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The Riewald Laboratory


Schuepbach RA, Madon J, Ender M, Galli P, Riewald M: Protease activated receptor-1 cleaved at R46 mediates cytoprotective effects. J Thromb Haemost, 10:1675-84, 2012

Schuepbach RA, Velez K, Riewald M. Activated protein C upregulates procoagulant tissue factor activity on endothelial cells by shedding TFPI's Kunitz 1 domain. Blood, 117:6338-46, 2011

Schuepbach RA, Riewald M. Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor. J Thromb Haemost, 8:379-88, 2010

Schuepbach RA, Feistritzer C, Fernandez JA, Griffin JH, Riewald M. Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1. Thromb Haemost 101:724-733, 2009

Riewald M. Thrombin and activated protein C: integrated to regulate vascular physiology. In: Thrombin: Physiology and Disease. Margoudakis ME, Tsopanoglou NE (Eds.), Springer, New York, NY, 2009. p. 63-80

Mosnier LO, Zampolli A, Kerschen EJ, Schuepbach RA, Banerjee Y, Fernandez JA, Yang XV, Riewald M, Weiler H, Ruggeri ZM, Griffin JH. Hyper anti-thrombotic, non-cytoprotective Glu149Ala-activated protein C mutant. Blood 113:5970-5978, 2009

Schuepbach RA, Feistritzer C, Brass LF, Riewald M. Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin. Blood 111:2667-2673, 2008

Riewald M, Schuepbach RA. Protective signaling pathways of activated protein C in endothelial cells. Arterioscler Thromb Vasc Biol 28:1-3, 2008

Feistritzer C, Schuepbach RA, Mosnier LO, Bush LA, Di Cera E, Griffin JH, Riewald M. Protective signaling by activated protein C is meachnistically linked to protein C activation on endothelial cells. J Biol Chem 281:20077-84, 2006

Feistritzer C, Lenta R, Riewald M. Protease-activated receptors-1 and -2 can mediate endothelial barrier protection: role in factor Xa signaling. J Thromb Haemost 12:2798-805, 2005

Feistritzer C, Riewald M. Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood 105:3178-3184, 2005

Riewald M, Ruf W. Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling. J Biol Chem 280:19808-19814, 2005

Feistritzer C, Mosheimer BA, Kaneider NC, Riewald M, Patsch JR, Wiedermann CJ. Thrombin affects eosinophil migration via protease-activated receptor-1. Int Arch Allergy Immunol 135:12-16, 2004

Riewald M , Ruf W: Role of coagulation protease cascades in sepsis. Crit Care 7:123-129, 2003

Ruf W, Riewald M: Tissue factor-dependent coagulation protease signaling in acute lung injury. Crit Care Med 31:S231-S237, 2003

Ruf W, Dorfleutner A, Riewald M: Specificity of coagulation factor signaling. J Thromb Haemost 1:1495-1503, 2003

Riewald M , Ruf W: Coagulation factors and PAR activation. Drug Dev Res 59:400-407, 2003

Riewald M, Petrovan RJ, Donner A, Ruf W: Activated protein C signals through the thrombin receptor PAR1 in endothelial cells. J Endotoxin Res 9:317-321, 2003

Riewald M , Ruf W: Orchestration of coagulation protease signaling by tissue factor. Trends Cardiovasc Med 12:149-154, 2002

Riewald M , Petrovan RJ, Donner A, Mueller BM, Ruf W: Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296:1880-1882, 2002

Riewald M , Kravchenko VV, Petrovan RJ, O’Brien PJ, Brass LF, Ulevich RJ, Ruf W: Gene induction by coagulation factor Xa is mediated by activation of PAR-1. Blood 97:3109-3116, 2001

Riewald M , Ruf W: Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci 98:7742-7747, 2001

Ruf W, Fischer EG, Huang HY, Miyagi Y, Ott I, Riewald M, Mueller BM: Diverse functions of protease receptor tissue factor in inflammation and metastasis. Immunol Res 21:289-292, 2000

Fischer EG, Riewald M, Huang HY, Miyagi Y, Kubota Y, Mueller BM, Ruf W: Tumor cell adhesion and migration supported by interaction of a receptor-protease complex with its inhibitor. J Clin Invest 104:1213-1221, 1999

Riewald M , Chuang T, Neubauer A, Riess H, Schleef RR: Expression of bomapin, a novel human serpin, in normal/malignant hematopoiesis and in the monocytic cell lines THP-1 and AML-193. Blood 91:1256-1262, 1998

Riewald M, Riess H. Treatment options for clinically recognized disseminated intravascular coagulation. Semin Thromb Hemost 24:53-59, 1998

Weisbach V, Putzo A, Zingsem J, Riewald M, Zimmermann R, Eckstein R, Riess H: Leukocyte depletion and storage of single-donor platelet concentrates. Vox Sang 72:20-25, 1997

Riewald M , Morgenstern KA, Schleef RR: Identification and characterization of the cytoplasmic antiproteinase (CAP) in human platelets. Evidence for the interaction of CAP with endogenous platelet proteins. J Biol Chem 271:7160-7167, 1996

Riewald M , Schleef RR: Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues. J Biol Chem 271:14526-14532, 1996

Riewald M , Hintz G, Ritter M, Schmidt M, Neubauer A, Riess H: High sensitivity and specificity of a coagulation assay for the detection of hetero- and homozygous factor V Leiden-based resistance to activated protein C. Blood 88:4398-4399, 1996

Riewald M , Schleef RR: Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow. J Biol Chem 270:26754-26757, 1995