•   Mailing Address
    The Scripps Research Institute
    10550 North Torrey Pines Road, DNC-118
    La Jolla, CA  92037

  •    Shipping Address
    Attn:  Chun Lab, DNC-118
    3215 Merryfield Row
    San Diego, CA  92121

  •    Physical Address
    The Scripps Research Institute
    Dorris Neuroscience Center
    3528 General Atomics Court
    San Diego, CA  92121
  •   Phone and Fax Numbers
    Lab      (858) 784-7041
    Admin  (858) 784-7039
    Fax      (858) 784-7084

Other Brain Disease Publications

Other Brain Disease Publications

118.  Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung H-L, Chen S, Vijayaraghavan R, Wong J, Chen C, Sheng X, Kaper F, Shen R, Ronaghi M, Fan JB, *Wang W, *Chun J, *Zhang K.  Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.  Science 2016;352(6293):1586-1590. *Co-senior authors.  PMC5038589

117.  Moon E, Han JE, Jeon S, Ryu JH, Choi JW, Chun J.  Exogenous S1P exposure potentiates ischemic stroke damage that is reduced possibly by inhibiting S1P receptor signaling.  Mediators Inflamm 2015;2015:492659.  PMC4630407

116.  Bushman DM, Kaeser GE, Siddoway B, Westra JW, Rivera RR, Rehen SK, Yung YC, Chun J.  Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains.  eLife 2015;4:e05116.  DOI:  10.7554/eLife.0516.  LINK TO ARTICLE

115.  Gole J, Gore A, Richards A, Chiu Y-J, Fung H-L, Bushman D, Chiang H-I, Chun J, Lo Y-H, Zhang K.  Massively parallel polymerase cloning and genome sequencing of single cells using the Microwell Displacement Amplification System (MIDAS).  Nature Biotechnol 2013;31(12):1126-1132.  PMC3875318  DOWNLOAD PDF

114.  Anliker B, Choi JW, Lin ME, Gardell SE, Rivera R, Kennedy G, Chun J.  Lysophosphatidic acid (LPA) and its receptor, LPA1, influence embryonic Schwann cell migration, myelination, and cell-to-axon segregation.  Glia 2013;61(12):2009-2022.  DOWNLOAD PDF

113.  Ma L, Nagai J, Chun J, Ueda H.  An LPA species (18:1 LPA) plays key roles in the self-amlification of spinal LPA production in the peripheral neuropathic pain model.  Mol Pain 2013;9(1):29.  PMC3691926  DOWNLOAD PDF

112.  Halder SK, Yano R, Chun J, Ueda H.  Involvement of LPA1 receptor signaling in cerebral ischemia-induced neuropathic pain.  Neuroscience 2013;235:10-15.  DOWNLOAD PDF

111.  Lysophospholipid receptors:  signaling and biochemistry. Edited by Chun J, Hla T, Spiegel S, Moolenaar W.  John Wiley & Sons, Inc., Hoboken, NJ. 2013. 

110.  Bushman DM, Chun J.  The genomically mosaic brain:  aneuploidy and more in neural diversity and disease.  Semin Cell Dev Biol 2013;24(4):357-369.  PMC3637860  DOWNLOAD PDF

109.  Peterson SE, Yang AH, Bushman DM, Westra JW, Yung YC, Barral S, Mutoh T, Rehen SK, Chun J.  Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development.  J Neurosci 2012;32(46):16213-16222. PMC3614491   DOWNLOAD PDF

108.  Garcia-Fernandez M, Castilla-Ortega E, Pedraza C, Blanco E, Hurtado-Guerrero I, Barbancho MA, Chun J, Rodriguez-de-Fonseca F, Estivill-Torrus G, Nunez LJ.  Chronic immobilization in the malpar1 knockout mice increases oxidative stress in the hippocampus.  Int J Neurosci 2012;122(10):583-589.

107.  Castilla-Ortega E, Pedraza C, Chun J, Fonseca FR, Estivill-Torrus G, Santin LJ.  Hippocampal c-Fos activation in normal and LPA1-null mice after two object recognition tasks with different memory demands.  Behav Brain Res 2012;232(2):400-405.   DOWNLOAD PDF

106.  Lin ME, Rivera RR, Chun J.  Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain.  J Biol Chem 2012;287(21):17608-17617. PMC3366844   DOWNLOAD PDF

105.  Mutoh T, Rivera R, Chun J.  Insights into the pharmacological relevance of lysophospholipid receptors.  Br J Pharmacol 2012;165(4):829-844. PMC3312481   DOWNLOAD PDF

104.  Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I.  Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2.  Epilepsy Behav 2011;22(4):659-665.   DOWNLOAD PDF

103.  Castillo-Badillo JA, Molina-Munoz T, Romero-Avila MT, Vazquez-Macias A, Rivera R, Chun J, Garcia-Sainz JA.  Sphingosine 1-phosphate-mediated a(1B)-adrenoceptor desensitization and phosphorylation:  Direct and paracrine/autocrine actions.  Biochim Biophys Acta 2011;1823(2):245-254. PMC22019450   DOWNLOAD PDF

102.  Castilla-Ortega E, Hoyo-Becerra C, Pedraza C, Chun J, Rodriguez De Fonseca F, Estivill-Torrus G, Santin LJ.  Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA(1) receptor knockout mice.  PLoS One 2011;6(9):e25522. PMC3183048.  Correction in PLoS One. 2011;6(11). doi: 10.1371/annotation/c105dab8-59b8-467a-9223-5bd92936e49a   DOWNLOAD PDF

101.  Yung YC, Mutoh T, Lin ME, Noguchi K, Rivera RR, Choi JW, Kingsbury MA, Chun J.  Lysophosphatidic acid signaling may initiate fetal hydrocephalus.  Sci Transl Med 2011;3:99ra87.  PMC3653407   DOWNLOAD PDF

100.  Herr KJ, Herr DR, Lee CW, Noguchi K, Chun J.  Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA1) signaling.  Proc Natl Acad Sci USA 2011;108(37):15444-15449. PMC3174597    DOWNLOAD PDF

99.  Peterson SE, Westra JW, Rehen SK, Young H, Bushman DM, Paczkowski CM, Yung YC, Lynch CL, Tran HT, Nickey KS, Wang YC, Laurent LC, Loring JF, Carpenter MK, Chun J.  Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy.  PLoS ONE 2011;6(8):e23018. PMC3156708   DOWNLOAD PDF

98.  Peterson SE, Chun J, Loring J.  FISH analysis of human pluripotent stem cells.  Methods Mol Biol 2011;767:191-200.   DOWNLOAD PDF

97.  Chun J, Westra JW, Bushman, D.  A reply to Iourov I. et al.  Neurodegen Dis 2011;8(1-2):38-40. 

96.  Nagai J, Uchida H, Matsushita Y, Yano R, Ueda M, Niwa M, Aoki J, Chun J, Ueda H.  Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidycholine.  Mol Pain 2010;6:78. PMC2989310   DOWNLOAD PDF

95.  Westra JW, Rivera RR, Bushman DM, Yung YC, Peterson SE, Barral S, Chun J.  Neuronal DNA content variation (DCV) with regional and individual differences in the human brain.  J Comp Neuro 2010;518(19):3981-4000. PMC2932632   DOWNLOAD PDF

94.  Dubin AE, Herr DR, Chun J.  Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis.  J Neuroscience 2010;30(21):7300-7039.  PMC2932640    DOWNLOAD PDF

93.  Castilla-Ortega E, Sánchez-López J, Hoyo-Becerra C, Matas-Rico E, Zambrana-Infantes E, Chun J, Fonseca FR, Pedraza C, Estivill-Torrús G, Santin LJ.  Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor.  Neurobiol Learn Mem 2010;94(1):73-82.  PMC3684252    DOWNLOAD PDF

92.  Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H.  Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.  J Neurochem 2010;113(4):1002-1011. PMC2908211    DOWNLOAD PDF

91.  Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J.  LPA receptors:  Subtypes and biological actions.  Ann Rev Pharmacol Toxicol 2010;50:157–186.   DOWNLOAD PDF

90.  Lin ME, Herr DR, Chun J.  Lysophosphatidic acid (LPA) receptors:  signaling properties and disease relevance. Prostaglandins Other Lipid Mediat 2010;91(3-4):130-138.  PMC2845529.    DOWNLOAD PDF

89.  Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H.  Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid:  an initiator of nerve injury-induced neuropathic pain.  Mol Pain 2009;5:64.  PMC2780384   DOWNLOAD PDF

88.  Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Brauer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R.  Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.  Cell 2009;138(6):1222-1235. PMC3716297    DOWNLOAD PDF

87.  Santin L, Bilbao A, Pedraza C, Matas-Rico E, Lopez-Barroso D, Castilla-Ortega E, Sanchez-Lopez J, Riquelme R, Varela-Nieto I, de la Villa P, Suardiaz M, Chun J, Fonseca FR, Estivill-86 G.  Behavioral phenotype of maLPA1-null mice:  Increased anxiety-like behavior and spatial memory deficits.  Genes Brain Behav 2009;8(8):772-784.    DOWNLOAD PDF

85.  Westra JW, Barral S, Chun J.  A reevaluation of tetraploidy in the Alzheimer’s disease brain.  Neurodegen Dis 2009;6(5-6):221-229. PMC2837890    DOWNLOAD PDF

84.  Yung YC, Kennedy G, Chun J.  Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR.  In Current Protocols in Neuroscience, Unit 3.8, Taylor G (Ed.), John Wiley & Sons, July 2009.  PMC2774705    DOWNLOAD PDF

83.  Teo ST, Yung YC, Herr DR, Chun J.  Lysophosphatidic acid in vascular development and disease.  IUBMB Life 2009;61(8):791-799.    DOWNLOAD PDF

82.  Mutoh T, Chun J.  Lysophosphatidic acid and sphingosine 1-phosphate activation of G Protein-Coupled Receptors.  In Bradshaw RA & Dennis EA (eds.) Handbook of Cell Signaling, second edition, Elsevier, 2009.

81.  Noguchi K, Herr D, Mutoh T, Chun J.  Lysophosphatidic acid (LPA) and its receptors.  Curr Opin Pharmacol 2009;9(1):15-23.   DOWNLOAD PDF

80.  Paczkowski C, Chun J.  Genomic disorder and gene expression in the developing CNS. In Squire LR (eds), Encyclopedia of Neuroscience, vol. 4, pp. 679-684.  Oxford:  Academic Press, 2009.

79.  Xie W, Matsumoto M, Chun J, Ueda H.  Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury.  Mol Pain 2008;4:46.  PMC2599895    DOWNLOAD PDF

78.  Matas-Rico E, Garcia-Diaz B, Llebrez-Zayas P, Lopez-Barroso D, Santin L, Pedraza C, Smith-Fernandez A, Fernandez-Llebrez P, Tellez T, Redondo M, Chun J, Rodriguez de Fonseca F, Estivill-Torrus G.  Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus.  Mol Cell Neurosci 2008;39(3):342-355.  PMC3667670    DOWNLOAD PDF

77.  Choi JW, Lee CW, Chun J.  Biological roles of lysophospholipid receptors revealed by genetic null mice:  an update.  Biochem Biophys Acta 2008;1781:531-539.  PMC2657083    DOWNLOAD PDF

76.  Inoue M, Xie W, Matsushita Y, Chun J, Aoki J, Ueda H.  Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.  Neurosci 2008;152(2):296-298.    DOWNLOAD PDF

75.  Inoue M, Ma L, Aoki J, Chun J, Ueda H.  Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.  Mol Pain 2008;4(1):6.  PMC2277392    DOWNLOAD PDF

74.  Westra JW, Peterson SE, Yung YC, Mutoh T, Barral S, Chun J.  Aneuploid mosaicism in the developing and adult cerebellar cortex.  J Comp Neurol 2008 507(6):1944-1951.    DOWNLOAD PDF

73.  Estivill-Torrus G, Llebrez-Zayas P, Matas-Rico E, Santin L, Pedraza C, De Diego I, Del Arco I, Fernandez-Llebrez P, Chun J, Rodriguez De Fonseca F.  Absence of LPA1 signaling results in defective cortical development.  Cerebral Cortex 2008;18(4):938-950.    DOWNLOAD PDF

72.  Mutoh T, Chun J.  Lysophospholipid activation of g protein-coupled receptors.  Subcell Biochem 2008;49:269-297.  

71.  Peterson S, Rehen S, Westra W, Yung Y, Chun J.  Spectral karyotyping and fluorescent in situ hybridization.  In Human Stem Cell Manual:  A Laboratory Guide, Chapter 6, pp. 71-84. Loring JF, Wesselschmidt Rl, Schwartz PH (eds).  Elsevier, 2007.

70.  Peterson SE, Westra JW, Paczkowski CM, Chun J.  Chromosomal mosaicism in neural stem cells.  In Neural Stem Cells Methods and Protocols, Chapter 16, pp. 197-204.  Weiner LP (ed.). Humana Press, 2008.  DOWNLOAD PDF

69.  Chun J.  “Extracellular Lipid Signals.” In the Wiley Encyclopedia of Chemical Biology, Tadhg P. Begley (ed.), 2008.

68.  Chun J.  How the lysophospholipid got its receptor.  The Scientist 2007;21(9):48-54.   DOWNLOAD PDF

67.  Herr D, Grillet N, Schwander M, Rivera R, Müller U, Chun J.  Sphingosine 1-phosphate signaling is required for maintenance of hair cells largely via activation of S1P2.  J Neurosci 2007;27(6):1474-1478.   DOWNLOAD PDF

66.  Rajendran RS, Zupanc MM, Losche A, Westra J, Chun J, Zupanc GKH.  Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish.  Dev Neurobiol 2007;67(10):1334-1347.    DOWNLOAD PDF

65.  Rivera R, Chun J.  Potential therapeutic roles of lysophospholipid signaling in autoimmune related disease.  Future Lipidology 2007;2(5):535-545.

64.  Herr D, Chun J.  Effects of LPA and S1P on the nervous system and implications for their involvement in diseaseCur Drug Targ 2007;8:155-167.   DOWNLOAD PDF

63.  Rehen SK, Kingsbury MA, Almeida BSV, Herr D, Peterson S, Chun J.  A new method of embryonic culture for assessing global changes in brain organization.  J Neurosci Meth 2006;158:100-108.    DOWNLOAD PDF

62.  Inoue M, Yamaguchi A, Kawakami M, Chun J, Ueda H.  Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain.  Mol Pain 2006;2:25.  PMC1562366    DOWNLOAD PDF

61.  Birgbauer E, Chun J.  New developments in the biological functions of lysophospholipids.  Cell Mol Life Sci 2006;63:2695-2701.   DOWNLOAD PDF

60.  Kingsbury MA, Yung YC, Peterson SE, Westra JW, Chun J.  Aneuploidy in the normal and diseased brain.  Cell Mol Life Sci 2006;63:2626-2641.    DOWNLOAD PDF

59.  Rivera R, Chun J.  Biological effects of lysophospholipids.  Rev Physiol Biochem Pharmacol 2008;160:25-46.    DOWNLOAD PDF

58.  Gardell SE, Dubin AE, Chun J.  Emerging medicinal roles for lysophospholipid receptors.  Trends in Mol Med 2006;12:65-75.    DOWNLOAD PDF

57.  Kingsbury MA, Friedman B, McConnell MJ, Rehen SK, Yang AH, Kaushal D, Chun J.  Aneuploid neurons are functionally active and integrated into brain circuitry.  Proc Natl Acad Sci USA 2005;102:6143-6147PMC1087909    DOWNLOAD PDF

56.  Rehen SK, Yung YC, McCreight MP, Yang AH, Almeida BSV, Kingsbury MA, Cabral KMS, Kaushal D, McConnell MJ, Anliker B, Fontanoz M, Chun J.  Constitutional aneuploidy in the normal human brain.  J Neurosci 2005;25:2176-2180. (cover art)    DOWNLOAD PDF

55.  Chun J.  Lysophospholipids in the nervous system.  J Prostagland Lipid Mediators 2005;77:46-51.   DOWNLOAD PDF

54.  Rehen S, Chun J.  Cell Death (during development of the central nervous system).  In Brain Development:  Normal Processes and the Effects of Alcohol and Nicotine, Chapter 5, pp. 73-90. Miller MW (ed.). Oxford University Press, 2005.

53.  McConnell MJ, Kaushal D, Yang AH, Kingsbury MA, Rehen SK, Treuner K, Helton R, Annas EG, Chun J, Barlow C.  Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in Atm-deficient but not the Trp53-deficient adult cerebral cortex.  J Neurosci 2004;24:8090-8096.  Download PDF

52.  Inoue M, Rashid H, Ryousuke Fujita R, Contos JJA, Chun J, Ueda H.  Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling.  Nature Med 2004;10:712-718.  Download PDF

51.  Chun J.  Choices, choices, choices.  Nature Neurosci 2004;7:323-325.  Download PDF

50.  Anliker B, Chun J. Lysophospholipid G protein-coupled receptors.  J Biol Chem 2004;279:20555-20558.  Download PDF

49.  Anliker B, Chun J.  Cell surface receptors in lysophospholipid signaling.  Sem Cell and Devel Biol 2004;15:457-465.  Download PDF

48.  Ishii I, Fukushima N, Ye X, Chun J.  Lysophospholipid receptors:  Signaling and biology.  Ann Rev Biochem 2004;73:321-354.  Download PDF

47.  Kingsbury MA, Rehen SK, Ye X, Chun J.  Genetics and cell biology of lysophosphatidic acid receptor-mediated signaling during cortical neurogenesis. J Cell Biochem 2004;92:1004-12.  Download PDF

46.  Kingsbury MA, Rehen SK, Contos JJA, Higgins C, Chun J.  Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding.  Nature Neurosci 2003;6:1292-1299.  (See also News & Views).  Download PDF

45.  Yang AH, Kaushal D, Rehen SK, Kriedt K, Kingsbury MA, McConnell MJ, Chun J.  Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells.  J Neurosci 2003;23:10454-10462.  Download PDF

44.  Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri AR, Summers RG, Chun J, Lee K-F, Gage FH.  Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function.  Proc Natl Acad Sci USA 2003;100:6777-6782.  PMC164523  Download PDF

43.  Kaushal D, Contos JJA, Treuner K, Yang AH, Kingsbury MA, Rehen SK, McConnell MJ, Okabe M, Barlow C, Chun J.  Alteration of gene expression by chromosome loss in the postnatal mouse brain.  J Neurosci 2003;23:5599-5606.  Download PDF

42.  McGiffert C, Contos JJA, Friedman B, Chun J.  Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1-3 in angiogenesis.  FEBS Lett 2002;531:103-108.  Download PDF

41.  Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J.  Genetic mosaicism in the brain:  A new paradigm for neuronal diversity.  Dir in Science 2002;1:53-55.  

40.  Chun J, Goetzl EJ, Hla,TL, Igarashi Y, Lynch KR, Moolenaar WH, Pyne S, Tigyi G.  International Union of Pharmacology.  XXXIV.  Lysophospholipid receptor nomenclature.  Pharmacol Rev 2002;54:265-269. Download PDF

39.  Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J.  Chromosomal variation in neurons of the developing and adult mammalian nervous system. Proc Natl Acad Sci USA, 2001;98:13361-13366.  PMC60876  Download PDF

38.  Ishii I, Friedman B, Ye X-Q, Kawamura S, McGiffert C, Contos JJA, Kingsbury M, Zhang G, Brown JH, Chun J.  Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3.  J Biol Chem 2001;276:33697-33704.  Download PDF

37.  Weiner JAW, Fukushima N, Contos JJA, Scherer SS, Chun J.  Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling.  J Neurosci 2001;21:7069-7078.  Download PDF

36.  Moeller T, Contos JJ, Musante DB, Chun J, Ransom BR.  Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells.  J Biol Chem 2001;276:25946-25952.  Download PDF

35.  Contos JJ, Fukushima N, Weiner JA, Kaushal D, Chun J.  Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior.  Proc Natl Acad Sci USA 2000;97:13384-13389.  PMC27233  Download PDF

34.  Pompeiano M, Blaschke AJ, Flavell RA, Srinivasan A, Chun J.  Decreased apoptosis in proliferative and postmitotic regions of the caspase 3 deficient embryonic CNS.  J Comp Neurol 2000;423:1-12.  Download PDF

33.  Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW.  Defective embryoic neurogenesis in ku, but not DNA-PKcs, deficient mice.  Proc Natl Acad Sci USA 2000;97:2668-2673.  PMC15987  Download PDF

32.  Chun J.  An alternative view of cell death, DNA breaks and possible rearrangements.  Trends in Neurosci 2000;23:407-408.  Download PDF

31.  Chun J, Weiner JA, Fukushima N, Contos JJA, Zhang G, Kumura Y, Dubin A, Ishii I, Hecht JH, Akita C, Kaushal D.  Neurobiology of receptor-mediated lysophospholipid signaling:  From the first lysophospholipid (LP) receptor to roles in nervous system function and development.  Ann NY Acad Sci 2000;905:110-117.  Download PDF

30.  Weiner JA, Chun J.  Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid.  Proc Natl Acad Sci 1999;96:5233-5238.  PMC21847  Download PDF

29.  Dubin AE, Bahnson T, Weiner JA, Fukushima N, Chun J.  Lysophosphatidic acid (LPA) stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts.  J Neurosci 1999;19:1371-1381.  Download PDF

28.  Nagai Y, Onodera O, Chun J, Strittmatter WJ, Burke JR.  Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network.  Exp Neurol 1999;155:195-203.  Download PDF

27.  Weiner JA, Hecht JH, Chun J.  The lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain.  J Comp Neurol 1998;398:587-589.  Download PDF

26.  Pompeiano M, Hvala M, Chun J.  Onset of apoptotic DNA fragmentation can precede cell elimination by days in the small intestinal vilus.  Cell Death and Diff 1998;5:702-709.  Download PDF

25.  Fukushima N, Kimura Y, Chun J.  A single receptor encoded by vzg-1/lpa1/edg-2 couples to G-proteins and mediates multiple cellular responses to lysophosphatidic acid (LPA).  Proc Natl Acad Sci USA 1998;95:6151-6156.  PMC27607  Download PDF

24.  Blaschke AJ, Weiner JA, Chun J.  Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the CNS.  J Comp Neurol 1998;396:39-50.  Download PDF

23.  Weiner JA, Chun J.  Maternally-derived immunoglobulin light chain is present in the fetal mammalian CNS.  J Neurosci 1997;17:3148-3156.  Download PDF

22.  Weiner JA, Chun J.  Png-1, a nervous system-specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development. J Comp Neurol 1997;381:130-142.  Download PDF

21.  Staley K, Blaschke AJ, Chun J.  Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA ends.  Cell Death and Differen 1997;4:66-75.  Download PDF

20.  Hecht JH, Weiner JA, Post SR, Chun J.  Ventricular zone gene -1 (Vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.  J Cell Biol 1996;135:1071-1083.  PMC2133395  Download PDF

19.  Blaschke AJ, Staley K, Chun J.  Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex.  Development 1996;122:1165-1174 (see comment in Neuron 1996;16:693).  Download PDF

18.  Chun J.  Developmental neurobiology:  A genetic Cheshire cat?  Curr Biol 1999;9:651-654.  Download PDF

17.  Chun J.  Lysophospholipid receptors:  Implications for neural signaling.  Crit Rev Neurobiol 1999;13:151-168.

16.  Chun J.  The first cloned and identified lysophospholipid (LP) receptor gene, vzg-1:  Implications for the nervous system and related receptors. Adv Exp Med Biol 1999;469:357-62.

15.  Chun J, Schatz DG.  Developmental neurobiology:  Alternative “ends” to a familiar story?  Curr Biol 1999;9:R251-R253.  Download PDF

14.  Chun J, Contos JJA, Munroe D.  A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs).  Cell Biochem Biophys 1999;30:213-242.

13.  Chun J, Schatz DG.  Rearranging views on neurogenesis:  Neuronal death in the absence of DNA end-joining proteins.  Neuron 1999;22:7-10.  Download PDF

12.  Chun J.  Detection of cells undergoing programmed cell death using in situ end labeling plus (ISEL+). In Apoptosis Detection, CHAPTER 5, pp. 35-45, in “Apoptosis detection and assay methods.” Zhu L, Chun J (eds.). BioTechniques Books, Natick, MA, 1998.

11.  Chun J.  Apoptotic DNA fragmentation detection using ligation mediated PCR (LMPCR).  In Apopotosis Detection, CHAPTER 4, pp. 23-33, in “Apoptosis detection and assay methods.” Zhu L, Chun J (eds.). BioTechniques Books, Natick, MA, 1998.

10.  Chun J, Blaschke AJ.  Unit 3.8, Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR.  In Current Protocols in Neuroscience.  Gerfen C, Mckay R (eds.).  John Wiley and Sons, Inc., 1997. PMC2774705

9.  Chun JJM, Schatz DG, Oettinger MA, Jaenisch R, Baltimore D.  The Recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system.  Cell 1991;64:189-200.

8.  Chun JJM, Shatz CJ.  The earliest-generated neurons of the cat cerebral cortex:  characterization by MAP2 and neurotransmitter immunohistochemistry during fetal life.  J Neurosci 1989;9:1648-1667.

7.  Chun JJM, Shatz CJ.  Interstitial cells of the adult neocortical white matter are the remnant of the early generated subplate neuron population.  J Comp Neurol 1989;282:555-569.

6.  Chun JJM, Shatz CJ.  Redistribution of synaptic vesicle antigens is correlated with the disappearance of a transient synaptic zone in the developing cerebral cortex.  Neuron 1988;1:297-310.

5.  Chun JJM, Shatz CJ.  A fibronectin-like molecule is present in the developing cat cerebral cortex and is correlated with subplate neurons.  J Cell Biol 1988;106:857-872.  PMC2115079

4.  Chun JJM, Nakamura MJ, Shatz CJ.  Transient cells of the developing mammalian telencephalon are peptide-immunoreactive neurons.  Nature 1987;325:617-620.

3.  Chun JJM, Schatz DG.  Recombination activating gene -1 (RAG-1) transcription in the mammalian CNS.  Chapter 22.  In Neuronal Cell Death and Repair, Vol. 6. Cuello AC (ed.).  Elsevier Science Publishers, Amsterdam, 1993.

2.  Schatz DG, Chun JJM.  V(D)J recombination and the transgenic brain blues.  New Biologist 1992;4:188-196.  

1.  Shatz CJ, Chun JJM, Luskin MB.  The role of the subplate in the development of the mammalian telencephalon.  In:  Development of the Cerebral Cortex, Vol. 7. Peters A, Jones EG (eds.).  Plenum Publishing Corp., New York, NY, 1988.

Return to top