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  1. Santucci, R.A., Erlich, J., Labriola, J., Wilson, M., Kao, K.J., Kickler, T.S., Spillert, C., Mackman, N. Measurement of tissue factor activity in whole blood. Thromb. Haemost. 83:445-454, 2000.
  2. Krikun,G., Schatz, F., Mackman, N., Guller, S., Demopoulos, R., Lockwood, C.J. Regulation of tissue factor gene expression in human endometrium by transcription factors Sp1 and Sp3. Mol. Endocrinol. 14:393-400, 2000.
  3. Yan, S.F., Lu, J., Zou, Y.S., Kisiel, W., Mackman, N., Leitges, M., Steinberg, S., Pinsky, D., Stern, D. Protein kinase C-beta and oxygen deprivation. A novel egr-1-dependent pathway for fibrin deposition in hypoxemic vasculature. J. Biol. Chem. 273:11921-11928, 2000.
  4. Xie, P., Browning, D.D., Hay, N., Mackman, N., Ye, R.D. Activation of NF-κB by bradykinin through a Gαq and Gβγ-dependent pathway that involves phosphoinositide 3-kinase and Akt. J. Biol. Chem. 275:24907-24914, 2000.
  5. Liu, R., O'Connell, M.A., Johnson, K., Pritzker, K., Mackman, N., Terkeltaub, R. Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor κB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. Arthritis Rheum. 43: 1145-1155, 2000.
  6. Dechend, R., Homuth, V., Wallukat, G., Kreuzer, J., Park, J.K., Theuer, J., Juepner, A., Gulba, D.C., Mackman, N., Haller, H., Luft, F.C. AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor. Circulation 101(20): 2382-2387, 2000.
  7. Parry, G.C., Mackman, N. Mouse embryogenesis requires the tissue factor extracellular domain but not the cytoplasmic domain. J.Clin.Invest. 105(11): 1547-1554, 2000.
  8. Yan, S.F., Lu, J., Xu, L., Zou, Y.S., Tongers, J., Kisiel, W., Mackman, N., Pinsky, D.J., Stern, D.M. Pulmonary expression of early growth response-1: biphasic time course and effect of oxygen concentration. J. Appl. Physiol.88(6): 2303-2309, 2000.
  9. Mueller, D.N., Mervaala, E.M., Dechend, R., Fiebeler, A., Park, J.K., Schmidt, F., Theuer, J., Breu, V., Mackman, N., Luther, T., Schneider, W., Gulba, D., Ganten, D., Haller, H., Luft, F.C. Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy. Am. J. Pathol. 157(1): 111-122, 2000.
  10. Luther, T., Dittert, D.D., Kotzsch, M., Erlich, J.H., Albrecht, S., Mackman, N., Müller, M. Functional implications of tissue factor localization to cell-cell contacts in myocardium. J.Pathol. 192(1): 121-130, 2000.
  11. Erlich, J.H., Boyle, E.M., Labriola, J., Kovacich, C., Santucci, R.A., Fearns, C., Morgan, E.N., Yun, W., Luther, T., Kojikawa, O., Martin, T.R., Pohlman, T.H., Verrier, E.D., Mackman, N. Inhibition of the tissue factor-thrombin pathway limits infarct size after myocardial ischemia-reperfusion injury by reducing inflammation. Am.J.Pathol. 157(2):1849-1862, 2000.
  12. Arbibe, L., Mira, J.P., Teusch, N., Kline, L., Guha, M., Mackman, N., Godowski, P.J., Ulevitch, R.J., Knaus, U.G. Toll-like receptor 2-mediated NF-κB activation requires a Rac1-dependent pathway. Nat.Immunol. 1(6):533-540, 2000.
  13. Yan, S.-F., Fujita,T., Lu, J., Okada, K., Xu, L., Zou, Y.S., Mackman, N., Pinsky, D.J., Stern, D.M. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat.Med. 6(12):1355-1361, 2000.
  14. Yan, S.F., Pinsky, D.J., Mackman, N., Stern, D.M. Egr-1: is it always immediate and early? J.Clin.Invest. 105:553-554, 2000.
  15. Mackman, N. LPS induction of gene expression in human monocytic cells. Immunol.Res. 21: 199-203, 2000.
  16. Marx, N., Mackman, N., Schönbeck, U., Yilmaz, N., Hombach, V., Libby, P., Plutzky, J. PPAR activators inhibit tissue factor expression and activity in human monocytes. Circulation, 103:213-219, 2001.
  17. Nishibe, T., Parry, G., Ishida, A., Aziz, S., Murray, J., Patel, Y., Rahman, S., Strand , K., Saito, K., Saito, Y., Hammond , W.P., Savidge, G.F., Mackman, N., Wijelath, E.S. Oncostatin M promotes biphasic tissue factor expression in smooth muscle cells: Evidence for Erk-1/2 activation. Blood, 97:692-699, 2001.
  18. Guha, M., Mackman, N. LPS induction of gene expression in human monocytes. Cell Signal, 13:85-94, 2001.
  19. Mackman, N . Gene targeting in hemostasis. Tissue factor. Front.Biosci. 6:d208-215, 2001.
  20. Guha, M., O’Connell, M.A., Pawlinski, R., Hollis, A., McGovern, P., Yan, S.-F., Stern, D., and Mackman, N. LPS activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and TNFα expression by inducing Elk-1 phosphorylation and Egr-1 expression. Blood, 98:1429-1439, 2001.
  21. Luther, T., Mackman, N. Tissue factor in the heart. Multiple roles in hemostasis, thrombosis and inflammation. Trends in Cardiovasc. Med., 11:307-312, 2001.
  22. Melis, E., Moons, L., De Mol, M., Herbert, J-M., Mackman, N., Collen, D., Carmeliet, P., Dewerchin, M. Normal development and survival of mice with deletion of the cytosolic domain of tissue factor.Biochem.Biophys.Res.Commun., 286:580-586, 2001.
  23. Pendurthi, U.R., Meng, F., Mackman, N., and Rao, V.M. Mechanism of resveratrol-mediated tissue factor gene expression. Thromb. Haemost. 87:155-162, 2002.
  24. Bavendiek, U., Libby, P., Kilbride, M., Reynolds, R., Mackman, N., Schonbeck, U. Induction of tissue factor expression in human endothelial cells via CD40 ligand is mediated by AP-1, NF-κB, and Egr-1. J.Biol.Chem. 277:25032-25039, 2002.
  25. Guha, M., Mackman, N. The PI3K-Akt pathway limits LPS activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J.Biol.Chem. 277:32124-32132, 2002.
  26. Pawlinski, R., Fernandes, A., Kehrle, B., Pedersen, B., Parry, G., Erlich, J., Pyo, R., Gutstein, D., Zhang, J., Melis, E., Carmeliet, P., Baretton, G., Luther, T., Taubman, M., Rosen, E., Mackman, N. Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction. Proc. Natl. Acad. SciUSA 99:15333-15338, 2002.
  27. Pawlinski, R., Pedersen, B., Kehrle, B., Aird, W.C., Frank, R.D., Guha, M., Mackman, N. Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model. Blood 101:3940-3947, 2003.
  28. Isermann, B., Sood, R., Pawlinski, R., Zogg, M., Kalloway, S., Degen, J.L., Mackman, N., Weiler, H. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat. Med. 9:331-337, 2003.
  29. Cramer, T., Yamanishi, Y., Clausen, B.E., Förster, I. , Pawlinski, R., Mackman, N., Haase, V.H., Jaenisch, R., Corr, M., Firestein, G., Gerber, H.P., Ferrara , N., Johnson, R.S. HIF-1α is essential for myeloid cell-mediated inflammation. Cell 112:645-657, 2003.
  30. Bea, F., Puolakkainen, M.H., McMillen, T., Hudson , F.N., Mackman, N., Chou Kuo, C., Campbell , L.A. , Rosenfeld , M.E. Chlamydia pneumoniae induces tissue factor expression in mouse macrophages via activation of Egr-1 and the MEK-ERK1/2 pathway. Circ. Res. 92:394-401, 2003.
  31. Chong, A.J., Pohlman, T.H., Hampton , C.R., Shimamoto, A., Mackman, N., Verrier, E.D. Tissue factor and thrombin mediate myocardial ischemia-reperfusion injury. Ann. Thorac. Surg. 75:S649-S655, 2003.
  32. Mackman, N. The role of the tissue factor-thrombin pathway in cardiac ischemic-reperfusion injury. Semin. Vasc. Med. 3:193-198, 2003.
  33. Mackman, N . How do oxidized phospholipids inhibit LPS signaling? Arterioscler. Thromb. Vasc. Biol. 23:1133-1136, 2003.
  34. Marsik, C., Graininger, M., Mackman, N., Osterud, B., Luther, T., Jilma, B. Effects of enalapril on disseminated intravascular thrombin formation during systemic inflammation. Cardiovasc. Res. 60:131-135, 2003.
  35. Marsik, C., Quehenberger, P., Mackman N., Osterud, B., Luther, T., Jilma, B. Validation of a novel tissue factor assay in experimental human endotoxemia. Thromb Res. 2003;111(4-5):311-5, 2003.
  36. Tenno, T., Oberg, F., Mackman, N., Nilsson, K., Siegbahn, A. PML/RARalpha plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells. Thromb. Haemost.90:930-939, 2003.
  37. Pawlinski, R., Pedersen, B., Schabbauer, G., Tencati, M., Holscher, T., Boisvert, W., Andrade-Gordon, P., Frank, R.D., Mackman, N. Role of tissue factor and protease activated receptors in a mouse model of endotoxemia.Blood 103:1342-13472004.
  38. Pawlinski, R., Mackman, N. Tissue factor, coagulation proteases, and protease-activated receptors in endotoxemia and sepsis. Crit. Care. Med. 32:S293-7, 2004.
  39. Reddy, K. Veera, Bhattacharjee, G., Schabbauer, G., Hollis, A., Kempf, K., Tencati, M., O’Connell, M., Guha, M., Mackman, N. Dexamethasone enhances LPS induction of tissue factor expression in human monocytic cells by increasing tissue factor mRNA stability. J. Leukocyte Biol. 76:145-151, 2004.
  40. Mackman, N. Role of tissue factor in hemostasis, thrombosis and vascular development. Arterioscler. Thromb. Vasc. Biol. 24(6):1015-1022, 2004.
  41. Schabbauer, G., Tencati, M., Pedersen, B., Pawlinski, R., Mackman, N. PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice. Arterioscler. Thromb. Vasc. Biol. 2004, In press.
  42. Chou, J., Mackman, N., Merrill-Skoloff, G., Pedersen, B., Furie, B.C., Furie, B. Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation. Blood, In press.


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