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Sergio Catz, Ph.D.

Associate Professor
Department of Molecular Medicine
California Campus
Laboratory Website
Scripps VIVO Scientific Profile
scatz@scripps.edu
(858) 784-7932

Education

Ph.D., University of Buenos Aires 1997
B.Sc., University of Buenos Aires 1991

Professional Experience

1998-2017 Associate Professor, Molecular and Experimental Medicine (MEM), The Scripps Research Institute

Selected References

All Publications

Zhang, J., Johnson, J. L., He, J., Napolitano, G., Ramadass, M., Rocca, C., Kiosses, W. B., Bucci, C., Xin, Q., Gavathiotis, E., Cuervo, A. M., Cherqui, S., et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. (2017). Journal of Biological Chemistry, 292(25), 10328-10346. PMCID: PMC5481548.

Catz, S. D. Editorial: The secrets of secretion. (2017). Journal of Leukocyte Biology, 102(1), 4-6.

Ramadass, M., Johnson, J. L. & Catz, S. D. Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis. (2017). Journal of Leukocyte Biology, 101(3), 693-702.

Rega, L. R., Polishchuk, E., Montefusco, S., Napolitano, G., Tozzi, G., Zhang, J., Bellomo, F., Taranta, A., Pastore, A., Polishchuk, R., Piemonte, F., Medina, D. L., et al. Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells. (2016). Kidney International, 89(4), 862-873.

Johnson, J. L., Ramadass, M., He, J., Brown, S. J., Zhang, J., Abgaryan, L., Biris, N., Gavathiotis, E., Rosen, H. & Catz, S. D. Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small GTPase Rab27a. (2016). Journal of Biological Chemistry, 291(50), 25965-25982. PMCID: PMC5207069.

Kurz, A. R. M., Pruenster, M., Rohwedder, I., Ramadass, M., Schafer, K., Harrison, U., Gouveia, G., Nussbaum, C., Immler, R., Wiessner, J. R., Margraf, A., Lim, D. S., et al. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. (2016). Journal of Clinical Investigation, 126(11), 4125-4139. PMCID: PMC5096904.

Ramadass, M. & Catz, S. D. Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation. (2016). Immunological Reviews, 273(1), 249-265.

Johnson, J. L., He, J., Ramadass, M., Pestonjamasp, K., Kiosses, W. B., Zhang, J. Z. & Catz, S. D. Munc13-4 Is a Rab11-binding protein that regulates Rab11-positive vesicle trafficking and docking at the plasma membrane. (2016). Journal of Biological Chemistry, 291(7), 3423-3438. PMCID: PMC4751385.

He, J., Johnson, J. L., Monfregola, J., Ramadass, M., Pestonjamasp, K., Napolitano, G., Zhang, J. & Catz, S. D. Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses. (2016). Molecular Biology of the Cell, 27(3), 572-587. PMCID: PMC4751605.

Napolitano, G., Johnson, J. L., He, J., Rocca, C. J., Monfregola, J., Pestonjamasp, K., Cherqui, S. & Catz, S. D. Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis. (2015). EMBO Molecular Medicine, 7(2), 158-174. PMCID: PMC4328646.