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The Quigley Laboratory


(Selected from over 150 publications)

Minder P, Zajac E, Quigley JP, Deryugina EI. EGFR regulates the development and microarchitecture of intratumoral angiogenic vasculature capable of sustaining cancer cell intravasation. Neoplasia 2015 Aug;17(8):634-49. PMID: 26408256

Deryugina EI, Quigley JP. Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature. Matrix Biol. 2015 May-Jul;44-46:94-112. Review. PMID: 25912949

Deryugina EI, Zajac E, Juncker-Jensen A, Kupriyanova TA, Welter L, Quigley JP. Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment. Neoplasia 2014 Oct 23;16(10):771-88. PMCID: PMC4212255

Vandooren J, Born B, Solomonov I, Zajac E, Saldova R, Senske M, Ugarte-Berzal E, Martens E, Van den Steen PE, Van Damme J, Garcia-Pardo A, Foreyen M, Deryugina EI, Quigley JP, Moestrup SK, Russ PM, Sagi I, Opdenakker G. Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1. Biochem J. 2015 Jan 15;465(2):259-70. PMCID: PMC4399976

Zajac E, Schweighofer B, Kupriyanova TA, Juncker-Jensen A, Minder P, Quigley JP, Deryugina EI. Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9. Blood 2013 Dec 12; 122(25):4054-67. PMCID: PMC3862278

Juncker-Jensen A, Deryugina EI, Rimann I, Zajac E, Kupriyanova TA, Engelholm LH, Quigley JP.  Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination.  Cancer Research 2013 Jul 15;73(14):4196-211.  PMCID: PMC3754905

Low-Marchelli JM, Ardi VC, Vizcarra EA, van Rooijen N, Quigley JP, Yang J.  Twist1 induces CCL2 and recruits macrophages to promote angiogenesis. Cancer Research 2013;73(2):622-71. PMCID: PMC3566985

Casar B, Rimann I, Kato H, Shattil SJ, Quigley JP, Deryugina EI.  In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated ß1 integrin and induction of FAK/PI3K/Akt motility signaling. Oncogene 2014 Jan 9;33(2):255-68. PMCID: PMC3931462

Deryugina EI and Quigley JP. Review Article: Cell surface remodeling by plasmin: a new function for an old enzyme. Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 564259, 21 pages. Epub 2012 Oct 14. PMCID: PMC3477900

Kato H, Liao Z, Mitsios JV, Wang HY, Deryugina EI, Varner JA, Quigley JP, Shattil SJ. The primacy of ß1 integrin activation in the metastatic cascade. PLoS One 2012;7(10):e46576. PMCID: PMC3463578

Botkjaer KA, Deryugina EI, Dupont DM, Bekes EM, Gardsvoll H, Thuesen CK, Chen Z, Ploug M, Quigley JP, Andreasen PA. Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multi-functional mechanism. Mol Cancer Res. 2012 10(12):1532-43. PMCID: PMC3528818

Casar B, He Y, Iconomou M, Hooper JD, Quigley JP, Deryugina EI. Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells. Oncogene 2012 Aug 30;31(35):3924-38. PMCID: PMC4350937

Quigley JP and Deryugina EI. Combating angiogenesis early: potential of targeting tumor-recruited neutrophils in cancer therapy.  Future Oncol. 2012 Jan;8(1):5-8. Editorial. PMID: 22149028

Bekes EM, Deryugina EI, Kuprianova TA, Zajac E, Botkjaer KA, Andreasen PA, Quigley JP. Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells.  Neoplasia 2011 Sep; 13(9):806-21.  PMCID: PMC3182273

Deryugina EI and Quigley JP.  Chapter 7: The role of matrix metalloproteinases in cellular invasion and metastasis.  Extracellular Matrix Degradation, Biology of Extracellular Matrix 2, 2011 DOI 10.1007/978-3-642-16861-1_7, Parks and Mecham (eds.), Springer-Verlag Berlin Heidelberg

Bekes EM, Schweighofer B, Kupriyanova TA, Ardi VC, Zajac E, Quigley JP, Deryugina EI.  Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation. Am J Pathol. 2011 Sep; 179(3):1455-70.  PMCID: PMC3157227

Complete List of Published Work in My Bibliography