Publications
Note: Underlined names indicate first and co-first authors, # indicates corresponding and co-corresponding authors.
- Xiao C, Douglas I, Janeway CA, Ghosh S. (1999) "ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway." Genes & Development 13: 2059-2071. , Medzhitov R, Carothers J,
- "Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis." Genes & Development 17: 2933-2949. , Shim JH, Kluppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S. (2003)
- "MicroRNA profiling of the murine hematopoietic system." Genome Biology 6(8): R71. , , , , Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, Rao A, Kosik KS. (2005)
- Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, Lee KY, Bussey C, Steckel M, Tanaka N, Yamada G, Akira S, Matsumoto K, Ghosh S. (2005) "TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo." Genes & Development 19: 2668-2681. ,
- "NF-kappaB, an evolutionarily conserved mediator of immune and inflammatory responses." Advances in Experimental Medicine and Biology 560: 41-45. , Ghosh S. (2005)
- "CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis." Journal of Cell Biology 172: 1045-1056. , , Hayden MS, Lee KY, Trombetta ES, Pypaert M, Nara A, Yoshimori T, Wilm B, Erdjument-Bromage H, Tempst P, Hogan BL, Mellman I, Ghosh S. (2006)
- "MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb." Cell 131: 146-159. corrigendum , Calado DP, Galler G, Thai TH, Patterson HC, Wang J, Rajewsky N, Bender TP, Rajewsky K. (2007)
- Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. (2007) "Regulation of the germinal center response by microRNA-155." Science 316: 604-608. , Calado DP, Casola S, Ansel KM,
- "Lymphoproliferative disease and autoimmunity in mice with elevated miR-17-92 expression in lymphocytes." Nature Immunology 9: 405-14. , , Calado DP, Patterson HC, Zhang B, Wang J, Henderson JM, Kutok JL, Rajewsky K. (2008)
- "MicroRNA Control in the Immune System: Basic Principles. Cell 136: 26-36. PMID: 19135886 and Rajewsky K. (2009)
- Xiao C, Hu WY, Han J, Sun P. (2010) "The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence." Cancer Res. 70:8547-57.. PMCID: PMC2970743 , Lai M, Chen M, Xie C, Liao R, Kang YJ,
- Xiao C, Han J, Sun P. (2012) "PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway." Mol Cancer Res. 10:810-20. PMCID: PMC3378811 , Lai M, Liao R, Cook R,
- Xiao C, Reddy EP, Lu J. (2012) "An in vivo functional screen uncovers miR-150-mediated regulation of hematopoietic injury response." Cell Rep. 2:1048-60. PMCID: PMC3487471 , Guo S, Bai H, Guo Y, Megyola CM, Cheng J, Heydari K,
- Xiao C# (2013) "MiR-17~92 family microRNAs are critical regulators of T follicular helper cell differentiation." Nature Immunology 14:849-57. PMID: 23812097 , , , Jin HY, Lim HW, Shepherd J, Fremgen D, Verdin E, Oldstone MBA, Qi H, Teijaro JR#,
- Xiao C (2013) "MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways." The EMBO J. 32:2377-91. PMID: 23921550 , , , Skalsky RL, Bethel K, Shepherd J, Kang SG, Liu WH, Sabouri-Ghomi M, Cullen BR, Rajewsky K,
- Xiao C, Vallance BA, Kang YJ (2013) "Activation of p38a in T Cells Regulates the Intestinal Host Defense against Attaching and Effacing Bacterial Infections." J Immunol. 191:2764-70. PMID: 23918973 , Bang BR, Kang SG, Ma J, Otsuka M, Kang J, Stahl M, Han J,
- Xiao C (2014) "microRNA-17~92 is a powerful cancer driver and a therapeutic target." Cell Cycle 13:495-6. PMID: 24419145 , Lai M,
- Xiao C, Jiang P, Crotty S, Victora GD, Showe LC, Tucker HO, Erikson J, Hu H (2014) "The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells. Nature Immunology 15:667-75. PMID: 24859450 , Geng J, Wen X, Bi E, Kossenkov AV, Wolf AI, Tas J, Choi YS, Takata H, Day TJ, Chang LY, Sprout SL, Becker EK, Willen J, Tian L, Wang X,
- Xiao C (2015) "Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation." Int Immunopharmacol. 28:854-8. PMID: 25870038 ,
- Xiao C, Sauer K (2015) "hCD2-iCre and Vav-iCre mediated gene recombination patterns in murine hematopoietic cells." PLoS One 10:e0124661. PMID: 25884630 , Shepherd J,
- Xiao C, Littman DR, Ott M, Verdin E (2015) "SIRT1 deacetylates RORγt and enhances Th17 cell generation." J Exp Med. 212:607-17. PMID: 25918343 , Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K,
- Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, Ghosh S, Shim JH (2015) "CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts." J Exp Med. 212:1283-301. PMID: 26195726 , Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D,
- Xiao C (2015) "MicroRNA Mechanisms of Action: What have We Learned from Mice?" Front Genet. 6:328. PMID: 26635864 ,
- Xiao C (2015) "Transfection of microRNA Mimics Should Be Used with Caution." Front Genet. 6:340. PMID: 26697058 , , Miletic AV, Lai M, Knight S, Sabouri-Ghomi M, Head SR, Macauley MS, Rickert RC,
- Xiao C# (2016) "The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity." Nature Immunology 2016 Feb 22. doi: 10.1038/ni.3385. [Epub ahead of print] PMID: 26901150 , Adams BD, Lai M, Shepherd J, Salvador-Bernaldez M, Salvador JM, Lu J, Nemazee D#,
- Xiao C#, Han J# (2016), "MicroRNA-17~92 inhibits colorectal cancer progression by targeting angiogenesis." Cancer Letters 376(2):293-302. PMID: 27080303 , Pan JS, Jin LX, Wu J, Ren YD, Chen P,
- Xiao C#, Chen Dong# (2016) "The microRNA-183-96-182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression." Immunity 44, 1284–1298. , Gonzalez-Martin A, Kim BS, Jin HY, Sabouri-Ghomi M, Xu S, Zheng P,
- Xiao C# (2016) "A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells." J Exp Med 213(9):1901-19. , Kang SG, Huang Z, Wu CJ, Jin HY, Maine CJ, Liu Y, Shepherd J, Sabouri-Ghomi M, Gonzalez-Martin A, Xu S, Hoffmann A, Zheng Y, Lu LF, Xiao N, Fu G#,
- Xiao C# (2016) "Regulation of B Cell Development and Tolerance by Different Members of the miR-17~92 Family MicroRNAs." Nature Communications 2;7:12207. doi: 10.1038/ncomms12207 , Gonzalez-Martin A, Cooper AB, Oda H, Jin HY, Shepherd J, He H, Zhu J Nemazee D#,
- Xiao C (2016) "Concurrent PI3K and NF-B activation drives B cell lymphomagenesis. Leukemia advance online publication" doi: 10.1038/leu.2016.204 , Lai M, Shephard J,
- Xiao C, "Liston A, Stupka E, Cittaro D, Abrignani S, Provero P, Dellabona P, Casorati G (2016) "miR-17~92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling." PNAS 113(51):E8286-E8295.
- Xiao C (2017) "Differential Sensitivity of Target Genes to Translational Repression by miR-17~92." PLoS Genetics 13(2):e1006623.
, Oda H, Chen P, Yang C, Zhou X, Kang SG, Valentine E, Kefauver J, Liao L, Zhang Y, Gonzalez-Martin A, Shepherd J, Morgan GJ, Mondala TS, Head SR, Kim PH, Xiao N, Fu G, Liu WH, Han J, Williamson JR,- Xiao C# (2017) "A critical role of periostin in B-cell acute lymphoblastic leukemia." Leukemia, 31(8):1835-1837.
, Zhao X, Huang J, Jia X, Deng M, Cui D, Du Z, Fu G#, Ouyang G#, and , Riba M, Garcia Manteiga JM, Tian L, Viganò V, Rossetti G, Pagani M, - Xiao C (2018) "An integrated polysome profiling and ribosome profiling method to investigate in vivo translatome. Methods Mol Biol, 1712:1-18. ,
- Xiao C, Zhang W, Han J, Debinski W, Xiang R, Sun P (2018) "miR-30 disrupts senescence and promotes cancer by targeting both p16INK4A and DNA damage pathways." Oncogene. 37(42):5618-5632. , Hong L, Xu X, Huang S, Herpai D, Li L, Xu Y, Truong L, Hu WY, Wu X,
- Xiao C (2018) "MicroRNA says no to mass production." Nature Immunology 19(10):1040-1042 , Liao K,