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The Sauer Lab


Elich, M. and Sauer, K. (2018) Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides. Front. Immunol. 9:931, 1-21. doi: 10.3389/fimmu.2018.00931.

Westernberg, L., Conche, C., Huang, Y.H., Rigaud, S., Deng, Y., Siegemund, S., Mukherjee, S., Nosaka, L., Das, J. and Sauer, K. (2016) Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent. eLife 5:e10786. DOI: 10.7554/eLife.10786. abstract

Lin, X., Pelletier, S., Gingras, S., Rigaud, S., Maine, CJ., Marquardt, K., Dai, YD., Sauer, K., Rodriguez, AR., Martin, G., Kupriyanov, S., Jiang, L., Yu, L., Green, DR., Sherman, LA. (2016) CRISPR-Cas9 mediated modification of the NOD mouse genome with Ptpn22R619W mutation increases autoimmune diabetes. Diabetes Apr 26. pii: db160061. abstract

Yea, K., Zhang, H., Xie, J., Jones, T.M., Lin, C.-W., Francesconi, W., Berton, F., Fallahi, M., Sauer, K., and Lerner, R.A. (2015) Agonist antibody that induces human malignant cells to kill one another. PNAS 112(45):E6158-65. abstract

Sauer, K. and Okkenhaug, K. (2015). Editorial: Lipid signaling in T cell development and function. Front. Immunol. 6:410. doi: 10.3389/fimmu.2015.00410. *Corresponding author. online version

Lawson, B.R., Gonzalez-Quintial, R., Eleftheriadis, T., Farrar, M.A., Miller, S.D., Sauer, K., McGavern, D.B., Kono, D.H., Baccala, R., and Theofilopoulos, A.N. (2015) Interleukin-7 is Required for CD4+ T Cell Activation and Autoimmune Neuroinflammation. Clinical Immunology 161, 260-269. abstract

Rigaud, S., and Sauer, K. (2015) IP3 3-Kinase B Prevents Bone Marrow Failure. Oncotarget 6, 15706-15707. abstract

Siegemund, S., Rigaud, S., Conche, C., Broaten, B., Schaffer, L., Westernberg, L., Head, S.R. and Sauer, K. (2015) IP3 3-Kinase B Controls Hematopoietic Stem Cell Homeostasis and Prevents Lethal Hematopoietic Failure in Mice. Blood 125, 2786-2797. abstract

Siegemund, S., Shepherd, J., Xiao, C. and Sauer, K. (2015) hCD2-iCre and Vav-iCre Mediated Gene Recombination Patterns in Murine Hematopoietic Cells. PLOS ONE 10, e0124661. abstract

Rybakin, V., Westernberg, L., Fu, G., Kim, H.O., Ampudia, J., Sauer, K. and Gascoigne, N.R.J. (2014) Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire. PLoS ONE 9, e114320. abstract

Xu, X., Jaeger, E. R., Wang, X., Lagler-Ferrez, E., Batalov, S., Mathis, N.L., Wiltshire, T., Walker, J. R., Cooke, M. P., Sauer, K.*, and Huang, Y. H.* (2014) Mst1 Directs Myosin IIa Partitioning of Low and Higher Affinity Integrins During T cell Migration. PLoS ONE 9, e105561. *Co-corresponding authors. abstract

Conche, C., and Sauer, K. (2014) Uncovering the PI3Ksome: Phosphoinositide 3-kinases and Counteracting PTEN Form a Signaling Complex with Intrinsic Regulatory Properties. Mol Cell Biol 34, 3356-3358. abstract

Fu, G., Casas, J., Rigaud, S., Rybakin, V., Lambolez, F., Brzostek, J., Hoerter, J.A.H., Paster, W., Acuto, O., Cheroutre, H., Sauer, K., and Gascoigne, N.R.J. (2013) Themis sets the signal threshold for positive and negative selection in T-cell development. Nature 504, 441-445. abstract

Mukherjee, S., Rigaud, S., Seok, S.-C., Fu, G., Prochenka, A., Dworkin, M., Gascoigne, N.R.J., Vieland, V.J., Sauer, K.* and Das, J.* (2013) In silico Modeling of Itk Activation Kinetics in Thymocytes Suggests Competing Positive and Negative IP4 Mediated Feedbacks Increase Robustness. PLoS ONE 8(9): e73937. *Co-corresponding authors. abstract

Sauer, K.*, Park, E., Siegemund, S., French, A.R., Wahle, J.A., Sternberg, L., Rigaud, S., Jonsson, A.H., Yokoyama, W.M. and Huang, Y.H.* (2013) Inositol Tetrakisphosphate Limits NK Cell Effector Functions by Controlling PI3K Signaling. Blood 121, 286-297. *Co-corresponding authors. abstract

Siegemund, S., and Sauer, K. (2012) Balancing pro- and anti-inflammatory TLR4 signaling. Nature Immunology 13, 1031-1033. abstract

Hirve, N., Levytskyy, R.M., Rigaud, S., Guimond, D.M., Zal, T., Sauer, K., and Tsoukas, C. (2012) A Conserved Motif in the ITK PH-Domain is required for Phosphoinositide Binding and TCR Signaling but Dispensable for Adaptor Protein Interactions. PLoS ONE 7, e45158. abstract

Fu, G., Hu, J., Niederberger-Magnenat, N., Rybakin, V., Casas, J., Yachi, P.P., Feldste in, S., Ma, B., Hoerter, J.A.H., Ampudia, J., Rigaud, S., Lambolez, F., Gavin, A.L., Sauer, K., Cheroutre, H., Gascoigne, N.R.J. Protein Kinase C Eta is Required for T Cell Activation and Homeostatic Proliferation. (2011) Science Signaling 4, ra84. abstract

Barouch-Bentov, R., and Sauer, K. Mechanisms of Drug Resistance in Kinases. (2011) Expert Opin. Investig. Drugs. 20; 153-208. abstract

Huang, Y.H., and Sauer, K. Lipid Signaling in T Cell Development and Function. (2010) Cold Spring Harb Perspect Biol, Nov;2(11):a002428. abstract

Sauer, K.*, and Cooke, M.P. Regulation of Immune Cell Development Through Soluble Inositol-1,3,4,5-tetrakisphosphate. (2010) Nature Reviews Immunology 10, 257-271. *Corresponding author. abstract

Poderycki, M., Tomimori, Y., Ando, T., Xiao, W., Maeda-Yamamoto, M., Sauer, K., Kawakami, Y., and Kawakami, T. (2010) A Minor Catalytic Activity of Src Family Kinases Is Sufficient for Maximal Activation of Mast Cells via the High-Affinity IgE Receptor. J Immunol. 184, 84-93. abstract

Lenox, L.E., Kambayashi, T., Okumura, M., Prieto, C., Sauer, K., Bunte, R.M., Jordan, M.S., Koretzky, G.A., Nichols, K.E. (2009) Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis. Journal of Allergy and Clinical Immunology 124, 1088-98. abstract

Sauer, K.*, Huang, Y.H., Lin, H., Sandberg, M., and Mayr, G.W. (2009) Phosphoinositide and Inositol Phosphate Analysis in Lymphocyte Activation. Current Protocols in Immunology, Chapter 11, Unit 11.1. *Corresponding author. abstract

Tinoco, R., Alcalde, V., Yang, Y., Sauer, K. and Zuniga, E.I. (2009) Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo. Immunity 31, 145-157. abstract

Fu, G., Vallée, S., Rybakin, V., McGuire, M.V., Ampudia, J., Brockmeyer, C., Salek, M., Fallen, P.R., Hoerter, J.A.H., Munshi, A., Huang, Y.H., Hu, J., Fox, H.S., Sauer, K., Acuto, O., and Gascoigne, N.R.J. (2009) Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling. Nature Immunology 10, 848 - 856. abstract

Elsaesser, H., Sauer, K., and Brooks, D.G. (2009) IL-21 is Required to Control Chronic Viral Infection. Science 324, 1569-1572. abstract

Barouch-Bentov, R., Che, J., Lee, C.C., Yang, Y., Herman, A., Jia, Y., Velentza, A., Watson, J., Sternberg, L., Kim, S., Ziaee, N., Miller, A., Jackson, C., Fujimoto, M., Young, M., Batalov, S., Liu, Y., Warmuth, M., Wiltshire, T., Cooke, M.P., and Sauer, K. (2009) A Conserved Salt Bridge in the G Loop of Multiple Protein Kinases Is Important for Catalysis and for in Vivo Lyn Function. Molecular Cell 33, 43-52. abstract

Huang, Y. H., Hoebe, K., and Sauer, K. (2008) New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B. Expert Opin Ther Targets 12, 391-413. abstract

Huang, Y. H., Grasis, J., Miller, A. T., Xu, R., Soonthornvacharin, S., Andreotti, A. H., Tsoukas, C. D., Cooke, M. P., and Sauer, K. (2007) Positive Regulation of Itk PH Domain Function by Soluble IP4. Science 316, 886-889. abstract. Free online reprint available here.

Miller, A. T., Sandberg, M., Huang, Y. H., Young, M., Sutton, S., Sauer, K., and Cooke, M. P. (2007) Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation. Nature Immunology 8, 514-521 abstract

Huang, Y. H., Barouch-Bentov, R., Herman, A. E., and Sauer, K. (2006) Integrating Traditional and Postgenomic Approaches to Investigate Lymphocyte Development and Function. In Advances in Experimental Medicine and Biology. Vol. 584. CD Tsoukas, ed. Springer, New York, NY. Pgs. 245-276. abstract

Chamberlain, P., Sandberg, M., Sauer, K., Cooke, M. P., Lesley, S., and Spraggon, G. (2005). Structural Insights into Enzyme Regulation of Inositol 1,4,5-Trisphosphate 3-Kinase B. Biochemistry 44: 14486-14493. abstract

Wen, B. G., Miller, A. T., Huang, Y. H., Pletcher, M. T., Warashina, M., Choe, S. H., Ziaee, N., Wiltshire, T., Cooke, M. P.*, and Sauer, K.*, (2004). Ms. T-less, an ENU-Induced Mouse Mutant Linking Impaired Expression of Ins(1,4,5)P3 3-kinase B (Itpkb) to Defective Erk Activation and Blocked Positive Selection (Bologna, Italy, Medimont S.r.l.). *Co-corresponding authors.

Wen, B. G., Pletcher, M. T., Warashina, M., Choe, S. H., Ziaee, N., Wiltshire, T., Sauer, K.*, and Cooke, M. P.* (2004). Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity. Proc Natl Acad Sci U S A 101, 5604-5609. *Co-corresponding authors. abstract

Salomon, A. R., Ficarro, S. B., Brill, L. M., Brinker, A., Phung, Q. T., Ericson, C., Sauer, K., Brock, A., Horn, D. M., Schultz, P. G., and Peters, E. C. (2003). Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proc Natl Acad Sci U S A 100, 443-448. abstract

Takaki, S., Tezuka, Y., Sauer, K., Kubo, C., Kwon, S. M., Armstead, E., Nakao, K., Katsuki, M., Perlmutter, R. M., and Takatsu, K. (2003). Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein. J Immunol 170, 703-710. abstract

Sauer, K., Liou, J., Singh, S. B., Yablonski, D., Weiss, A., and Perlmutter, R. M. (2001). Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes. J Biol Chem 276, 45207-45216. abstract

Lehner, C.F., Jacobs, H.W., Sauer, K. and Meyer, C.A. (2001). Regulation of the Embryonic Cell Proliferation by Drosophila Cyclin D and Cyclin E Complexes. Novartis Found. Symp. 237, 43-54; Discussion 54-57. abstract

Takaki, S., Sauer, K., Iritani, B.M., Chien, S., Ebihara, Y., Tsuji, K-I, Takatsu, K., and Perlmutter, R.M. (2000). Control of B Cell Production by the Adaptor Protein Lnk: Definition of a Conserved Family of Signal-Modulating Proteins. Immunity 13, 599-609. abstract

Farrar, M., Doerfler, P., and Sauer, K. (1998). Signal Transduction Pathways Regulating the Development of αβ T Cells. Biochim. Biophys. Acta 1377, F35-F78. abstract

Lane, M.E., Sauer, K., Wallace, K., Jan, Y.N., Lehner, C.F., and Vaessin, H. (1996). Dacapo, a Cyclin-Dependent Kinase Inhibitor, Stops Cell Proliferation during Drosophila Development. Cell 87, 1225-1235. abstract

Sauer, K., Weigmann, K., Sigrist, S., and Lehner, C.F. (1996). Novel Members of the cdc2-related Kinase Family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE Kinase. Mol. Biol. Cell 7, 1759-1769. abstract

Sauer, K. and Lehner, C.F. (1996). The role of Cyclin E in the regulation of entry into S phase. Progress in Cell Cycle Research 1, 125-139. abstract

Sauer, K., Knoblich, J.A., Richardson, H., and Lehner, C.F. (1995). Distinct modes of Cyclin E/Cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis. Genes Dev. 9, 1327-1339. abstract

Knoblich, J.A., Sauer, K., Jones, L., Richardson, H., Saint, R., and Lehner, C.F. (1994). Cyclin E controls S-phase progression and its downregulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell 77, 107-120. abstract

Green, S.R., Fullekrug, J., Sauer, K., and Tuite, M.F. (1991). Isolation and characterization of a bovine cDNA encoding eukaryotic initiation factor 2α . Biochem. Biophys. Acta 1090, 277-280. abstract


Edited Books

Sauer, K. and Okkenhaugh, K., Editors. (2015) Research Topic/eBook "Lipid Signaling in T Cell Development and Function". Frontiers in T Cell Biology. link