The Saez Laboratory

Publications

Epple. R., Cow, C., Xie, Y., Azimioara, M., Russo, R., Wang, X., Wityak, J., Karanewsky, D.S., Tuntland,T., Nguyeñ-Tran, V.T., Cuc, C., Huang, D., Saez, E., Spalding, T., Gerken, A., Iskandar, M., Seidel, HM. and S.S. Tian. Novel Bisaryl Substituted Thiazoles and Oxazoles as Highly Potent and Selective Peroxisome Proliferator-Activated Receptor δ Agonists. Journal of Medicinal Chemistry 2010 53:77-105.

Jain, T. and E. Saez. Highly parallel introduction of nucleic acids into mammalian cells grown in microwell arrays. Lab Chip 2009. 9: 3557-3566.

Zhu, J., Mounzih, K., Chehab, E.C., Mitro, N., Saez, E. and F.F. Chehab. Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerols accumulation and glucose uptake. Journal of Lipid Research 2009. Dec 25. [Epub ahead of print]

Sironi, L., Mitro, M., Cimino, M., Gelosa, P., Guerrini, U., Tremoli, E., and Saez, E. Treatment with LXR agonists after focal cerebral ischemia prevents brain damage. FEBS letters 2008, 582(23-24):3396-400.

Wu, C., Delano, D.L., Mitro, N., Su, S.V., Janes, J., McClurg, P., Batalov, S., Welch, G.L., Zhang, J., Orth, A.P., Walker, J.R., Glynne, R.J., Cooke, M.P., Takahashi, J.S., Shimomura, K., Kohsaka, A., Bass, J., Saez, E., Wiltshire, T., Su, AI. Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. PLoS Genet 2008, 4(5):e1000070.

Commerford, S.R., Vargas, L., Dorfman, S.E., Mak, P.A., Mitro, N., Rocheford, E.C., Li, X., Kennedy, P., Mullarkey, T.L., and Saez, E. Dissection of the anti-diabetic effect of liver X receptor ligands. Molecular Endocrinology 2007, 21(12):3002-1.

Molteni, V., Li, X., Nabakka, J., Liang, F., Wityak, J., Koder, A., Vargas, L., Romeo, R., Mitro, N., Mak, P.A., Seidel, H.M., Haslam, J.A., Tuntland, T., Spalding, T.A., Brock, A., Bradley, M., Castrillo, A., Tontonoz, P. and Saez, E. N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRβ. The Journal of Medicinal Chemistry 2007 50(17):4255-9.

Waki, H., Park, K.W., Mitro, N., Pei, L., Damoiseaux, R., Wilpitz, D.C., Reue, K., Saez, E. and P. Tontonoz. The Small Molecule Harmine Is an Antidiabetic Cell-Type-Specific Regulator of PPARγ Expression. Cell Metabolism 2007, 5: 357-70.

Mitro, N., Vargas, L., Romeo, R., Koder, A., and Saez, E. T0901317 is a potent PXR ligand: Implications for the biology ascribed to LXR. FEBS Lett. 2007, 581: 1721-6.

Mitro, N., Mak, P., Vargas, L., Godio, C., Hampton, E., Molteni, V., Kresuch, A. and Saez, E. 2006. The nuclear receptor LXR is a glucose sensor. Nature 2007, 445: 219-23.

Epple, R., Russo, R., Azimioara, M., Cow, C., Xie, Y., Wang, X., Wityak, J., Karanewsky, D., Gerken, A., Iskandar, M., Saez, E., Seidel, M. H. and S.S. Tian. 3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists: Part 2. Bioorg Med Chem Lett 2006, 16: 5488-92.

Cho, C.Y., Koo, S-H., Wang, Y., Callaway, S., Hedrick, S., Mak, P.A., Orth, A.P., Peters, E.C., Saez, E., Montminy, M., Schultz, P.G. and S.K. Chanda. Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. Cell Metabolism 2006, 3: 367-378.

Galimi*, F., Saez*, E., Gall, J.G., Hoong, N., Cho, G., Evans, R.M., and I.M. Verma. Development of ecdysone-regulated lentiviral vectors. Molecular Therapy 2005, 11: 142-148. *Joint first authors

Joseph, S.B., Bradley, M., Castrillo, A., Bruhn, K., Mak, P., Pei, L. Hogenesch, J., O�Connell, R.M., Cheng, G., Saez, E., Miller, J. and P. Tontonoz. LXR-dependent gene expression is important for macrophage survival and the innate immune response to bacterial pathogens. Cell 2004, 119: 299-309.

Saez, E., Rosenfeld, J.R., Livolsi, A., Olson, P., Lombardo, E., Nelson, M.C., Banayo, E., Cardiff, R.D., Izpisua/Belmonte, J.C. and R.M. Evans. PPARγ signaling exarcebates mammary gland tumor development. Genes and Development 2004, 18: 528-540.

Saez, E., Olson, P. and R.M. Evans. Genetic deficiency in PPARg does not alter development of experimental prostate cancer. Nature Medicine 2003, 9: 5419-5424.

Laffitte, B.A., Chao, L.C., Li, J., Walczak, R., Hummasti, S., Joseph, S.B., Castrillo, A., Wilpitz, D.C., Mangelsdorf, D.J., Collins, J.L., Saez, E. and P. Tontonoz. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. PNAS 2003, 100: 5419-5424.

Saez, E., Nelson, M.C., Eshelman, B., Banayo, E., Koder, A., Cho, G.J., and R.M. Evans. Identification of ligands and coligands for the ecdysone-regulated gene switch. PNAS 2000, 97: 14512-14517.

Chawla, A., Saez, E., and R.M. Evans. "Don't know much bile-ology". Cell 2000, 103: 1-4.

Saez, E., Tontonoz, P., Nelson, M.C., Alvarez, J.G., U, T-M., Baird, S.M., Thomazy, V.A., and R.M. Evans. Activators of the nuclear receptor PPARγ enhance colon polyp formation. Nature Medicine 1998, 4:1058-1061.

Serova, L., Saez, E., Spiegelman, B.M., and E.L. Sabban. c-Fos deficiency inhibits induction of mRNA for some, but not all, neurotransmitter biosynthetic enzymes by immobilization stress. Journal of Neurochemistry 1998, 70: 1935-1940.

Saez, E., No, D., West, A., and R.M. Evans. Inducible gene expression in mammalian cells and transgenic mice. Current Opinion in Biotechnology 1997, 8:608-616.

Rutberg, S.E., Saez, E., Lo, S., Jang, S.-I., Markova, N., Spiegelman, B.M. and S.H. Yuspa. Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters. Oncogene 1997, 15: 1337-1346.

Holmes, S.G., Rose, A.B., Steuerle, K., Saez, E., Sayegh, S., Lee, Y.M. and J.R. Broach. Hyperactivation of the silencing proteins Sir2p and Sir3p, causes chromosome loss. Genetics 1997, 145:605-614.

Rutberg, S.E., Saez, E., Glick, A., Dlugosz, A.A., Spiegelman, B.M. and S.H. Yuspa. Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins. Oncogene 1996, 13: 167-176.

Saez, E., Oppenheim, H., Van Etten, R.E. and B.M. Spiegelman. C-fos is not essential for v-abl-induced lymphomagenesis. Cancer Research 1995, 55: 6196-6199.

Saez, E., Rutberg, S.E., Mueller, E., Oppenheim, H., Smoluk, J., Yuspa, S. H. and B.M. Spiegelman. C-fos is required for malignant progression of skin tumors. Cell 1995, 82: 721-732.