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The Leman Lab


Frenkel-Pinter, M.; Haynes, J. W.; Mohyeldin, A. M.; C, M.; Sargon, A. B.; Petrov, A. S.; Krishnamurthy, R.; Hud, N. V.; Williams, L. D.; Leman, L. J. "Mutually stabilizing interactions between proto-peptides and RNA." Nat. Commun. 2020, 11, 3137.

Chen, P. B.; Black, A. S.; Sobel, A. L.; Zhao, Y.; Mukherjee, P.; Molparia, B.; Moore, N. E.; Aleman Muench, G. R.; Wu, J.; Chen, W.; et al. "Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis." Nat. Biotechnol. 2020.

Frenkel-Pinter, M.; Samanta, M.; Ashkenasy, G.; Leman, L. J. "Prebiotic peptides: Molecular hubs in the origin of life." Chem. Rev. 2020, 120, 4707-4765.

Frenkel-Pinter, M.; Haynes, J. W.; Martin, C.; Petrov, A. S.; Burcar, B. T.; Krishnamurthy, R.; Hud, N. V.; Leman, L. J.; Williams, L. D. "Selective incorporation of proteinaceous over nonproteinaceous cationic amino acids in model prebiotic oligomerization reactions." Proc. Natl. Acad. Sci. U. S. A. 2019, 116, 16338-16346.

Mukherjee, P.; Leman, L. J.; Griffin, J. H.; Ghadiri, M. R. "Design of a DNA-programmed plasminogen activator." J. Am. Chem. Soc. 2018, 140, 15516-15524.

Beierle, J. M.; Ura, Y.; Ghadiri, M. R.; Leman, L. J. "Templated self-assembly of dynamic peptide nucleic acids." Biochemistry 2018, 57, 160-172. 

Zhao, Y.; Leman, L. J.; Search, D. J.; Garcia, R. A.; Gordon, D. A.; Maryanoff, B. E.; Ghadiri, M. R. "Self-assembling cyclic D,L-alpha-peptides as modulators of plasma HDL function. A supramolecular approach toward antiatherosclerotic agents." ACS Cent. Sci. 2017, 3, 639-646.

Maolanon, A. R., Kristensen, H. M. E., Leman, L. J., Ghadiri, M. R., and Olsen, C. A. Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes. ChemBioChem. 2017, 18, 5-49.

Leman, L. J. and Ghadiri, M. R. "Potentially Prebiotic Synthesis of α-Amino Thioacids in Water." Synlett 2017, 28, 68-72.

Leman, L. J., Huang, Z.-Z., and Ghadiri, M. R. "Peptide bond formation in water mediated by carbon disulfide." Astrobiology 201515, 709-716.

Leman, L. J. "The potential of apolipoprotein mimitic peptides in the treatment of atherosclerosis." Clin. Lipidol. 201510, 215-217.

Zhao, Y., Black, A. S., Bonnet, D. J., Maryanoff, B. E., Curtiss, L. K., Leman, L. J., and Ghadiri, M. R. "In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I." J. Lipid Res. 2014, epub ahead of print, DOI: 10.1194/jlr.M049262

Leman, L. J., Maryanoff, B. E., and Ghadiri, M. R. "Molecules That Mimic Apolipoprotein A-I: Potential Agents for Treating Atherosclerosis." J. Med. Chem. 201457, 2169-2196.

Zhao, Y., Imura, T., Leman, L. J., Curtiss, L. K., Maryanoff, B. E., and Ghadiri, M. R. "Mimicry of High-Density Lipoprotein: Functional Peptide-Lipid Nanoparticles Based on Multivalent Peptide Constructs.J. Am. Chem. Soc. 2013135, 13414-13424.

Vickers, C. J., Olsen, C. A., Leman, L. J., and Ghadiri, M. R. "Discovery of HDAC inhibitors that lack an active site Zn2+-binding functional group." ACS Med. Chem. Lett. 2012, ASAP article.

Hutt, D. M., Olsen, C. A., Vickers, C. J., Herman, D., Chalfant, M., Montero, A., Leman, L. J., Burkle, R., Maryanoff, B. E., Balch, W. E., and Ghadiri, M. R. "Potential agents for treating cystic fibrosis: Cyclic tetrapeptides that restore trafficking and activity of ΔF508-CFTR." ACS Med. Chem. Lett. 2011, 2, 703-707.

Ura, Y., Beierle, J. M., Leman, L. J., Orgel, L. E., and Ghadiri, M. R. "Self-assembling sequence-adaptive peptide nucleic acids." Science 2009, 325, 73-77.

Ura, Y., Al-Sayah, M., Montenegro, J., Beierle, J. M., Leman, L. J., and Ghadiri, M. R. "Dynamic polythioesters via ring-opening polymerization of 1,4-thiazine-2,5-diones." Org. Biomol. Chem. 2009, 7, 2878-2884.

Huang, Z.-Z., Leman, L. J., and Ghadiri, M. R. "Biomimetic catalysis of diketopiperazine and dipeptide syntheses." Angew. Chem., Int. Ed. 2008, 47, 1758-1761.

Leman, L. J., Weinberger, D. A., Huang, Z.-Z., Wilcoxen, K. M., and Ghadiri, M. R. "Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering." J. Am. Chem. Soc. 2007, 129, 2959-2966. PMCID: PMC2453064

Wilcoxen, K. M., Leman, L. J., Weinberger, D. A., Huang, Z.-Z., and Ghadiri, M. R. "Biomimetic catalysis of intermodular aminoacyl transfer." J. Am. Chem. Soc. 2007, 129, 748-749.

Yadav, M. K., Leman, L. J., Price, D. J., Brooks, C. L., III, Stout, C. D., and Ghadiri, M. R. "Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution." Biochemistry 2006, 45, 4463-4473.

Leman, L. J., Orgel, L. E., and Ghadiri, M. R. "Amino acid dependent formation of phosphate anhydrides in water mediated by carbonyl sulfide." J. Am. Chem. Soc. 2006, 128, 20-21.

Yadav, M. K., Redman, J. E., Leman, L. J., Alvarez-Gutierrez, J. M., Zhang, Y., Stout, C. D., and Ghadiri, M. R. "Structure-based engineering of internal cavities in coiled-coil peptides." Biochemistry 2005, 44, 9723-9732.

Leman, L., Orgel, L., and Ghadiri, M. R. "Carbonyl sulfide-mediated prebiotic formation of peptides." Science 2004, 306, 283-286.