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The Gerace Laboratory

2000 - Present
1991 - 1999 
1981 - 1990
1978 - 1980





1991 - 1999

Lyman, S.K., Gerace, L. and Baserga, S.J. (1999) Human Nop5/Nop58 is a  component common to the box C/D small nucleolar ribonucleoproteins.  RNA  5:1597-604. PubMed
Kehlenbach, R.H., Dickmanns, A., Kehlenbach, A., Guan, T., and Gerace, L. (1999) A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. J. Cell Biol. 145:645-657. PubMed
Hu, T. and Gerace, L. (1998) cDNA cloning and analysis of the expression of nucleoporin p45. Gene 221:245-253. PubMed
Saphire, A.C., Bark, S.J., Gerace, L. (1998) All four homochiral enantiomers of a nuclear localization sequence derived from c-Myc serve as functional import signals. J. Biol Chem. 273: 29764-29769. PubMed
Kehlenbach, R.H., Dickmanns, A., and Gerace, L. (1998) Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT in vitro. J. Cell Biol. 141:863-874.PubMed
Melchior, F. and Gerace, L. (1998) Two-way trafficking with Ran. Trends Cell Biol. 8:175-177.PubMed
Furukawa, K., Fritze, C.E., and Gerace, L. (1998) The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain. J. Biol. Chem. 273:4213-4219. PubMed
Mahajan, R., Gerace, L., and Melchior, F. (1998) Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association. J. Cell Biol. 140:259-270.PubMed
Westendorf, J.M., Konstantinov, K.N., Wormsley, S., Shu, M-D., Matsumoto-Taniura, N., Pirollet, F., Klier, F.G., Gerace, L., and Baserga, S.J. (1998). M phase phosphoprotein 10 (MPP10) is a U3 small nucleolar ribonucleoprotein component.  Mol. Biol. Cell 9:437-449. PubMed
Clarkson, W.D., Corbett, A.H., Paschal, B.M., Kent, H.M., McCoy, A.J., Gerace, L., Silver, P.A., and Stewart, M. (1997) Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not Bind GDP-Ran.  J. Mol. Biol. 272:716-730 PubMed
Yang, L., Guan, T., and Gerace, L. (1997) Lamin binding fragment of LAP2 inhibits increase in nuclear volume during the cell cycle and progression into S phase. J. Cell Biol. 139:1077-1087.PubMed
Delphin, C., Guan, T., Melchior, F., and Gerace, L. (1997) RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex.  Mol. Biol. Cell. 8:2379-2390. PubMed
Paschal, B., Fritze, C., Guan, T., and Gerace, L. (1997) High levels of the GTPase Ran/TC4 relieve the requirement for nuclear protein import factor NTF2. J. Biol. Chem. 272:21534-21539. PubMed
Yang, L., Guan, T., and Gerace, L. (1997) Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis.  J. Cell Biol. 137:1199-1210.PubMed
Von Mikecz, A., Konstantinov, K., Buchwald, D.S., Gerace, L., and Tan, E.M. (1997) High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome. Arthritis Rheum. 40:295-305. PubMed
Mahajan, R., Delphin, C., Guan, T., Gerace, L., and Melchior, F. (1997) A small ubiquitin related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell 88:97-107. PubMed
Konstantinov, K., von Mikecz, A., Buchwald, D., Jones, J., Gerace, L., and Tan, E.M. (1996) Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome. J. Clin. Invest. 98:1888-1896. PubMed
Taniura-Matsumoto, N., Pirollet, F., Monroe, R., Gerace, L., and Westendorf, J.M. (1996) Identification of novel M-phase phosphoproteins by expression cloning. Mol. Biol. Cell 7:1455-1469.PubMed
Hu, T., Guan, T. and Gerace, L. (1996) Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins.  J. Cell Biol. 134:589-601. PubMed
Paschal, B.M., Delphin, C., and Gerace, L. (1996) Nucleotide specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97.  Proc. Natl. Acad. Sci. USA 93:7679-7683. PubMed
Sweet, D.J. and Gerace, L. (1996) A GTPase distinct from Ran is involved in nuclear protein import.  J. Cell Biol. 133:971-983. PubMed
Melchior, F., Guan, T., Paschal, B., and Gerace, L. (1996)  Biochemical and structural analysis of nuclear protein import.  Cold Spring Harbor Symp. Quant. Biol. LX:707-716.
Sweet, D.J. and Gerace, L. (1995) Taking from the cytoplasm and giving to the pore:  soluble transport factors in nuclear protein import. Trends Cell Biol. 5:444-447. PubMed
Gerace, L. (1995) Nuclear export signals and the fast track to the cytoplasm.  Cell 82:341-344.
Guan, T., Müller,  S., Klier, G., Panté,  N., Blevitt, J.M.,  Haner,  M.,  Paschal, B.,  Aebi, U., and Gerace, L. (1995) Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex.  Mol. Biol. Cell 6:1591-1603.  PubMed
Melchior, F., Guan, T., Yokoyama, N., Nishimoto, T., and Gerace, L. (1995) GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import.  J. Cell Biol. 131:1-11.PubMed
Taniura, H., Glass, C. and Gerace, L. (1995) A chromatin binding site in the tail domain of nuclear lamins that interacts with core histones.  J. Cell Biol. 131:33-44. PubMed
Martin, L., Crimaudo, C. and Gerace, L. (1995) cDNA cloning and characterization of lamina-associated polypeptide 1C (LAP1C), an integral protein of the inner nuclear membrane.  J. Biol. Chem. 270:8822-8828. PubMed
Melchior, F. and Gerace, L. (1995) Mechanisms of nuclear protein import. Curr. Op. Cell Biol. 7:310-318.
Paschal, B.M., and Gerace, L. (1995) Identification of NTF2, a cytosolic factor for nuclear import which interacts with nuclear pore complex protein p62.  J. Cell Biol. 129:925-937. PubMed
Furukawa, K., Panté, N., Aebi, U., and Gerace, L. (1995) cDNA cloning of lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope. EMBO J. 14:1626-1636. PubMed
Melchior, F., Sweet, D.J. and Gerace, L. (1995) Analysis of Ran/TC4 function in nuclear protein import. Meth. Enzymol. 257:279-291.
Greber, U. and Gerace, L. (1995) Depletion of calcium from the lumen at the endoplasmic reticulum reversibly inhibits passive diffusion and signal-mediated transport into the nucleus. J. Cell Biol. 128:5-14. PubMed
Konstantinov, K., Foisner, R., Byrd, D., Liu, F.-T., Tsai, W.-M., Wiik, A., and Gerace, L. (1995) Integral membrane proteins associated with the nuclear lamina are novel autoimmune antigens of the nuclear envelope.  Clin. Immunol. Immunopathol. 74:89-99. PubMed
Byrd, D.A., Sweet, D.J., Panté, N., Konstantinov, K.N., Guan, T., Saphire, A.C.S., Mitchell, P.J., Cooper, C.S., Aebi, U., and Gerace, L. (1994) Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex.  J. Cell Biol. 127:1515-1526. PubMed
Gerace, L. and Foisner, R. (1994) Integral membrane proteins and dynamic organization of the nuclear envelope.  Trends Cell Biol. 4:127-131. PubMed
Westendorf, J. and Gerace, L. (1994) Cloning of cDNAs for M phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope. Proc. Natl. Acad. Sci. USA 91:714-718. PubMed
Glass, C., Glass, J., Taniura, H., Hasel, C. and Gerace, L. (1993) The alpha helical rod domain of lamins A and C contains a chromosome binding site.  EMBO J. 12:4413-4424. PubMed
Melchior, F., Paschal, B., Evans, J., and Gerace, L. (1993) Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor.  J. Cell Biol. 123:1649-1660. PubMed
Foisner, R. and Gerace, L. (1993)  Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes and binding is modulated by mitotic phosphorylation.  Cell 73:1267-1279.PubMed
Adam, S.A., Sterne-Marr, R. and Gerace, L. (1992) Analysis of nuclear protein import using digitonin-permeabilized cells. Meth. Enzymol. 219:97-109.
Gerace, L. (1992) Molecular trafficking through the nuclear pore complex. Curr. Op. Cell Biol. 4:637-645. PubMed
Greber, U.F. and Gerace, L. (1992) Nuclear protein import is inhibited by an antibody to a lumenal epitope of a nuclear pore complex glycoprotein.  J. Cell Biol. 116:15-30. PubMed
Sterne Marr, R., Blevitt, J., Adam, S.A. and Gerace, L. (1992) O-linked glycoproteins of the nuclear pore complex interact with a cytosolic factor required for nuclear protein import.  J. Cell Biol. 116:271-280. PubMed
Millar, J.B., Blevitt, J., Gerace, L., Sadhu, K., Featherstone, C. and Russell, P. (1991) p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells. Proc. Natl. Acad. Sci. USA 88:10500-10504. PubMed
Adam, S.A., Sterne-Marr, R. and Gerace, L. (1991) In vitro nuclear protein import using permeabilized mammalian cells. Meth. Cell Biol. 35:469-482. PubMed
Adam, S.A. and Gerace, L. (1991) Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import.  Cell 66:837-847. PubMed
Seydel, U. and Gerace, L. (1991) A 28,000 Da GDP/GTP-binding protein specific to the nuclear envelope.  J. Biol. Chem. 266:7602-7608.