| C-H activation: How can we cleave C-H bonds without using forcing conditions? |
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We have systematically established a new approach of using weak coordination between substrates and a metal catalyst to promote effective C-H activation. The success of this approach hinges upon a) optimizing the distance between substrate and catalyst as well as the conformation of the complex, and b) ligand acceleration by lowering the transition-state energy.
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| Weak coordination: |
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| Ligand acceleration: |
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| Positional selectivity |
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We have developed a toolkit for meta-selective C-H activation.
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| Enantioselectivity |
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We are one of the few labs to perform C-H activation reactions in an enantioselective fashion.
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