BLACKMONDLAB

PUBLICATIONS

2025

Higgs PG, Blackmond DG. Autocatalytic symmetry breaking and chiral amplification in a feedback network combining amino acid synthesis and ligation. Proc Natl Acad Sci U S A. 2025, 122 (20), e2423683122. PMID: 40377991.

Yu J, Blackmond DG. Nonclassical Nonlinear Effects (nc-NLEs) Provide Mechanistic Insights in Asymmetric Catalytic Cascade Reactions. ACS Catalysis. 2025, 15(5), 3890–7.

Yang S, Deng M, Daley RA, Daru A, Wolf WJ, George DT, Ma S, Werley BK, Samolova E, Bailey JB, Gembicky M, Marshall J, Wisniewski SR, Blackmond DG, Engle KM. Palladium Bisphosphine Monoxide Complexes: Synthesis, Scope, Mechanism, and Catalytic Relevance. J Am Chem Soc. 2025, 147 (1), 409-25. PMID: 39686735.

2024

Deng, M.; Yu, J.; Blackmond, D.G. Kinetic resolution as a general approach to enantioenrichment in prebiotic chemistry. Acc Chem Res 2024, 57 (16), 2234-44. PMID: 39115809.

Blackmond, D.G.; Emmert, M.; Huryn, D.M.; Neidig, M.L.; Schaub, T.; Topczewski, J.J.; Bravo-Altamirano, K.; Buchan, Z.; Cabrera, P.J. Academia or industry: Lessons on choosing career paths─There may be more than one fork in the road ahead. Org Lett 2024, 26 (14), 2682-2685. PMID: 38606472.

Yu, J.; Darú, A.; Deng, M.; Blackmond, D.G. Prebiotic access to enantioenriched amino acids via peptide-mediated transamination reactions. Proc Natl Acad Sci USA 2024, 121 (7), e2315447121. PMID: 38315856.

Deng, M.; Yu, J.; Blackmond, D.G. Symmetry breaking and chiral amplification in prebiotic ligation reactions. Nature 2024, 626 (8001), 1019-1024. PMID: 38418914.

2023

Burés, J.; Armstrong, A.; Blackmond, D.G. A tutorial on kinetic-assisted mechanistic analysis in asymmetric aminocatalysis. In: Asymmetric organocatalysis: New strategies, catalysts, and opportunities. Eds. L. Albrecht; A. Albrecht; L. Dell'Amico. Wiley VCH Verlag GmbH, 2023; pp. 657-678.

de Gombert, A.; Darù, A.; Ahmed, T.S.; Haibach, M.C.; Li-Matsuura, R.; Yang, C.; Henry, R.F.; Cook, S.P.; Shekhar, S.; Blackmond, D.G. Mechanistic insight into Cu-catalyzed C–N coupling of hindered aryl iodides and anilines using a pyrrol-ol ligand enables development of mild and homogeneous reaction conditions. ACS Catal 2023, 13 (5), 2904-2915.

2022

Wei, B.; Sharland, J.C.; Blackmond, D.G.; Musaev, D.G.; Davies, H.M.L. In-situ kinetic studies of Rh(II)-catalyzed C-H functionalization to achieve high catalyst turnover numbers. ACS Catal 2022, 12 (21), 13400-13410. PMID: 37274060.

Ali, C.; Blackmond, D.G.; Burés, J. Kinetic rationalization of nonlinear effects in asymmetric catalytic cascade reactions under Curtin-Hammett conditions. ACS Catal 2022, 12 (10), 5776-5785. PMID: 35633899.

Hao, W.; Joe, C.L.; Darù, A.; Ayers, S.; Ramirez, A.; Sandhu, B.; Daley, R.A.; Chen, J.S.; Schmidt, M.A.; Blackmond, D.G. Kinetic and thermodynamic considerations in the Rh-catalyzed enantioselective hydrogenation of 2-pyridyl-substituted alkenes. ACS Catal 2022, 12 (10), 5961-5969. PMID: 37727697.

Gnaim, S.; Bauer, A.; Zhang, H.J.; Chen, L.; Gannett, C.; Malapit, C.A.; Hill, D.E.; Vogt, D.; Tang, T.; Daley, R.A.; Hao, W.; Zeng, R.; Quertenmont, M.; Beck, W.D.; Kandahari, E.; Vantourout, J.C.; Echeverria, P.G.; Abruna, H.D.; Blackmond, D.G.; Minteer, S.D.; Reisman, S.E.; Sigman, M.S.; Baran, P.S. Cobalt-electrocatalytic HAT for functionalization of unsaturated C-C bonds. Nature 2022, 605 (7911), 687-695. PMID: 35614246.

Hao, W.; Joe, C.L.; Ayers, S.; Darù, A.; Daley, R.A.; Chen, J.S.; Domanski, M.; Schmidt, M.A.; Blackmond, D.G. Ru-catalyzed enantioselective hydrogenation of 2-pyridyl-substituted alkenes and substrate-mediated H/D exchange. ACS Catal 2022, 12 (2), 1150-1160. PMID: 36386561.

Ragan, J.A.; Chen, K.; Blackmond, D.G.; Tadross, P.M. Excellence in industrial organic synthesis 2021. J Org Chem 2022, 87 (4), 1879. PMID: 35176854.

2021

Huang, Y.; Knouse, K.W.; Qiu, S.; Hao, W.; Padial, N.M.; Vantourout, J.C.; Zheng, B.; Mercer, S.E.; Lopez-Ogalla, J.; Narayan, R.; Olson, R.E.; Blackmond, D.G.; Eastgate, M.D.; Schmidt, M.A.; McDonald, I.M.; Baran, P.S. A P(V) platform for oligonucleotide synthesis. Science 2021, 373 (6560), 1265-1270. PMID: 34516793.

Legnani, L.; Darù, A.; Jones, A.X.; Blackmond, D.G. Mechanistic insight into the origin of stereoselectivity in the ribose-mediated Strecker synthesis of alanine. J Am Chem Soc 2021, 143 (20), 7852-7858. PMID: 33979125.

Burés, J.; Armstrong, A.; Blackmond, D.G. Downstream paradigm in enamine catalysis: Comment on “On stereocontrol in organo-catalytic α-chlorinations of aldehydes”. ChemRxiv 2021, https://doi.org/10.26434/chemrxiv.14519733.v1.

Gao, Y.; Hill, D.E.; Hao, W.; McNicholas, B.J.; Vantourout, J.C.; Hadt, R.G.; Reisman, S.E.; Blackmond, D.G.; Baran, P.S. Electrochemical Nozaki-Hiyama-Kishi coupling: Scope, applications, and mechanism. J Am Chem Soc 2021, 143 (25), 9478-9488. PMID: 34128671.

Barton, L.M.; Chen, L.; Blackmond, D.G.; Baran, P.S. Electrochemical borylation of carboxylic acids. Proc Natl Acad Sci USA 2021, 118 (34), e2109408118. PMID: 34404720.

Yu, J.; Jones, A.X.; Legnani, L.; Blackmond, D.G. Prebiotic access to enantioenriched glyceraldehyde mediated by peptides. Chem Sci 2021, 12 (18), 6350-6354. PMID: 34084433.

Hu, J.; Cochrane, W.G.; Jones, A.X.; Blackmond, D.G.; Paegel, B.M. Chiral lipid bilayers are enantioselectively permeable. Nat Chem 2021, 13 (8), 786-791. PMID: 34112989.

Hao, W.; Bay, K.L.; Harris, C.F.; King, D.S.; Guzei, I.A.; Aristov, M.M.; Zhuang, Z.; Plata, R.E.; Hill, D.E.; Houk, K.N.; Berry, J.F.; Yu, J.-Q.; Blackmond, D.G. Probing catalyst speciation in Pd-MPAAM-catalyzed enantioselective C(sp3)–H arylation: Catalyst improvement via destabilization of off-cycle species. ACS Catal 2021, 11 (17), 11040-11048.

Matsuura, R.; Karunananda, M.K.; Liu, M.; Nguyen, N.; Blackmond, D.G.; Engle, K.M. Mechanistic studies of Pd(II)-catalyzed E/Z isomerization of unactivated alkenes: evidence for a monometallic nucleopalladation pathway. ACS Catal 2021, 11 (7), 4239-4246. PMID: 34422450.

2020

Hill, D.E.; Yu, J.Q.; Blackmond, D.G. Insights into the  role of transient chiral mediators and pyridone ligands in asymmetric Pd-catalyzed C-H functionalization. J Org Chem 2020, 85 (21), 13674-13679. PMID: 32991170.

Schmidt, O.P.; Blackmond, D.G. Temperature-scanning reaction protocol offers insights into activation parameters in the Buchwald–Hartwig Pd-catalyzed amination of aryl halides. ACS Catal 2020, 10 (15), 8926-8932.

Jones, A.X.; Wen, L.; Legnani, L.; Chen, J.; Blackmond, D.G. Asymmetric amplification in peptide-catalyzed formation of tetrose sugars from nearly racemic amino acids. J Syst Chem 2020, 8, 63-72.

Murray, J.I.; Sanders, J.N.; Richardson, P.F.; Houk, K.N.; Blackmond, D.G. Isotopically directed symmetry breaking and enantioenrichment in attrition-enhanced deracemization. J Am Chem Soc 2020, 142 (8), 3873-3879. PMID: 32027134.

Blackmond, D.G. Autocatalytic models for the origin of biological homochirality. Chem Rev 2020, 120 (11), 4831-4847. PMID: 31797671. — Invited contribution to a special issue on “Prebiotic Chemistry”

Wei, B.; Sharland, J.C.; Lin, P.; Wilkerson-Hill, S.M.; Fullilove, F.A.; McKinnon, S.; Blackmond, D.G.; Davies, H.M.L. In situ kinetic studies of Rh(II)-catalyzed asymmetric cyclopropanation with low catalyst loadings. ACS Catal 2020, 10 (2), 1161-1170.