Publications

1. Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C.  Deficiency of protein C in congenital thrombotic disease.  J Clin Invest 68:1370-1373, 1981.

2. Branson HE, Katz J, Marble R, Griffin JH.  Inherited protein C deficiency and a coumarin-responsive chronic relapsing purpura fulminans syndrome in a neonate.  Lancet November 19, 1165-1168, 1983.

3. Schwarz HP, Fischer M, Hopmeier P, Batard MA, Griffin JH.  Plasma protein S deficiency in familial thrombotic disease.  Blood 64:1297-1300, 1984.

4. Greengard JS, Sun X, Xu X, Fernandez JA, Evatt B, Griffin JH.  Activated protein C resistance caused by Arg506Gln mutation in factor Va.  Lancet 343:1361-1362, 1994.

5. Greengard JS, Eichinger S, Griffin JH, Bauer KA.  Variability of thrombosis among homozygous siblings resistant to activated protein C due to Arg506Gln-Factor V.  N Engl J Med 331:1559-1562, 1994.

6. Heeb MJ, Kojima Y, Greengard JS, Griffin JH.  Activated protein C resistance:  Molecular mechanisms based on studies using purified Gln506-factor V.  Blood 85:3405-3411, 1995.

7. Griffin JH.  The thrombin paradox.  Nature 378:337-338, 1995.

8. Heeb MJ, Kojima Y, Hackeng TM, Griffin JH.  Binding sites for blood coagulation Factor Xa and protein S involving residues 493-506 in Factor Va.  Protein Science 5:1883-1889, 1996.

9. Gale AJ, Sun X, Heeb MJ, Griffin JH.  Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va.  Prot Sci 6:132-140, 1997.

10. Griffin J, Kojima K, Banka CL, Curtiss LK, Fernandez JA.  High density lipoprotein enhancement of anticoagulant activities of plasma protein S and activated protein C.  J. Clin. Invest.103:219-227, 1999.

11. Macko R, Killewich L, Fernandez JA, Cox K, Rosen M, Gruber A, Griffin JH. Brain specific protein C activation during carotid artery occlusion in humans. Stroke 30:542-545, 1999.

12. Deguchi H, Fernandez JA, Hackeng TM, Banka CL, Griffin JH. Cardiolipin is a normal component of human plasma lipoproteins. Proc Natl Acad Sci USA  97:1743-1748, 2000.

13. Gale A, Heeb MJ, Griffin JH. The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites. Blood  96:585-593, 2000.   

14. Pellequer JL, Gale AJ, Getzoff ED, Griffin JH. Three-dimensional model of coagulation factor Va bound to activated protein C. Thrombos Haemost 84: 849-857, 2000.

15. Hackeng TM, Fernandez JA, Dawson PE, Kent SB, Griffin JH. Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S. Proc Nat Acad Sci USA, 97: 14074-14078, 2000.

16. Shibata, M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. Anti-inflammatory, antithrombotic and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation, 103: 1799-805, 2001.

17. Deguchi H, Fernandez JA, Pabinger I, Heit JA, Griffin JH. Plasma glucosylceramide deficiency as potential risk factor for venous thrombosis and modulator of anticoagulant protein C pathway. Blood, 97:1907-14, 2001.

18. Deguchi H, Fernandez JA, Griffin JH. Neutral glycosphingolipid-dependent inactivation of coagulation factor Va by activated protein C and protein S. J Biol Chem 277:8861-8865, 2002.

19. Lentz SR, Miller FJ, Piegors DJ, Erger RA, Fernandez JA, Griffin JH, Heistad DD. Anticoagulant responses to thrombin improve during regression of antherosclerosis in monkeys. Circulation 106:842-846, 2002.

20. Gale AJ, Xu X, Pellequer J-L, Getzoff ED, Griffin JH. Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of factor Va by activated protein C. Protein Science 11:2091-2101, 2002.

21. Lentz SR, Piegors DJ, Fernandez JA, Erger RA, Arning E, Malinow MR, Griffin JH, Bottiglieri T, Haynes WG, Heistad DD. Effect of hyperhomocysteinemia on protein C activation and activity. Blood 100:2108-2112, 2002.

22. Gale AJ, Tsavaler A, Griffin JH. Molecular characterization of an extended binding site for factor Va in the positive exosite of activated protein C. J Biol Chem 277:28836-28840, 2002.

23. Cheng T, Liu D, Griffin JH, Fernandez JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV.  Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective in a murine stroke model through EPCR and PAR-1. Nature Medicine 9:338-342, 2003.

24. Liu D, Guo H, Griffin JH, Fernandez JA, Zlokovic BV. Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation, 107:1791-1796, 2003.

25. Fernandez JA, Xu X, Liu D, Zlokovic B, Griffin JH. Recombinant murine activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells Mol Dis, 30:271-276, 2003.

26. Domotor E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood, 101:4797-4801, 2003.

27. Yegneswaran S, Deguchi H, Griffin JH. Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human and bovine activated protein C with negatively charged phospholipid vesicles.  J Biol Chem, 278:14614-14621, 2003.

28. Mosnier LO, Griffin JH. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease activated receptor-1 and endothelial cell protein C receptor. Biochem J, 373:65-70, 2003.

29. Yegneswaran S, Mesters RM, Griffin JH. Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex. J Biol Chem, 278: 33312-33318, 2003.

30. Gale AJ, Griffin JH.  Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va. Proteins, in press 2004.

31. Deguchi H, Yegneswaran S, Griffin JH.  Sphingolipids as bioactive regulators of thrombin generation.  J Biol Chem, in press 2004.

32. Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernandez JA, Griffin JH, Zlokovic BV.  Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron, in press 2004.