Professor Jin-Quan Yu
The Scripps Research Institute
10550 North Torrey Pines Rd.
BCC372
La Jolla, CA 92037

Phone: 858-784-7942
Fax: 858-784-7949
e-mail: yu200@scripps.edu



 

Welcome to the Yu Lab Website

    Thank you for your interest in the Yu Group! This website provides up-to-date information concerning our research in the area of transition metal-catalyzed C−H activation. For prospective graduate students and postdoctoral fellows, relevant research projects that are currently in progress in our laboratory are summarized in the Research and Publications sections. A downloadable PDF file of our published work is also included. The Members section should provide a perspective on the composition of our group, both in terms of size and diversity.

    For a look at our research program when we started in 2002, see: [Link]

Prof. Jin-Quan Yu
yu200@scripps.edu

 

Research Highlights from the Yu Group: 2002-current

*Discovery of Ligands for Enantioselective C–H Activation Reactions

Mono-N-protected chiral amino acids are the first class of ligands to effect a wide range of Pd(II)-catalyzed enantioselective C–H activation reactions. The stereochemistry of the a-chiral center of the ligand is relayed to the C–H activation transition state through conformational gearing.

 

*Ligand-Accelerated Catalysis in C–H Activation Reactions

Mono-N-protected chiral amino acids have been found to accelerate a wide range of Pd(II)-catalyzed C–H activation reactions including olefination, cross-coupling with organometallic reagents, and C–O bond-forming reactions.

 

*Ligand-Promoted Non-Directed C–H Activation Reactions

A series of carefully tailored mono- and bidentate pyridine ligands have been shown to effect unprecedented regioselective C–H activation reactions.