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Scripps Laboratories for tRNA Synthetase Research

My Vo, Ph.D.


Photo of My Vo

B.S., Biochemistry, Washington State University, 1996
Ph.D., Chemistry, University of Minnesota, 2007

Current Research Focus:
The NH2-terminal catalytic fragment of human tyrosyl-tRNA synthetase (mini-TyrRS) has been shown to regulate angiogenesis. My research is focused on understanding the mechanism of pro-angiogenic function of mini-TyrRS.

Mitra, M., Wang, W., Vo, M.-N., Rouzina, I., Barany, G., and Musier-Forsyth, K. (2013). The N-terminal zinc finger and flanking basic domains represent the minimal region of the human immunodeficiency virus type-1 nucleocapsid protein for targeting chaperone function. Biochemisty 52: 8226-8236.

Vo, M.-N., Yang, X.-L., and Schimmel, P. (2011).  Dissociating quaternary structure regulates cell-signaling functions of a secreted human tRNA synthetase. J. Biol. Chem. 286: 11563-11568.

Vo, M.-N., Barany, G., Rouzina, I., and Musier-Forsyth, K. (2009). Effect of Mg2+ and Na+ on the nucleic acid chaperone activity of HIV-1 nucleocapsid protein: Implications for reverse transcription. J. Mol. Biol. 386: 773-788.

Vo, M.-N., Barany, G., Rouzina, I., and Musier-Forsyth, K. (2009). HIV-1 nucleocapsid protein switches the pathway of transactivation response element RNA/DNA annealing from loop-loop “kissing” to “zipper”. J. Mol. Biol. 386: 789-801 .

Stewart-Maynard, K. M., Cruceanu, M., Wang, F., Vo, M.-N., Gorelick, R. J., Williams, M. C., Rouzina, I., and Musier-Forsyth, K. (2008). Retroviral nucleocapsid proteins display nonequivalent levels of nucleic Acid chaperone activity. J. virol. 82: 10129-10142.

Liu, H. W., Zeng, Y., Landes, C. F., Kim, Y. J., Zhu, Y., Ma, X., and Vo, M.-N., Musier-Forsyth, K., and Barbara, P. F. (2007). Insights on the role of nucleic acid/protein interactions in chaperoned nucleic acid rearrangements of HIV-1 reverse transcription. Proc. Natl. Acad. Sci. U. S. A. 104: 5261-5267.

Vo, M.-N., Barany, G., Rouzina, I., and Musier-Forsyth, K. (2006).  Mechanistic studies of Mini-TAR RNA/DNA annealing in the absence and presence of HIV-1 nucleocapsid protein. J. Mol. Biol. 363: 244-261.

Bhattacharya, N., Dufour, J. M., Vo, M.-N., Okita, J., Okita, R., and Kim, K. H. (2005).  Differential effects of pthalates In the testis and liver.  Biology of Reproduction 72: 745-754.

Dufour, J. M.*, Vo, M.-N.*, Bhattacharya, N., Okita, J., Okita, R., and Kim, K. H.  (2003). Peroxisome proliferators discrupt retinoic acid receptor alpha signaling in the testis. Biology of Reproduction 68: 1215-1224. (* These authors contributed equally to this work).

Glozak,, M. A., Li, Y., Reuille, R., Kim, K. H., Vo, M.-N., and Rogers, M. B. (2003). Trapping and characterization of novel retinoid response elements.  Molecular Endocrinology 17: 27-41.

Braun, K. W., Vo, M.-N., and Kim, K. H.  (2002). Positive regulation of retinoic acid receptor alpha by protein kinase C and mitogen-activated protein kinase in sertoli cells.  Biology of Reproduction 67: 29-37.

Akmal, K., Dufour, J. M., Vo, M.-N. and Kim, K. H. (1998).  Ligand-dependent regulation of retinoic acid receptor alpha in rat testis:  in vivo response to depletion and repletion of vitamin A.  Endocrinology 139: 1239-1248.

Academic Honors:
NIH Howard Hughes Undergraduate Research Fellowship, 1995-1996
NIH Chemistry/Biochemistry Interface Pre-doctoral Training Grant, 2003-2005


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