105. Mukherjee, P., Leman, L.J., Griffin, J.H., and Ghadiri, M.R. "Design of a DNA-Programmed Plasminogen Activator". J. Am. Chem. Soc. 2018, 140, 15516-15524.
104. Beierle, J.M., Ura, Y., Ghadiri, M.R., and Leman, L.J. "Templated Self-Assembly of Dynamic Peptide Nucleic Acids." Biochemistry 2018, 57, 160-172.
103. Lai, J.-I., Leman, L.J., Ku, S., Vickers, C.J., Olsen, C.A., Montero, A., Ghadiri, M.R., and Gottesfeld, J.M. "Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells." Bioorg. Med. Chem. Lett. 2017, 27, 3289-3293.
102. Zhao, Y., Leman, L. J., Search, D. J., Garcia, R. A., Gordon, D. A., Maryanoff, B. E., and Ghadiri, M. R. "Self-Assembling Cyclic D,L-a-Peptides as Modulators of Plasma HDL Function. A Supramolecular Approach toward Antiatherosclerotic Agents." ACS Cent. Sci. 2017, 3, 639-646.
101. Malins, L. R., deGruyter, J. N., Robbins, K. J., Scola, P. M., Eastgate, M. D., Ghadiri, M. R., and Baran, P. S. Peptide macrocyclization inspired by non-ribosomal imine natural products. J. Am. Chem. Soc. 2017, 139, 5233-5241.
100. Maolanon, A. R., Kristensen, H. M. E., Leman, L. J., Ghadiri, M. R., and Olsen, C. A. "Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes." ChemBioChem 2017, 18, 5-49.
99. Leman, L. J. and Ghadiri, M. R. Potentially prebiotic synthesis of α-amino thioacids in water. Synlett 2017, 28, 68-72.
98. Leman, L. J., Huang, Z.-Z., and Ghadiri, M. R. Peptide Bond Formation in Water Mediated by Carbon Disulfide. Astrobiology 2015, 15, 709-716.
97. Zhao, Y., Black, A. S., Bonnet, D. J., Maryanoff, B. E., Curtiss, L. K., Leman, L. J., and Ghadiri, M. R. "In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I." J. Lipid Res. 2014, 55, 2053-2063.
96. Leman, L. J., Maryanoff, B. E., and Ghadiri, M. R. "Molecules That Mimic Apolipoprotein A-I: Potential Agents for Treating Atherosclerosis." J. Med. Chem. 2014, 57, 2169-2196.
95. Zhao, Y., Imura, T., Leman, L. J., Curtiss, L. K., Maryanoff, B. E., and Ghadiri, M. R. "Mimicry of High-Density Lipoprotein: Functional Peptide-Lipid Nanoparticles Based on Multivalent Peptide Constructs." J. Am. Chem. Soc. 2013, 135, 13414-13424.
94. Montenegro, J., Ghadiri, M. R., and Granja, J. R. "Ion Channel Models Based on Self-Assembling Cyclic Peptide Nanotubes." Acc. Chem. Res. 2013, 46, 2955-2965.
93. Vickers, C. J., Olsen, C. A., Leman, L. J., and Ghadiri, M. R. "Discovery of HDAC inhibitors that lack an active site Zn2+-binding functional group." ACS Med. Chem. Lett. 2012, 3, 505-508.
92. Olsen, C. A., Montero, A., Leman, L. J., and Ghadiri, M. R. "Macrocyclic peptoid-peptide hybrids as inhibitors of class I histone deacetylases." ACS Med. Chem. Lett. 2012, 3, 749-753.
91. Montero, A., Gastaminza, P., Law, M., Cheng, G., Chisari, F. V., and Ghadiri, M. R. "Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus." Chem. Biol. 2011, 18, 1453-1462.
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90. Hutt, D. M., Olsen, C. A., Vickers, C. J., Herman, D., Chalfant, M. A., Montero, A., Leman, L. J., Burkle, R., Maryanoff, B. E., Balch, W. E., et al. "Potential agents for treating cystic fibrosis: Cyclic tetrapeptides that restore trafficking and activity of ΔF508-CFTR." ACS Med. Chem. Lett. 2011, 2, 703-707.
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89. Chu, J., Gonzalez-Lopez, M., Cockroft, S., Amorin, M., Ghadiri, M. R. "Real-Time Monitoring of DNA Polymerase Function and Stepwise Single-Nucleotide DNA Strand Translocation through a Protein Nanopore." Angew. Chem., Int. Ed. 2010, 49, 10106-10109.
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88. Olsen, C. A., and Ghadiri, M. R. "Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha-3-beta-tetrapeptides." J. Med. Chem. 2009, 52, 7836-7846.
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87. Ura, Y., Al-Sayah, M., Montenegro, J., Beierle, J. M., Leman, L. J., and Ghadiri, M. R. "Dynamic polythioesters via ring-opening polymerization of 1,4-thiazine-2,5-diones." Org. Biomol. Chem. 2009, 7, 2878-2884.
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86. Ura, Y., Beierle, J. M., Leman, L. J., Orgel, L. E., and Ghadiri, M. R. "Self-assembling sequence-adaptive peptide nucleic acids." Science 2009, 325, 73-77.
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85. Motiei, L., Rahimipour, S., Thayer, D. A., Wong, C.-H., and Ghadiri, M. R. "Antibacterial cyclic DL-alpha-glycopeptides." Chem. Commun. 2009, 3693-3695.
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84. Horne, W. S., Olsen, C. A., Beierle, J. M., Montero, A., and Ghadiri, M. R. "Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous
triazole-modified cyclic tetrapeptides." Angew. Chem., Int. Ed. 2009, 48, 4718-4724.
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83. Beierle, J. M., Horne, W. S., van Maarseveen, J. H., Waser, B., Reubi, J. C., and Ghadiri, M. R. "Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds
for rational drug design: receptor-selective somatostatin analogues." Angew. Chem., Int. Ed. 2009, 48, 4725-4729.
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82. Picuri, J. M., Frezza, B. M., and Ghadiri, M. R. "Universal translators for nucleic acid diagnosis."
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81. Montero, A., Beierle, J. M., Olsen, C. A., and Ghadiri, M. R. "Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures." J. Am. Chem. Soc. 2009, 131, 3033-3041.
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80. Voelcker, N. H., Alfonso, I., and Ghadiri, M. R. "Catalyzed oxidative corrosion of porous silicon
used as an optical transducer for ligand-receptor interactions." ChemBioChem 2008, 9, 1776-1786.
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79. Voelcker, N. H., Guckian, K. M., Saghatelian, A., and Ghadiri, M. R. "Sequence-addressable DNA logic." Small 2008, 4, 427-431.
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78. Cheng, G., Montero, A., Gastaminza, P., Whitten-Bauer, C., Wieland, S. F., Isogawa, M., Fredericksen, B., Selvarajah, S., Gallay, P. A., Ghadiri, M. R., and Chisari, F. V. "A virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro." Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 3088-3093.
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77. Huang, Z.-Z., Leman, L. J., and Ghadiri, M. R. "Biomimetic catalysis of diketopiperazine and dipeptide syntheses." Angew. Chem., Int. Ed. 2008, 47, 1758-1761.
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76. Cockroft, S. L., Chu, J., Amorin, M., and Ghadiri, M. R. "A single-molecule nanopore device
detects DNA polymerase activity with single-nucleotide resolution." J. Am. Chem. Soc. 2008,
130, 818-820.
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75. Frezza, B. M., Cockroft, S. L., and Ghadiri, M. R. "Modular multi-level circuits from immobilized
DNA-based logic gates." J. Am. Chem. Soc. 2007, 129, 14875-14879.
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74. Gianneschi, N. C., and Ghadiri, M. R. "Design of molecular logic devices based on a
programmable DNA-regulated semisynthetic enzyme." Angew. Chem., Int. Ed. 2007, 46, 3955-3958.
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73. Fletcher, J. T., Finlay, J. A., Callow, M. E., Callow, J. A., and Ghadiri, M. R. "A combinatorial
approach to the discovery of biocidal six-residue cyclic D,L-alpha-peptides against the bacteria
methicillin-resistant Staphylococcus aureus (MRSA) and E. coli and the biofouling algae ulva linza
and Navicula perminuta." Chem.–Eur. J. 2007, 13, 4008-4013.
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72. Leman, L. J., Weinberger, D. A., Huang, Z.-Z., Wilcoxen, K. M., and Ghadiri, M. R. "Functional
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coil peptides via rational active site engineering." J. Am. Chem. Soc. 2007, 129, 2959-2966.
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71. Wilcoxen, K. M., Leman, L. J., Weinberger, D. A., Huang, Z.-Z., and Ghadiri, M. R. "Biomimetic
catalysis of intermodular aminoacyl transfer." J. Am. Chem. Soc. 2007, 129, 748-749.
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70. Yadav, M. K., Leman, L. J., Price, D. J., Brooks, C. L., III, Stout, C. D., and Ghadiri, M. R.
"Coiled coils
at the edge of configurational heterogeneity. Structural analyses of parallel
and
antiparallel homotetrameric
coiled coils reveal configurational sensitivity to a single
solvent-exposed
amino acid substitution."
Biochemistry 2006, 45, 4463-4473.
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69. Ashkenasy, N., Horne, W. S., and Ghadiri, M. R. "Design of self-assembling peptide nanotubes
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68. Leman, L. J., Orgel, L. E., and Ghadiri, M. R. "Amino acid dependent formation of phosphate anhydrides in water mediated by carbonyl sulfide." J. Am. Chem. Soc. 2006, 128, 20-21.
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67. Nicolaou, K. C., Zak, M., Rahimipour, S., Estrada, A. A., Lee, S. H., O'Brate, A., Giannakakou,
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66. Van Maarseveen, J. H., Horne, W. S., and Ghadiri, M. R. "Efficient route to C2 symmetric heterocyclic
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65. Dartois, V., Sanchez-Quesada, J., Cabezas, E., Chi, E., Dubbelde, C., Dunn, C., Granja, J.,
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64. Horne, W. S., Wiethoff, C. M., Cui, C., Wilcoxen, K. M., Amorin, M., Ghadiri, M. R., and
Nemerow, G. R. "Antiviral cyclic D, L-alpha-peptides: Targeting a general biochemical
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63. Yadav, M. K., Redman, J. E., Leman, L. J., Alvarez-Gutierrez, J. M., Zhang, Y., Stout, C. D., and Ghadiri, M. R. "Structure-based engineering of internal cavities in coiled-coil peptides."
Biochemistry 2005, 44, 9723-9732.
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62. Ashkenasy, N., Sanchez-Quesada, J., Bayley, H., and Ghadiri, M. R. "Recognizing a single base in an
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61. Horne, W. S., Ashkenasy, N., and Ghadiri, M. R. "Modulating charge transfer through cyclic D,L-alpha-peptide
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60. Horne, W. S., Yadav, M. K., Stout, C. D., and Ghadiri, M. R. "Heterocyclic peptide backbone modifications
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59. Leman, L., Orgel, L., and Ghadiri, M. R. "Carbonyl sulfide-mediated prebiotic formation of peptides." Science 2004, 306, 283-286.
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58. Ashkenasy, G., and Ghadiri, M. R. "Boolean logic functions of a synthetic peptide network." J. Am. Chem.
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57. Ashkenasy, G., Jagasia, R., Yadav, M., and Ghadiri, M. R. "Design of a directed molecular network." Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 10872-10877.
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56. Sanchez-Quesada, J., Saghatelian, A., Cheley, S., Bayley, H., and Ghadiri, M. R. "Single DNA
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55. Horne, W. S., Stout, C. D., and Ghadiri, M. R. "A heterocyclic peptide nanotube." J. Am. Chem.
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54. Saghatelian, A., Voelcker, N. H., Guckian, K. M., Lin, V. S. Y., and Ghadiri, M. R. "DNA-based
photonic logic gates: AND, NAND, and INHIBIT." J. Am. Chem. Soc. 2003, 125, 346-347.
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53. Saghatelian, A., Guckian, K. M., Thayer, D. A., and Ghadiri, M. R. "DNA detection and signal amplification via an engineered allosteric enzyme." J. Am. Chem. Soc. 2003, 125, 344-345.
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52. Redman, J. E., Wilcoxen, K. M., and Ghadiri, M. R. "Automated mass spectrometric sequence
determination of cyclic peptide library members." J. Comb. Chem. 2003, 5, 33-40.
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51. Redman, J. E., and Ghadiri, M. R. "Synthesis of photoactive p-azidotetrafluorophenylalanine
containing peptide by solid-phase Fmoc methodology." Org. Lett. 2002, 4, 4467-4469.
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50. Sanchez-Quesada, J., Isler, M. P., and Ghadiri, M. R. "Modulating ion channel properties of transmembrane peptide nanotubes through heteromeric supramolecular assemblies." J. Am. Chem.
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49. Fernandez-Lopez, S., Kim, H.-S., Choi, E. C., Delgado, M., Granja, J. R., Khasanov, A., Kraehenbuehl, K., Long, G., Weinberger, D. A., Wilcoxen, K. M., and Ghadiri, M. R. "Antibacterial
agents based on the cyclic D,L-alpha-peptide architecture." Nature 2001, 412, 452-456.
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48. Sanchez-Quesada, J., Kim, H. S., and Ghadiri, M. R. "A synthetic pore-mediated transmembrane
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47. Bong, D. T., and Ghadiri, M. R. "Chemoselective Pd(0)-catalyzed peptide coupling in water." Org. Lett. 2001, 3, 2509-2511.
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46. Bong, D. T., and Ghadiri, M. R. "Self-assembling cyclic peptide cylinders as nuclei for
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45. Bong, D. T., Clark, T. D., Granja, J. R., and Ghadiri, M. R. "Self-assembling organic nanotubes." Angew. Chem., Int. Ed. 2001, 40, 988-1011.
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44. Saghatelian, A., Yokobayashi, Y., Soltani, K., and Ghadiri, M. R. "A chiroselective peptide replicator." Nature 2001, 409, 797-801.
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43. Kennan, A. J., Haridas, V., Severin, K., Lee, D. H., and Ghadiri, M. R. "A de novo designed peptide
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42. Sanchez-Quesada, J., Ghadiri, M. R., Bayley, H., and Braha, O. "Cyclic Peptides as Molecular
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41. Bong, D. T., Janshoff, A., Steinem, C., and Ghadiri, M. R. "Membrane partitioning of the cleavage
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40. Bong, D. T., Steinem, C., Janshoff, A., Johnson, J. E., and Ghadiri, M. R. "A highly membrane-
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39. Vollmer, M. S., Clark, T. D., Steinem, C., and Ghadiri, M. R. "Photoswitchable hydrogen-bonding in
self-organized cylindrical peptide systems." Angew. Chem., Int. Ed. 1999, 38, 1598-1601.
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38. Granja, J. R., and Ghadiri, M. R. "Self-assembling peptide nanotubes." NATO ASI Ser., Ser. C 1999, 526, 61-66.
37. Steinem, C., Janshoff, A., Vollmer, M. S., and Ghadiri, M. R. "Reversible photoisomerization of self-organized
cylindrical peptide assemblies at air-water and solid interfaces." Langmuir 1999, 15, 3956-3964.
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36. Janshoff, A., Bong, D. T., Steinem, C., Johnson, J. E., and Ghadiri, M. R. "An animal virus-derived peptide
switches membrane morphology: possible relevance to nodaviral transfection processes." Biochemistry 1999, 38,
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35. Clark, T. D., Kobayashi, K., and Ghadiri, M. R. "Covalent capture and stabilization of cylindrical beta-sheet
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34. Rapaport, H., Kim, H. S., Kjaer, K., Howes, P. B., Cohen, S., Als-Nielsen, J., Ghadiri, M. R., Leiserowitz, L.,
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33. Mutz, M. W., Case, M. A., Wishart, J. F., Ghadiri, M. R., and McLendon, G. L. "De novo design of protein function:
predictable structure-function relationships in synthetic redox proteins." J. Am. Chem. Soc. 1999, 121, 858-859.
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1. Ghadiri, M. R., and Choi, C. "Secondary structure nucleation in peptides. Transition metal ion stabilized
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