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Scripps Laboratories for tRNA Synthetase Research

Haissi Cui, Ph.D.


Haissi Cui

2016 PhD/Postdoctoral Fellow, Technical University of Munich, Chair of Biochemistry, Germany
2014 PhD (Dr. rer. nat.), University Hospital Klinikum rechts der Isar, Institute of Molecular Immunology and Experimental Oncology, Germany
2011 M.Sc. Biochemistry, Technical University of Munich, Germany
2009 B.Sc. Biochemistry, Technical University of Munich, Germany

Current Research Focus:
Elucidating novel functions of ArgRS.

Cui H*, Baur R*, Le Chapelain C, Dubiella C, Heinemeyer W, Huber EM, Groll M (2017) Structural Elucidation of a Nonpeptidic Inhibitor Specific for the Human Immunoproteasome. Chembiochem 18: 523–526.

Dubiella C*, Cui H*, Groll M (2016) Tunable Probes with Direct Fluorescence Signals for the Constitutive and Immunoproteasome. Angew Chem Int Ed Engl 55: 13330–13334.

Dubiella C, Baur R, Cui H, Huber EM, Groll M (2015) Selective Inhibition of the Immunoproteasome by Structure-Based Targeting of a Non-catalytic Cysteine. Angew Chem Int Ed Engl 54: 15888–15891.

Beck P*, Cui H*, Hegemann JD, Marahiel MA, Krüger A, Groll M (2015) Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation. ChemMedChem 10: 1969–1973. 

Kobuch J, Cui H, Grünwald B, Saftig P, Knolle PA, Krüger A (2015) TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice. Haematologica 100: 1005–1013.

Cui H, Seubert B, Stahl E, Dietz H, Reuning U, Moreno-Leon L, Ilie M, Hofman P, Nagase H, Mari B, et al. (2015) Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes. Oncogene 34: 3640–3650.

Seubert B*, Cui H*, Simonavicius N, Honert K, Schäfer S, Reuning U, Heikenwalder M, Mari B, Krüger A (2015) Tetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization. Int J Cancer 136: 2304–2315.

Dubiella C, Cui H, Gersch M, Brouwer AJ, Sieber SA, Krüger A, Liskamp RMJ, Groll M (2014) Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site. Angew Chem Int Ed Engl 53: 11969–11973.

Seubert B*, Grünwald B*, Kobuch J*, Cui H*, Schelter F, Schaten S, Siveke JT, Lim NH, Nagase H, Simonavicius N, et al. (2015) Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice. Hepatol Baltim Md 61: 238–248.

Stein ML, Cui H, Beck P, Dubiella C, Voss C, Krüger A, Schmidt B, Groll M (2014) Systematic comparison of peptidic proteasome inhibitors highlights the α-ketoamide electrophile as an auspicious reversible lead motif. Angew Chem Int Ed Engl 53: 1679–1683.

Cui H*, Grosso S*, Schelter F, Mari B*, Krüger A* (2012) On the Pro-Metastatic Stress Response to Cancer Therapies: Evidence for a Positive Co-Operation between TIMP-1, HIF-1α, and miR-210. Front Pharmacol 3: 134.

Hoesl MG, Larregola M, Cui H, Budisa N (2010) Azatryptophans as tools to study polarity requirements for folding of green fluorescent protein. J Pept Sci  16: 589–595.

* Authors contributed equally.


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