CYP24A1
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Electron density of the detergent CHAPS in the active site of the open conformation of CYP24A1. |
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Mitochondrial P450 enzymes catalyze highly specific reactions in the biosynthesis and degradation of hormones; CYP24A1 oxidizes the active form vitamin D, and therefore is an ideal target for inhibitor development to treat diseases linked to vitamin D insufficiency, including chronic kidney disease and cancer. |
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Projects
Transhydrogenase
CYP24A1
HIV Protease
Cytochrome ba3 oxidase
Cytochrome P450s
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10550 North Torrey Pines Rd., MB-8