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    The Scripps Research Institute
    10550 North Torrey Pines Road, DNC-118
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    Attn:  Chun Lab, DNC-118
    3215 Merryfield Row
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    Dorris Neuroscience Center
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Genomic Mosaicism Publications


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Aneuploidy, Cell Death, and More

45.  Bushman DM, Kaeser GE, Siddoway B, Westra JW, Rivera RR, Rehen SK, Yung YC, Chun J.  Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains.  eLife 2015;4:e05116.  DOI:  10.7554/eLife.0516.  PMC4337608  LINK TO ARTICLE

44.  Gole J, Gore A, Richards A, Chiu Y-J, Fung H-L, Bushman D, Chiang H-I, Chun J, Lo Y-H, Zhang K.  Massively parallel polymerase cloning and genome sequencing of single cells using the Microwell Displacement Amplification System (MIDAS).  Nature Biotechnol 2013;31(12):1126-1132.  PMC3875318  DOWNLOAD PDF

43.  Bushman DM, Chun J.  The genomically mosaic brain:  aneuploidy and more in neural diversity and disease.  Semin Cell Dev Biol 2013;24(4):357-369.  PMC3637860

42.  Peterson SE, Yang AH, Bushman DM, Westra JW, Yung YC, Barral S, Mutoh T, Rehen SK, Chun J.  Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development.  J Neurosci  2012;32(46):16213-16222. PMC3614491   DOWNLOAD PDF

41.  Peterson SE, Westra JW, Rehen SK, Young H, Bushman DM, Paczkowski CM, Yung YC, Lynch CL, Tran HT, Nickey KS, Wang YC, Laurent LC, Loring JF, Carpenter MK, Chun J.  Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy.  PLoS ONE 2011;6(8):e23018. PMC3156708    DOWNLOAD PDF

40.  Peterson SE, Chun J, Loring J.  FISH analysis of human pluripotent stem cells.  Methods Mol Biol 2011;767:191-200.    DOWNLOAD PDF

39.  Chun J, Westra JW, Bushman, D.  A reply to Iourov I. et al.  Neurodegen Dis 2011;8(1-2):38-40. 

38.  Westra JW, Rivera RR, Bushman DM, Yung YC, Peterson SE, Barral S, Chun J.  Neuronal DNA content variation (DCV) with regional and individual differences in the human brain.  J Comp Neuro 2010;518(19):3981-4000. PMC2932632    DOWNLOAD PDF

37.  Westra JW, Barral S, Chun J.  A reevaluation of tetraploidy in the Alzheimer’s disease brain.  Neurodegen Dis 2009;6(5-6):221-229. PMC2837890    DOWNLOAD PDF

36.  Yung YC, Kennedy G, Chun J.  Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR.  In Current Protocols in Neuroscience, Unit 3.8, Taylor G (Ed.), John Wiley & Sons, July 2009.  PMC2774705    DOWNLOAD PDF

35.  Paczkowski C, Chun J.  Genomic disorder and gene expression in the developing CNS. In Squire LR (eds), Encyclopedia of Neuroscience, vol. 4, pp. 679-684.  Oxford:  Academic Press, 2009.

34.  Westra JW, Peterson SE, Yung YC, Mutoh T, Barral S, Chun J.  Aneuploid mosaicism in the developing and adult cerebellar cortex.  J Comp Neurol 2008 507(6):1944-1951.    DOWNLOAD PDF

33.  Peterson S, Rehen S, Westra W, Yung Y, Chun J.  Spectral karyotyping and fluorescent in situ hybridization.  In Human Stem Cell Manual:  A Laboratory Guide, Chapter 6, pp. 71-84. Loring JF, Wesselschmidt Rl, Schwartz PH (eds).  Elsevier, 2007.

32.  Peterson SE, Westra JW, Paczkowski CM, Chun J.  Chromosomal mosaicism in neural stem cells.  In Neural Stem Cells Methods and Protocols, Chapter 16, pp. 197-204.  Weiner LP (ed.). Humana Press, 2008.    DOWNLOAD PDF

31.  Rajendran RS, Zupanc MM, Losche A, Westra J, Chun J, Zupanc GKH.  Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish.  Dev Neurobiol 2007;67(10):1334-1347.    DOWNLOAD PDF

30.  Chao C, Herr D, Chun J, Xu Y.  Ser18 and Ser23 phosphorylation is required for p53-dependent apoptosis and tumor suppression.  EMBO J 2006;25:2615-2622.  PMC1478190    DOWNLOAD PDF

29.  Kingsbury MA, Yung YC, Peterson SE, Westra JW, Chun J.  Aneuploidy in the normal and diseased brain.  Cell Mol Life Sci 2006;63:2626-2641.    Download PDF

28.  Kingsbury MA, Friedman B, McConnell MJ, Rehen SK, Yang AH, Kaushal D, Chun J.  Aneuploid neurons are functionally active and integrated into brain circuitry.  Proc Natl Acad Sci USA 2005;102:6143-6147PMC1087909    DOWNLOAD PDF

27.  Rehen SK, Yung YC, McCreight MP, Yang AH, Almeida BSV, Kingsbury MA, Cabral KMS, Kaushal D, McConnell MJ, Anliker B, Fontanoz M, Chun J.  Constitutional aneuploidy in the normal human brain.  J Neurosci 2005;25:2176-2180. (cover art)    DOWNLOAD PDF

26.  Rehen S, Chun J.  Cell Death (during development of the central nervous system).  In Brain Development:  Normal Processes and the Effects of Alcohol and Nicotine, Chapter 5, pp. 73-90. Miller MW (ed.). Oxford University Press, 2005.

25.  McConnell MJ, Kaushal D, Yang AH, Kingsbury MA, Rehen SK, Treuner K, Helton R, Annas EG, Chun J, Barlow C.  Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in Atm-deficient but not the Trp53-deficient adult cerebral cortex.  J Neurosci 2004;24:8090-8096.    DOWNLOAD PDF

24.  Chun J.  Choices, choices, choices.  Nature Neurosci 2004;7:323-325.    DOWNLOAD PDF

23.  Yang AH, Kaushal D, Rehen SK, Kriedt K, Kingsbury MA, McConnell MJ, Chun J.  Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells.  J Neurosci 2003;23:10454-10462.    DOWNLOAD PDF

22.  Kaushal D, Contos JJA, Treuner K, Yang AH, Kingsbury MA, Rehen SK, McConnell MJ, Okabe M, Barlow C, Chun J.  Alteration of gene expression by chromosome loss in the postnatal mouse brain.  J Neurosci 2003;23:5599-5606.    DOWNLOAD PDF

21.  Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J.  Genetic mosaicism in the brain:  A new paradigm for neuronal diversity.  Dir in Science 2002;1:53-55.  

20.  Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J.  Chromosomal variation in neurons of the developing and adult mammalian nervous system. Proc Natl Acad Sci USA 2001;98:13361-13366.  PMC60876    DOWNLOAD PDF

19.  Chun J.  Selected comparison of immune and nervous system development.  Adv Immunol 2001;77:297-322.    DOWNLOAD PDF

18.  Pompeiano M, Blaschke AJ, Flavell RA, Srinivasan A, Chun J.  Decreased apoptosis in proliferative and postmitotic regions of the caspase 3 deficient embryonic CNS.  J Comp Neurol 2000;423:1-12.    DOWNLOAD PDF

17.  Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW.  Defective embryoic neurogenesis in ku, but not DNA-PKcs, deficient mice.  Proc Natl Acad Sci USA 2000;97:2668-2673.  PMC15987    DOWNLOAD PDF

16.  Chun J.  An alternative view of cell death, DNA breaks and possible rearrangements.  Trends in Neurosci 2000;23:407-408.    Download PDF

15.  Weiner JA, Chun J.  Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid.  Proc Natl Acad Sci 1999;96:5233-5238.  PMC21847    DOWNLOAD PDF

14.  Pompeiano M, Hvala M, Chun J.  Onset of apoptotic DNA fragmentation can precede cell elimination by days in the small intestinal vilus.  Cell Death and Diff 1998;5:702-709.    DOWNLOAD PDF

13.  Blaschke AJ, Weiner JA, Chun J.  Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the CNS.  J Comp Neurol 1998;396:39-50.    DOWNLOAD PDF

12.  Staley K, Blaschke AJ, Chun J.  Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA ends.  Cell Death and Differen 1997;4:66-75.    DOWNLOAD PDF

11.  Blaschke AJ, Staley K, Chun J.  Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex.  Development 1996;122:1165-1174 (see comment in Neuron 1996;16:693).    DOWNLOAD PDF

10.  Chun J.  Developmental neurobiology:  A genetic Cheshire cat?  Curr Biol 1999;9:651-654.    DOWNLOAD PDF

9.  Chun J, Schatz DG.  Developmental neurobiology:  Alternative “ends” to a familiar story?  Curr Biol 1999;9:R251-R253.    DOWNLOAD PDF

8.  Chun J, Schatz DG.  Rearranging views on neurogenesis:  Neuronal death in the absence of DNA end-joining proteins.  Neuron 1999;22:7-10.    DOWNLOAD PDF

7.  Chun J.  Detection of cells undergoing programmed cell death using in situ end labeling plus (ISEL+). In Apoptosis Detection, CHAPTER 5, pp. 35-45, in “Apoptosis detection and assay methods.” Zhu L, Chun J (eds.). BioTechniques Books, Natick, MA, 1998.

6.  Chun J.  Apoptotic DNA fragmentation detection using ligation mediated PCR (LMPCR).  In Apopotosis Detection, CHAPTER 4, pp. 23-33, in “Apoptosis detection and assay methods.” Zhu L, Chun J (eds.). BioTechniques Books, Natick, MA, 1998.

5.  Chun J, Blaschke AJ.  Unit 3.8, Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR.  In Current Protocols in Neuroscience.  Gerfen C, Mckay R (eds.).  John Wiley and Sons, Inc., 1997. PMC2774705

4.  Chun JJM, Schatz DG, Oettinger MA, Jaenisch R, Baltimore D.  The Recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system.  Cell 1991;64:189-200.

3.  Chun JJM, Schatz DG.  Recombination activating gene -1 (RAG-1) transcription in the mammalian CNS.  Chapter 22.  In Neuronal Cell Death and Repair, Vol. 6. Cuello AC (ed.).  Elsevier Science Publishers, Amsterdam, 1993.

2.  Schatz DG, Chun JJM.  V(D)J recombination and the transgenic brain blues.  New Biologist 1992;4:188-196.  

1.  Shatz CJ, Chun JJM, Luskin MB.  The role of the subplate in the development of the mammalian telencephalon.  In:  Development of the Cerebral Cortex, Vol. 7. Peters A, Jones EG (eds.).  Plenum Publishing Corp., New York, NY, 1988.

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