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The Surh Laboratory


Ernst, B., D.-S. Lee, J. M. Chang, J Sprent and C. D. Surh.  The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery.  Immunity 11:173-181 (1999).

Anderson, K. L., H. Perkin, C. D. Surh, S. Venturini, R. A. Maki, and B. E. Torbett.  Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells.  J. Immunol.  164;1855-1861 (2000).

Hwang, I, J. F. Huang., H. Kishimoto, A. Brunmark, P. A. Peterson, M.R. Jackson, C. D. Surh, Z. Cai, and J. Sprent.  T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells. J. Exp. Med. 191:1137-48, (2000).

Surh, C. D., B. Ernst, D.-S. Lee, W. Dummer, and E. LeRoy.  Role of self-major histocompatibility complex/peptide ligands in selection and maintenance of a diverse T cell repertoire.  Immunol. Res. 21/2-3:331-339 (2000).

Surh, C. D. and J. Sprent.  Homeostatic T Cell Proliferation. How far can T cells be activated to self-ligands?  J. Exp. Med.  192:F9-F14 (2000).

Dummer, W., B. Ernst, E. LeRoy, D.-S. Lee, and C. D. Surh.  Autologous regulation of naïve T cell homeostasis within the T cell compartment.  J. Immunol.  166:2460-2468 (2001).

Sprent, J. and C. D. Surh.  Generation and maintenance of memory T cells.  Curr. Opin. Immunol. 13:248-254 (2001).

Tan, J.T., E. Dudl, E. LeRoy, R. Murray, J. Sprent, K.I. Weinberg, and C. D. Surh.  IL-7 is critical for homeostatic proliferation and survival of naïve T cells.  Proc. Natl. Acad. Sci. USA 98:8732-7 (2001).

Ostler, T., T. Hussell, C.D. Surh, P. Openshaw, and S. Ehl.  Long-term persistence and reactivation of T cell memory in the lung of mice infected with respiratory syncytial virus.  Eur. J. Immunol. 31:2574-82 (2001).

Gapin, L., J.L. Matsuda, C.D. Surh, and M. Kronenberg. NKT cells derive from double-positive thymocytes that are positively selected by CD1d.  Nat. Immunol. 2:971-8 (2001).

Surh, C.D. and J. Sprent. Regulation of naïve and memory T cell homeostasis. Microbes and Infection, 4:51-6 (2002).

Zhang, X., H. Fujii, H. Kishimoto, E. LeRoy, C.D. Surh, and J. Sprent.  Aging leads to disturbed homeostasis of memory phenotype CD8+ cells.  J. Exp. Med. 195:283-93 (2002).

Sprent, J. and C.D.Surh.  T cell memory.  Annu. Rev. Immunol. 20:551-79 (2002).

Tan, J.T., B. Ernst, W.C. Kieper, E. LeRoy, J. Sprent, and C.D. Surh.  Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells.  J. Exp. Med. 195:1523-1532 (2002).

Kieper, W.C., J.T. Tan, B. Bondi-Boyd, L. Gapin, J. Sprent, R. Ceredig, and
C.D. Surh.  Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells.  J. Exp. Med. 195:1533-1539 (2002).

Matsuda J.L., L. Gapin, S. Sidobre, W. C. Kieper, J. T. Tan, R. Ceredig, C. D. Surh, M. Kronenberg.  Homeostasis of Va14i NKT cells.  Nat. Immunol. 3:966-74 (2002).

Judge A.D., X. Zhang, H. Fujii. C.D. Surh, and J. Sprent.  Interleukin 15 Controls both Proliferation and Survival of a Subset of Memory-Phenotype CD8+ T Cells. J. Exp. Med. 196:935-46 (2002).

Surh CD, Tan J, Kieper WC, Ernst B.  Factors regulating naive T cell homeostasis. Adv Exp Med Biol. 512:73-80 (2002).

Sprent J, Surh CD.  Cytokines and T cell homeostasis. Immunol Lett. 22;85(2):145-9 (2003).

Sprent J, Surh CD.  Knowing one's self: central tolerance revisited.  Nat Immunol. 4:303-4 (2003).

Rosen H, Alfonso C, Surh CD, McHeyzer-Williams MG.  Rapid induction of medullary thymocyte phenotypic maturation and inhibition of thymic egress at low nanomolar concentrations of sphingosine 1-phosphate receptor agonist. Proc. Natl. Acad. Sci. 100(19):10907-12 (2003).

Kaech SM, Tan JT, Wherry EJ, Konieczny BT, Surh CD, Ahmed, R.  Selective expression of interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.  Nat. Immunol. 4(12):1191-8 (2003).

Kondrack RM, Harbertson J, Tan J, McBreen ME, Surh CD, Bradley LM.  Interleukin 7 regulates the survival and generation of memory CD4 cells. J. Exp. Med. 198(12):1797-806 (2003).

Kieper WC, Burghardt JT, Surh CD.  A role for TCR affinity in regulating naïve T cell homeostasis. J. Immunol. 172:40-44 (2004).

Kieper WC, Troy A, Burghardt JT, Ramsey C., Lee JY, Jiang H-Q, Dummer W, Shen H, Cebra JJ, Surh CD.  Cutting Edge: Recent immune status determines the source of antigens that drive homeostatic T cell expansion. J Immunol. 174:3158-63 (2005).

Baccala R, Witherden D, Gonzalez-Quintial R, Dummer W, Surh CD, Havran WL, Theofilopoulos AN.  Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol. 174:4606-12 (2005).

Surh CD, Sprent J.  Regulation of mature T cell homeostasis. Semin Immunol. 17:183-91 (2005).

Gattinoni L, Finkelstein SE, Klebanoff CA, Antony PA, Palmer DC, Spiess PJ, Hwang LN, Yu Z, Wrzesinski C, Heimann DM, Surh CD, Rosenberg SA, Restifo NP.  Removal of homeostatic cytokine links by lymhodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells.  J. Exp. Med. 202:907-912 (2005).

Davey GM, Starr R, Cornish AL, Burghardt T, Alexander WS, Carbone FR, Surh CD, Heath WR.  SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naïve CD8 T cells, limiting their autoimmune potential. J. Exp. Med. 202:1099-108 (2005).

Lee SK, Surh CD. Role of interleukin-7 in bone and T-cell homeostasis.  Immunol. Rev. 208:169-80 (2005).

Ramsey C, Hässler S, Marits P, Kämpe O, Surh CD, Peltonen L, Winqvist O. Increased antigen presenting cell mediated T-cell activation in mice and patients missing the autoimmune regulator. Eur. J. Immunol. 36:305 (2006).

*Boyman O, Kovar M, Rubinstein MP, Surh CD, Sprent J. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 311:1924-7 (2006).

Surh CD, Sprent J. On the TRAIL of homeostatic memory T cells. Nat. Immunol. 7:439-41 (2006).

Rubinstein MP, Kovar M, Purton JF, Cho JH, Boyman O, Surh CD, Sprent J.  Converting IL-15 to a superagonist by binding to soluble IL-15Ralpha.  Proc Natl Acad Sci U S A. 103:9166-71. (2006)

Boyman O, Cho JH, Tan JT, Surh CD, Sprent J.  A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells. J Exp Med. 203:1817-25 (2006).

Surh CD, Boyman O, Purton JF, Sprent J. Homeostasis of memory T cells. Immunol Rev. 211:154-63 (2006).

McKay D, Shigeoka A, Rubinstein M, Surh C, Sprent J.  Simultaneous deletion of MyD88 and Trif delays major histocompatibility and minor antigen mismatch allograft rejection.  Eur J Immunol. 36:1994-2002 (2006).

Tan JT, Surh CD.  T cell memory. Current Topics in Microbiology and Immunology. Pulendran, B and Ahmed, R (Eds). 311:85-115 (2006).

Boyman O, Surh CD, Sprent J.  Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease. 
Expert Opin Biol Ther. 6:1323-31. (2006)

*Purton JF, Tan JT, Rubinstein MP, Kim DM, Sprent J, Surh CD.  Anti-viral CD4+ memory T cells are IL-15 dependent. J Exp Med. 204:951-61 (2007).

Boyman O, Purton JF, Surh CD, Sprent J.  Cytokines and T-cell homeostasis. Curr Opin Immunol. 19:320-6 (2007).

Hanick NA, Rickert M, Varani L, Bankovich AJ, Cochran JR, Kim DM, Surh CD, Garcia KC.  Elucidation of the Interleukin-15 Binding Site on Its Alpha Receptor by NMR.  Biochemistry. 46:9453-9461 (2007).

Cho JH, Boyman O, Kim HO, Hahm B, Rubinstein MP, Surh CD, Sprent J.  An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2. J Exp Med. 204:1787-801 (2007).

Purton JF, Sprent J, Surh CD.  Commentary: Staying alive – naïve CD4+ T cell homeostasis.  Eur J Immunol. 37: 2367-9 (2007).

Lee S, Chung J, Ha IS, Yi K, Lee JE, Kang HG, Choi I, Oh KH, Kim JY, Surh CD, Ahn C.  Hydrogen peroxide increases human leukocyte adhesion to porcine aortic endothelial cells via NF{kappa}B-dependent up-regulation of VCAM-1. Int Immunol. 19(12):1349-59 (2007).

Sprent J, Cho JH, Boyman O, Surh CD.  T cell homeostasis.  Immunol Cell Bio. 86:312-9 (2008).

Ramsey C, Rubinstein MP, Kim DM, Cho JH, Sprent J, Surh CD.  The lymphopenic environment of CD132 (gc)-deficient hosts elicits rapid homeostatic proliferation of naïve T cells via IL-15.  J. Immunol. 180:5320-6 (2008).

Purton JF, Martin CE, Surh CD. Enhancing T cell memory: IL-7 as an adjuvant to boost memory T-cell generation. Immunol Cell Biol. 86:385-386 (2008).

Boyman O, Ramsey C, Kim K, Sprent J, and Surh CD.  IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T cell expansion without lymphopenia. J. Immunol. 180:7265-75 (2008).

Bayer AL, Lee JY, de la Barrera A, Surh CD, Malek TR.  A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. J. Immunol. 181:225-34 (2008).

Rubinstein MP, Lind NA, Purton JF, Filippou P, Best JA, McGhee PA, Surh CD, Goldrath AW. IL-7 and IL-15 differentially regulate CD8+ T cell subsets during contraction of the immune response. Blood. 2008 Nov 1;112(9):3704-12. Epub 2008 Aug 8

Verdeil G, Marquardt K, Surh CD, Sherman LA. Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy. Proc Natl Acad Sci U S A. 105(43):16683-8 (2008)

Sprent J, Surh CD. Re-entry of mature T cells to the thymus: an epiphenomenon? Immunol Cell Biol. 2008 Dec 2. [Epub ahead of print]

*Surh CD, Sprent J. Homeostasis of naïve and memory T cells. Immunity 29:848-862 (2008).

van Leeuwen EM, Sprent J, Surh CD. Generation and maintenance of memory CD4(+) T Cells. Curr Opin Immunol. 2009 Apr;21(2):167-72. Epub 2009 Mar 11.

Webster KE, Walters S, Kohler RE, Mrkvan T, Boyman O, Surh CD, Grey ST, Sprent J. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med. 2009 Apr 13;206(4):751-60. Epub 2009 Mar 30.

Awong G, Herer E, Surh CD, Dick JE, La Motte-Mohs RN, Zuniga-Pflucker JC. Characterization in vitro and engraftment potential in vivo of human progenitor T-cells generated from hematopoietic stem cells. Blood. 2009 Jul 30;114(5):972-82. Epub 2009 Jun 2.

Surh CD, Sprent J. Glimpsing the real CD4+ T cell response. Nat Immunol. 2010 Jan;11(1):47-9.

*Cho JH, Kim HO, Surh CD, Sprent J. TCR-dependent regulation of lipid rafts controls naïve CD8+ T cell homeostasis. Immunity. 2010 Feb 26;32(2):214-26. Epub 2010 Feb 4.

*Létourneau S, van Leeuwen EMM, Krieg C, Martin C, Pantaleo G, Sprent J, Surh CD, Boyman O. IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor a subunit CD25. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2171-6. Epub 2010 Jan 19.

Martin CE, Kim, DM, Sprent J, Surh CD.  Is IL-7 from dendritic cells essential for the homeostasis of CD4+ T cells? Nat Immunol. 2010 Jul;11(7):547-8; author reply 548.