrheae”, J. Am. Chem.Soc., 123, 10909–10918 (2001).
  382. A. Heine, G. DeSantis, J. G.Luz, M. Mitchell, C.-H. Wong, I. A. Wilson, “Observation of covalentintermediates in an enzyme mechanism at atomic resolution”, Science, 294, 369–374, (2001).
  383. M. Mitchell, L. Qaio, C.-H.Wong, “Chemical-enzymatic synthesis of iminocyclitol phosphonic acids”, Adv.Synth. Catal., 343, 596–599 (2001).
  384. B. Buhler, Y.-C. Lin, G. Morris,A. Olson, C.-H. Wong, D. D. Richman, J. H. Elder, B. E. Torbett, “Viral evolutionin response to the broad-based retroviral protease inhibitor TL-3”, J. Virol.,75, 9502–9508 (2001).
  385. E. Chapman, C.-H. Wong, “A pHsensitive colorimetric assay for the high-throughput screening of enzymeinhibitors and substrates: a case study using kinases”, Bioorg. Med. Chem.,10, 551–555 (2002).
  386. Y.-Y. Wang, K.-H. Khoo, S.-T.Chen, C.-C. Lin, C.-H. Wong, C.-H. Lin, “Studies on the immunomodulating andantitumor activities of Ganoderma lucidum (Reishi) polysaccharides: Functional and proteomic analysis of afucose-containing glycoprotein responsible for the activities”, Bioorg. Med.Chem., 10, 1057–1062 (2002).
  387. C.-T. Guo, X.-L. Sun, O. Kanie,K. F. Shortridge, T. Suzuki, D. Miyamoto, K. I.-P. J. Hidari, C.-H. Wong, Y.Suzuki, “An O-glycoside of sialic acidderivative that inhibits both hemagglutinin and sialidase activities ofinfluenza viruses”, Glycobiology, 12,183–190 (2002).
  388. T. Kanemitsu, C.-H. Wong, O.Kanie, “Solid-phase synthesis of oligosaccharides and on-resin quantitativemonitoring using gated decoupling 13C-NMR”, J. Am. Chem. Soc.,124, 3591–3599 (2002).
  389. Z. Zhang, K. Niikura, X. Huang,C.-H. Wong, “A new strategy for the one-pot synthesis of sialylatedoligosaccharides”, (Ray Lemieux special issue) Can. J. Chem., 80, 1051–1054(2002).
  390. J. Liu, G. DeSantis, C.-H. Wong,“Structure-based rationalization of aldolase-catalyzed asymmetric synthesis”,(in honor of J. B. Jones) Can. J. Chem., 80, 643–645 (2002).
  391. J. Liu, C.-H. Wong, “Aldolase-catalyzedasymmetric synthesis of novel pyranose synthons as a new entry to heterocyclesand epothilones”, Angew. Chem. Int. Ed., 41, 1404–1407 (2002).
  392. T. J. Tolbert, C.-H. Wong, “Newmethods for proteomic research: preparation of proteins with N-terminal cysteines for labeling andconjugation”, Angew. Chem. Int. Ed., 41, 2171–2174 (2002); Angew.Chem., 114, 2275 (2002).
  393. M. C. Bryan, O. Plettenburg, P.Sears, D. Rabuka, S. Wacowich-Sgarbi, C.-H. Wong, “Saccharide display onmicrotiter plates”, Chem. Biol., 9, 713–720 (2002).
  394. O. Plettenburg, C.-H. Wong, “Rapidpreparation of glycolipid libraries by cross metathesis”, Adv. Synth. Catal.,344, 622–626 (2002).
  395. O. Plettenburg, V. Narkevitch,C.-H. Wong, “Synthesis of a-galactosyl ceramide, a potent immunostimulatoryagent”, J. Org Chem., 67, 4559–4564 (2002).
  396. M. L. Mitchell, F. Tian, L. V.Lee, C.-H. Wong “Synthesis and evaluation of transition-state analogueinhibitors of a-1,3-fucosyltransferases”, Angew.Chem. Int. Ed., 41 (16), 3041–3044, (2002). Angew. Chem., 114, 3167–3170(2002).
  397. J. Liu, C.-Y. Huang, C.-H. Wong,“An efficient method for the preparation of 2-hydroxy- and 2 aminoglycals fromglycosyl sulfoxides”, Tetrahedron Lett., 43, 3447–3448 (2002).
  398. J. Liu, C.-H. Wong, “Anefficient method for the cleavage of p-methoxybenzylidene(PMP), tetrahydropyranyl (THP) and 1,3-dithiane protecting groups bySelectfluor”, Tetrahedron Lett., 43, 3915–3917 (2002).
  399. J. Liu, C.-H. Wong, “Selectfluor-mediatedallylstannation of aldehydes and imines”, Tetrahedron Lett., 43, 3915–3917(2002).
  400. R. Sadamoto, K. Niikura, P.S.Sears, H. Liu, C.-H. Wong, A. Suksomcheep, F. Tomita, K. Monde, S.-I.Nishimura, “Cell-wall engineering of living bacteria”, J. Am. Chem. Soc.,124, 9018–9019 (2002).
  401. A. Brik, Y.-C. Lin, J. Elder,C.-H. Wong, “A quick diversity-oriented amide-forming reaction to optimizeP-subsite residues of HIV protease inhibitors”, Chem. Biol., 9, 891–896 (2002).
  402. M. L. Mitchell, L. V. Lee, C.-H.Wong, “Synthesis and evaluation of six-membered GDP-iminocyclitol”, TetrahedronLett., 43, 5691–5793 (2002).
  403. Z. Zhang, C.-H. Wong, “Regioselectivebenzoylation of sugars mediated by excessive Bu2SnO: observation oftemperature promoted migration”, Tetrahedron, 58, 6513–6519 (2002).
  404. F. Fazio, M. C. Bryan, O. Blixt, J. C. Paulson, C.-H. Wong,“Synthesis of sugar arrays in microtiter plates”, J. Am. Chem. Soc.,124, 14397–14402 (2002).
  405. E. Chapman, S. Ding, P. G.Schultz, C.-H. Wong, “A potent, and highly selective sulfotransferase inhibitor”, J. Am. Chem. Soc., 124, 14524–14525 (2002).
  406. P. T. Nyffeler, C.-H. Liang, K. M.Koeller, C.-H. Wong, “The chemistry of amine-azide interconversion: Catalyticdiazotransfer and regioselective azide reduction”, J. Am. Chem. Soc., 124,10773–10778 (2002).
  407. K.-K. T. Mong, C.-H. Wong, “Thereactivity based one-pot synthesis of Lewis y carbohydrate hapten: A colon-rectalcancer antigen determinant”, Angew. Chem. Int. Ed., 41, 4087–4090,(2002); Angew. Chem., 114, 4264–4267 (2002).
  408. M. M. G. M. Thunnissen, B.Andersson, B. Samuelsson, C.-H. Wong, J. Z Haeggstrom, “Crystal structures ofleukotriene A4 hydrolase in complex with captopril and two competitivetight-binding inhibitors”, FASEB J., 16 (12), 1648-1650 (2002).
  409. A. R. Sawkar, W.-C. Cheng, E.Beutler, C.-H. Wong, W. E. Balch, J. W. Kelly, “Chemical chaperones increasethe cellular activity of N370S b-glucosidase; a therapeuticstrategy for Gaucher disease”, Proc. Natl. Acad. Sci. U.S.A., 99,15428–15433 (2002).
  410. E. Chapman, M. C. Bryan, C.-H.Wong, “Mechanistic studies of b-arylsulfotransferase IV,” Proc.Natl. Acad. Sci. U.S.A., 100, 910–915 (2003).
  411. C.-H. Wong, M. C. Bryan, P. T.Nyffeler, H. Liu, E. Chapman, “Synthesis of carbohydrate-based antibiotics”, PureAppl. Chem., 75, 179–186 (2003).
  412. G. DeSantis, J. Liu, D. P.Clark, A. Heine, I. A. Wilson, C.-H. Wong, “Structure-based mutagenesisapproaches toward expanding the substrate specificity and enantioselectivity ofd-2-deoxy-ribose-5-phosphatealdolase”, Bioorg. Med. Chem., 11, 43–52 (2003).
  413. T. K-K. Mong, C.-Y. Huang, C.-H.Wong, “A new reactivity-based one-pot synthesis of N-acetyllactosamine oligomers”, J. Org. Chem., 68, 2135–2142(2003).
  414. M. Wada, C.-C. Hsu, D. Franke,M. Mitchell, A. Heine, I. Wilson, C.-H. Wong, “Directed evolution of N-acetylneuraminic acid aldolase tocatalyze enantiomeric aldol reactions”, Bioorg. Med. Chem., 11,2091–2098 (2003).
  415. M. G. Silvestri, G. DeSantis,C.-H. Wong, “Asymmetric aldol reactions using aldolases”, Top. Stereochem.,23, 267–342 (2003).
  416. A. Brik, C.-H. Wong, “HIV-1protease: Mechanism and drug discovery”, Org. Biomol. Chem., 1, 1–14(2003).
  417. H. Liu, T. K. Ritter, R.Sadamoto, P.S. Sears, M. Wu, C.-H. Wong, “Acceptor specificity and inhibition ofthe bacterial cell-wall glycosyltransferase Mur G”, ChemBioChem, 4, 603–609(2003).
  418. H. Liu, L. Wang, A. Brock, C.-H.Wong, P. G. Schultz, “A method for the generation of glycoprotein mimetics”, J.Am. Chem. Soc., 125, 1702–1703 (2003).
  419. T. K.-K. Mong, H. K. Lee, S. G.Duron, C.-H. Wong, “Reactivity-based one-pot synthesis of fucose GM1oligosaccharide: A sialylated antigenic epitope of small-cell lung cancer”, Proc.Natl. Acad. Sci. U.S.A., 100, 797–802 (2003).
  420. C. C. Mak, A. Brik, D. L.Lerner, J. H. Elder, G. M. Morris, A. J. Olson, C.-H. Wong, “Design andsynthesis of broad-based mono- and bicyclic inhibitors of HIV and FIV proteases”, Bioorg. Med. Chem., 11, 2025–2040 (2003).
  421. L. V. Lee, M. L. Mitchell, S.-J.Huang, V. V. Fokin, K. B. Sharpless, C.-H. Wong, “A potent and highly selectiveinhibitor of human a-1,3-fucosyltransferase viaclick chemistry”, J. Am. Chem. Soc., 125, 9588–9599 (2003).
  422. C.-Y. Wu, C.-F. Chang, J. S.-Y.Chen, C.-H. Wong, C.-H. Lin, “Rapid diversity-oriented synthesis in microtiterplates for in situ screening: discoveryof potent and selective a-fucosidase inhibitors”, Angew.Chem. Int. Ed., 42, 4661–4664 (2003).
  423. A. Brik, J. Muldoon, Y.-C. Lin,J. H. Elder, D. Goodsell, A. J. Olson, V. V. Fokin, K. B. Sharpless, C.-H.Wong, “Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV proteaseinhibitors”, ChemBioChem, 4, 1246–1248 (2003).
  424. T. K. Ritter, K.-K. T. Mong, H.Liu, T. Nakatani, C.-H. Wong, “A programmable one-pot oligosaccharide synthesisfor diversifying the sugar domains of natural products: A case study ofvancomycin”, Angew. Chem. Int. Ed., 42, 4657-4660 (2003).
  425. C.-H. Wong, M. C. Bryan, “Sugararrays in microtiter plates”, Methods Enzymol., 362, 218-225 (2003).
  426. K.-K. T. Mong, L. V. Lee, J. R.Brown, J. D. Esko, C.-H. Wong, “Synthesis of N-acetyl-lactosamine derivatives with variation in the aglyconmoiety for the study of inhibition of sialyl Lewis X expression”, ChemBioChem.,4, 835-840 (2003).
  427. D. Franke, T. Machajewski, C.-C.Hsu, C.-H. Wong, “One-pot synthesis of l-fructoseusing coupled multienzyme systems based on rhamnulose-1-phosphate aldolase”. J.Org. Chem., 68, 6828-6831 (2003).
  428. F. Fazio, C.-H. Wong, “RuCl3-promotedamide formation from azides and thioacids”, Tetrahedron Lett., 44, 9083-9085(2003)
  429. T. Feizi, F. Fazio, W. Chai, C.-H. Wong, “Carbohydratemicroassays – a new set of technologies at the frontier of glycomics”, Curr.Opin. Struct. Biol., 13, 637-645 (2003).
  430. C.-H. Wong, F.-S. Liang, “Surface plasmon resonance study of RNA-aminoglycosideinteractions”, in Methods in Enzymol,362, 340-353 (2003).
  431. A. Heine, J. G. Luz, C. -H.Wong and I. A. Wilson, “Analysis of the class I aldolase binding sitearchitecture based on the crystal structure of 2-deoxyribose-5-phosphatealdolase at 0.99A resolution", J . Mol . Biol ., 343, 1019-1034 (2004).
  432. F. Agnelli, S. J. Sucheck, K. A. Marby, D. Rabuka, S.-L.Yao, P. S. Sears, F.-S. Liang, C.-H Wong: “Dimeric aminoglycosides asantibiotics”, Angew Chem. Int. Ed., 43, 1562-1566 (2004).
  433. J. Liu, C.-C Hsu, C.–H. Wong, “Sequential aldolcondensation catalyzed by DERA mutant Ser238Asp and a formal total synthesis ofAtorvastatin”, Tetrahedron Lett., 45, 2439-2441 (2004).
  434. C.-W. Cheng, K.-C. Lin, F.-M. Pan, S. Sinchaikul, C.-H.Wong, W.-C. Su, C.-H. Hsu, S.-T. Chen, “Facile synthesis of metal-chelatingpeptides on chip for protein array”, Bioorg. Med. Chem. Lett., 14, 1987-1990(2004).
  435. H.-K.Lee, C. N. Scanlan, C.-Y. Huang, A. Y. Chang, D. A. Calarese, R. A. Dwek, P. M.Rudd, I. A. Wilson, D. R. Burton, C.-H. Wong “Reactivity based one-potsynthesis of oligomannoses: defining antigens recognized by 2G12, a broadlyneutralizing anti-HIV-1 antibody”, Angew. Chem. Int. Ed., 43, 1000-1003(2004).
  436. C.-H. Chou, C.-S. Wu, C.-H. Chen, L.-D. Lu, S.S.Kulkarni, C.-H. Wong, S.-C. Hung, “Regioselective glycosylation of neamine core:A facile entry to kanamycin B related analogues”, Org. Lett., 6, 585-588 (2004).
  437. H. N. Yu, J.-I.Furukawa, T. Ikeda, C.-H. Wong, “Novel efficient routesto heparin monosaccharides and disaccharides achieved via regio- andstereoselective glycosidation”, Org. Lett., 6, 723-726 (2004).
  438. S. G.Duron, T. Polat, C.-H. Wong, “ N-(Phenylthio)-ε-caprolactam: A new promoter forthe activation of thioglycosides”, Org. Lett., 6, 839-841 (2004).
  439. T.-J.Cheng, A. Brik, C.-H. Wong, C.-C. Kan, “Model system for high-throughputscreening of novel human immunodeficiency virus protease inhibitors in Escherichia coli”, Antimicrob. AgentChemother., 48, 2437-2447 (2004).
  440. M. C. Bryan, C.-H. Wong, “Aminoglycoside array for thehigh-throughput analysis of small molecule–RNA interactions”, TetrahedronLett., 45, 3639-3642 (2004).
  441. F.Fazio, M. C. Bryan, H.-K. Lee, A. Chang, C.-H. Wong, “Assembly of sugars onpolystyrene plates: a new facile microarray fabrication technique”, TetrahedronLett., 45, 2689-2692 (2004).
  442. L. V. Lee, K. E. Bower, F.-S. Liang, J. Shi,D. Wu, S. J. Sucheck, P. K. Vogt, C.-H. Wong, “Inhibition of the proteolyticactivity of anthrax lethal factor by aminoglycosides”, J. Am. Chem. Soc.,126, 4774-4775 (2004).
  443. M. C. Bryan, L. V. Lee, C.-H. Wong, “High-throughputidentification of fucosyltransferase inhibitors using carbohydrate microarrays,” Bioorg. Med. Chem. Lett., 14:3185-3188 (2004).
  444. E.Chapman, M.D. Best, S. R. Hanson, C.-H. Wong, “Sulfotransferases: structure,mechanism, biological activity, inhibition and synthetic utility,” Angew.Chem. Int. Ed., 43:3526-3548 (2004).
  445. S. R. Hanson, M.D. Best, C.-H. Wong, “Sulfatases:mechanism, biological activity, inhibition and synthetic utility,” Angew.Chem. Int. Ed., 43:5736-5763 (2004).
  446. M. D. Best, A. Brik, E. Chapman, L. V. Lee, W.-C. Cheng,C.-H. Wong, “Rapid discovery of potent sulfotransferase inhibitors bydiversity-oriented reaction in microplates followed by in situ screening”, ChemBioChem, 5, 811-819 (2004).
  447. D.Klostermeier, P. Sears, C.-H. Wong, D. P. Millar, J. R. Williamson, “Athree-fluorophore FRET assay for high-throughput screening of small-moleculeinhibitors of ribosome assembly”, Nucleic Acid. Res., 32, 2707-2715(2004).
  448. T. J. Tolbert, C.-H. Wong, “Carbohydrate chains:enzymatic and chemical synthesis”, in Encyclopedia of Biological Chemistry,Elsevier: New York, NY, Volume 1, pp 307–313 (2004).
  449. D.Franke, C.-C. Hsu, C.-H. Wong, “Directed evolution of aldolases”, MethodsEnzymol., 388, 224-238 (2004).
  450. M. C. Bryan, F. Fazio, H.-K. Lee, C.-Y. Huang, A. Chang,M. D. Best, D. A. Calarese, O. Blixt, J. C. Paulson, D. Burton, I. A. Wilson,C.-H. Wong, “Covalent display of oligosaccharide arrays in microtiter plates”, J.Am. Chem. Soc., 126, 8640-8641 (2004).
  451. C.-F. Chang, C.-W. Ho, C.-Y. Wu, T. A. Chao,C.-H. Wong, C.-H. Lin, “Discovery of picomolar slow tight-binding inhibitors ofa-fucosidase”, Chem.Biol., 11, 1301-1306 (2004).
  452. J.Liu, M. M. D. Numa, H. Liu, S.-J. Huang, P. Sears, A. R. Shikhman, C.-H. Wong,“Novel synthesis and high-throughput screening of N-acetyl-b-hexosaminidase inhibitor libraries targeting osteoarthritis”, J.Org. Chem., 69, 6273-6283 (2004).
  453. F.-S.Liang, S.-K. Wang, T. Nakatani, C.-H. Wong, “Targeting RNAs by TobramycinAnalogs”, Angew. Chem., 43, 6496-6500 (2004).
  454. H.-S.Chen, Y.-F. Tsai, S. Lin, C.-C. Lin, K.-H. Khoo, C.-H. Lin, C.-H. Wong,“Studies on the Immuno-Modulating and Antitumor Activities of Ganoderma lucidum (Reishi)Polysaccharides”, Bioorg. Med. Chem., 12, 5595-5601 (2004).
  455. C. M. Chien, J.-L. Cheng, W.-T. Chang, M.-H. Tien, W.-Y.Wu, Y.-H. Chang, H.-Y. Chang, J.-F. Hsieh, C.-H. Wong, S.-T. Chen,“Polysaccharides of Ganoderma lucidum altercell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cordblood”, Bioorg. Med. Chem., 12, 5603-5609 (2004).
  456. H.-Y.Hsu, K.-F. Hua, C.-C. Lin, C.-H. Lin, C.-H. Wong, “Extract of Reishi polysaccharides induces cytokine expression viatoll-like receptor 4-modulated protein kinase signaling pathways”, J.Immunol., 173, 5989-5999 (2004).
  457. C.-Y.Wu, J.-T. Jan, H.-H. Ma, C.-J. Kuo, H.-F. Juan, Y.-S. E. Cheng, H.-H. Hsu,H.-C. Huang, D. Wu, A. Brik, F.-S. Liang, R.-S. Liu, J.-M. Fang, S.-T. Chen,P.-H. Liang, C.-H. Wong, “Small molecules targeting severe acute respiratorysyndrome (SARS) human coronavirus”, Proc. Natl. Acad. Sci. U.S.A., 101, 10012-10017(2004).
  458. M.-P.Heck, S. P. Vincent, B. W. Murray, F. Bellamy, C.-H. Wong, C. Mioskowski,“Cyclic amidine sugars as transition-state analogue inhibitors of glycosidases:potent competitive inhibitors of mannosidases”, J. Am. Chem. Soc., 126, 1971-1979(2004).
  459. P. T.Nyffeler, L. Eltepu, N. A. Boyle, C.-H. Wong, A. Eschenmoser, R. A. Lerner, P.Wentworth, Jr., “Dihydrogen trioxide (HOOOH) is generated during the thermochemicalreaction between hydrogen peroxide and ozone”, Angew. Chem. Int. Ed., 43,4656-4659 (2004).
  460. H.Lin, D.A. Thayer, C.-H. Wong, C. T. Walsh, “Macrolactamization of glycosylatedpeptide thioesters by the thioesterase domain of tyrocidine synthetase”, Chem.Biol., 11, 1635-1642 (2004).
  461. O.Blixt, S. Head, T. Mondala, C. Scanlan, M.E. Huflejt, R. Alvarez, M.C. Bryan,F. Fazio, D. Calarese, J. Stevens, N. Razi, I. van Die, D. Burton, I. A.Wilson, R. Cummings, N. Bovin, C.-H. Wong, J.C. Paulson, “Printed covalentglycan array for ligand profiling of diverse glycan binding proteins”, Proc.Natl. Acad. Sci. U.S.A., 101, 17033-17038 (2004).
  462. J. H.Chen, Y.-W. Chang, C.-W. Yao, T.-S. Chiueh, S.-C. Huang, K.-Y. Chien, A. Chen,F.-Y. Chang, C.-H. Wong, Y.-J. Chen, “Plasma proteome of severe acuterespiratory syndrome (SARS) analyzed by two-dimensional gel eletrophoresis andmass spectrometry”, Proc. Natl. Acad. Sci. U.S.A., 101, 17039-17044(2004).
  463. S. R.Hanson, M. D. Best, M. C. Bryan, C.-H. Wong, “Chemo-enzymatic synthesis of oligosaccharidesand glycoproteins”, Trends Biochem. Sci., 29, 656-663 (2004).
  464. V. P.Mocharla, B. Colasson, L. V. Lee, S. Romper, K. B. Sharpless, C.-H. Wong, H. C.Kolb, “ In situ click chemistry:enzyme-generated inhibitors of carbonic anhydrate II”, Angew. Chem. Int. Ed.,44, 116-120 (2004).
  465. P.Nyffeler, C.-H. Wong, “SelectflourÔ: mechanistic insight and application”, Angew.Chem. Int. Ed., 44, 192-212 (2004).
  466. T. J.Tolbert, D. Franke, C.-H. Wong, “A new strategy for glycoprotein synthesis:ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as TEV protease cleavable fusionprotein”, Bioorg. Med. Chem., 13, 909-915 (2005).
  467. D.Wu, G.-W. Xing, M. Poles, Y. Kinjo, B. Sullivan, O. Plettenburg, M. Kronenberg,M. Tsuji, D. D. Ho, C.-H. Wong, “Bacterial glycolipids and analogs as antigensfor CD1d-restricted NKT cells,” Proc. Natl. Acad. Sci. U.S.A., 102, 1351-1356(2005).
  468. M.Fridman, V. Belakhov, L. V. Lee, F.-S. Liang, C.-H. Wong, T. Baasov, “Dualeffect of synthetic aminoglycosides: antibacterial activity against Bacillus anthracis and inhibition ofanthrax lethal factor”, Angew. Chem. Int. Ed., 44, 447-452 (2005).
  469. Y.Kinjo, D. Wu, G. Kim, G.-W. Xing, M. Poles, D. D. Ho, M. Tsuji, K. Kawahara,C.-H. Wong, M. Kronenberg, “Recognition of bacterial glycosphingolipids bynatural killer T cells”, Nature, 434, 520-525 (2005).
  470. G.-T.Fan, Y.-s. Pan. K.-C. Lu, Y.-P. Cheng, W.-C. Lin, S. Lin, S.-H. Lin, C.-H.Wong, J.-M. Fang, C.-C. Lin, “Synthesis of a-galactosyl ceramide and the related glycolipids forevaluation of their activities on mouse splenocytes”, Tetrahedron, 61, 1855-1862(2005).
  471. A.Brik, C.-Y. Wu, M.D. Best, C.-H. Wong, “Tetrabutylammonium fluoride-assistedrapid N9-alkylation on purine ring: application to combinatorialreactions in microtiter plates for the discovery of potent sulfotransferaseinhibitors in situ”, Bioorg. Med.Chem., 13, 4622-4626 (2005).
  472. G.-W.Xing, D. Wu, M.A. Poles, A. Horowitz, M. Tsuji, D. D. Ho, C.-H. Wong,“Synthesis and human NKT cell stimulating properties of 3- O-sulfo-a/b-galactosylceramides”, Bioorg.Med. Chem., 13, 2907-2916 (2005).
  473. A.Brik, J. Alexandratos, Y.-C. Lin, J. H. Elder, A. J. Olson, A. Wlodawer, D. S.Goodsell, C.-H. Wong, “1,2,3-Triazole as a peptide surrogate in the rapidsynthesis of HIV protease inhibitors”, ChemBioChem, 6, 1167-1169 (2005).
  474. H. N. Yu, D.A. Thayer, M.C. Galan,C.-H. Wong, “A general strategy to S-linkedglycopeptides”, Angew. Chem. Int. Ed., 44, 4596-4599 (2005).
  475. M. M.D. Numa, L. V. Lee, C.-C. Hsu, K. E. Bower, C.-H. Wong, “Identification ofnovel anthrax lethal factor inhibitors generated by combinatorialPictet–Spengler reaction followed by screening in situ”, ChemBioChem, 6, 1002-1006 (2005).
  476. C.-H.Wong, “Protein glycosylation: new challenges and opportunities”, J. Org.Chem., 70, 4219-4225 (2005).
  477. J.-J.Shie, J.-M. Fang, C.-J. Kuo, T.-H. Kuo, P.-H. Liang, H.-J. Huang, W.-B. Yang,C.-H. Lin, J.-L. Chen, Y. T. Wu, C.-H. Wong, “Discovery of potent anilideinhibitors against the severe acute respiratory syndrome 3CL protease”, J.Med. Chem., 48, 4469-4473 (2005).
  478. J.-J.Shie, J.-M. Fang, T.-H. Kuo, C.-J. Kuo, P.-H. Liang, H.-J. Huang, Y.-T. Wu,J.-T. Jan, Y.-S.E. Cheng, C.-H. Wong, “Inhibition of the severe acute respiratorysyndrome 3CL protease by peptidomimetic a,b-unsaturated esters”, Bioorg. Med. Chem., 13, 5240-5252 (2005).
  479. C.-Y.Wu, A. Brik, S.-K. Wang, Y.-H. Chen, C.-H. Wong, “Tetrabutylammoniumfluoride-mediated rapid alkylation reaction in microtiter plates for discoveryof enzyme inhibitors in situ”, ChemBioChem,6 (12), 2176–2180 (2005).
  480. C.-C.Hsu, Y. Zhang, M. Wada, D. Franke, C.-H. Wong, “Directed evolution of d-sialicacid aldolase l-3-deoxy- manno-2-octulosonicacid (l-KDO) aldolases”, Proc. Natl. Acad. Sci. U.S.A., 102, 9122–9126(2005).
  481. S. H.Wei, H. Rosen, M. P. Matheu, M. G. Sanna, S.-K. Wang, E. Jo, C.-H. Wong, I.Parker, M. D. Cahalan, “Sphingosine 1-phosphate type 1 receptor agonisminhibits transendothelial migration of medullary T cells to lymphatic sinuses”, Nat. Immunol., 6 (12), 1228–1235 (2005).
  482. D. A.Calarese, H.-K. Lee, C.-Y. Huang, M. D. Best, R. D. Astronomo, R. L. Stanfield,H. Katinger, D. R. Burton, C.-H. Wong, I. A. Wilson “Dissection of thecarbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12”, Proc. Natl. Acad. Sci. U.S.A., 102 (38), 13372–13377 (2005).
  483. D. M.Zajonc, I. Maricic, D. Wu, R. Halder, K. Roy, C.-H. Wong, V. Kumar, I. A.Wilson, “Structural basis for CD1d presentation of a sulfatide derived frommyelin and its implications for autoimmunity”, J. Exp. Med., 202 (11), 1517–1526(2005).
  484. A. R.Sawkar, S. L. Adamski-Werner, W.-C. Cheng, C.-H. Wong, E. Beutler, K.-P.Zimmer, J. W. Kelly, “Gaucher disease-associated glucocerebrosidases showmutation-dependent chemical chaperoning profiles”, Chem. Biol., 12 (11),1235–1244 (2005).
  485. S. Sinchaikul, F.-M. Pan, C.-W.Cheng, C.-H. Wong, J.-M. Fang, M.-J. Tseng, S.-T. Chen, “Protein microarray using alpha-amino acids as metaltags on chips”, Bioorg . Med . Chem . Lett ., 15 (5), 1413-1416 (2005).
  486. M.Brigl, P. van den Elzen, X. Chen, J. H. Meyers, D. Wu, C.-H. Wong, P. A.Illarianov, G. S. Besra, M. B. Brenner and J. E. Gumperz, “Conserved andheterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors”, J. Immunol., 176 (6), 3625-3634 (2006).
  487. P.-H.Liang, W.-C. Cheng, Y.-L. Lee, H.-P. Yu, Y.-T. Wu, Y.-L. Lin, C.-H. Wong,“Novel five-membered iminocyclitol derivatives as selective and potentglycosidase inhibitors: new structures for antivirals and osteoarthritis”, ChemBioChem,7 (1), 165-173 (2006).
  488. L. Liu, C. S. Bennett, C.-H. Wong, “Advances inglycoprotein synthesis,” Chem. Commun., 1, 21–33 (2006).
  489. F.-S.Liang, A. Brik, Y.-C. Lin, J. H. Elder, C.-H. Wong, “Epoxide opening in waterand in situ screening for rapidinhibitors in microtiter plate”, Bioorg. Med. Chem., 14 (4), 1058–1062(2006).
  490. C.-Y.Huang, D. A. Thayer, A. Y. Chang, M. D. Best, J. Hoffman, S. Head, C.-H. Wong,“Carbohydrate microarray for profiling the antibodies interacting with Globo H tumorantigen”, Proc. Natl. Acad. Sci. U.S.A., 103 (1), 15–20 (2006).
  491. L.Liu, Z. Hong, C.-H. Wong, “Convergent glycopeptide synthesis by tracelessStaudinger ligation and enzymatic coupling”, ChemBioChem, 7 (3), 429-432(2006).
  492. M.-H.Chuang, M.-S. Wu, W.-L. Lo, J.-T. Lin, C.-H. Wong, S.-H. Chiou, “Theantioxidant protein alkylhydroperoxidereductase of Helicobacter pylori switches from a peroxide reductase toa molecular chaperone function”, Proc. Natl. Acad. Sci. U.S.A., 103 (8),2552-2557 (2006).
  493. D.Wu, D. M. Zajonc, M. Fujio, B.A. Sullivan, Y. Kinjo, M. Kronenberg, I. A.Wilson, C.-H. Wong, “Design of NKT-cell activators: structure and function of amicrobial glycosphingolipid bound to mouse CD1d”, Proc. Natl. Acad. Sci.U.S.A., 103 (11), 3972-3977 (2006).
  494. C.-Y. Wu, K.-Y. King, C.-J. Kuo, J.-M. Fang, Y.-T. Wu,M.-Y. Ho, C.-L. Liao, J.-J. Shie, P-H. Liang, C.-H. Wong, “Stable benzotriazoleesters as mechanism-based inactivators of the severe acute respiratory syndrome3CL protease”, Chem. & Biol., 13, 261-268 (2006).
  495. A.Brik, C.-Y. Wu, C.-H. Wong, “Microtiter plate based chemistry and in situ screening: a useful approach forenzymatic inhibitor discovery”, Org. Biomol. Chem., 4, 1446–1457(2006).
  496. J.-C.Lee, C.-Y. Wu, J. V. Apon, G. Siuzdak,C.-H. Wong, “Reactivity-based one-potsynthesis of tumor-associated antigen N3 minor octasaccharide for thedevelopment of a photocleavable DIOS-MS sugar array”, Angew. Chem.Int. Ed., 45 (17), 2753-2757 (2006).
  497. A.Brik, Y.-Y. Yang, S. Ficht, C.-H. Wong, “Sugar-assisted glycopeptide ligation”, J. Am. Chem. Soc., 128, 5626-5627 (2006).
  498. H.-Y. Hsu,K.-F. Hua, Y.-C. Su, L.-C. Chu, H.-W. Chiu, C.-H. Wong, S. U-S. Yang, L. K.Chao, “Alkali-soluble polysaccharides of Rhizoclonium riparium algainduces IL-1 gene expression via protein kinase signaling pathways”, J.Agricultural & Food Chem., 54, 3558-3565 (2006).
  499. H. Qiu, A. Gabrielsen, H. E.Agardh, M. Wan, A. Wetterholm, C.-H. Wong, U. Hedin, J. Swedenborg, G. K.Hansson, B. Samuelsson, G. Paulsson-Berne, J. Z. Haeggstrom, “Expression of5-lipoxygenase and leukotriene A4 hydrolase in human atheroscleroticlesions correlate with symptoms of plaque instability”, Proc. Natl. Acad. Sci. U.S.A., 103 (21), 8161-8166 (2006).
  500. L. J. Whalen, C.-H. Wong,“Enzymes in organic synthesis: aldolase-mediated synthesis of iminocyclitolsand novel heterocycles”, Aldrichimica Acta, 39 (3), 63-71 (2006).
  501. Y.-C. Lin, A. Brik, A. P., K. Tam, A.Parseval, B. E. Torbett, C.-H. Wong, J. H. Elder, “Altered gag polyproteincleavage specificity of feline immunodeficiency virus/human immunodeficiencyvirus mutant proteases as demonstrated in a cell-based expression system”, J.Virology, 80 (16), 7832-7834 (2006).
  502. M. Fujio, D. Wu, R.Garcia-Navarro, D. D. Ho, M. Tsuji,C.-H. Wong, “Structure-based discoveryof glycolipids for CD1d-mediated NKT cell activation: tuning the adjuvantversus immunosuppression activity”, J. Am. Chem. Soc.,128, 9022-9023 (2006).
  503. F.-S. Liang, W. A. Greenberg, J. A. Hammond, J. Hoffmann, S. R. Head,C.-H. Wong, “Evaluation of RNA binding specificity of aminoglycosides with DNA microarrays”, Proc. Nat. Acad. Sci. U.S.A., 103 (33), 12311-12316 (2006).
  504. M. G.Sanna, S.-K. Wang, P. J. Gonzalez-Cabrera, A. Don, D. Marsolais, M. P. Matheu,S. H. Wei, I. Parker, E. Jo, W.-C. Cheng, M. D. Cahalan, C.-H. Wong, H. Rosen,“Enhancement of capillary leakage and restoration of lymphocyte egress by achiral S1P1 antagonist in vivo”, NatureChem. Biol., 2 (8), 434-441 (2006).
  505. M. Sawa, T.-L. Hsu, T. Itoh, M. Sugiyama, S. R. Hanson,P. K. Vogt, and C.-H. Wong, “Glycoproteomic probes for fluorescent imaging offucosylated glycans in vivo”, Proc. Nat. Acad. Sci. U.S.A., 103 (33), 12371-12376 (2006).
  506. K.-T.Huang, B.-C. Wu, C.-C. Lin, S.-C. Luo, C. Chen, C.-H. Wong, C.-C. Lin,“Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containingPSGL-1 glycopeptide,” Carbohydrate Res., 341 (12), 2151-2155 (2006).
  507. Y. Kinjo, E. Tupin, D. Wu, M. Fujio, R. Garcia-Navarro, M. R. E. I.Benhnia, D. M. Zajonc, G. Ben-Menachem, G. D. Ainge, G. F. Painter, A.Khurana, K. Hoebe, S. M. Behar, B. Beutler, I. A. Wilson, M. Tsuji, T.J.Sellati, C.-H. Wong, M. Kronenberg, “NKT cells recognize diacylglycerolantigens from pathogenic bacteria”, Nature Immunol., 7 (9), 978-986 (2006).
  508. H. Liu, C.-H. Wong, “Characterization of a transglycosylase domain of Streptococcuspneumonia PBP1b”, Bioorg. Med. Chem., 14, 7187-7195 (2006).
  509. D.Thayer, C.-H. Wong, “Vancomycin analogs with improved biological activity: acombined one-pot enzymatic glycosylation and chemical diversification strategy”, Chem. AnAsian J., 1, 445-452 (2006).
  510. L. Liu, Z.-Y. Hong, C.-H. Wong, “Three-step synthesis of sialic acids andderivatives”, Angew. Chem. Int. Ed., 45 (44), 7417-21 (2006).
  511. K.-I. Lin, Y.-Y. Kao, H.-K. Kuo, W.-B. Yang, A. Chou, H.-H. Lin, A.L.-T. Yu, C.-H. Wong, “Reishi polysaccharides induce immunoglobulin productionthrough the TLR4/TLR2-mediated induction of transcription factor Blimp-1”, J. Biol. Chem., 281(34), 24111-24123 (2006).
  512. Y.-S. E. Cheng, K.-H. Lo, H.-H. Hsu, Y.-M. Shao, W.-B. Yang, C.-H. Lin,C.-H. Wong, “Screening for HIV protease inhibitors by protection againstactivity-mediated cytotoxicity in Escherichia coli”, J. VirologicalMethods, 137 (1), 82-87 (2006).
  513. A. Brik, S. Ficht, C.-H. Wong, “Strategies for the preparation ofhomogenous glycoproteins”, Curr. Opin. Chem. Biol., 10 (6) 638-44, (2006).
  514. A. Brik, S. Ficht, Y.-Y. Yang, C. Bennett, C.-H. Wong, “Sugar-assistedligation (SAL) of N-linked glycopeptides with broad sequence tolerance at theligation junction”, J. Am. Chem. Soc., 128 (46), 15026-33 (2006).
  515. S. Hanson, L. Whalen, C.-H. Wong, “Synthesis and evaluation of generalmechanism-based inhibitors of sulfatases based on (difluoro)methyl phenolsulfate and phenol cyclic sulfamate motifs”, Bioorg. Med. Chem., 14(24), 8386-8395 (2006).
  516. M. Sugiyama, L. J. Whalen, Z.-Y. Hong, W. A. Greenberg,C.-H. Wong, “borate as a phosphate ester mimic in aldolase-catalyzed reactions:practical syntheses of L-fructose and L-iminocyclitols”, Adv. Syn. Catal.,348, 2555-2559 (2006).
  517. J.-C. Lee, W. A. Greenberg, C.-H. Wong, “Programmablereactivity-based one-pot oligosaccharide synthesis”, Nature Protocols, 1(6), 3143-3152 (2006).
  518. S.-C. Cheng, W.-B. Yang, S.-W. Chin, C.-C. Lin, C.-H.Lin, Y.-J. Chen, P.-C. Lin, M.-F. Wu, C.-H. Wong, S.-L. Hsieh, “Profiling ofpolysaccharide-receptor interaction with recombinant innate immunityreceptor-Fc fusion proteins”, Glycobiology, 11, 1131-1132 (2006).
  519. Z. Yu, A. R. Sawkar, L. J. Whalen, C.-H. Wong, J. W.Kelly, “Isofagomine- and2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacologicalchaperones for Gaucher disease intervention”, J. Med. Chem.,50, 94-100 (2007).
  520. T.-L. Hsu, S. R. Hanson, K. Kishikawa, S.-K.Wang, M. Sawa, C.-H. Wong, “Alkynyl sugar analogs for the labeling andvisualization of glycoconjugates in cells”, Proc. Nat. Acad. Sci. U.S.A.,104 (8), 2614-2619 (2007).
  521. M.-L. Michel, A. C. Keller, C. Paget, M. Fujio, F. Trottein, P. B.Savage, C.-H. Wong, E. Schneider, M. Dy, & M. C. Leite-de-Moraes,“Identification of an IL-17–producing NK1.1neg iNKT cell population involvedin airway neutrophilia”, J. Exper. Med., 204 (5), 995-1001 (2007).
  522. S. R. Hanson, T.-L Hsu, E. Weerapana, K. Kishikawa, G. M. Simon, B. F.Cravatt, C.-H. Wong, “Tailored glycoproteomics and glycan site mapping usingsaccharide-selective bioorthogonal probes”, J. Am. Chem. Soc., 129 (23), 7266-7267(2007).
  523. N.-Y. Hsu, W.-B. Yang, C.-H. Wong, Y.-C. Lee, R.-T. Lee, Y.-S. Wang,C.-H. Chen, “Matrix-assisted laser desorption/ionization mass spectrometry ofpolysaccharides with 20,40,60-trihydroxyacetophenone as matrix”, RapidCommun. Mass Spectrom., 21, 2137-2146 (2007).
  524. Y.-Y. Yang, S. Ficht, A. Brik, C.-H. Wong,“Sugar-assisted ligation in glycoprotein synthesis”, J. Am. Chem. Soc.,129 (24), 7690-701 (2007).
  525. Y.-J. Chang, J.-R. Huang, Y.-C. Tsai, J.-T. Hung, D. Wu, M. Fujio, C.-H. Wong, A. L. Yu, “Potent immune-modulating andanti-cancer effects of NKT cell stimulatory glycolipids”, Proc.Nat. Acad. Sci. U.S.A., 104 (25), 10299-10304 (2007).
  526. A. Brik, C.-H. Wong, “Sugar-assisted ligation for the synthesis ofglycopeptides”, Chemistry-A Euro. J., 13 (20), 5670-5675 (2007).
  527. S. M. Dean, W. A. Greenberg, C.-H. Wong“Recent advances in aldolase-catalyzed asymmetric synthesis”, Adv. Syn.Catal., 349, 1308-1320 (2007).
  528. M. Sugiyama, Z-Y. Hong, W. A. Greenberg, C.-H. Wong, “ In vivo selection for the directed evolution of L-rhamnulose aldolase from L-rhamnulose-1-phosphatealdolase (RhaD)”, Bioorg. Med. Chem., 15 (17), 5905-5911 (2007).
  529. S. Ficht, R.J. Payne, A. Brik, C.-H. Wong, “Second generationsugar-assisted ligation: an effective new method for the synthesis of cysteine-containingglycopeptides”, Angew. Chem. Int. Ed., 46 (31), 5975-5979 (2007).
  530. C. S. Bennett, C.-H. Wong, “Chemoenzymatic approaches to glycoproteinsynthesis”, Chem. Soc. Rev., 36(8), 1227-1238 (2007).
  531. E. Kaltgrad, S. Sen Gupta, S. Punna, C.-Y.Huang, A. Chang, C.-H. Wong, M. G. Finn, O. Blixt, “Anti-carbohydrateantibodies elicited by polyvalent display on a viral scaffold”, ChemBioChem,8 (12), 1455-1462 (2007).
  532. M.-T. Wei, K.-F. Hua, J. Hsu, A. Karmenyan,K.-Y. Tseng, C.-H. Wong, H.-Y. Hsu, A. Chiou, “The interaction oflipopolysaccharide with membrane receptors on macrophages pretreated withextract of Reishi polysaccharides measured by optical tweezers”, OpticalSoc. Amer., 15 (17), 11020-11032 (2007).
  533. P.-H. Liang, S.-K. Wang, C.-H. Wong, “Quantitativeanalysis of carbohydrate−protein interactions using glycan microarrays: 2009 determination of surface andsolution dissociation constants”, J. Am. Chem. Soc., 129 (36), 11177-11184 (2007).
  534. Y.-M. Shao, W.-B. Yang, H.-P. Peng, M.-F. Hsu, K.-C. Tsai, T.-H. Kuo, A.-S. Yang, A . H.-J. Wang, P.-H. Liang, C.-H. Lin, C.-H. Wong, “Structure-baseddesign and synthesis of highly potent SARS-CoV 3CL protease inhibitors”, ChemBioChem, 8 (14), 1654-1657(2007).
  535. K.-F. Hua, H.-Y Hsu, L.-K. Chao, S.-T. Chen, W.-B. Yang, J. Hsu,C.-H. Wong, “ Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signaltransduction of cytokine expression”, J. Cell. Physiol., 212, 537-550(2007).
  536. J.-J. Shie, J.-M. Fang, S.-Y. Wang, K.-C. Tsai, Y.-S. E. Cheng, A.-S.Yang, S.-C. Hsiao, C.-Y. Su, C.-H. Wong, “Synthesis of Tamiflu and itsphosphonate congeners possessing potent anti-influenza activity”, J. Am. Chem. Soc., 129(39), 11892-11893 (2007).
  537. C. Casey, C.-H. Wong, “Partly cloudy with a chance of showers”, Chem.Biol., 2 (9), 573-576 (2007).
  538. T. Polat, C.-H. Wong, “Anomeric reactivity-basedone-pot synthesis of heparin-like oligosaccharides”, J. Am. Chem. Soc., 129 (42), 12795-12800 (2007).
  539. R. J. Payne, S. Ficht, S. Tang, A. Brik, Y.-Y. Yang, D.A. Case, C.-H.Wong, “Extended sugar-assisted ligations: development, scope and applications”, J.Am. Chem. Soc., 129 (44), 13527-13536 (2007).
  540. M. Sugiyama, Z. Hong, P.-H. Liang, L. J. Whalen, W. A. Greenberg, C.-H.Wong, “D-Fructose-6-phosphate aldolase catalyzed one-pot synthesis ofiminocyclitols”, J. Am. Chem. Soc., 129 (47), 14811-14817 (2007).
  541. K.-C. Cheng, H.-C. Huang, J.-H. Chen, J.-W. Hsu, H.-C. Cheng, C.-H. Ou, W.-B. Yang, S.-T. Chen, C.-H. Wong, H.-F. Juan, “ Ganodermalucidum polysaccharides in humanmonocytic leukemia cells: from gene expression to network construction”, BMC Genomics, 8 (1), 411 (2007).
  542. S. R. Hanson, W. A. Greenberg, C.-H. Wong,“Probing glycans with the copper(I)-catalyzed [3+2] azide-alkyne cycloaddition”, QSAR Comb. Sci., 26, 1243-1252 (2007).
  543. T.-J. R. Cheng, M.-T. Sung, H.-Y. Liao, Y.-F.Chang, C.-W. Chen, C.-Y. Huang, L.-Y. Chou, Y.-D. Wu, Y.-H. Chen, Y.-S. E.Cheng, C.-H. Wong, C. Ma, W.-C. Cheng, “Domain requirement of moenomycinbinding to bi-functional transglycosylases and its application forhigh-throughput drug discovery”, Proc. Nat. Acad. Sci. U.S.A., 105 (2), 431-436(2008).
  544. D. Wu, M. Fujio, C.-H. Wong, “Glycolipids as immunostimulating agents”, Bioorg. Med. Chem., 16, 1073–1083 (2008).
  545. T. R. Northen, J.-C. Lee, L. Hoang, J. Raymond,D.-R. Hwang, S. M. Yannone, C.-H. Wong, G. Siuzdak, “A nanostructure-initiatormass spectrometry based enzyme activity assay”, Proc. Nat. Acad.Sci. U.S.A., 105 (10), 3678-3683 (2008).
  546. S.-K. Wang, P.-H. Liang, R. Astronomo, T.-L.Hsu, S.-L. Hsieh, D. Burton, C.-H. Wong, “Targeting the carbohydrates on HIV-1:interaction of oligomannose dendrons with human monoclonal antibody 2G12 andDC-SIGN”, Proc. Nat. Acad. Sci., U.S.A., 105 (10), 3690-3695 (2008).
  547. P.-H. Liang, C.-Y. Wu, W. A. Greenberg, C.-H. Wong, “Glycanarrays: perspectives in biological and medical applications”, Current Opin.Chem. Biol., 12 (1), 86-92 (2008).
  548. S. Ficht, R. Payne, R. Guy, C.-H. Wong, “Solid-phasesynthesis of peptide- and glycopeptide thioesters via side chain anchoringstrategies”, Chemistry- A Euro. J., 14 (12), 3620-3629 (2008).
  549. Y.-M. Shao, W.-B. Yang, T.-H. Kuo, K.-C. Tsai, C.-H. Lin, A.-S. Yang, P.-H. Liang, C.-H. Wong, “Design,synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV3CL protease”, Bioorg. Med.Chem ., 16, 4652-4660 (2008).
  550. R.Payne, S. Ficht, W. A. Greenberg, C.-H. Wong, “Cysteine-free peptide andglycopeptide ligation by direct aminolysis”, Angew. Chem. Int. Ed., 47, 4411-4415(2008).
  551. S.-T. Chen, Y.-L. Lin, M.-T. Huang, M.-F. Wu, S.-C. Cheng, H.-Y. Lei,C.-K. Lee, T.-W. Chiou, C.-H. Wong, S.-L. Hsieh, “CLEC5A is critical for denguevirus-induced lethal disease”, Nature, 453, 672-676 (2008).
  552. N.-Y. Hsu, S. Y.Tseng, C.-Y. Wu, C.-T. Ren, Y.-C. Lee, C.-H. Wong, C.-H. Chen, “Desorption ionization of biomolecules on metals”, Analyt.Chem., 80, 5203-5210 (2008).
  553. R.D. Astronomo, H. K. Lee, C. N. Scanlan, R. Pantophlet, C. Y. Huang, I. A. Wilson, O. Blixt, R. A. Dwek, C.-H. Wong, D. R. Burton,“A glycoconjugate antigen based onthe recognition motif of a broadly-neutralising human immunodeficiency virusantibody, 2G12, is immunogenic but elicits antibodies unable to bind to theself glycans of gp120”, J. Virology, 82, 6359-6368 (2008).
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  555. Y. Kinjo, B. Pei, S. Bufali, R. Raju, S. K. Richardson, M. Imamura, M. Fujio, D.Wu, A. Khurana, K.  Kawahara, C.-H.Wong, A. R. Howell, P. H. Seeberger, M. Kronenberg, “Natural Sphingomonas glycolipids vary greatly in their ability toactivate natural killer T cells”, Chem. Biol., 15 (7), 654-664 (2008).
  556. C.-C. Wang, Y.-L. Huang, C.-T. Ren, C.-W. Lin,J.-T. Hung, J.-C. Yu, A. Yu, C.-Y. Wu, C.-H. Wong, “Glycan microarray of Globo H and relatedstructures for quantitative analysis of breast cancer”, Proc. Nat. Acad.Sci., U.S.A., 105, 11661-11666 (2008).
  557. W.-W. Chang, C. H. Lee, P. Lee, J. Lin, C.-W.Hsu, J.-T. Hung, J.-J. Lin, J.-C. Yu, L. E. Shao, J. Yu, C.-H. Wong, A. L. Yu, “Expression of Globo H and SSEA3 in breastcancer stem cells and the involvement of fucosyl transferases 1 & 2 inGlobo H synthesis”, Proc. Nat. Acad. Sci., U.S.A., 105, 11667-11672 (2008).
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  559. J.-J.Shie, J.-M. Fang, C.-H. Wong, “A concise and flexible synthesis of the potentanti-influenza agents – Tamiflu and Tamiphosphor”, Angew. Chem. Int. Ed., 47 (31), 5788-5791 (2008).
  560. P.-H.Liang, M. Imamura, X. Li, D. Wu, M. Fujio, R. Guy, B.-C. Wu, M. Tsuji, C.-H.Wong, “Quantitative microarray analysis of intact glycolipid-CD1d interactionand correlation with cell-based cytokine production”, J. Am. Chem. Soc., 130 (37), 12348-12354 (2008).
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  563. C.-S. Shi, G.-Y. Shi, S.-M. Hsiao,Y.-C. Kao, K.-L. Kuo, C.-Y. Ma, C.-H. Kuo, B.-I. Chang, C.-F. Chang, C.-H. Lin,C.-H. Wong, H.-L. Wu, “Lectin-like domain of thrombomodulin binds to itsspecific ligand Lewis Y antigen and neutralizes lipopolysaccharide-inducedinflammatory response”, Blood, 112 (9), 3661-3670 (2008).
  564. M. W. Chen, T.-J. R. Cheng,Y. Huang, J.-T. Jan, S.-H. Ma, A. L. Yu, C.-H. Wong, D. D. Ho, “Aconsensus-hemagglutinin-based DNA vaccine that protects mice against divergentH5N1 Influenza viruses”, Proc. Nat. Acad. Sci., U.S.A., 105 (36), 13538-43(2008).
  565. M.-L. Chen, A. K. Adak, N.-C. Yeh,W.-B. Yang, Y.-J. Chuang, C.-H. Wong, K.-C. Hwang, J.-R. R. Hwu, S.-L. Hsieh,C.-C. Lin, “Fabrication of an oriented Fc-fused lectin microarray throughboronate formation”, Angew. Chem.Int. Ed., 47 (45), 8627-8630 (2008).
  566. M. J.Giffin, H. Heaslet, A. Brik, Y.-C. Lin, G. Cauvi, C.-H. Wong, D.E. McRee, J.H. Elder, C.D. Stout, B. E. Torbett, “Acopper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potentinhibitor of a multidrug-resistant HIV-1 protease variant”, J. Med. Chem., 51(20), 6263-6270(2008).
  567. E. Tupin, M. R.-E.-I. Benhnia, Y.Kinjo, R. Patsey, C. Lena, M. Haller, M. J. Caimano, M. Imamura, C.-H. Wong, S.Crotty, J. D. Radolf, T. J. Sellati, M. Kronenberg, “NKT cells prevent chronicjoint inflammation following infection with Borreliaburgdorferi”, Proc.Nat. Acad. Sci. U.S.A., 105(50), 19863-19868 (2008).
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  569. S. R. Hanson, E. K. Culyba, T. L. Hsu, C.-H. Wong, J. W. Kelly, E. T. Powers, “The Core Trisaccharide of anN-linked Glycoprotein intrinsically accelerates folding and enhances stability”, Proc. Nat. Acad. Sci.U.S.A., 106 (9), 3131-3136 (2009).
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  571. M.-T. Sung, Y.-T. Lai, C.-Y. Huang, L.-Y. Chou, H.-W. Shih, W.-C. Cheng, C.-H. Wong, C. Ma, “Crystal structure of the membrane-bound bifunctionaltransglycosylase PBP1b from Escherichiacoli”, Proc. Nat. Acad. Sci.U.S.A., 106 (22), 8824-8829 (2009).
  572. Z.Hong, L. Liu, M. Sugiyama, Y. Fu, C.-H. Wong, “Concise synthesis ofiminocyclitols via petasis-type aminocyclization”, J. Am. Chem. Soc., 131 (24), 8352–8353 (2009).
  573. L. Motiei, S. Rahimipour,D. A. Thayer, C.-H. Wong and M. R. Ghadiri, “Antibacterial cyclic D,L-alpha-glycopeptides”, ChemComm., 7 (25), 3693-3695 (2009).
  574. W.-H. Wen, M. Lin, C.-Y. Su, S.-Y. Wang, Y.-S. E. Cheng, J.-M. Fang and C.-H. Wong, “Synergistic effect of zanamivir–porphyrin conjugates on inhibition ofneuraminidase and inactivation of influenza virus”, J. Med. Chem.,52 (15), 4903-4910 (2009).
  575. C.-H.Wong, “Enzymes for glycoprotein synthesis”, C HIMIA, 63 (6), 318-326 (2009).
  576. C.-H.Liang, C.-C. Wang, Y.-C. Lin, C.-H. Chen, C.-H. Wong, C.-Y. Wu, “Iron oxide/gold core/shell nanoparticles forultrasensitive detection of carbohydrate-protein interactions”, AnalyticalChemistry,81 (18), 7750-7756 (2009).
  577. J. C. Lewis, S. Bastian, C. S. Bennett,Y. Fu, Y. Mitsuda, M. M. Chen, W. A. Greenberg, C.-H.Wong, and F. H. Arnold, “ChemoenzymaticElaboration of Monosaccharides Using Engineered Cytochrome P450BM3Demethylases”, Proc. Nat.Acad. Sci. U.S.A., 106 (39), 16550-16555 (2009).
  578. C.-C. Wang, J.-R. Chen, Y.-C.Tseng, C.-H. Hsu, Y.-F.Hung, S.-W. Chen, C.-M. Chen, K.-H. Khoo, T.-J.Cheng, Y.-S. E. Cheng, J.-T. Jan, C.-Y. Wu, C. Ma, and C.-H. Wong, “Glycanson influenza hemagglutinin affect receptor binding and immune response”, Proc. Nat. Acad.Sci. U.S.A., 106 (43), 18137-18142 (2009).
  579. A. Schiefner, M. Fujio, D.Wu, C.-H. Wong and I. A. Wilson, “Structural evaluation of potent NKT cellagonists: implications for design of novel stimulatory ligands”, J. Mol.Bio., 394 (1), 71-82 (2009).
  580. M.-H. Chuang, S.-H.Chiou, C.-H. Huang, W.-B. Yang and C.-H. Wong, “The lifespan-promoting effectof acetic acid and Reishi polysaccharide”, Bioorg. Med. Chem ., 17(22), 7831-7840 (2009).
  581. T.-L. Hsu, S.-C. Cheng, W.-B. Yang, S.-W. Chin, B.-H. Chen, M.-T. Huang, S.-L. Hsieh, C.-H. Wong, “Profiling carbohydrate-receptor interaction with recombinant innateimmunity receptor-Fc fusion proteins”, J. Biol. Chem., 284(50), 34479-34489 (2009).
  582. R. J. Payne and C.-H. Wong, “Advances in chemical ligationstrategies for the synthesis of glycopeptides and glycoproteins”, ChemComm., 46, 21-43(2010).     
  583. C.-H.Hsu, K.-C. Chu, Y.-S. Lin, J.-L. Han, Y.-S. Peng, C.-T. Ren, C.-Y. Wu, C.-H.Wong, “Highly alpha-selective sialyl phosphate donors for efficient preparationof natural sialosides”, Chemistry-A European Journal, 16, 1754-1760(2010).
  584. C.-Y. Liu, C.-W. Guo, Y.-F. Chang, J.-T. Wang, H.-W. Shih, Y.-F. Hsu, C.-W. Chen, S.-K. Chen, Y.-C. Wang, T.-J. Cheng,C. Ma, C.-H. Wong, J.-M. Fang, W.-C. Cheng, “Synthesis and evaluation of a newfluorescent transglycosylase substrate: lipid II-based molecule possessing adansyl-C20 polyprenyl moiety”, Org Lett., 12 (7), 1608-1611 (2010).
  585. C.-C. Chang, A.F. Ku,Y.-Y. Tseng, W.-B. Yang, J.-M. Fang, and C.-H. Wong,“6,8-Di-C-glycosyl flavonoids from Dendrobiumhuoshanense”,  J.Nat. Prod.,73 (2), 229-232 (2010).
  586. R. D. Astronomo, E. Kaltgrad, A. K. Udit, S.-K. Wang, R. Pantophlet, C.-Y. Huang, J. C. Paulson, C.-H. Wong, M. G. Finn and D. R. Burton, “Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds”, Chemistry & Biology, 17 (4), 357-370(2010).
  587. H.-W. Shih, K.-T. Chen, S.-K. Chen, C.-Y. Huang, T.-J. Cheng, C. Ma, C.-H.Wong, W.-C.Cheng, “Combinatorialapproach toward synthesis of small molecule libraries as bacterialtransglycosylase inhibitors”, Organic & Biomolecular Chemistry, 8 (11), 2586-2593 (2010).
  588. W.-H.Wen, S.-Y. Wang, K.-C. Ysai, Y.-S. E. Cheng,A.-S. Yang, J.-M. Fang, C.-H. Wong,“Analogues of zanamivir withmodified C4-substituents as the inhibitors against the group-1 neuraminidasesof influenza viruses”, Bioorg.Med. Chem ., 18 (11), 4074-4084 (2010).
  589. S. Otsuki, S. Hanson, S. Miyaki, S. Grogan, M. Kinoshita, H. Asahara, C.-H. Wong, M. Lotz, “Extracellular sulfatases support cartilage homeostasisby regulating BMP and FGF signaling pathways”, Proc. Nat. Acad. Sci.U.S.A., 107 (22), 10202-10207 (2010).
  590. C.-S. Tsai, P.-Y. Liu, H.-Y. Yen, T.-L. Hsu,C.-H. Wong, “Development of trifunctionalprobes for glycoproteomic analysis”, ChemComm.,46 (30), 5575-5577 (2010).
  591. X. Li, D. Wu, M. Fujio, M. Imamura, S. Vasan, C.-H. Wong, D. D. Ho, M. Tsuji, “Design of apotent CD1d-binding NKT cell ligand as a vaccine adjuvant”, Proc. Nat. Acad. Sci.U.S.A., 107 (29), 13010-13015 (2010).
  592. K.-H. Lin, J.-J. Liang, W.-I. Huang, S.-Y. Lin-Chu, C.-Y. Su, Y.-L. Lee, J.-T. Jan, Y.-L. Lin, Y.-S. E. Cheng, and C.-H. Wong, “ In vivo protection of bacterial and viral infections in murinemodels using a synthetic new alpha-GalCeranalog”, Antimicrobial Agents andChemotherapy, 54 (10), 4129-4136 (2010).
  593. S.-H. Chang, J.-L. Han, Susan Y. Tseng, H.-Y. Lee,C.-W. Lin, Y.-C. Lin, W.-Y. Jeng, A. H.-J. Wang, C.-Y. Wu, C.-H. Wong, “Glycanarray on aluminum oxide coated glass slides through phosphonate chemistry”, J.Am. Chem. Soc., 132 (38), 13371-13380 (2010).
  594. J.-J. Shie,C.-A.Chen,C.-C. Lin,A.F. Ku,T.-J. R. Cheng, J.-M.Fang,and C.-H. Wong, Regioselective synthesis of Di- C-glycosylflavones possessing anti-inflammation activities”, Organic & Biomolecular Chemistry, 8 (19), 4451-4462(2010).
  595. H.-Y. Liao, C.-H. Hsu, S.-C. Wang, C.-H. Liang,H.-Y. Yen, C.-Y. Su, J.-T. Jan, C.-T. Ren, T.-J. Cheng, C.-Y. Wu, C.-H. Wong, “Differentialreceptor binding affinities of influenza hemagglutinins on glycan arrays”, J.Am. Chem. Soc., 132 (42), 14849-14856 (2010).
  596. C.-Y. Su, T.-J. R. Cheng, M.-I. Lin, S.-Y. Wang, W.-I. Huang, S.-Y. Lin-Chua, Y.-H. Chen, C.-Y. Wu, M. M. C. Lai, W.-C. Cheng, Y.-T. Wu, M.-D.Tsai, Y.-S. E. Cheng, C.-H. Wong, “High-throughput identificationof compounds targeting influenza RNA-dependent RNA Polymerase activity”, Proc. Nat. Acad. Sci. U.S.A., 107 (45), 19151-19156(2010).
  597. M. Schelwies, D. Brinson, Y.-H. Hong, M. K. Lotz, C.-H. Wong, and S. R. Hanson, “GlcN-6-sulfamate heparan analogs as inhibitors of endosulfatases”, ChemBioChem, 11 (17), 2393-2397 (2010).
  598. J. C. Lewis, S. M.Mantovani, Y. Fu, C. D. Snow, R. S. Komor, C.-H. Wong, F. H. Arnold, “Combinatorial alanine substitution enables rapidoptimization of cytochrome P450BM3 for selective hydroxylation oflarge substrates”, ChembioChem, 11 (18), 2502-2505 (2010).
  599. W.-Y. Chen, W.-B. Yang, C.-H. Wong, D.T.-B. Shih, “Effect of Reishi polysaccharides on human stem/progenitor cells”, Bioorg.Med. Chem., 18 (24), 8583-8591 (2010).
  600. T.-J. R. Cheng, Y.-T. Wu, S.-T. Yang, A. Loh, S.-K. Chen, Y.-H. Chen, W.-I. Huang, C.-H. Yuan, H.-W. Shih, Y.-S. E. Cheng, W.-C. Cheng, C.-H. Wong, “High-throughputidentification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and thetransglycosylase”, Bioorg. Med. Chem., 18 (24), 8512-8529(2010).
  601. C.-H. Liang, S.-K.Wang, C.-W. Lin, C.-C. Wang, C.-H. Wong, C.-Y. Wu, “Effects of neighboring glycans on antibody-carbohydrate interaction”, Angew. Chem. Int. Ed., 50 (7), 1608-1612 (2011).
  602. E. K. Culyba, J. L. Price, S. R. Hanson, A. Dhar,C.-H. Wong, M. Gruebele, E. T. Powers and J. W. Kelly,“Protein native-state stabilization byplacing aromatic side chains in N-glycosylated reverse turns”, Science, 331 (6017), 571-575(2011).
  603. M. W. Chen, H.-Y. Liao, T.-J. R.Cheng, C.-T. Ren, C.-Y. Wu, Y. Huang, D. D. Ho, C.-H.Wong, “Broadly neutralizing DNAvaccine with site specific mutation alters the antigenicity and sugar bindingactivities of influenza hemagglutinin”, Proc. Nat. Acad. Sci.U.S.A., 108 (9), 3510-3515 (2011).
  604. R. T. Lee, T.-L. Hsu, S.K. Huang, S.-L. Hsieh, C.-H. Wong, and Y. C. Lee, “Survey of immune-related,mannose/fucose-binding C-Type lectin receptors revealswidely divergent sugar-binding specificities”, Glycobiology,21 (4), 512-520 (2011).
  605. C.-Y. Chou, T.-P. Ko, K.-J. Wu, K.-F. Huang, C.-H. Lin,C.-H. Wong, A. H.-J. Wang, “Modulation of substrate specificities of D-sialicacid aldolase through single mutations of Val251”, J. Bio l . Chem., 286 (16), 14057-14064 (2011).
  606. B.-L. Tsai, J.-L. Han, C.-T.Ren, C.-Y. Wu and C.-H. Wong, “Programmable one-pot synthesis of tumor-associated carbohydrate antigensLewis X dimer and KH-1 epitopes”, Tetrahedron Letters, 52 (17), 2132-2135 (2011).
  607. C.-F. Chang, J.-F. Pan,C.-N. Lin, C.-H. Wong, C.-H. Lin, “Rapid characterization of sugar-binding specificityby in-solution proximity binding with photosensitizers”, Glycobiology, 21 (7), 895-902 (2011).
  608. C.-Y. Wu and C.-H. Wong, “Chemistry and glycobiology”, ChemComm, 47(22), 6201-6207 (2011).
  609. C.-Y. Wu and C.-H. Wong, “Programmable one-potglycosylation”, Topics in Current Chemistry, 301, 223-252 (2011).
  610. Y.-C. Liu, H.-Y. Yen, C.-Y. Chen, C.-H. Chen, P.-F. Cheng, Y.-H. Juan, C.-H. Chen, K.-H. Khoo, C.-J. Yu, P.-C. Yang, T.-L. Hsu, C.-H. Wong, “Sialylation and fucosylation of epidermal growthfactor receptor suppress its dimerization and activation in lung cancer cells”, Proc. Nat. Acad. Sci. U.S.A., 108 (28), 11332-11337(2011).
  611. R. Schmaltz, S. R. Hanson, C.-H. Wong, “Enzymes in the synthesis of glycoconjugates”, Chemical Reviews,111 (7), 4259-4307 (2011).
  612. K.-C.Liu, P.-S. Lee, S.-Y. Wang, Y.-S. E. Cheng, J.-M. Fang and C.-H. Wong, “Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir”, Bioorg. Med. Chem., 19, 4796-4802 (2011).
  613. H.-L. Yen, C.-H. Liang, C.-Y. Wu, H. L. Forrest, A.Ferguson, K.-T. Choy, J. Jones, D. D.-Y. Wong, P. P.-H. Cheung, C.-H. Hsu, O. T.Li, K. M. Yuen, R. W. Y. Chan, L. L. M. Poon, M. C. W. Chan, J. Nicholls, S.Krauss, C.-H. Wong, Y. Guan, R. G. Webster, R. J. Webby & J. S. M. Peiris,“Hemagglutinin-neuraminidase balanceconfers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets”, Proc. Nat. Acad. Sci. U.S.A., 108 (34), 14264-14269 (2011).
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  616. L. M. Walker, M. Huber, K. J. Doores, E. Falkowska, R.Pejchal, J.-P. Julien, S.-K. Wang, P.-Y. Chan-Hui, P. W. Hammond, O. A. Olsen,A. Ramos, P. Phung, T. Wrin, M. D. Simek, S. Fling, C.-H. Wong, S. Phogat, W.C. Koff, I. A. Wilson, D. R. Burton, P. Poignard, “Broad neutralizationcoverage of HIV by multiple highly potent antibodies”, Nature, 477(7365), 466-470 (2011).
  617. K.-C. Chu, C.-T. Ren, C.-P. Lu, C.-H. Hsu, T.-H. Sun, T.-A. Chao,Y.-F. Lin, S.-H. Wu, C.-H. Wong and C.-Y. Wu, “Efficient and stereoselective synthesis of α(2→9)oligosialic acids up to dodecamer”, Angew. Chem. Int. Ed., 50 (40), 9391-9395 (2011).
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  623. T.-N. Wu, K.-H. Lin, Y.-J. Chang, J.-R. Huang, J.-Y. Cheng, A. L. Yu, and C.-H. Wong, “Avidity of CD1d-ligand-receptor ternary complexcontributes to Th1 polarization and anticancer efficacy”, Proc. Nat. Acad. Sci. U.S.A., 108(42), 17275-17280 (2011).
  624. J.-J. Shie, J.-M. Fang, P.-T. Lai, W.-H. Wen, S.-Y. Wang, Y.-S. Cheng, K.-C. Tsai, A.-S. Yang, C.-H. Wong, “A practical synthesis of zanamivir phosphonate congenerswith potent anti-influenza activity”, J. Am. Chem. Soc., 133(44), 17959-17965 (2011).
  625. D. Punyadarsaniya, C.-H. Liang, C.Winter, H. Petersen, S. Rautenschlein, I. Hennig-Pauka, C. Schwegmann-Wessels, C.-Y. Wu, C.-H. Wong, G. Herrler, “Infection of differentiated porcine airwayepithelial cells by influenza virus: differential susceptibility to infection byporcine and avian viruses”, PLOS One, 6(12), e28429 (2011).
  626. S.-H. Chen, D.-R. Hwang, G.-H. Chen, N.-S. Hsu, Y.-T. Wu, T.-L. Li, C.-H. Wong, “Engineeringtransaldolase in Pichia stipitis toimprove bioethanol production”, ACS Chem . Biol., 7 (3), 481-486 (2012).
  627. J. Lenger, M. Schröder, E. C. Ennemann, B. Müller, C.-H. Wong, T. Noll, T. Dierks, S. R. Hanson, N. Sewald , “Evaluation of sulfatase-directed quinonemethide traps for proteomics”, Bioorg.Med. Chem., 20(2), 622-627 (2012).
  628. Y. Hsu, X.-A. Lu, M. Zulueta, C.-M.Tsai, K.-I. Lin, S.-C. Hung, C.-H. Wong, “Acyl and silyl group effects in reactivity-based one-potglycosylation: synthesis of embryonic stem cell surface carbohydrates Lc4and IV2Fuc-Lc4”, J. Am. Chem. Soc., 134 (10), 4549-4552(2012).
  629. C.-Y.Huang, H.-W. Shih, L-Y. Lin, Y.-W. Tien, T.-J. R. Cheng, W.-C. Cheng, C.-H.Wong and C. Ma, “Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog andelucidation of the mechanism of peptidoglycan synthesis”, Proc. Nat. Acad. Sci. U.S.A., 109(17), 6496-6501 (2012).
  630. S.-C.Hung, M. Zulueta, S.-Y. Lin, Y.-T. Lin, C.-J. Huang, C.-C. Wang, C.-C. Ku,Z.-H. Shi, C.-L. Chyan, D. Irene, L.-H. Lim, T.-I. Tsai, Y.-P.  Hu, S. Arco, C.-H. Wong, “α-Glycosylation byD-glucosamine-derived donors: synthesis of heparosan and heparin analogs thatinteract with mycobacterial heparin-binding hemagglutinin”, J. Am. Chem. Soc., 134: 8988-8995 (2012).
  631. M.-H. Hsieh, J.-T.Hung, Y.-W. Liw, Y.-J. Lu, C.-H. Wong, A. L. Yu, and P.-H. Liang, “Synthesis and evaluation of acyl-chain- and galactose-6’’-modifiedanalogues of α-GalCer for NKT cell activation”, ChemBioChem, 13 (11),1689-1697 (2012).
  632. J.L. Price,E. K. Culyba,W. Chen, A. N. Murray, S.R. Hanson,C.-H. Wong,E. T. Powers,J. W. Kelly, “ N-glycosylationof enhanced aromatic sequons to increase glycoprotein stability”, Biopolymers, 98 (3), 195-211(2012).
  633. H.-W. Shih, Y.-F. Chang, W.-J. Li, F.-C. Meng,C.-Y. Huang, C. Ma, T.-J. R. Cheng, C.-H. Wong, W.-C. Cheng, “Effect of thepeptide moiety of lipid II on bacterial transglycosylase”, Angew. Chem. Int. Ed., 51 (40), 10123-10126 (2012).
  634. K.-C.Liu, J.-M. Fang, J.-T. Jan, T.-J. R. Cheng, S.-Y. Wang, Y.-S. E. Cheng, K.-C. Tsai, A.-S. Yang, and C.-H. Wong, “Enhanced anti-influenza agentsconjugated with anti-inflammatory activity”, J. Med. Chem., 55 (19), 8493-8501 (2012).
  635. T.-J. R. Cheng, S. Weinheimer, E. B. Tarbet, J.-T. Jan, Y.-S. E. Cheng, J.-J. Shie, C.-L. Chen, C.-A.Chen, W.-C. Hsieh, P.-W. Huang, W.-H. Lin, S.-Y. Wang, J.-M. Fang, O. Y.-P. Hu, and C.-H. Wong, “Developmentof oseltamivir phosphonate congeners as anti-influenza agents”, J. Med. Chem., 55 (20), 8657-8670(2012).
  636. T.-J. R.Cheng, S.-Y. Wang, W.-H. Wen, C.-Y. Su, M. Lin, W.-I. Huang, M.-T. Liu, H.-S.Wu, N-S. Wang, C.-K. Cheng, C.-L. Chen, C.-T. Ren, C.-Y. Wu, J.-M. Fang, Y.-S.E. Cheng and C.-H. Wong, “Chemical probes for drug resistance assessment bybinding competition (RABC) oseltamivir susceptibility evaluation”, Angew. Chem. Int. Ed., 52, 366-370 (2013).
  637. E. Al-Shareffi, J.-L. Chaubard, C.Leonhard-Melief, C.-H.Wong, and R. S. Haltiwanger, “6-alkynylfucose is a bioorthogonal analogue for O-fucosylation of epidermalgrowth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2”, Glycobiology, 23 (2),188-198 (2013).
  638. K.-T. Chen, Y.-C.Kuan, W.-C. Fu, P.-H. Liang, T.-J.R. Cheng, C.-H. Wong, and W.-C. Cheng, “Rapid preparation of mycobacterium N-glycolyl lipid I andlipid II derivatives: a biocatalytic approach”, Chemistry-A European Journal, 19 (3), 834-838 (2013).
  639. K. J. Doores, M.Huber, K. M. Le, S.-K.Wang, C. Doyle-Cooper, A. Cooper, R.Pantophlet, C.-H. Wong, D.Nemazee, D. R. Burton, “2G12-expressingB cell lines inform HIV carbohydrate vaccine design strategies”, Journalof Virology,87 (4), 2234-2241 (2013).
  640. C.-Y. Chen, Y.-H. Jan, Y.-H. Juan, C.-J. Yang,M.-S. Huang, C.-J. Yu, P.-C. Yang, M. Hsiao, T.-L. Hsu, C.-H. Wong,“Fucosyltransferase 8 as a functional regulator of non-small cell lung cancer”, Proc. Nat. Acad. Sci. U.S.A., 110 (2), 630-635 (2013).
  641. Y.-L.Huang, J.-T. Hung, S. K.-C. Cheung, H.-Y. Lee, K.-C. Chu,S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu,C.-H. Wong “Carbohydrate-based vaccines with a glycolipid adjuvant for breastcancer”, Proc. Natl. Acad. Sci. U.S.A., 110, 2517-2522 (2013).
  642. C.-S. Tsai, H.-Y. Yen, M.-I. Lin, T.-I. Tsai, S.-Y.Wang, W.-I. Huang, T.-L. Hsu, Y.-S. E. Cheng, J.-M. Fang, C.-H. Wong, “A cellpermeable probe for identification and imaging of sialidases”, Proc. Nat. Acad. Sci. U.S.A., 110, 2466-2471 (2013).
  643. T.-C. Hung, C.-W. Lin, T.-L. Hsu, C.-Y. Wu, C.-H.Wong, “Investigation of SSEA-4 binding protein in breast cancer cells”, J. Am. Chem. Soc., 135(16), 5934-5937 (2013).
  644. C.-C. Tsai, C.-R. Lin, H.-Y. Tsai, C.-J. Chen, W.-T. Li, H.-M. Yu, Y.-Y. Ke, W.-Y. Hsieh, C.-Y. Chang, C.-Y. Wu, S.-T. Chen, C.-H. Wong, “The immunologically activeoligosaccharides isolated from wheatgrass modulate monocytes via toll-likereceptor-2 signaling”, J. Bio l . Chem., 288 (24), 17689-17697 (2013).
  645. C.-Y. Yang, J.-B. Chen, T.-F. Tsai, Y.-C. Tsai, C.-Y. Tsai, P.-H.Liang, T.-L. Hsu, C.-Y. Wu, M. G. Netea,  C.-H. Wong, S.-L.Hsieh, “CLEC4F is an inducible C-type lectin in F4/80-positive cells and isinvolved in alpha-galactosylceramide presentation in liver”, PLOS ONE, 8 (6), e65070 (2013).
  646. S.-C. Lin, J.-T. Jan, B. Dionne, M. Butler, M.-H.Huang, C.-Y. Wu, C.-H. Wong, S.-C. Wu, “Different immunity elicited byrecombinant H5N1 hemagglutinin proteins containing pauci-mannose, high-mannose,or complex type N-glycans”, PLOS ONE, 8 (6),e66719 (2013).
  647. H.-W. Huang, C.-H. Chen, C.-H. Lin, C.-H. Wong, K.-I. Lin, “B cell maturation antigen is modified by a single N-glycan chain that modulates ligandbinding and surface retention”, Proc. Nat. Acad. Sci. U.S.A., 110 (27),10928-10933 (2013).
  648. K. Ohara, C.-C. Lin, P.-J. Yang, W.-T. Hung, W.-B. Yang, T.-J. Cheng, J.-M. Fang, C.-H. Wong, “Synthesisand bioactivity of b-(1→4)-linked oligomannoses and partially acetylated derivatives”, J. Org. Chem., 78(13), 6390-6411 (2013).
  649. W. Chen, S. Enck, J. Price, D. Powers, E. Powers, C.-H. Wong, H. J. Dyson, J. Kelly, “Structuraland energetic basis of carbohydrate-aromatic packing interactions in proteins”, J. Am. Chem. Soc., 135(26), 9877-9884 (2013).
  650. C.-H. Wang, S.-T. Li, T.-L. Lin, Y.-Y. Cheng, T.-H. Sun, J.-T. Wang, T.-J. Cheng, K.-K. Mong, C.-H. Wong, C.-Y. Wu, “ Synthesis of N eisseria meningitidis serogroupW135 capsular oligosaccharides for immunogenicity comparisonand vaccine development ”, Angew. Chem. Int. Ed., 52 (35), 9157-9161 (2013).
  651. H.-Y. Chuang,C.-T. Ren, C.-A. Chao, C.-Y. Wu, S. Shivatare;T.-J. R. Cheng, C.-Y. Wu, C.-H. Wong, “Synthesis and vaccine evaluationof the tumor associated carbohydrate antigen RM2 from prostate cancer”, J. Am. Chem. Soc., 135(30), 11140-11150 (2013).
  652. S.-F. Liao, C.-H.Liang, M.-Y. Ho, T.-L. Hsu, T.-I.Tsai, Y. S.-Y. Hsieh, S.-T. Li, Y.-Y.Cheng, S.-M. Tsao, T.-Y. Lin,Z.-Y. Lin, W.-B.Yang, C.-T. Ren, K.-I. Lin, K.-K. Khoo, C.-H. Lin, H.-Y. Hsu, C.-Y. Wu, C.-H. Wong, “Immunization offucose-containing polysaccharides from Reishi mushroom induces antibodies against tumor-associated Globo H-series epitopes”, Proc. Nat.Acad. Sci. U.S.A., 110 (34), 13809-13814 (2013).
  653. S. Shivatare, S.-H. Chang, T.-I. Tsai, C.-T. Ren, H.-Y. Chuang, L. Hsu, C.-W. Lin, S.-T. Li, C.-Y. Wu, C.-H. Wong, “Efficient convergent synthesis ofbi-, tri-, and tetraantennary complex type N-glycansand their HIV-1 antigenicity”, J. Am. Chem. Soc., 135 (41), 15382-15391 (2013).
  654. T.-I. Tsai, H.-Y. Lee, S.-H. Chang, C.-H. Wang,Y.-C. Tu, Y.-C. Lin, D.-R. Hwang, C.-Y. Wu, C.-H. Wong, “Effective sugar nucleotide regeneration for thelarge-scale enzymatic synthesis of Globo H and SSEA4”, J. Am. Chem. Soc., 135(39), 14831-14839 (2013).
  655. N. Padte, M. B. Carrera, C. A. McManus, B. Grasperge, A. Gettie, J. Coelho-dos-Reis, X. Li, N. Levenkova, D. Wu, J. T.Bruder, M. Sedegah, N. Petterson, T. Richie, C.-H. Wong, D. D. Ho, S. Vasan, M. Tsuji, “A glycolipid adjuvant,7DW8-5, enhances CD8+ T cell responses induced by an adenovirus-vectored malariavaccine in non-human primates”, PLOS ONE, 8 (10), e78407 (2013).
  656. S.-H.Huang, W.-S. Wu, L.-Y., Huang, W.-F., Huang, W.-C., Fu, S.-T. Yang, P.-T. Chen,J.-M. Fang, W.-C. Cheng, T.-J. Cheng, C.-H. Wong, “A new continuousfluorometric assay for bacterial transglycosylase using Förster resonanceenergy transfer”, J. Am. Chem. Soc., 135 (45), 17078-17089 (2013).
  657. R. Bryk, N. Arango, C. Maksymiuk, A. Balakrishnan,Y.-T. Wu, C.-H. Wong, T. Masquelin, P. Hipskind, C. D. Lima, and C. Nathan, “Lipoamide channel-binding sulfonamides selectivelyinhibit mycobacterial lipoamide dehydrogenase”, Biochemistry,52 (51), 9375-9384 (2013).
  658. T.-L. Hsu, G. Lin, A. Koizumi, K. Brehm, N. Hada, P.-K.Chuang, C.-H.Wong, S.-L. Hsieh, A. Diaz, “The surface carbohydrates of the Echinococcus granulosus larva interact selectively with the rodentKupffer cell receptor”, Molecular & BiochemicalParasitology, 192 (1-2), 55-59 (2013).
  659. J.-M. Fang, Y.-S. Chen, H.-M. Yu, J.-J. Shie, T.-J.R. Cheng, C.-Y. Wu, C.-H. Wong, “Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessinganti-inflammatory activity”, Bioorg.Med. Chem., 22 (5),1766-72 (2014).
  660. C.-S. Chu, P.-W. Lo, Y.-H. Yeh, P.-H. Hsu, S.-H. Peng, Y.-C. Teng, M.-L. Kang, C.-H. Wong and L.-J. Juan, “O-GlcNAcylation regulatesEZH2 protein stability and function”, Proc. Nat. Acad. Sci.U.S.A., 111 (4), 1355-1360 (2014).
  661. J.-R. Chen, Y.-H. Yu, Y.-C. Tseng, W.-L. Chiang, M.-F. Chiang, Y.-A. Ko, Y.-K. Chiu,S.-H. Ma, C.-Y. Wu, J.-T. Jan, K.-I. Lin, C. Ma and C.-H. Wong,“Vaccination of monoglycosylatedhemagglutinin induces cross-strain protection against influenza virusinfections”, Proc. Nat. Acad. Sci. U.S.A., 111 (7), 2476-2481 (2014).
  662. Y.-W. Lou, P.-Y. Wang, S.-C. Yeh, P.-K. Chuang,S.-T. Li, C.-Y. Wu, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, “Stage-specific embryonic antigen-4 as a potential therapeutic target inglioblastoma multiforme and other cancers”, Proc. Nat. Acad. Sci. U.S.A.,111 (7), 2482-2487 (2014).
  663. J -R. Huang, Y.-C. Tsai, Y.-J. Chang, J.-C. Wu, J.-T. Hung, K.-H. Lin, C.-H. Wong and Alice L. Yu, “α-GalCer but not phenyl-glycolipids induced NKT cellanergy and IL-33 mediated MDSC accumulation via upregulation of egr2/3”, Journal of Immunology,192 (4), 1972-1981 (2014).
  664. A.-K. Sauer, C.-H. Liang, J. Stech, B. Peeters, P. Quéré, C.Schwegmann-Wessels,C.-Y. Wu, C.-H. Wong, G. Herrler ,“Characterization of the sialic acid binding activityof influenza A viruses using soluble variants of the H7 and H9 hemagglutininsubtypes as lectins”, PLOS ONE, 9 (2), e89529 (2014).
  665. J. Lin, Y.-J. Chang, W.-B. Yang, A. L. Yu, and C.-H. Wong, “The multifaceted effects of Dendrobium huoshanense on immunefunctions with the induction of Interleukin-1 receptor antagonist (IL-1ra) inmonocytes”, PLOS ONE, 9 (4), e94040 (2014).
  666. S.-C. Lin, W.-C. Liu, J.-T. Jan, C.-H. Wong, S.-C. Wu, “GlycanMasking of hemagglutinin for adenovirus vector and recombinant protein immunizations elicits broadlyneutralizing antibodies against H5N1 avian influenza viruses”, PLOS ONE, 9 (3),e92822 (2014).
  667. J.-J. Shie, Y.-C. Liu,Y.−M. Lee, C. Lim, J.-M. Fang, C.-H. Wong, “Anazido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation”, J.Am. Chem. Soc., 136 (28), 9953-9961(2014).
  668. P.-C. Chen, P.-K. Chuang, C.-H. Chen, J.-R. Chen, S.-W. Lin, C. Ma, T.-L. Hsu,C.-H. Wong, “Role of N-linked glycans in the interactions of theHCV envelope glycoproteins with cellular receptors”, ACS Chemical Biology,9 (7), 1437-1443 (2014).
  669. E. Falkowska, A. Ramos, K. J. Doores, J. H. Lee, C. Blattner, A. Ramirez, R. Derking, M. J. van Gils, C.-H. Liang, R. Mcbride, S. S. Shivatare, C.-Y. Wu, P.-Y.Chan-Hui, Y. Liu, T. Feizi, M. B. Zwick, W. C. Koff, M. S. Seaman, K. Swiderek, J. P. Moore, J. C. Paulson,C.-H. Wong, A. B. Ward, I. A. Wilson,R. W. Sanders, P. Poignard, andD. R. Burton, “Broadlyneutralizing HIV antibodies define a novel glycan-dependent epitope on thepre-fusion conformation of gp41 on cleaved Envelope trimmers”, Immunity, 40 (5),657-668 (2014).
  670. Y.-Y. Tseng, J.-M. Liou, T.-L. Hsu, W.-C. Cheng, M.-S. Wu, C.-H. Wong, “Development of bacterial transglycosylase inhibitorsas new antibiotics: moenomycin A treatment for drug-resistant Helicobacter pylori”, Bioorg. Med. Chem. Lett., 24 (11), 2412-2414 (2014).
  671. C.-L. Chen, T.-C. Lin, S.-Y. Wang, J.-J. Shie, K.-C. Tsai, Y.-S. E.Cheng, J.-T. Jan, C.-J. Lin, J.-M. Fang, and C.-H. Wong, “Tamiphosphor monoesters as effective anti-influenza agents”, Eur. J. Med. Chem.,81, 106-118 (2014).
  672. L.-Y.Huang, S.-H. Huang, Y.-C. Chang, W.-C. Cheng, T.-J. R. Cheng, and C.-H. Wong, “Enzymaticsynthesis of Lipid II and analogues”, Angew. Chem. Int. Ed., 53 (31), 8060-8065 (2014).
  673. C.-Y. Wang, C.-Y. Wu, T.-J. Hung, C.-H. Wong, C.-H. Chen, “Sequence-constructive SELEX: A new strategy forscreening DNA aptamer binding to Globo H”, Biochem. Biophys. Res. Commun., 452 (3), 484-489(2014).
  674. C.-H. Hsu, M. Schelwies, S. Enck, L.-Y. Huang, S.-H. Huang, Y.-F. Chang, T.-J. Cheng, W.-C. Cheng, C.-H. Wong, “Iminosugar C-glycoside analoguesof alpha-D-GlcNAc-1-phosphate: synthesis and bacterial transglycosylaseinhibition”, J.Org. Chem., 79 (18), 8629-37 (2014).
  675. J.-T. Hung, Y.-C. Tsai, W.-D. Lin, J.-T. Jan, K.-H. Lin, J.-R. Huang, J.-Y. Cheng, M.-W. Chen, C.-H. Wong, and A. L. Yu, “Potent adjuvant effects ofnovel NKT stimulatory glycolipids on hemagglutinin based DNA vaccine for H5N1influenza virus”, Antiviral Res., 107, 110-118 (2014).
  676. B.-T. Hong, C.-L. Chen, J.-M. Fang, S.-Y. Wang, W.-I. Huang, Y.-S. E. Cheng, and Chi-Huey Wong, “Oseltamivir hydroxamate and acylsulfonamide derivatives as influenza neuraminidase inhibitors”, Bioorg. Med. Chem., 22 (23), 6647-6654(2014).
  677. H.-Y. Lee, C.-Y. Chen, T.-I. Tsai, S.-T. Li, K.-H.Lin, Y.-Y. Cheng, C.-T. Ren, T.-J. Cheng, C.-Y. Wu, C.-H. Wong, “Immunogenicitystudy of Globo H derivatives with modification at the reducing or non-reducingend of the tumor antigen”, J. Am.Chem. Soc., 136 (48), 16844-16853(2014).
  678. S. Danishefsky, Y.-K. Shue, M. Chang, C.-H. Wong,“Development of Globo-H cancer vaccine”, Accounts of Chemical Research, 48(3), 643-652 (2015).
  679. C.-C. Tsai, C.-R. Lin, H.-Y. Tsai, C.-J. Chen, W.-T.Li, H.-M. Yu, Y.-Y. Ke, W.-Y. Hsieh, C.-Y. Chang, Y.-T. Wu, S.-T. Chen, C.-H.Wong, “The immunologically active oligosaccharides isolated from wheatgrassmodulate monocytes via toll-like receptor-2 signaling”, J. Biol. Chem., 290(19), 11935 (2015).
  680. H.-Y. Yen, Y.-C. Liu, N.-Y. Chen, C.-F. Tsai, Y.-T.Wang, Y.-J. Chen, T.-L. Hsu, P.-C. Yang, C.-H. Wong, “Effect of sialylation onEGFR phosphorylation and resistance to tyrosine kinase inhibition”, Proc. Nat. Acad.Sci. U.S.A., 12 (22), 6955-6960 (2015).
  681. C.-H. Wong, “Chemistry in Taiwan and AcademiaSinica”, Angew. Chem. Int.Ed.,54 (46), 13472-13473 (2015).
  682. Y.-L. Huang, F.-S. Pai, Y.-T. Tsou, H.-C. Mon, T.-L.Hsu, C.-Y. Wu, T.-Y. Chou, W.-B. Yang, C.-H. Chen, C.-H. Wong, S.-L. Hsieh, “HumanCLEC18 gene cluster contains C-type lectins with differential glycan-bindingspecificity”, J.Bio l . Chem., 290 (35), 21252-21263(2015).
  683. T.-W. Lin, H.-T. Chang, C.-H. Chen, C.-H. Chen, S.-W.Lin, T.-L. Hsu, C.-H. Wong, “Galectin-3 binding protein and galectin-1interaction in breast cancer cell aggregation and metastasis”, J. Am. Chem.Soc., 137 (30), 9685-9693 (2015).
  684. X. Li, A. Kawamura, C. Andrews, J. Miller, D. Wu; T.Tsao, M. Zhang, D. Oren, N. N. Padte, S. A. Porcelli, C.-H. Wong, S. H. I. Kappe,D. D. Ho, M. Tsuji, “Co-localization of a CD1d-binding glycolipid with a radiation attenuated sporozoite vaccine inLN-resident DCs for a robust adjuvant effect”, Journal of Immunology, 195(6), 2710-2721 (2015).
  685. C.-W. Lin, M.-H. Tsai, S.-T. Li, T.-I. Tsai, K.-C. Chu, Y.-C. Liu, M.-Y. Lai, C.-Y. Wu, Y.-C. Tseng, S. S. Shivatare, C.-H. Wang, P. Chao,S.-Y. Wang, H.-W. Shih, Y.-F. Zeng, T.-H. You, J.-Y. Liao, Y.-C. Tu, Y.-S. Lin, H.-Y. Chuang, C.-L. Chen, C.-S. Tsai, C.-C. Huang, N.-H. Lin, C. Ma, C.-Y. Wu, and C.-H. Wong, “A common glycan structure on immunoglobulin G for enhancement ofeffector functions”, Proc. Nat. Acad. Sci. U.S.A., 112 (34), 10611-10616 (2015).
  686. J.-T. Chen, K.-L.Ku, C.-H.Chen, M. Hsiao, C.-P. Chiang, T.-L. Hsu, M.-H. Chen, and C.-H. Wong, “Glycoprotein B7-H3 as a marker for oralcancer: overexpression and aberrant glycosylation in tumor growth and immuneresponse”, Proc. Nat. Acad. Sci.U.S.A., 112 (42), 13057-13062 (2015).
  687. Y.-Y. Ke, C.-H. Tsai, H.-M. Yu, Y.-C. Jao, J.-M.Fang, C.-H. Wong, “Latifolicinin A from a fermented soymilk product and thestructure-activity relationship of synthetic analogues as inhibitors of breastcancer cell growth”, J Agric Food Chem., 63 (44), 9715-9721 (2015).
  688. S. K. C. Cheung, P.-K. Chuang, H.-W. Huang, W. W.Hwang-Verslues, C. H.-H. Cho, W.-B. Yang, C.-N. Shen, M. Hsiao, T.-L. Hsu, C.-F. Chang, C.-H. Wong, “Stage-specificembryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significantmarkers for breast cancer stem cells”, Proc. Nat. Acad. Sci.U.S.A., 113(4), 960-965 (2016).
  689. S. S. Shivatare, S.-H. Chang, T.-I. Tsai, S. Y.Tseng, Y.-S. Lin, Y.-Y. Cheng, C.-T. Ren, S. Pawar, C.-S. Tsai, H.-W. Shi, Y.-F.Zeng, C.-H. Liang, P. D. Kwong, D. R. Burton, C.-Y. Wu and C.-H. Wong, “Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIVantibodies”, Nature Chemistry, 8 (4), 338-46 (2016).
  690. G. B. E. Stewart-Jones, C. Soto, T. Lemmin, G.-Y.Chuang, A. Druz, R. Kong, P. V. Thomas, K. Wagh, T. Zhou, A.-J. Behrens, T.Bylund, C. W. Choi, J. R. Davison, I. S. Georgiev, M. G. Joyce, Y. D. Kwon, M.Pancera, J. Taft, Y. Yang, B. Zhang, S. S. Shivatare, V. S. Shivatare, C.-C. D.Lee, C.-Y. Wu, C. A. Bewley, D. R. Burton, W. C. Koff, M. Connors, M. Crispin,B. T. Korber, C.-H. Wong, J. R. Mascola and P. D. Kwong, “Trimeric HIV-1-Envstructures define glycan shields from clades A, B, and G”, Cell, 165, 813-826 (2016).
  691. P.-C. Wang, J.-M. Fang, K.-C.Tsai, S.-Y. Wang, W.-I. Huang, Y.-S. Cheng, R. C., C.-H. Wong, “Peramivirphosphonate derivatives as influenza neuraminidase inhibitors”, J. Med.Chem., 59 (11), 5297-5310 (2016).
  692. L. Krasnova and C.-H. Wong, “Understanding thechemistry and biology of glycosylation with glycan synthesis”, Annual Reviewof Biochemistry, 85, 599-630 (2016).
  693. L. Krasnova and C.-H. Wong, “Exploring human glycosylation for better therapies”, Molecular Aspects of Medicine, S0098-2997 (16), 30013-30019(2016).
  694. S.-C.Yeh, P.-Y. Wang, Y.-W. Lou, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, “Glycolipid GD3 and GD3 synthase are key drivers forglioblastoma stem cells and tumorigenicity”, Proc. Nat. Acad. Sci. U.S.A., 113 (20), 5592-5597(2016).
  695. T.-C. Kuo, L.-W. Li, S.-H. Pan, J.-M. Fang, J.-H.Liu, T.-R. Cheng, C.-J. Wang, P.-F. Hung, H.-Y. Chen, T.-M. Hong, Y.-L .Hsu, C.-H.Wong, P.-C. Yang, “Purine-type compounds induce microtubule fragmentation andlung cancer cell death through interaction with katanin”, J. Med. Chem.,59 (18), 8521-34 (2016).
  696. C.-H. Hsu, S. Park, D. E. Mortenson, B. L. Foley,X. Wang, R. J. Woods, D. A. Case, E. T. Powers, C.-H. Wong, H. J. Dyson, J. W.Kelly, “The dependence of carbohydrate-aromatic interaction strengths on thestructure of the carbohydrate”, J. Am. Chem. Soc., 138 (24), 7636-7648(2016). 
  697. D. Sok, M. Pauthner, B. Briney, J.-H. Lee, K. L. Saye-Francisco,J. Hsueh, A. Ramos, K.-M. Le, M. Jones, J. G. Jardine, R. Bastidas, A. Sarkar,C.-H. Liang, S. S. Shivatare, C.-Y. Wu, W. R. Schief, C.-H. Wong, I. A. Wilson,A. B. Ward, J. Zhu, P. Poignard, D. R. Burton, “A prominent site of antibodyvulnerability on HIV envelope incorporates a motif associated with CCR5 bindingand its camouflaging glycans”, Immunity, 45 (1), 31-45 (2016).
  698. D. T. MacLeod, N. M. Choi, B. Briney, F. Garces, L.S. Ver, E. Landais, B. Murrell, T. Wrin, W. Kilembe, C.-H. Liang, A. Ramos,C.-B. Bian, L. Wickramasinghe, L. Kong, K. Eren, C.-Y. Wu, C.-H. Wong, S. L.Kosakovsky Pond, I. A. Wilson, D. R. Burton, P. Poignard, “Early antibodylineage diversification and independent limb maturation lead to broad HIV-1neutralization targeting the env high-mannose patch”, Immunity, 44 (5), 1215-1226(2016).
  699. S. Y. Tseng, W.-H. Cho, J. Su, S.-H. Chang, D.Chiang, C.-Y. Wu, C.-N. Hsiao, C.-H. Wong, “Preparation of aluminumoxide-coated glass slides for glycan microarray”, ACS Omega, 1 (5), 773–783 (2016).
  700. T.-N. Wu, K.-H. Lin, Y.-T. Wu, J.-R. Huang, J.-T.Hung, J.-C. Wu, C.-Y. Chen, K.-C. Chu, N.-H. Lin, A. L. Yu, C.-H. Wong, “Phenylglycolipids with different glycosyl groups exhibit marked differences in murineand human iNKT cell activation”, ACS Chem. Biol., 11 (12), 3431-3441(2016).
  701. Y.-L. Lo, G.-G. Liou, C.-H. Lu, M. Hsiao, T.-L.Hsu, C.-H. Wong, “Dengue virus infection is through a cooperative interactionbetween a mannose receptor and CLEC5A on macrophage as a multivalenthetero-complex”, PLOS ONE, 11 (11), e0166474 (2016).
  702. Y. Kizuka, S. Funayama, H. Shogomori, M. Nakano, K.Nakajima, R. Oka, S. Kitazume, Y. Yamaguchi, M. Sano, H. Korekane, T.-L. Hsu,H.-Y. Lee, C.-H. Wong and N. Taniguchi, “High sensitivity and low toxicity fucose probe for glycan imaging andbiomarker discovery”, Cell Chem. Biol., 23 (7), 782-792 (2016).
  703. C.-Y. Wu, C.-W. Lin, T.-L. Tsai, C.-C. D. Lee,H.-Y. Chuang, J.-B. Chen, M.-H. Tsai, B.-R. Chen, P.-W. Lo, C.-P. Liu, V. S.Shivatare and C.-H. Wong, “Influenza A surface glycosylation and vaccinedesign”, Proc.Nat. Acad. Sci. U.S.A., 114 (2), 280-285 (2017).
  704. T.-I.Tsai, S.-T. Li, C.-P. Liu, K. Chen, S. S. Shivatare, C.-W. Lin, S.-F. Liao,C.-W. Lin, T.-L. Hsu, Y.-T. Wu, M.-H. Tsai, M-Y. Lai, N.-H. Lin, C.-Y. Wu,C.-H. Wong, “An effective bacterial fucosidase for glycoprotein remodeling”, ACSChem. Biol., 12 (1), 63-72 (2017).
  705. J.-J.Shie, Y.-C. Liu, J.-C. Hsiao, J.-M. Fang, C.-H. Wong, “A Cell-Permeable andTriazole-forming fluorescence probe for glycoconjugate imaging in live cells”, Chem Comm, 53 (9), 1490-1493 (2017).
  706. W.Yang, D. Punyadarsaniya, R. Lambertz, D. Lee, C.-H. Liang, D. Höper, S. Leist,A. Hernandez-Caceres, J. Stech, M. Beer, C.-Y. Wu, C.-H. Wong, K. Schughart, F.Meng, and G. Herrler, “Mutations during the adaptation of H9N2 avian influenzavirus to the respiratory epithelium of pigs enhance the sialic acid bindingactivity and the virulence in mice”, J. Virol., 91 (8), pii: e02125-16 (2017).
  707. C.-L.Chen, J.-C. Hsu, C.-W. Lin, C.-H. Wang, M.-H. Tsai, C.-Y. Wu, C.-H. Wong, C.Ma, “Crystal structure of a homogeneous IgG-Fc glycoform with the N-glycandesigned to maximize the antibody dependent cellular cytotoxicity”, ACSChem. Biol., 12 (5), 1335-1345 (2017).
  708. A. M.Stax, J.Tuengel, E. Girardi, N. Kitano, L. L.Allan, J. I. Alvarez, V. Li, D. Zheng, W. J. Panenka, C.-H. Wong, S. van Calenbergh, D. M. Zajonc, P. van den Elzen, “Autoreactivity to sulfatideby human invariant NKT cells”, J.Immuno., 199 (1), 97-106 (2017).
  709. T. H. Tseng, T.-W. Lin, C.-Y. Chen, C.-H. Chen,J.-L. Lin, T.-L. Hsu, C.-H. Wong, “Substrate preference and interplay offucosyltransferase 8 and N-acetylglucosaminyltransferases”, J. Am. Chem.Soc., 139 (28), 9431-9434 (2017).
  710. Y.-W. Huang,H.-I. Yang, Y.-T. Wu, T.-L. Hsu, T.-W. Lin, J. Kelly, C.-H. Wong, “Residuescomprising the enhanced aromatic sequon influence protein N-glycosylation efficiency”, J. Am. Chem. Soc., 139 (37), 12947-12955 (2017).
  711. C.-Y. Ting, Y.-W. Lin, C.-Y. Wu, C.-H. Wong,“Design of disaccharide modules for the programmable one-pot synthesis ofbuilding blocks with LacNAc repeats for asymmetric N-glycans”, Asian J. Org.Chem., 6 (12), 1800–1807 (2017).
  712. L.-Y. Huang,S.-C. Wang, T.-J. R. Cheng, C.-H. Wong “Undecaprenyl phosphate phosphataseactivity of undecaprenol kinase regulates the lipid pool in Gram-positivebacteria”, Biochemistry, 56 (40), 5417-5427 (2017).
  713. Y. Kizuka, M. Nakano, Y. Yamaguchi, K. Nakajima, R. Oka, K. Sato, C.-T. Ren, T.-L. Hsu, C.-H. Wong, N. Taniguchi, “An alkynyl-fucose halts hepatoma cell migration andinvasion by inhibiting GDP-fucose-synthesizing enzyme FX, TSTA3”, Cell Chem Biol.,24 (12), 1467-1478 (2017).
  714. R. Andrabi, C.-Y. Su, C.-H. Liang,S.-S. Shivatare, B. Briney, J. E. Voss, S. K. Nawazi, C.-Y. Wu, C.-H. Wong,D. R. Burton, “Glycans function as anchors for antibodies and helpdrive HIV broadly neutralizing antibody development”, Immunity, 47 (3), 524-537(2017).
  715. H.-W. Cheng, R.-J. Chein, T.-J. Cheng, P.-S. Wu,H.-Y. Wu, P.-F. Hung, C.-J. Wang, Y.-L. Hsu, J.-M. Wong, A. Yuan, C.-H. Wong,P.-C. Yang, S.-H. Pan, “2-anilino-4-amino-5-aroylthiazole-type compound AS7128inhibits lung cancer growth through decreased iASPP and p53 interaction”, CancerScience, 109 (3), 832-842 (2018).
  716. C.-P. Liu, T.-I Tsai, T. Cheng, V. S. Shivatare,C.-Y. Wu, C.-Y. Wu, C.-H. Wong, “Glycoengineering of antibody (Herceptin)through yeast expression and in vitro enzymatic glycosylation”, Proc. Nat. Acad. Sci. U.S.A., 115 (4), 720-725 (2018).
  717. S. S.Shivatare, V. S. Shivatare, C.-Y. Wu, C.-H. Wong, “Chemo-enzymatic synthesis of N-glycansfor array development and HIV antibodies profiling”, Journal of VisualizedExperiments, 132, (2018).
  718. W.-S. Wu, W.-C. Cheng, T.-R. Cheng, C.-H. Wong,“Affinity-based screen for inhibitors of bacterial transglycosylase”, J. Am.Chem. Soc., 140 (8), 2752-2755, (2018).
  719. C.-F. Huang, K. S. Liang, T.-L. Hsu, T.-T. Lee,Y.-Y. Chen, S.-M. Yang, H.-H. Chen, S.-H. Huang, W.-H. Chang, T.-K. Lee, P.Chen, K.-E. Peng, C.-C. Chen, C.-Z. Shi, Y.-F. Hu, G. Margaritondo, T.Ishikawa, C.-H. Wong and Y. Hwu, “Free-electron-laser coherent diffractionimages individual drug-carrying liposome particles in solution”, Nanoscale,10 (6), 2820-2824 (2018).
  720. V. S. Shivatare, S. S. Shivatare, C.-C. Lee, C.-H.Liang, K.-S. Liao, Y.-Y. Cheng, G. Saidachary, C.-Y. Wu, N.-H. Lin, P. D. Kwong,D. Burton, C.-Y. Wu, C.-H. Wong, “Unprecedented role of hybrid N-glycans asligands for HIV-1 broadly neutralizing antibodies”, J. Am. Chem. Soc., 140(15), 5202-5210 (2018).
  721. T. Zhou, A. Zheng, U. Baxa, G.-Y. Chuang, I. S.Georgiev, R. Kong, S. O’Dell, S. Shahzad-ul-Hussan, C.-H. Shen, Y. Tsybovsky,R. T. Bailer, S. K. Gift, M. K. Louder, K. McKee, R. Rawi, C. H. Stevenson, G.B. E. Stewart-Jones, J. D. Taft, E. Waltari, Y. Yang, B. Zhang, S. S.Shivatare, V. S. Shivatare, C.-C. D. Lee, C.-Y. Wu, NISC Comparative SequencingProgram, J. C. Mullikin, C. A. Bewley, D. R. Burton, V. R. Polonis, L. Shapiro,C.-H. Wong, J. R. Mascola, P. D. Kwong, and X. Wu, “A neutralizing antibodyrecognizing primarily n-linked glycan targets the silent face of the hivenvelope”, Immunity, 48 (3), 500-513 (2018).
  722. X. Wang, L. Krasnova, K. B. Wu, W.-S. Wu, T.-J. Cheng,C.-H. Wong, “Towards new antibiotics targeting bacterial transglycosylase:synthesis of a lipid II analog as stable transition-state mimic inhibitor”, Bioorg. Med. Chem. Lett. 28 (16), 2708-12 (2018).
  723. P.-W. Lo, J.-J. Shie, C.-H. Chen, C.-Y. Wu, T.-L. Hsu, C.-H. Wong, “ O-GlcNAcylation regulatesthe stability and enzymatic activity of the histone methyltransferase EZH2”, Proc.Nat. Acad. Sci. U.S.A., 115 (28), 7302-7307 (2018).
  724. S. S. Shivatare, L.-Y. Huang, Y.-F. Zeng, J.-Y.Liao, T.-H. You, S.-Y. Wang, T. Cheng, C.-W. Chiu, P. Chao, L.-T. Chen, T.-I.Tsai, C.-C. Huang, C.-Y. Wu, N.-H. Lin, and C.-H. Wong, “Development of Endo-S2mutants for the synthesis of homogeneous antibody glycoforms to elucidateeffector functions”, Chem, Comm., 54 (48), 6161-6164 (2018).
  725. S. Dey and C.-H. Wong, “Programmable one-potsynthesis of heparin pentasaccharides enabling access to regiodefined sulfatederivatives”, Chemical Science, 9 (32), 6685-6691 (2018).
  726. S. Dey, S. O. Bajaj, T.-I. Tsai, H.-J. Lo, K. Wu,and C.-H. Wong, “Synthesis of modularbuilding blocks using glycosyl phosphate donors for the construction of asymmetricN-Glycans”, Tetrahedron, 74 (41), 6003-6011 (2018).
  727. C.-W. Cheng, Y. Zhou, W.-H. Pan, S. Dey, C.-Y. Wu,W.-L. Hsu, and C.-H. Wong, “Hierarchical and programmable one-pot synthesis ofoligosaccharides”, Nature Communications, 9 (1), 5202, (2018)
  728. C.-H. Wong and L. Krasnova, “Highlights in chemicalglycobiology”, Israel Journal of Chemistry, 59, 18-22 (2019).
  729. L. Krasnova and C.-H. Wong, “Oligosaccharide synthesisand translational innovation”, J. Am. Chem. Soc., 141 (9), 3735-54 (2019).
  730. S.-C. Wang, H.-Y. Liao, J.-Y. Zhang, T.-J. R.Cheng, C.-H. Wong, “Development of a universal influenza vaccine usinghemagglutinin stem protein produced from Pichia pastoris”, Virology, 526(2), 125-137 (2019).
  731. P.-K. Chuang, M. Hsiao, T.-L. Hsu, C.-F. Chang,B.-R. Chen, H.-W. Huang, S.-M. Yang, C. W. Kuo, P. Chen, P.-T. Chiu, I.-J.Chen, J.-S. Lai, C.-D. T. Yu, and C.-H. Wong, “Functional study and signaling pathwayof globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5)in breast cancer”, Proc. Nat. Acad. Sci. U.S.A., 116 (9), 3518-23 (2019).
  732. Y.-C. Tseng, C.-Y. Wu, M.-L. Liu, T.-H. Chen, W.-L.Chiang, Y.-H. Yu, J.-T. Jan, K.-I. Lin, C.-H. Wong and C. Ma, “Egg-basedinfluenza split virus vaccine with monoglycosylation induces cross-strainprotection against influenza virus infections”, Proc. Nat. Acad. Sci. U.S.A., 116(10), 4200-05 (2019).
  733. H.-J. Lo, L. Krasnova, S. Dey, T. Cheng, H. Liu,T.-I. Tsai, K. B. Wu, C.-Y. Wu, and C.-H. Wong, “Synthesis ofsialidase-resistant oligosaccharide and antibody glycoform containing α2,6-linked3Fax-Neu5Ac”, J. Am. Chem. Soc., 141 (16), 6484-6488 (2019).
  734. X. Chen,C.-H. Wong, C. Ma, “Targeting the bacterial transglycosylase: antibioticdevelopment from a structural perspective”, ACS Infectious Diseases, 5,1493-1504 (2019).
  735. S. Dey, H.-J. Lo, C.-H. Wong, “An efficient modular one-pot synthesis of heparin-based anticoagulant Idraparinux”, J. Am. Chem. Soc., 141, 10309-10314 (2019).
  736. C.-W. Cheng, Y. Zhou, W.-H. Pan, S. Dey, C.-Y. Wu, W.-L. Hsu, and C.-H. Wong, “Hierarchical and programmable one-pot oligosaccharide synthesis”, J. Vis. Exp.151, e59987. Doi: 10.3791/59987. (2019).
  737. M.-S. Lin,T.-M. Hong, T.-H. Chou, S.-C. Yang, M.-C. Chung, C.-W. Weng, M.-L. Tsai, T.-R. Cheng, J.-J.-W., T.-C. Lee, C.-H. Wong, R.-J. Chein, P.-C. Yang, “4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin”, Eur. J. Med. Chem.181, 111584. PMID  31419740 DOI:  10.1016/j.ejmech.2019.111584. (2019).
  738. M.-R. Huang, Y.-L. Hsu, T.-C. Lin, T.-J. Cheng, L.-W. Li, W.-W. Tseng, Y.-S. Chou, J.-H. Liu, S.-H. Pan, J.-M. Fang, C.-H. Wong, “Structure-guided development of purine amide, hydroxamate, and amidoxime for the inhibition of non-small cell lung cancer”, Eur. J. Med. Chem., 181, 111551. (2019). PMID  31376567 DOI:  10.1016/j.ejmech.2019.07.054.
  739. C.-Y. Lin, H.-Y. Wu, P.-S. Wu, Y.-L. Hsu, T.-J. Cheng, J.-H. Liu, R.-J. Huang, T. H. Hsiao, C.-J. Wang, P.-F. Hung, A. Lan, Y.-J. Chen, S.-H. Pan, R.-J. Chein, C.-H. Wong, P.-C. Yang, “Suppression of drug-resistant non-small-cell lung cancer with inhibitors targeting minichromosomal maintenance protein”, J. Med. Chem. 63, 3172-3187 (2020).
  740. C.-W. Cheng, C.-Y. Wu, W.-L. Hsu, C.-H. Wong, “Programmable One-pot Synthesis of Oligosaccharides”, Biochemistry, 59, 3078-3088 (2020). PMID 31454239 DOI:  10.1021/acs.biochem.9b00613.
  741. L.-T. Chiu, N. Sabbavarapu, W.-C. Lin, C.-Y. Fang, C.-C. Wu, T.-J. Cheng, C.-H. Wong, S.-C. Hung, “Trisaccharide sulfate and its sulfonamide as an effective substrate and inhibitor of human endo-O-sulfatase-1”, J. Am. Chem. Soc., 142, 5282-5292 (2020).
  742. J. Woodring, S.-H. Lu, L. Krasnova, S.-C. Wang, J.-B. Chen, C.-C. Chou, Y.-C. Huang, T.-J. Cheng, Y.-T. Wu, Y.-H. Chen, J.-M. Fang, M.-D. Tsai, C.-H. Wong, “Disrupting the conserved salt bridge in the trimerization of influenza a nucleoprotein”, J. Med. Chem., 63, 205-215 (2020).
  743. C.-F. Huang, W.-H. Chang, T.-K. Lee, Y. Joti, Y. Nishino, T. Kimura, A. Suzuki, Y. Bessho,T.-T. Lee, M.-C. Chen, S.-M. Yang, Y. Hwu, S.-H. Huang, P.-N. Lee, P. Chen, Y.-C. Tseng, C. Ma, T.-L. Hsu, C.-H. Wong, K. Tono, T. Ishikawa, and K. Liang, “XFEL coherent diffraction imaging for weakly scattering particles using heterodyne interference”, AIP Advances, 10, 055219; doi: 10.1063/1.5129406. (2020).
  744. W.-F. Wang, M.-Y. Jade Lu, T.-J. R. Cheng, Y.-C. Tang, Y.-C. Teng, T.-Y. Hwa, Y.-H. Chen, M.-Y. Li, M.-H. Wu, P.-C. Chuang, R. Jou, C.-H. Wong, and W.-H. Li “Genomic analysis of mycobacterium tuberculosis isolates and construction of a beijing lineage reference genome” Genome Biol. Evol., 12, 3890–3905 (2020).
  745. E. A. Wang, W.-Y. Chen, C.-H. Wong, “Multiple Growth Factor Targeting by Engineered Insulin-like Growth Factor Binding Protein-3 Augments EGF Receptor Tyrosine Kinase Inhibitor Efficacy”, Scientific Reports, 10, (2020).
  746. S. Dey, H.-J. Lo, C.-H. Wong, “Programmable One-Pot Synthesis of Heparin Pentasaccharide Fondaparinux”, Org. Lett., 22, 4638−4642 (2020).
  747. Y.-H. Chang, J.-C. Wu, H.-M. Yu, H.-T. Hsu, Y.-T. Wu, A. L.-T. Yu, C.-D. T. Yu and C.-H. Wong, “Design and synthesis of glyco-peptides as anticancer agents targeting thrombin-protease activated receptor-1 interaction”, Chem. Comm. 56, 5827-5830 (2020).
  748. H.-Y. Liao, S.-C. Wang, Y.-A. Koa, K.-I. Lin, C. Ma, T.-J. R. Cheng, and C.-H. Wong, “Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes”, Proc. Natl. Acad. Sci. U.S.A., 117, 17757-17763 (2020).
  749. Y.-M. Liu, M. Shahed-Al-Mahmud, X. Chen, T.-H. Chen, K.-S. Liao, J. M. Lo, Y.-M Wu., M.-C. Ho, C.-Y. Wu, C.-H. Wong, J.-T. Jan, C. Ma, “A carbohydrate-binding protein from the edible Lablab beans effectively blocks the infections of influenza viruses and SARS-CoV-2”, Cell Reports, 32, 107992.
  750. S. Pawar, L. Hsu, T. N. Reddy, M. Ravinder, C.-T. Ren, Y.-W. Lin, Y.-Y. Cheng, T.-W. Lin, T.-L. Hsu, S.-K. Wang, C.-H. Wong, C.-Y. Wu, “Synthesis of asymmetric N-glycans as common core substrates for structural diversification through selective enzymatic glycosylation” ACS Chem. Biol., 15, 2382–2394 (2020).
  751. C.-Y. Wu, H.-Y. Chuang, C.-H. Wong, “Influenza virus neuraminidase regulates host CD8+ T-cell response”, Communications Biology, 3:748 (2020).
  752. S. Shivatare and C.-H. Wong, “Synthetic carbohydrate chemistry and translational medicine”, (Invited Perspective), J. Org. Chem., 85, 15780-15800 (2020).
  753. J.-T. Jan, T.-J. R. Cheng, Y.-P. Juang, H.-H. Ma, Y.-T. Wu, W.-B. Yang, C.-W. Cheng, X. Chen, J.-J. Shie, W.-C. Cheng, R.-J. Chein, S.-S. Mao, P.-H. Liang, C. Ma, S.-C. Hung and C.-H. Wong, “Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection”, Proc. Natl. Acad. Sci. U.S.A., 118, (2020). PMID: 33452205; PMCID: PMC7865145;
  754. V. Gannedi, B. K. Villuri, S. N. Reddy, C.-C. Ku, C.-H. Wong and S.-C. Hung “Practical remdesivir synthesis through one-pot organo-catalyzed asymmetric (s)-p-phosphoramidation”, J. Org. Chem. 86, 4977-85 (2021).
  755. C.-W. Chang, M.-H. Lin, C.-K. Chan, K.-Y. Su, C.-H. Wu, W.-C. Lo, S. Lam, Y.-T. Cheng, P.-H. Liao, C.-H. Wong, C.-C. Wang "Automated Quantification of Hydroxyl Reactivities: Prediction of Glycosylation Reactions", Angew. Chem. Int. Ed. 60, 12413-12423. 10.1002/anie.202013909. (2021).
  756. H.-Y. Liao, H.-Y. Huang, X. Chen, C.-W. Cheng, S.-W. Wang, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, H.-H. Ma, Y.-H. Chang, C.-Y. Tsai, P.-Y. Huang, S.-Y. Chang, T.-L. Chao, H.-C. Kao, Y.-M. Tsai, Y.-H. Chen, C.-Y. Chen, K.-C. Lee, C.-Y. Wu, J.-T. Jan, K.-I. Lin, T.-J. R. Cheng, C. Ma and C.-H. Wong “Impact of glycosylation on SARS-CoV-2 infection and broadly protective vaccine design” bioRxiv. May 25 (2021).
  757. S. S. Shivatare, T.-J. Chen, Y.-Y. Cheng, V. S. Shivatare, T.-I. Tsai, H.-Y. Chaung, C.-Y. Wu and C.-H. Wong “Immunogenicity evaluation of N-glycans recognized by HIV broadly neutralizing antibodies” ACS Chem. Biol. (2021).
  758. R.-H. Lee, Y.-J. Wang, T.-Y. La, T.-L. Hsu, P.-K. Chuang and C.-H. Wong “Combined effect of anti-SSEA4 and anti-Globo H antibodies on breast cancer cells” ACS Chem. Biol. (2021).
  759. Y.-A. Ko ,Y.-H. Yu , Y.-F. Wu, Y.-C. Tseng, C.-L. Chen, K.-S. Goh, H.-Y. Liao, T.-H. Chen, T.-J. R. Cheng, A.-S. Yang, C.-H. Wong, C. Ma , K.-I. Lin “A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells”  PLoS Pathog 17(8): e1009724. (2021).
  760. C.-Y. Chen, Y.-W. Lin, S.-W. Wang, Y.-C. Lin, Y.-Y. Cheng, C.-T. Ren, C.-H. Wong, and C.-Y. Wu “Facial synthesis of Globo H analog glycoconjugates and their immunogenicity studies”, submitted.
  761. C.-W. Lin, Y.-J. Wang, T.-Y. Lai, T.-L. Hsu, S.-Y. Han, H.-C. Wu, C.-N. Shen, V. Dang, M.-W. Chen, L.-B. Chen and C.-H. Wong “Homogeneous antibody and CAR-T cell targeting glycan on pancreatic cancer” Proc. Natl. Acad. Sci. U.S.A. In Press.
  762. Y.-Y. Tseng, J.-M. Liou, W.-C. Cheng, J.-T. Hsu, T.-L. Hsu, M.-S. Wu, C.-H. Wong “Eradication of multidrug-resistant Helicobacter Pylori with moenomycin A in combination with clarithromycin or metronidazole” Submitted.


C.-H. Wong and G. M. Whitesides, “Enzymes in Synthetic Organic Chemistry,” Pergamon Press, 1994.

Famulok, E.-L. Winnacker, C.-H. Wong, “Combinatorial Chemistry in Biology,” Springer-Verlag, Berlin, 1999.

Cornils, W. A. Herrmann, R. Schlögl, C.-H. Wong, “Catalysis from A to Z–A Concise Encyclopedia,” Wiley-VCH, Weinheim, Germany, 1999.

C.-H Wong: “Carbohydrate-based Drug Discovery” Vols. I & II, Wiley-VCH, Weinheim, Germany, 2003.

C.-H. Wong and P. G. Wang, eds. “Carbohydrates, Nucleosides and Nucleic Acids.”  Comprehensive Natural Products II: Chemistry and Biology (“CONAP II”), Vol. 6, 10 vols. Elsevier, Missouri, USA, 2009.

N. Taniguchi, T. Endo, G. W. Hart, P. H. Seeberger,  C.-H. Wong, eds. “Glycoscience: Biology and Medicine”, Springer Japan, 2014.

Book Chapters

  1. K.-T. Wang, C.-H. Wong, “Total synthesis of cobra cardiotoxin,” in  Proceeding of the Fifth American Peptide Symposium, M. Goodman, J. Meienhofer, eds., Wiley, New York, pp 528–531 (1977).
  2. G. M. Whitesides, C.-H. Wong, A. Pollak, “Asymmetric synthesis using cofactor-requiring enzymes,” in  Asymmetric Reactions and Processes in Chemistry, E. L. Eliel and S. Otsuka, eds., ACS Symposium Series, the American Chemical Society, 185, 205–218 (1982).
  3. C.-H. Wong, “Aldolases as catalysts in organic synthesis,” in  Enzymes as Catalysts in Organic Synthesis (Schneider, M. P ed.), D. Reidel Publishing Co., 1986, pp 199–216.
  4. C.-H. Wong, “Nicotinamide cofactor-requiring enzymatic synthesis in organic solvent-water biphasic systems,”  Biocatalysis in Organic Media (C. Laane, ed.), Wageningen, The Netherlands, 1986, pp 197–208.
  5. C.-H. Wong, D. G. Drueckhammer, H. M. Sweers, “Chemoenzymatic synthesis of fluorosugars,”  ACS Symposium Series on Fluorocarbohydrates: Chemistry and Biochemistry (N. F. Tylor, ed.), 1988, pp 29–42.
  6. C.-H. Wong, “Enzyme-catalyzed synthesis of carbohydrates,” in  Trends in Synthetic Carbohydrate Chemistry, ACS Symposium Series 386 (Horton, D.; Hawkins, L. D.; McGarvey, G. J.; eds.), American Chemical Society, Washington, D.C. 1989, pp 317–335.
  7. C.-H. Wong, “Enzymes in organic synthesis: aldol reactions as a route to unusual sugars,” in  Bioproducts and Bioprocesses (A. Fiechter, H. Okada, R. D. Tanner, eds.), Springer-Verlag, 1989, pp 147–154.
  8. J. A. Bibbs, Z. Zhong, C.-H. Wong, “Modification of protease for peptide synthesis,” in Proceedings of symposium on materials synthesis utilizing biological processes, in  Materials Synthesis Utilizing Biological Processes (Rieke, P. C.; Calvert, P. D.; Alper, M. eds.), Materials Research Society, Pittsburgh, Pennsylvania, 1990, pp 223–228.
  9. C.-H. Wong, “Aldolases in organic synthesis,” in  Biocatalysis (Abramowicz, D. ed.) Van Nostrand Reinhold, New York, 1990, p 319.
  10. C.-H. Wong, “Aldolases in synthesis of Fluorosugars,” In: “Selective fluorination in organic and bioorganic chemistry.” Welch, J. T. (ed.),  American Chemical Society Symposium Series 456, American Chemical Society, Washington, D.C., pp 156–162 (1991).
  11. C.-H. Wong, “Microbial aldolases in carbohydrate synthesis,” In  Enzymes in carbohydrate synthesis. Bednarski, M., Simon, E. (eds.),  American Chemical Society Symposium Series, No. 406, American Chemical Society, Washington, D.C., 1991, pp 23–37.
  12. C.-H. Wong, “Engineering enzymes for the synthesis of carbohydrates and peptides” in Harnessing Biotechnology for the 21st Century (M. R. Ladisch, a. Bose, eds.)  ACS Conference Proceedings Series, American Chemical Society, Washington, D.C. 1992, pp 168–171.
  13. C.-H. Wong, Y. Ichikawa, T. Kajimoto, K. K.-C. Liu, Y.-C. Lin, G. C. Look, “Chemical-enzymatic synthesis of carbohydrates” in  Microbial Reagents in Organic Synthesis, (S. Servi, ed.) Kluwer Academic Publishers,  NATO ASI Series , 1992, pp 35–42.
  14. Y. Ichikawa, G. C. Look, G.-J. Shen, P. Sears, P. Wang, C.-H. Wong, “Recent development in enzymatic synthesis of oligosaccharides and glycopeptides” in  Carbohydrates and Carbohydrate Polymers, M. Yalpani, ed., ATL Press, pp 1–16 (1993).
  15. R. L. Halcomb, C.-H. Wong, “Asymmetric synthesis based on enzymes” in  Stereocontrolled Organic Synthesis (B. M. Trost, ed.) IUPAC, Blackwell Scientific Publications, Oxford, England, 1994, p 413.
  16. Y. Ichikawa, C.-H. Wong, “Topochemistry and inhibition of selectin-mediated cell adhesion: Chemical-enzymatic synthesis of inhibitors related to E-selectin recognition” in  The Alfred Benzon Symposium No. 36, Complex Carbohydrates in Drug Research (K. Bock, H. Clausen, P. Krogsgaard-Larsen, H. Kofod), Blackwell Scientific Publications, Oxford, UK, 1994, pp 118–133.
  17. C.-H. Wong, “Topochemistry and inhibition of carbohydrate-mediated cell adhesion” in  New Perspectives in Drug Design, Academic Press, London, 1995, pp 35–50.
  18. R. L. Halcomb, C.-H. Wong, “Enzymatic synthesis of glycoside bonds” in  Handbook of enzyme catalysis in organic synthesis (K. Dranz, H. Waldmann, eds.) VCH, Germany, 1995, pp 279–316.
  19. I. Henderson, C.-H. Wong, “Formation of carbon-carbon bonds” in  Handbook of enzyme catalysis in organic synthesis (K. Dranz, H. Waldmann, eds.) VCH, Germany, 1995, pp 547–580.
  20. C.-H. Wong, “Practical synthesis of oligosaccharides based on glycosyltransferases and glycosylphosphites” in  Modern methods in carbohydrate synthesis, (S. H. Khan, R.A. O’Neill, eds.), Harwood Academic Publishers, Amsterdam, The Netherlands, 1996, pp 467–491.
  21. M. Hendrix, C.-H. Wong, “Enzymatic synthesis of carbohydrates” in  Bioorganic Chemistry: Carbohydrates. (S. M. Hecht, ed.) Oxford University Press, Oxford, 1999, pp 198–243.
  22. K. D. Kreutter, C.-H. Wong, “Enzyme inhibitors” in  Stimulating Concepts in Chemistry (M. Shibasaki, J. F. Stoddart, F. Vogtle eds), Wiley-VCH Verlag GmbH, Weinheim, Germany, pp 355–368 (2000).
  23. Z. Zhang, C.-H. Wong, “Glycosylation methods: use of phosphites” in  Carbohydrates in Chemistry and Biology (B. Ernst, G. W. Hart, P. Sinay, eds), Wiley-VCH Verlag GmbH, Weinheim, Germany, pp 117–134 (2000).
  24. K. M. Koeller, C.-H. Wong, “Recycling of sugar nucleotides in enzymatic glycosylation” in  Carbohydrates in Chemistry and Biology (B. Ernst, G. W. Hart, P. Sinay, eds), Wiley-VCH Verlag GmbH, Weinheim, Germany, pp 663–684 (2000).
  25. T. J. Tolbert, C.-H. Wong, “Glycoprotein synthesis” in  Yearbook of Science & Technology, McGraw-Hill Professional, New York, pp 159–162 (2003).
  26. T. J. Tolbert, C.-H. Wong, “Conjugation of glycopeptide thioesters to expressed protein fragments,” in  Methods in Molecular Biology, C. M. Niemeyer, Ed., Humana Press: Totowa, New Jersey, Vol. 283, pp 255–266, (2004).
  27. T. J. Tolbert, C.-H. Wong, “Subtilisin-catalyzed glycopetide condensation,” in  Methods in Molecular Biology, C. M. Niemeyer, Ed., Humana Press: Totowa, New Jersey, Vol. 283, 267–279, (2004).
  28. C. Scanlan, D. Calarese, H. K. Lee, O. Blixt, C.-H. Wong, I. Wilson, D. Burton, R. Dwek, P. Rudd, “Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design,” in  Glycobiology and Medicine: Proceedings of the 7th Jenner Glycobiology and Medicine Symposium, Advances in Experimental Medicine and Biology, (J. S. Axford, Ed.) Kluwer Academic/Plenum Publishers, Oxford, UK, Volume 564, pp 71-84, (2005).
  29. C.-H. Wong, W. A. Greenberg, “Asymmetric synthesis using Deoxyribose-5-phosphate Aldolase,” in  Asymmetric Synthesis – The Essentials, M. Christmann, S. Brase, ed., Wiley-VCH Verlag GmbH & Co., KGaA, Germany, pp. 217-221, (2007).
  30. C. S. Bennett, R. J. Payne, K. M. Koeller, C.-H. Wong, “Synthesis and applications of biologically relevant glycopeptides,” in  Glycoscience (B. Fraser-Reid, K. Tatsuta, J. Thiem, eds.), Springer-Verlag, pp. 1795-1858, (2008).
  31. W. A. Greenberg, C.-H. Wong, “One-step synthesis of L-fructose using rhamnulose-1-phosphate aldolase in borate buffer” in  From Practical Methods for Biocatalysis and Biotransformations, J. Whittall, P. Sutton, Eds., John Wiley & Sons, Inc., New York, NY, pp. 203-205, (2010).
  32. J.-W. Hsu, H.-C. Huang, S.-T. Chen, C.-H. Wong, H.-F. Juan, “ Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia THP-1 cells via caspase and p53 activation,”  Evidence Based Complementary and Alternative Medicine, Volume 2011, Article ID 358717, 13 pages, (2011).
  33. T.J. Tolbert, C.-H. Wong, “Carbohydrate Chains: Enzymatic and Chemical Synthesis,” in Encyclopedia of Biological Chemistry (William Lennarz, M. Lane, eds), Academia Press, 2013.
  34. C.-Y. Wu, C.-H. Wong “Automated programmable one-pot synthesis of glycans” in  Glycoscience: Biology and Medicine, (N.  Taniguchi, T.  Endo, G. W.  Hart ,   P. H.  Seeberger, C.-H.  Wong, eds.), Springer Japan, 2014, pp. 45-52.
  35. C.-Y. Wu, C.-H. Wong “Vaccines” in   Glycoscience: Biology and Medicine, (N.  Taniguchi, T.  Endo, G. W.  Hart ,   P. H.  Seeberger, C.-H.  Wong, eds.), Springer Japan, 2014, pp. 1529-1508.
  36. C.-Y. Wu, C.-H. Wong “Preparation of glycan array and its applications” in   Glycoscience: Biology and Medicine, (N.  Taniguchi, T.  Endo, G. W.  Hart ,   P. H.  Seeberger, C.-H.  Wong, eds.), Springer Japan, 2014, pp. 35-43.
  37. C.-Y. Wu, C.-H. Wong “Imaging by click chemistry” in   Glycoscience: Biology and Medicine, (N.  Taniguchi, T.  Endo, G. W.  Hart ,   P. H.  Seeberger, C.-H.  Wong, eds.), Springer Japan, 2014, pp. 459-465.
  38. C.-Y. Wu, C.-H. Wong “Automation in glycan synthesis” in  Glycoscience: Biology and Medicine, (N.  Taniguchi, T.  Endo, G. W.  Hart ,   P. H.  Seeberger, C.-H.  Wong, eds.), Springer Japan, 2014, pp. 345-351.
  39. T.-I. Tsai, C.-Y. Wu, C.-H. Wong “Large-scale enzymatic synthesis of glycans with cofactor regeneration” in   Glycoscience: Biology and Medicine, (N.  Taniguchi, T.  Endo, G. W.  Hart ,   P. H.  Seeberger, C.-H.  Wong, eds.), Springer Japan, 2014, pp. 409-417.
  40. C.-H. Wong “Chemo-enzymatic synthesis of glycans: overview” in  Glycoscience: Biology and Medicine, (N.  Taniguchi, T.  Endo, G. W.  Hart ,   P. H.  Seeberger, C.-H.  Wong, eds.), Springer Japan, 2014, pp. 293-294.
  41. C.-H. Wong “Homogeneous glycoproteins: overview” in  Glycoscience: Biology and Medicine, (N.  Taniguchi, T.  Endo, G. W.  Hart ,   P. H.  Seeberger, C.-H.  Wong, eds.), Springer Japan, 2014, pp. 959-962.
  42. C.-H. Wong “Molecular probes for glycosylation: overview” in  Glycoscience: Biology and Medicine, (N.  Taniguchi, T.  Endo, G. W.  Hart ,   P. H.  Seeberger, C.-H.  Wong, eds.), Springer Japan, 2014, pp. 455-457.
  43. C.-H. Wong and Naoyuki Taniguchi “Current status and new challenges in glycoscience: overview” in  Glycoscience: Biology and Medicine, (N.  Taniguchi, T.  Endo, G. W.  Hart ,   P. H.  Seeberger, C.-H.  Wong, eds.), Springer Japan, 2014, pp. 11-14.


  1. G. M. Whitesides, P. F. Mazenod, C.-H. ­Wong, “Preparation of 6-Deoxy-d-Fructose and 6-deoxy-L-Sorbose” US Patent No. 4,440,854 (1­­984).
  2. G. M. Whitesides, P. F. Mazenod, C.-H. ­Wong, “Preparation of 6-Deoxy-d-Fructose and 6-deoxy-L-Sorbose” US Patent No. 4,440,854 (1­­984).
  3. C.-H. Wong, W. J. Hennen, “Process for the enzymatic synthesis of nucleosides” US Patent No. 5075225 (1991).
  4. C.-H. Wong, Y.-F. Wang, W. J. Hennen, “Enantio- and Regioselective Synthesis of Organic Compounds Using Enol Esters as Irreversible Transacylation Reagents” US Patent No, 5106750 (1992).
  5. C.-H. Wong, J. R. Durrwachter, R. L. Pederson, “Fructose-1,6-diphosphate Aldolase Catalyzed Stereoselective Synthesis of Sugars” US Patent No. 5,143,831 (1992).
  6. P.N. Bryan, M. Pantoliano, M. L. Rollence, C.-H. Wong, “Biosynthetic uses of thermostable proteases” US Patent No. 5,116,741 (1992).
  7. C.-H. Wong, “l-Isomeric sugars having formed stereogenic centers of (R)-configuration: Methods and compositions” US Patent No. 5,162,513 (1992).
  8. C.-H. Wong, W. J. Hennen, “2-Deoxy Derivatives of N-Acetyl Neuraminic Acid and Their Preparation” US Patent No. 5,239,091 (1993).
  9. C.-H. Wong, K. K.-C. Liu, “2-Methyl-5-hydroxymethyl and 2,5-dimethyl-3,4-dihydroxypyrrolidines” US Patent No. 5,229,523 (1993).
  10. C.-H. Wong, C. W. Bradshaw, “Lactobacillus kefir alcohol dehydrogenase” US Patent No. 5,225,339 (1993).
  11. C.-H. Wong, G.-J. Shen, Y. Ichikawa, “A method and composition for synthesizing sialylated glycosyl compounds” US Patent No. 5,278,299 (1994).
  12. C.-H. Wong, T. Kajimoto, K. K.-C. Liu, L. Chen, “Process for forming Omega-deoxy-azasugars” US Patent No. 5,276,120 (1994).
  13. C.-H. Wong, K. K.-C. Liu, “Aldolase enzyme process for making 5-azido-5-deoxy-hexulose-1-phosphate” US Patent No. 5,352,591 (1994).
  14. C.-H. Wong, T. Sugai, G.-J. Shen, “KDO aldolase and condensation reactions employed therewith” US Patent No. 5,358,859 (1994).
  15. C.-H. Wong, F. Gaeta, “Combined use of b-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one-pot synthesis of oligosaccharides” US Patent No. 5,374,541 (1994).
  16. C.-H. Wong, M. Schuster, “Process for solid-phase glycopeptide synthesis” US Patent No. 5,369,017 (1994).
  17. C.-H. Wong, G. C. Look, “Enzymatic process for producing a galactosyl b-1,3-glycal disaccharide using b-galactosidase” US Patent No. 5,403,726 (1995).
  18. W. Yuan, C.-H. Wong, B. Samuelsson, “Novel tight-binding inhibitors of leukotriene A4 hydrolase” US Patent No. 5,455,271 (1995).
  19. C. W. Bradshaw, C.-H. Wong, G.-J. Shen, “Pseudomonas sp. ATCC 49794 PED alcohol dehydrogenase” US Patent No. 5,385,833 (1995).
  20. C.-H. Wong, C. W. Bradshaw, “Lactobacillus kefir alcohol dehydrogenase” US Patent No. 5,342,767 (1995).
  21. C.-H. Wong, K. K.-C. Liu, “Fructosyl C-glycoside nucleoside analogs” US Patent No. 5,393,879 (1995).
  22. C.-H. Wong, Y. Ichikawa, “Oligosaccharide enzyme substrates and inhibitors: Methods and composition” US Patent No. 5,461,143 (1995), Australian Patent No. 668505 (1996), Canadian Patent No. 2106301 (1999).
  23. C.-H. Wong, “N-Acetylgalactosaminyl or N-acetylglucosaminyl transfer using N-acetylglucosaminyl-1-phosphate or N-acetylgalactosaminyl-1-phosphate as precursor and glycosyl-nucleotide regeneration” US Patent No. 5, 516, 665 (1996).
  24. C.-H. Wong, Y.-F. Wang, W. J. Hennen, “Enantio- and regio-selective synthesis of organic compounds using enol esters as irreversible transacylation reagents” US Patent No. 5,585,252 (1996).
  25. C.-H. Wong, R. L. Pederson, Y.-F. Wang, “Azido diacetal propane derivatives” US Patent No. 5,565,585 (1996).
  26. C.-H. Wong, W. J. Hennen, “2-Deoxyderivatives of N-acetylneuraminic acid and their preparation” US Patent No. 5,554,771 (1996).
  27. C.-H. Wong, J. R. Durrwachter, R. L. Pederson, “Aldolase catalyzed stereoselective synthesis of arabinohexulose, xyloheptulose, threohexulose and xylohexulose” US Patent No. 5,576,426 (1996).
  28. C.-H. Wong, H. Kondo, “Thio Linked Glycosyl Compounds” US Patent No. 5,514,784 (1996).
  29. C.-H. Wong, H. Kondo, “Carbon Linked Glycosyl Compounds” US Patent No. 5,597,906 (1997).
  30. C.-H. Wong, T. Kajimoto, “Sialyl Lewis X mimetics” US Patent No. 5,599,915 (1997).
  31. C.-H. Wong, “Sialyl Lewis x mimetics incorporating fucopeptides” US Patent No. 5,614,615 (1997).
  32. C.-H. Wong, T. Kajimoto, K. C. Liu, L. Chen, “Omega-deoxy-azasugars” US Patent No. 5,596,005 (1997).
  33. C.-H. Wong, G. C. Look, “A facile enzymatic synthesis of galactosyl-b-1,3-glycals” Australian Patent No. 672029 (1997); Canadian Patent No. 2,139,506 (1998).
  34. C.-H. Wong, Y. Ichikawa, G.-J. Shen, “Oligosaccharide enzyme substrates and inhibitors: methods and compositions” US Patent No. 5,593,887 (1997), US Patent No. 5,759,823 (1998), US Patent No. 6,168,934 (2001), EP0576592 (2000).
  35. C.-H. Wong, “Method for synthesizing 2-ketoaldonic acids” US Patent No. 5,759,825 (1998).
  36. C.-H. Wong, S. Takayama, “Synthesis of 9-0-acetyl N-acetyl-neuraminic acid oligosaccharides” US Patent No. 5,766,887 (1998) C.-H. Wong, T. Hayashi, “Process for preparing nucleoside inhibitors of glycosyltransferases” US Patent No. 5,770,407 (1998).
  37. C.-H. Wong, H. J. M. Gijsen, “Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives” US Patent No. 5,795,749 (1998).
  38. C.-H. Wong, T. G. Marron, T. J. Woltering, G. Weitz-Schmidt, “Sialyl Lewis x mimetics incorporating mannopeptides” US Patent No. 5,837,862 (1998).
  39. C.-H. Wong, F. Moris-Varas, C.-C. Lin, “Inhibitors of E-, P-, and L-selectin binding” US Patent No. 5,830,871 (1998).
  40. C.-H. Wong, H. Kondo, “Glycosylation of peptides using glycosyl phosphite reagents” US Patent No. 5854391 (1998).
  41. C.-H. Wong, T. Kimura, “Transglycosylation reactions employing a-galactosidase” US Patent No. 5,876,981 (1999).
  42. C.-H. Wong, T. Sugai, G.-J. Shen, “Biologically pure culture of aureobacterium barkeri: KDO-37-2” US Patent No. 5, 869,316 (1999).
  43. C.-H. Wong, C.-H. Lin, G.-J. Shen, “One-pot enzymatic sulfation process using 3¢-phosphoadenosine-5¢-phosphosulfate and recycled phosphorylated adenosine intermediates” US Patent No. 5,919673 (1999).
  44. R. A. Lerner, C.-H. Wong, D. L. Boger, S. J. Henriksen, “Inhibitors of oleamide hydrolase” US Patent No. 5,856,537 (1999), US Patent No. 6,096,784 (2000).
  45. C.-H. Wong, C.-C. Lin, T. Kajimoto “Sialyl Lewis X mimetics incorporating fucopeptides” US Patent No. 5,962,660 (1999).
  46. C.-H. Wong, S. Takayama, B. Orsat, W. Moree, “Enantioselective enzymatic protection of amines” US Patent No. 5981267 (1999).
  47. C.-H. Wong, D. Slee, K. Laslo “HIV protease inhibitors” US Patent No. 6900238 (2005). EP0873519 (1999).
  48. C.-H. Wong, C.-C. Lin, T. Woltering “Sialyl Lewis X mimetics incorporating fucopeptides” US Patent No. 5962660 (1999).
  49. C.-H. Wong, Y. Ichikawa, G.-J. Shen, “Production of fucosylated carbohydrates by enzymatic fucosylation; synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose” US Patent No. 6319695B1 (2001), Russian Patent No. 2125092 (1999).
  50. C.-H. Wong, C.-H. Lin, “Ketoaldonic acids having formed stereogenic centers of R configuration: Methods and Compositions” US Patent No. 6,080,563 (2000).
  51. C.-H. Wong, M. Hendrix, P. Alper, S. Priestley “Nucleic acid binders having a hydroxyamine motif” US Patent No. 6,120,997 (2000).
  52. C.-H. Wong, “Inhibition of human fucosyltransferases with N-Linked Lewis-X and LacNAc analogs” U.S. Patent No. 6,232,450 (2001).
  53. C.-H. Wong, M. D. Burkart “Enzymatic sulfation of biomolecules” US Patent No. 6255088 (2001).
  54. C.-H. Wong “Mannosyl transfer with regeneration of GDP-mannose” US Patent No. 6,485,930 (2002).
  55. C.-H. Wong, F. Moris-Varas “Hydroxyazepanes as inhibitors of glycosidases and HIV protease” US Patent No. 6,462,143 (2002); US Patent No. 6,462,193 (2002).
  56. C.-H. Wong, Z. Zhang, I. Ollmann, T. Bassov, X. S. Yeh “Programmable one-pot oligosaccharide synthesis” US Patent No. 6,538,117 (2003), and 7,019,131 (2006).
  57. C.-H. Wong, “Enzymatic synthesis of l-fucose and l-fucose analogs” US Patent No. 6,713,287 (2004).
  58. T. Lee, J. H. Elder, C.-H. Wong “HIV/FIV protease inhibitors with small P3 residues” PCT Patent Application No. PCT/US1998/025964, US Patent No. 6,803,466 (2004).
  59. C.-H. Wong, S. J. Sucheck “Bifunctional antibiotics” US Patent No. 6921810 (2005).
  60. F. W. Okumu, Y. Ichikawa, S.-B. Huang, M. Lotz, Y.-K. Shue, N. K. Orida, C.-H. Wong “Treatment of degenerative cartilage conditions in a mammal with glycosidase inhibitors” US Patent Application No. 10/586,578, European Patent Application No. EP20050706017, Canadian Patent Application No. CA 2553866 (2005).
  61. C.-H. Wong, D. R. Burton, I. A. Wilson “Arrays with cleavable linkers” PCT Patent Application No. PCT/US2005/022517, Australian Patent Application No. 2005258281, Canadian Patent Application No. 2571431, European Patent Application No. 2005789058, Japanese Patent Application No. 2007518318 (2005), Germany Patent Application, US Patent Application No. 11/645,273, US Patent Application No. 11/645,188 (2006).
  62. C.-H. Wong, J. Liu “Iminocyclitol inhibitors of hexoaminidase and glycosidase” US Patent No. 7135578 (2006).
  63. C.-H. Wong, C.-Y. Wu, J.-T. Jan “Anti-coronavirus compounds” US Patent No. 8,481,571 (2013), Taiwan Patent No. I372048 (2012), Chinese Patent No. CN1949977B (2010), New Zealand Patent No. NZ550945 (2010).
  64. Y.-Y Wang, K.-H. Khoo, S.-T. Chen, C.-C. Lin, C.-H. Wong, C.-H. Lin, H.-S. Chen, Y.-F. Tsai “Immuno-modulating antitumor activities of Ganoderma Lucidum (Reishi) polysaccharides” US Patent No. 7,135,183 (2006), US Patent No. 7,323,176 (2008), US Patent No. 7,560,114 (2009), Taiwan Patent No. I281399 (2007).
  65. Brik, Y.-Y. Yang, S. Ficht, R. Payne and C.-H. Wong “Method of preparing glycopeptides” US Patent No. 8,816,050 (2014), European Patent No. 1996609 (2016), Japanese Patent No. 5885378 (2016).
  66. C.-H. Wong, R. Xu, S. R. Hanson, Z. Zhang, Y.-Y. Yang, P. G. Schultz “Site-specific incorporation of mucin-type N-acetylgalactosamine a-O-threonine into protein in E. Coli” US Patent No. 7378263 (2008).
  67. C.-H. Wong, J.-M. Fang, J.-J. Shie, Y.-S. Cheng, J.-T. Jan “Synthesis Of oseltamivir containing phosphonate congeners with anti-influenza activity” US Patent No. 7,888,337 (2011), Chinese Patent No. ZL200880113461.2 (2013), Australian Patent No. 2008292859 (2014), Japanese Patent No. 5509080 (2014), Korean Patent No. 10-1535691 (2015), PCT Patent Application No. PCT/US2008/074914 (2008), Canadian Patent No. 2697837 (2016), European Patent No. EP2190439 (2016).
  68. C.-H. Wong, C.-Y. Wu, C.-C. Wang, Alice L. Yu “Cancer diagnosis based on levels of antibodies against Globo-H and its fragments” Chinese Patent No. CN102066940B (2015), European Patent No. 2307887B1 (2014), Hong Kong Patent No. HK1153273 (2014), Australian Patent No. 2009271411(2013), Japanese Patent No. 5216139 (2013), Korean Patent No. 10-1324109 (2013), Mexican Patent No. 315453 (2013), New Zealand Patent No. 590064 (2012), US Patent No. 8,158,367 (2012), Indian Patent Application No. 201738034602 (2017), Mexican Patent Application No. MX/a/2014/004316 (2014), PCT Patent Application No. PCT/US09/47532 (2009), Canadian Patent No. CA 2,728,574 (2020), Indian Patent Application No. 184/KOLNP/2011 (2009).
  69. C.-H. Wong, C.-Y. Wu, A. Yu, J. Yu “Globo H and related anti-cancer vaccines with novel glycolipid adjuvants” Canadian Patent No. 2728341 (2019), Chinese Patent No. CN105535955B (2019), Mexican Patent No. 350230 (2017), Indian Patent No. 314985 (2019), Japanese Patent No. 6151319 (2017), US Patent No. 9,603,913B2 (2017), Taiwan Patent No. I583393 (2017), Hong Kong Patent No. HK1153645 (2017).European Patent No. EP2310047A1 (2016), Chinese Patent No. ZL200980122743.3 (2016), Korean Patent No. 10-1677279 (2016), Australian Patent No. 2014201215 (2016), US Patent No. 9,028,836 B2 (2015), Japan Patent No. 5795655 (2015), Japanese Patent No. 5628158 (2014), Australian Patent No. 2009269127 (2014), Mexican Patent No. 319370 (2014), Taiwan Patent No. I392502 (2013), New Zealand Patent No. 590140 (2012), US Patent No. 8,268,969 (2012).
  70. M. Tsuji, D. D. Ho, C.-H. Wong, D. Wu, M. Fujio, X. Li “Glycolipids and analogues thereof as antigens for NKT cells” US Patent No. 8,586,051 (2013), US Patent No. 8,163,290 (2012), US Patent No. 7,923,013 (2011), US Patent No. 7,534,434 (2009).
  71. C.-H. Wong, A. Yu, Y.-J. Chang, K.-H. Lin, J.-T. Hung “Alpha-galactosyl ceramide analogs and their use as immunotherapies”, Korean Patent No. 10-1755526 (2017), Indian Patent No. 302381 (2018), Canadian Patent No. CA 2,756,053 (2018), Australian Patent No. 2009268381 (2016), Philippines Patent No. 1-2011-500318 (2016), European Patent No. EP2320947 (2015), Chinese Patent No. ZL200980138107.X (2015), Indonesia Patent No. IDP000038138 (2015), South Africa Patent No. 2011/01128 (2014), UK Patent No. GB2461656 (2012), Singapore Patent No. 168917 (2012), US Patent No. 7,928,077 (2011).
  72. C.-H. Wong, C.-Y. Wu, S. Y. Tseng, “Glycan arrays on PTFE-like aluminum coated glass slides and related methods” US Patent No. 10,274,488 (2019), Japanese Patent No. 6475673 (2019), Japanese Patent No. 5986745 (2016), US Patent No. 8,680,020 (2014), European Patent No. EP2318832 (2013), US Patent Application No. 16/365,579 (2019).
  73. K.-F. Hua, H.-Y. Hsu, C.-H. Wong “Methods and compositions associated with administration of an extract of Ganoderma lucidum” US Patent No. 7,687,064 (2009).
  74. T.-R. Tu, C.-F. Li, S.-H. Su, C.-H. Wong, E. Fan “Compositions and methods for treating psoriasis by Ganoderma lucidum (Reishi) polysaccharides” US Patent No. 7,947,283 (2011).
  75. T.-R. Tu, C.-F. Li, S.-H. Su, C.-H. Wong, E. Fan “Compositions and methods for treating allergies, auto-immune diseases, and improving skin condition by Ganoderma lucidum (Reishi) polysaccharides” US Patent No. 7,785,600 (2010).
  76. C.-H. Wong, S.-L. Hsieh, T.-L. Hsu, S.-C. Cheng, S.-T. Chen “Methods and reagents for the analysis and purification of polysaccharides” US Patent No. 7998482 (2011), US Patent No. 7,943,134 (2011), Taiwan Patent No. I333959 (2010).
  77. C.-H. Wong, C.-Y. Wu “Methods for modifying human antibodies by glycan engineering” US Patent No. 10,087,236 (2018), US Patent Application No. 16/150,190 (2018), US Patent Application No. 16/150,164 (2018).
  78. C.-H. Wong, C.-Y. Wu “Alpha-selective sialyl phosphate donors for preparation of sialosides and sialoside arrays for influenza virus” European Patent No. 2411528 (2015), US Patent No. 8,507,660 (2013).
  79. C.-H. Wong, C. Ma, C.-C. Wang, J.-R. Chen “Methods and compositions for immunization against virus” US Patent No. 10307475B2 (2019), US Patent No. 8,741,311 (2014), Australian Patent No. 2016203431 (2018), Chinese Patent No. ZL201080022917.1 (2017), Korean Patent No. 10-1793195 (2017), Israel Patent No. 215430 (2017), Chile Patent No. 55277 (2017), Australian Patent No. 2010229675 (2016), Colombia Patent No. 30288 (2016), Taiwan Patent No. I510247 (2015), Mexican Patent No. 327466 (2015), US Patent Application No. 16/431,099 (2019), Korean Patent Application No. 10-2017-7031207 (2010), Israel Patent Application No. 248607 (2010), PCT Patent Application No. PCT/US10/28968 (2010), European Patent No. EP 2411049 (2020), Canadian Patent Application No. CA 2,756,206 (2010), Brazil Patent Application No. BR PI10126350 (2010), Chinese Patent Application No. 201710696137.9 (2017), Hong Kong Patent Application No. 18106115.7 (2018).
  80. S.-M. Liang, Y.-P. Chen, W.-B. Yang, C.-H. Wong “Reishi F3 sub fraction polysaccharides and methods of using same” US Patent No. 8,071,105 (2011).
  81. C.-H. Wong, E. Fan, H.-Y. Hsu, T.-R. Tu, W.-C. Lin, C.-F. Li, S.-T. Weng, W.-T. Wang “Reishi polysaccharide-based compositions and methods for treatment of cancer” Taiwan Patent No. I606835 (2017), PCT Patent Application No. PCT/US2011/033831 (2011).
  82. C.-H. Wong, C. A. Ma, Y.-C. Tseng “Methods for producing virus particles with simplified glycosylation of surface proteins” US Patent No. 9,920,347 (2018), US Patent No. 9,403,878 B2 (2016), Australian Patent No. 2016204276 (2018), Australian Patent No. 2011323141 (2016), Korean Patent No. 10-1927421 (2018), Japanese Patent No. 6166178 (2017), Russian Patent No. 2607452 (2017), Mexican Patent No. 349530 (2017), Taiwan Patent No. I537385 (2016), Colombian Patent No. 30832 (2016), Chinese Patent Application No. 201711437066.7 (2017), Mexican Patent Application No. MX/a/2017/009717 (2017), Japanese Patent No. 6773513 (2020), Korean Patent No. 10-2156209 (2020), PCT Patent Application No. PCT/US 2011/59449 (2011), Israel Patent No. 226143 (2020), EP Patent No. 2635693 (2020), Chinese Patent Application No. 201180063980.4 (2011), Chile Patent No. 59812 (2020), Canadian Patent Application No. 2854619 (2011), Brazil Patent Application No. BR 1120130111984 (2011).
  83. C.-H. Wong, C.-Y. Wu, C.-H. Liang, A.-S. Yang “Glycan arrays for high throughput screening of viruses” US Patent No. 10,338,069 (2019), US Patent Application No. 16/458,986 (2019), PCT Patent Application No. PCT/US2011/32192 (2011).
  84. C.-H. Wong, J.-M. Fang, J.-J. Shie, Y.-S. Cheng “Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses” US Patent No. 9,874,562 B2 (2018), US Patent No. 9,403,855 (2016), Korean Patent No. 101915647 (2018), Chinese Patent No. ZL 201510157505.3 (2018), European Patent No. 2975409 (2018), Australian Patent No. 2011250970 (2017), Korean Patent No. 10-1745386 (2017), Japanese Patent No. 5947289 (2016), Chinese Patent No. ZL 201180034218.3 (2016), European Patent No. 2568976 (2015), Canadian Patent No. 2,835,489 (2018), PCT Patent Application No. PCT/US2011/35982 (2011).
  85. C.-H. Wong, Y.-T. Wu “Compounds and methods for treating tuberculosis infection” US Patent No. 9,073,941 (2015).
  86. C.-H. Wong, T.-L. Hsu, S. Hanson, Masaaki Sawa “Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells” US Patent No. 10,317,393 (2019), US Patent No. 7,960,139 (2011), US Patent Application No. 16/415,411 (2019), US Patent No. 9,816,981 (2017).
  87. C.-H. Wong, T.-L. Hsu, S. Hanson “Tailored glycoproteomic methods for the sequencing, mapping and identification of cellular glycoproteins” US Patent No. 7,943,330 (2011).
  88. P.-H. Liang, Y.-L. Lin, C.-H. Wong “Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis therapeutics” US Patent No. 8,273,788 (2012), US Patent No. 7,919,521 (2011).
  89. C.-H. Wong, T.-L. Hsu, S. Hanson, M. Sawa “Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo” US Patent No. 8,329,413 (2012), US Patent No. 7,910,319 (2011).
  90. D. Ho, Y. Hung, M.-W. Chen, R. T. J. Cheng, C.-H. Wong, A. Yu “Flu vaccines and methods of use thereof” Taiwan Patent No. I403518 (2013), US Patent No. 7,981,428 (2011), US Patent No. 8,030,029 (2011).
  91. S.-L. Hsieh, C.-H. Wong, T.-L. Hsu, S.-T. Chen “Compositions and methods for identifying response targets and treating flavivirus infection responses” Chinese Patent No. ZL200880129343.0 (2014), Taiwan Patent No. I403586 (2013), US Patent No. 8460669 (2013), US Patent No. 7943134 (2011), UK Patent Application No. PI 0822472-2 (2014), EP Patent Application No. 08 873 539.4 (2014), Indian Patent Application No. 7325/DELNP/2010 (2014).
  92. C.-H. Wong, Y.-S. Cheng, H.-M. Yu, T.-J. Cheng, C.-Y. Wu, J.-M. Fang “Compositions and methods for treating inflammation and inflammation-related disorders by Plectranthus amboinicus extract” US Patent No. 8,105,636 (2012).
  93. C.-H. Wong, Alice L. Yu , W.-B. Yang, E. Fan, H.-Y. Hsu, P. Lee T.-R. Tu, C.-C. Hung “Hirsutella sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses” US Patent No. 8,486,914 (2013).
  94. C.-H. Wong, P.-H. Liang “Quantitative microarray of intact glycolipid CD1d interaction and correlation with cell-based cytokine production” US Patent No. 8,383,554 (2013).
  95. C.-H. Wong, J.-M. Fang, W.-B. Yang, T.-J. R. Cheng, Y. S.-Y. Hsieh, C. Chien, C.-C. Lin, H.-Y. Wen “Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense” Taiwan Patent No. I488636 (2015), US Patent No. 8,354,127 (2013).
  96. Yu, J. Yu, K.-I. Lin, W.-B. Yang, C.-H. Wong “Fungal immunostimulatory compositions” US Patent No. US 8,906,380 B2 (2014), Taiwan Patent No. I386220 (2013).
  97. C.-H. Wong, J.-M. Fang, Y.-S. E. Cheng, C.-S. Tsai “Cell-permeable probes for identification and imaging of sialidases” US Patent No. 10,214,765 (2019), US Patent No. 9,914,956 B2 (2018), EP Patent No. EP 2885311 (2020), Japanese Patent No. 6302909 (2018), PCT Patent Application No. PCT/US2013/55472 (2013).
  98. C.-H. Wong, J.-M. Fang, J.-J. Shie “Benzocyclooctyne compounds and uses thereof” US Patent No. 9,547,009 (2017), Japanese Patent No. 6211084 (2017), PCT Patent Application No. PCT/US2013/56018 (2013), EP Patent Application No. 13830785.5 (2013).
  99. C.-H. Wong, J.-M. Fang, K.-C. Liu, J.-T. Jan, T.-J. R. Cheng, Y.-S. E. Cheng “Enhanced anti-influenza agents conjugated with anti-inflammatory activity” Israel Patent No. 235117 (2019), US Patent No. 9,914,956 (2018), Chinese Patent No. ZL201380030579.X (2018), Australian Patent No. 2013245756 (2018), Japanese Patent No. 6174117 (2017), PCT Patent Application No. PCT/US2013/36308 (2013), Mexican Patent No. 369397 (2019), Korean Patent No. KR 10-2195657 5 (2020), EP Patent No. EP 2841066 (2021), Canadian Patent Application No. 2,870,335 (2013), Japanese Patent Application No. 2021-122971 (2021).
  100. C.-H. Wong, T.-I. Tsai, C.-Y. Wu “Large scale enzymatic synthesis of oligosaccharides” Australian Patent No. 2018200094 (2019), Japanese Patent No. 6462756 (2019), Hong Kong Patent No. 1207668 (2019), Canadian Patent No. 2882294 (2019), Chinese Patent No. ZL 201380044460.8 (2018), Australian Patent No. 2016206315 (2018), Australian Patent No. 2013305937 (2016), Japanese Patent No. 6125637 (2017), Taiwan Patent No. I573876 (2017), Taiwan Patent No. I567200 (2017), Taiwan Patent No. I563092 (2016), Taiwan Patent No. I563091 (2016), Taiwan Patent No. I510627 (2015), US Patent No. 9,340,812 (2016), Korean Patent No. 10-1685628 (2016), Australian Patent No. 2019203313 (2020), Hong Kong Patent Application No. 18113821.8, 18113820.9, 18113822.7, 18113819.2, 18113818.3 (2018), Chinese Patent Application No. 201810425413.2, 201810425113.4, 201810425034.3 (2018), Chinese Patent No. ZL201810425064.4 (2021), Chinese Patent No. ZL201810424957.7 (2021), Japanese Patent No. 6647382 (2020), US Patent Application No. 15/003,362 (2016), PCT Patent Application No. PCT/US2013/55731(2013), Indian Patent Application No. 365/DELNP/2015 (2013), EP Patent Application No. EP 13 830306.0 (2013), Japanese Patent Application No. 2020-003624 (2020), Canadian Patent No. 3052909 (2019).
  101. C.-H. Wong, T.-J. Cheng, C. Ma, W.-C. Cheng “Antibiotic compositions and related screening methods” US Patent No. 8,916,540 B2 (2014).
  102. C.-H. Wong, P.-H. Liang “Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants” US Patent No. 8,906,832 B2 (2014), US Patent Application No. 14/565,323 (2014).
  103. F. H. Arnold, C.-H. Wong, Y. Mitsuda, M. M. Yu Chen, C. Bennett, W. Greenberg, J. C. Lewis, S. Bastian, “Methods and compositions for preparation of selectively protected carbohydrates” US Patent No. 8,802,401 (2014).
  104. C.-H. Wong, C.-Y. Wu, C.-H. Wang, S.-T. Li “Glycan conjugates and use thereof” US Patent No. 9981030 (2018), EP Patent No. EP 3013347 (2019), PCT Patent Application No. PCT/US2014/044740 (2014).
  105. C.-H. Wong, C.-Y. Wu, H.-Y. Chuang, C.-T. Ren “RM2 antigens and use thereof” EP Patent No. 3013365 (2019), US Patent No. 10,086,054 B2 (2018), PCT Patent Application No. PCT/US2014/044465 (2014).
  106. C.-H. Wong, C.-Y. Wu, H.-Y. Hsu, S.-F. Liao, C.-H. Liang “Antibody-mediated anti-tumor activity induced by Reishi mushroom polysaccharides” Taiwan Patent No. I599370 (2017), PCT Patent Application No. PCT/US2014/48325 (2014), US Patent No. 10,307,470 (2019).
  107. C.-H. Wong, A. Yu, K.-H. Lin, T.-N. Wu “Human iNKT cell activation using glycolipids with altered glycosyl groups” Japanese Patent No. 6486368 (2019), Israel Patent No. 244326 (2019), US Patent No. 10,111,951 B2 (2018), US Patent No. 9,782,476 B2 (2017), Korean Patent Application No. 10-2016-7008727 (2014), EP Patent No. 3041484 (2021), Chinese Patent No. ZL201480049320.4 (2021), Canadian Patent Application No. 2923579 (2014), PCT Patent Application No. PCT/US14/054617 (2014), Australian Patent No. 2014317889 (2020), US Patent No. 10,918,714 (2021).
  108. C.-H. Wong, Y.-W. Lou, C.-W. Lin, S.-C. Yeh, T.-L. Hsu, C.-Y. Wu, Han-Chung Wu, “Compositions and methods for treatment and detection of cancers” US Patent No. 9,982,041 (2018), US Patent No. 9,975,965 B2 (2018), US Patent No. 10,150,818 (2018), US Patent Application No. 16/184,203 (2018), US Patent Application No. 15/989,860 (2018), PCT Patent Application No. PCT/US2016/015856 (2016), PCT Patent Application No. PCT/US15/11748 (2015), PCT Patent Application No. PCT/US15/040,199 (2015), Chinese Patent No. ZL 201580004867.7 (2020), Chinese Patent No. ZL 201580073451.0 (2021), EP Patent No. 3094352 (2020), EP Patent No. 3245225 (2021), .
  109. C.-H. Wong, J.-M. Fang, J.-J. Shie “Reactive labelling compounds and uses thereof” Japanese Patent No. 6562942 (2019), US Patent No. 10,119,972 B2 (2018), US Patent No. 9,759,726 B2 (2017), Japanese Patent No. 6884177 (2021), PCT Patent Application No. PCT/US2015/022977 (2015), Taiwan Patent No. I687428(2020), Chinese Patent No. ZL 201580016671.X (2020), EP Patent Application No. 15770237.4 (2015), Taiwan Patent Application No. 109107959 (2020).
  110. C.-H. Wong, C.-Y. Wu, Ming-Hung Tsai “Anti-CD20 glycoantibodies and uses thereof” Taiwan Patent No. I670078 (2019), PCT Patent Application No. PCT/US15/32740 (2015), US Patent Application No. 14/723,020 (2015), US Patent Application No. 17/211,619 (2021), Japanese Patent Application No. 2016-569717 (2015), Chinese Patent Application No. 201580027984.5 (2015), EP Patent Application No. 15799789.1 (2015), Australian Patent Application No. 2015267047 (2015), Australian Patent Application No. 2021200784 (2021), Canadian Patent Application No. 2950415 (2015), Korean Patent Application No. 10-2016-7036516 (2015), Israel Patent Application No. 249186 (2015).
  111. C.-H. Wong, C.-Y. Wu “Anti-HER2 glycoantibodies and uses thereof” US Patent No. 10,005,847 B2 (2018), PCT Patent Application No. PCT/US2015/32738 (2015), Taiwan Patent No. I679020 (2019), Japanese Patent Application No. 2106-569745 (2015), Chinese Patent Application No. 201580027983.0 (2015), EP Patent Application No. 15800387.1 (2015), Australian Patent Application No. 2015267045 (2015), Canadian Patent Application No. 2950440 (2015), Korean Patent Application No. 10-2016-7036523 (2015), Israel Patent Application No. 249188 (2015), US Patent No. 10,618,973, Japanese Patent Application No. 2020-131843 (2020).
  112. C.-H. Wong, C.-Y. Wu “Anti-TNF-alpha glycoantibodies and uses thereof” PCT Patent Application No. PCT/US2015/32737 (2015), US Patent Application No. 14/722,775 (2015), Taiwan Patent No. I732738 (2021), Japanese Patent Application No. 2016-569732 (2015), Chinese Patent Application No. 201580027936.6 (2015), EP Patent Application No. 15800059.6 (2015), Australian Patent Application No. 2015267044 (2015), Canadian Patent Application No. 2950433 (2015), Korean Patent Application No. 10-2016-7036499 (2015), Israel Patent Application No. 249184 (2015), Japanese Patent Application No. 2020-131845 (2020).
  113. C.-H. Wong, T.-I. Tsai “Fucosidase from bacteroides and methods using the same” PCT Patent Application No. PCT/US2015/032744 (2015), US Patent Application No. 14/722,612 (2015), Taiwan Patent No. I717319 (2021), Japanese Patent Application No. 2016-569720 (2015), Chinese Patent Application No. 201580027982.6 (2015), EP Patent No. 3149161 (2021), EP Patent Application No. 21162500.9 (2015), Australian Patent Application No. 2015267051 (2015), Canadian Patent Application No. 2950577 (2015), Korean Patent Application No. 10-2016-7036507 (2015), Israel Patent No. 249183 (2021), Japanese Patent Application No. 2020-123040 (2020).
  114. C.-H. Wong, C.-Y. Wu, H.-Y. Lee “Novel glycan conjugates and use thereof” Korean Patent No. 10-2003138 (2019), US Patent No. 10155823B2 (2018), Japanese Patent No. 6401380 (2018), Canadian Patent No. 2959030 (2018), Australian Patent No. 2015305332 (2018), New Zealand Patent No. 729243 (2018), Taiwan Patent No. I587871 (2017), Chinese Patent No. ZL 201580045205.4 (2020), EP Patent No. 3183262 (2020), Mexican Patent No. 382791 (2021), Indian Patent No. 337688 (2020), PCT Patent Application No. PCT/US15/46197 (2015).
  115. C.-H. Wong, A. Yu, K.-H. Lin, T.-N. Wu “Human iNKT cell activation using glycolipids” US Patent No. 9,879,042 B2 (2018), US Patent No. 10,533,034 (2020), PCT Patent Application No. PCT/US2015/049014 (2015), Australian Patent No. 2015315294 (2020), Japanese Patent Application No. 2017-513138 (2015), Chinese Patent Application No. 201580048074.5 (2015), EP Patent Application No. 15839183.9 (2015), Canadian Patent Application No. 2960712 (2015), Korean Patent Application No. 10-2017-7009106 (2015), Israel Patent Application No. 250957 (2015), Taiwan Patent Application No. 104129739 (2015).
  116. C.-H. Wong, C.-Y. Wu, “Novel glycan conjugates and methods of use thereof” US Patent No. 10,342,858 (2019), Chinese Patent No. ZL 201580074177.9 (2019), PCT Patent Application No. PCT/US2015/46420 (2015), Taiwan Patent No. I736523 (2021), Japanese Patent No. 6779887 (2020), Australian Patent Application No. 2015378564 (2015), Australian Patent Application No. 2021200283(2021), Canadian Patent Application No. 2972072 (2015), EP Patent Application No. 3248005  (2020), Israel Patent Application No. 253161 (2015), Korean Patent Application No. 10-2017-7023508 (2015) , US Patent Application No. 16/502,844 (2019), Japanese Patent Application No. 2020-104476 (2020), EP Patent Application No. 20204837.7 (2020).
  117. C.-H. Wong, C.-Y. Wu, C. Ma, “Compositions and methods relating to universal glycoforms for enhanced antibody efficacy” Taiwan Patent No. I654202 (2019), US Patent No. 10,023,892 B2 (2018), US Patent No. 10,118,969 B2 (2018), US Patent Application No. 16/018,400 (2018), PCT Patent Application No. PCT/US2016/015858 (2016), Australian Patent No. 2016211176 (2021), Canadian Patent Application No. 2973886 (2016), Chinese Patent Application No. CN 201680008450.2 (2016), EP Patent Application No. 16744256.5 (2016), Japanese Patent Application No. 2017-540167 (2016), Korean Patent Application No. 10-2017-7024323 (2016), Israel Patent Application No. 253497 (2016), Taiwan Patent No. I717333 (2021), Japanese Patent No. 6894239 (2021), Canadian Patent Application No. 2950423 (2015), Korean Patent Application No. 10-2016-7036488 (2015), Israel Patent Application No. 249195 (2015), PCT Patent Application No. PCT/US2015/032745 (2015), Chinese Patent Application No. 201580027960.X (2015), EP Patent Application No. 15799981.4 (2015), Australian Patent Application No. 2015267052 (2015), Australian Patent Application No. 2021200644 (2021), Japanese Patent Application No. 2019-231775 (2019) .
  118. C.-H. Wong, C.-Y. Wu, Sarah K.-C. Cheung, P.-K. Chuang, T.-L. Hsu, “Cancer markers and methods of use thereof” PCT Patent Application No. PCT/US2016/014771 (2016), US Patent No. 10,495,645 (2019), EP Patent No. 3248013 (2020), Taiwan Patent No. I710571 (2020), Japanese Patent Application No. 2017-538630 (2016), Japanese Patent Application No. 2021-036533 (2021), Chinese Patent No. ZL 201680006858.6 (2020), Chinese Patent Application No. 202010870629.7 (2020), Australian Patent No. 2016209056 (2021), Canadian Patent Application No. 2972731 (2016), Korean Patent Application No. 10-2017-7023545 (2016), Israel Patent Application No. 253160 (2016), US Patent Application No. 16/698,529 (2019).
  119. C.-H. Wong, T.-J. Cheng, R.-J. Chein, P.-C. Yang, S.-H. Pan, “4, 9-Dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxamide derivatives and uses thereof for treating proliferative diseases and infectious diseases” PCT Patent Application No. PCT/US17/19964 (2017), US Patent Application No. 16/081,490 (2017), Taiwan Patent No. I722106 (2021), Chinese Patent Application No. 201780013241.1 (2017).
  120. C.-H. Wong, T.-J. Cheng, J.-M. Fang, P.-C. Yang, S.-H. Pan, L.-W. Li, “Purine compounds possessing anticancer activity” PCT Patent Application No. PCT/US2017/016453 (2017), US Patent No. 10,765,681 (2020), Taiwan Patent No. I722106 (2021) Chinese Patent Application No. 201780009107.4 (2017).
  121. C.-H. Wong, C.-Y. Wu, Sachin S Shivatare, “Methods for modular synthesis of N-glycans and arrays thereof” US Patent No. 10,336,784 (2019), PCT Patent Application No. PCT/US2017/021454 (2017), Taiwan Patent Application No. 106107652 (2017), Australian Patent Application No. 2017231749 (2017), Canadian Patent Application No. 3016170 (2017), Chinese Patent Application No. 201780027439.5 (2017), EP Patent Application No. 17764050.5 (2017), Israel Patent Application No. 261517 (2017), Japanese Patent Application No. 2018-547330 (2017), Korean Patent Application No. 10-2018-7028421 (2017).
  122. C.-H. Wong, C.-Y. Wu, “Recombinant virus, composition comprising the same, and uses thereof” PCT Patent Application No. PCT/US17/60510 (2017), US Patent Application No. 16/348,421 (2017), Taiwan Patent Application No. I725253 (2021), Taiwan Patent Application No. 110109141 (2021), EP Patent Application No. 17870305.4 (2017), Japanese Patent Application No. 2019-524087 (2017), Korean Patent Application No. 10-2019-7014670 (2017), Canadian Patent Application No. 3042447 (2017), Israel Patent Application No. 266526 (2017), Indian Patent Application No. 201927018133 (2017), Chinese Patent Application No. 201780068958.6 (2017).
  123. C.-H. Wong, C.-Y. Wu, N.-H. Lin, C.-C. Huang, L.-Y. Huang, Sachin S. Shivatare, T. Cheng, L.-T Chen, “Endoglycosidase mutants for glycoprotein remodeling and methods of using it” US Patent No. 10,000,747 (2018), US Patent No. 10,407,673 (2019), PCT Patent Application No. PCT/US2017/048252 (2017), EP Patent Application No. 17844364.4 (2017), Israel Patent Application No. 264873 (2017), Indian Patent Application No. 201927010495 (2017), Korean Patent No. 10-2166120 (2020), Chinese Patent Application No. 201780051835.1 (2017), Canadian Patent Application No. 20173034876 (2017), Australian Patent No. 20170315677 (2021), Taiwan Patent No. I706035 (2020), Japanese Patent Application No. 2019-531870 (2017).
  124. C.-H. Wong, C. Ma, T.-J. Cheng, W.-C. Cheng “Crystal structure of bifunctional transglycosylase pbp1b from E. coli and inhibitors thereof” US Patent No. 9,890,111 B2 (2018).
  125. N.-H. Lin, C.-C. Huang, C.-Y. Chen, K.-C. Chu, C.-H. Wong, H.-C. Wu, “Antibodies, binding fragments, and methods of use” US Patent No. 10,538,592 (2020), EP Patent Application No. 17844307.3 (2017), Israel Patent Application No. 264795 (2017).
  126. H.-J. Lo, C.-H. Wong, “Sialidase-resistant saccharide and method of making and using the same” PCT Patent Application No. PCT/US20/14608 (2020), Taiwan Patent Application No. 109111324 (2020).
  127. C.-H. Wong, H.-Y. Liao, S.-C. Wang, Y.-A. Ko, K.-I. Lin, C. Ma, T.-J. Cheng, “Chimeric influenza vaccines” PCT Patent Application No. PCT/US2021/031406 (2021), Taiwan Patent Application No. 110116591 (2021).
  128. S.-C. Hung, C.-H. Wong, T.-J. Cheng, “Compounds and methods for treating osteoarthritis” Taiwan Patent Application No. 110106062 (2021), Japanese Patent Application No. 2021-026160 (2021), US Patent Application No. 17/182,156 (2021).
  129. S.-C. Hung, C.-H. Wong, V. Gannedi, B. K. Villuri, N. S. Reddy, C.-C. Ku, “One-pot diastereoselective synthesis of Remdesivir” US Patent Application No. 63/089,028 (2020).
  130. S.-C. Hung, C.-H. Wong, J.-T. Jan, T.-J. Cheng, C. Ma, R.-J. Chein, W.-B. Yang, Y.-T. Wu, P.-H. Liang, “Methods for treating SARS-COV-2 infection” US Patent Application No. 63/119,573 (2020).
  131. C. Ma, C.-H. Wong, H.-Y. Huang, “Monoglycosylated spike vaccine for SARS-CoV-2 and its variants of concern” US Patent Application No. 63/190,199 (2021).



Professor Wong's CV

Research Interests

Lab Members