Welcome to Dave Stout's lab
home Research Publications Lab Members Contacts The Scripps Research Institute

HIV Protease

  HIV crystal collage
Various HIV protease crystals used for fragment screening and data collection at SSRL.

HIV protease (PR) is a proven target for drugs that suppress HIV AIDS, but treatment leads to multi-drug-resistant mutants. As a strategy to defeat the evolution of viral resistance, we are employing fragment based lead discovery to develop novel classes of allosteric PR inhibitors able to act in synergy with FDA approved drugs.


  HIV crystal collage
Electron density for a chemical "fragment' bound in a pocket on the surface of HIV protease
when the active site is occupied with an inhibitor.





HIV Protease

Cytochrome ba3 oxidase

Cytochrome P450s

Home    |    Research    |    Publications    |    Lab Members    |    Contacts    |    Scripps Research