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Kristian G. Andersen, Ph.D.

Assistant Professor
Director of Infectious Disease Genomics, STSI
Department of Immunology and Microbiology
California Campus
Laboratory Website
Scripps VIVO Scientific Profile
andersen@scripps.edu
(858) 554-5737

Scripps Research Joint Appointments

Assistant Professor, Department of Integrative Structural and Computational Biology
Faculty, Graduate Program

Other Joint Appointments

Director of Infectious Disease Genomics, Scripps Translational Science Institute
Affiliated Member, Broad Institute of MIT and Harvard

Research Focus

Originally from Denmark, Dr. Andersen received his Ph.D. from the University of Cambridge and the MRC Laboratory of Molecular Biology in 2009. He was the recipient of the Carlsberg Foundation PhD Scholarship from 2005-2008 and was awarded a postdoctoral fellowship from the same foundation from 2009-2011. In 2008 he was awarded the Max Perutz prize for “outstanding graduate research” at the University of Cambridge.

His research has spanned many research areas and disciplines. Using experimental animal models and molecular biological techniques, Dr. Andersen elucidated the evolutionary history of regulatory T cell-mediated tolerance mechanisms. He then exploited that knowledge to develop novel immune-based therapies and showed that they could be used for the treatment of arthritis, diabetes, and transplantation rejection in a number of different animal models.

Dr. Andersen’s more recent research has focused on the complex relationship between host and pathogen. Using a combination of next-generation sequencing, experimentation and computational biology he has spearheaded large international collaborations investigating the spread and evolution of highly deadly pathogens, including Ebola virus and Lassa virus. This work provided insights into the emergence and transmission of Ebola virus during the 2014-2015 epidemic in West Africa, and formed the foundation for the usage of genomic tools during a rapidly evolving outbreak.

Education

Ph.D. (Immunology), University of Cambridge 2008
M.Phil. (Immunology), University of Cambridge 2005
B.Sc. (Molecular Biology & Chemistry), Aarhus University 2004
Diploma (Medical Biochemistry), University of Kent 2003

Professional Experience

Postdoc
Harvard University & Broad Institute of MIT and Harvard

Graduate
University of Cambridge & MRC Laboratory of Molecular Biology

Undergraduate
Aarhus University & University of Kent, Canterbury

Awards & Professional Activities

2009 Postdoctoral fellowship, Carlsberg Foundation
2008 Max Perutz Prize for ‘outstanding graduate research’, The Max Perutz Fund
2005 Scholarship for studies at the University of Cambridge, Carlsberg Foundation

Selected References

All Publications

Grubaugh, N. D. & Andersen, K. G. Experimental evolution to study virus emergence. (2017). Cell, 169(1), 1-3.

Quick, J., Grubaugh, N. D., Pullan, S. T., Claro, I. M., Smith, A. D., Gangavarapu, K., Oliveira, G., Robles-Sikisaka, R., Rogers, T. F., Beutler, N. A., Burton, D. R., Lewis-Ximenez, L. L., et al. Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples. (2017). Nature Protocols, 12(6), 1261-1276.

Dudas, G., Carvalho, L. M., Bedford, T., Tatem, A. J., Baele, G., Faria, N. R., Park, D. J., Ladner, J. T., Arias, A., Asogun, D., Bielejec, F., Caddy, S. L., et al. Virus genomes reveal factors that spread and sustained the Ebola epidemic. (2017). Nature, 544(7650), 309-315.

Lemieux, J. E., Tran, A. D., Freimark, L., Schaffner, S. F., Goethert, H., Andersen, K. G., Bazner, S., Li, A., McGrath, G., Sloan, L., Vannier, E., Milner, D., et al. A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse. (2016). Nature Microbiology, 1.

Radin, J. M., Topol, E. J., Andersen, K. G. & Steinhubl, S. R. A laboratory in your pocket. (2016). Lancet, 388(10054), 1875-1875.

Goba, A., Khan, S. H., Fonnie, M., Fullah, M., Moigboi, A., Kovoma, A., Sinnah, V., Yoko, N., Rogers, H., Safai, S., Momoh, M., Koroma, V., et al. An outbreak of Ebola virus disease in the Lassa fever zone. (2016). Journal of Infectious Diseases, 214, S110. PMCID: PMC5050470.

Rambaut, A., Dudas, G., de Carvalho, L. M., Park, D. J., Yozwiak, N. L., Holmes, E. C. & Andersen, K. G. Comment on "Mutation rate and genotype variation of Ebola virus from Mali case sequences". (2016). Science, 353.

Folarin, O. A., Ehichioya, D., Schaffner, S. F., Winnicki, S. M., Wohl, S., Eromon, P., West, K. L., Gladden-Young, A., Oyejide, N. E., Matranga, C. B., Deme, A. B., James, A., et al. Ebola virus epidemiology and evolution in Nigeria. (2016). Journal of Infectious Diseases, 214, S102. PMCID: PMC5050462.

Diehl, W. E., Lin, A. E., Grubaugh, N. D., Carvalho, L. M., Kim, K., Kyawe, P. P., McCauley, S. M., Donnard, E., Kucukural, A., McDonel, P., Schaffner, S. F., Garber, M., et al. Ebola virus glycoprotein with increased infectivity dominated the 2013-2016 epidemic. (2016). Cell, 167(4), 1088-1098. PMCID: PMC5115602.

Robinson, J. E., Hastie, K. M., Cross, R. W., Yenni, R. E., Elliott, D. H., Rouelle, J. A., Kannadka, C. B., Smira, A. A., Garry, C. E., Bradley, B. T., Yu, H., Shaffer, J. G., et al. Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits. (2016). Nature Communications, 7. PMCID: PMC4866400.

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Publications