Nuclear Magnetic Resonance

The Research Services’ Nuclear Magnetic Resonance Facility provides state-of-the-art NMR spectroscopy to researchers in Scripps Research, as well as spectral service to local biotech communities.

The Facility houses a total of six NMR spectrometers:

  • Bruker AVIII HD 600 NMR spectrometer equipped with a 5 mm CPQCI (H-C-N-P) CryoProbe            
    • This spectrometer also has a 1.7 mm CPTCI (H-C-N) CryoProbe.  This probe can be installed upon requested for experiments on micro-gram scale compounds 
  • Bruker AVIII HD 600 NMR spectrometer equipped with a 5 mm CPDCH (C-H) CryoProbe            
    • This CryoProbe provides high sensitivity for C-13 NMR experiments 
  • Bruker AV NEO 500 NMR spectrometer with a 5 mm BBFO Smart Probe 
  • Bruker AVIII 400 NMR spectrometer equipped with 5 MM BBFO probe 
  • Bruker AV NEO 399 spectrometer equipped with a 5 mm BBFO Smart Probe            
    • All BBFO probes have the capabilities to perform NMR experiments on nuclei with resonance frequencies between Ag-109 and P-31, as well as H-1, and F-19 
  • Bruker DPX-400 NMR spectrometer equipped with a QNP (H-F-P-C) probe and a B-ACS 120 sample changer

All NMR spectrometers are setup for routine high resolution solution state 1D and 2D NMR experiments.


The core has four Bruker nuclear magnetic resonance (NMR) instruments:

  • Bruker AVANCE III 700 MHz instruments with QCI Cryoprobe.
  • Bruker AVANCE NEO 600 MHz instruments with TCI Cryoprobe and SampleCase
  • Bruker AVANCE NEO 400 MHz instruments with SampleXpress
  • Bruker AVANCE 400 MHz instruments with SampleXpress
Those instruments perform all sorts of multi-dimension NMR experiments, and detect a variety of nuclei. By connecting these highly sensitive instruments to the internet via a proprietary Scripps Florida server, our scientists and their collaborators can access the collected data from their office or laboratory.

Training, various experiments setup, data collection and analysis:

While priority of use is always given to Scripps Research Florida researchers, time on the instruments is also made available on a fee-for-service basis to outside users.

Fee-for-Service Pricing
(Subject to change; call for current pricing and quotes)

All spectra are run by Scripps Florida personnel, and results are accessible to outside customers by a proprietary Internet link.

  •     Time on 400 MHz instrument: $80/hour
  •     Time on 700 MHz instrument: Call for pricing