Healthy Aging - Wellderly

In 2007, researchers at the Scripps Research Translational Institute launched the Wellderly study in the hopes of unlocking the genetic secrets behind lifelong health. Genetic factors that protect against disease in genetically exceptional individuals have been successfully translated to drugs for the general population. This ongoing study has enrolled more than 1,400 people from across the country ranging in age from 80 to 105, who have not developed any common chronic medical conditions or diseases.

Initial findings, published in 2016 in the scientific journal Cell, suggest a possible link between long-term cognitive health and protection from chronic diseases, including cancer, heart disease and diabetes, which account for 90 percent of all deaths in the United States, and more than 75 percent of the healthcare costs.

Pathogenic Huntingtin repeat expansions in patients with frontotemporal dementia and amyotrophic lateral sclerosis, Neuron, February 2021

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture, Nature Genetics, February 2021

Reliability of genomic variants across different next-generation sequencing platforms and bioinformatic processing pipelines, BMC Genomics, January 2021

Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional patways in Parkinson disease, Acta Neuropathologica, June 2020

SG-ADVISER mtDNA: a web server for mitochondrial DNA annotation with data from 200 samples of a healthy aging cohort, BMC Bioinformatics, August 2017

Whole Genome Sequencing of a Healthy Aging Cohort, Cell, April 2016

Healthy Aging May Not Require Winning the Genetic Lottery, KPBS News, April 2016

‘Wellderly’ have more gene variants for good cognition study finds, San Diego Union-Tribune, April 2016

Genetic secrets of the healthy elderly unveiled, Nature News, April 2016

These Are The Genes Behind Health Aging, TIME, April 2016

Scientists search for the genes behind health aging, CBS News, April 2016

A Long Life is Genetically Different From a Healthy One, Buzzfeed, April 2016

Is this the secret to the Queen’s long life? Study finds a ‘cocktail’ of genes that protect people form disease as they age, Daily Mail, April 2016

Secrets of the 'Wellderly', Robert Lee Hotz, The Wall Street Journal, September 2008

Genomic data from this study has been made freely available to the scientific community through the European Genome-phenome Archive.