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The Krishnamurthy Lab

Research in our group is focused on the use of synthetic organic chemistry and methodology to

  • experimentally address questions concerning the origins of life with respect to the advent of functional monomers and the emergence of informational polymers.
  • fashion artificial informational polymers in order to expand the interface between synthetic nucleic acids and the natural biopolymers (proteins and RNA/DNA).
  • make available novel molecular tools that may provide new avenues for probing biological systems and for research in synthetic biology.
  • make available diverse novel molecules and intermediates that would be useful in chemical therapeutics.

                       Group Members (May 2019)



Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions


The Depsipeptide route to Peptides in a Prebiotic Scenario



Speaking to the Synthetic Organic Chemists


Synlett 2017 Cover


An Alternative Paradigm to the Emergence of RNA

RNA is a Destination and not a Destiny