March 27, 2017
Scientists Discover New Class of Anti-Diabetes Compounds that Reduce Liver Glucose Production
Scientists may have found a new tool for studying—and maybe even treating—Type 2 diabetes, the form of diabetes considered responsible for close to 95 percent of cases in the United States.
March 27, 2017
Philip Dawson Named Dean of The Scripps Research Institute’s Graduate Program
Dawson brings to his new role more than 25 years’ experience at TSRI as a student, alumnus, faculty member and associate dean.
March 20, 2017
Researchers Discover Key to Drug Resistance in Common Breast Cancer Treatment
Scientists from the Florida campus of The Scripps Research Institute (TSRI), the University of California (UC), San Diego and the University of Illinois have found that two immune system molecules may be key to the development of drug resistance in estrogen-driven breast cancers.
March 16, 2017
Scripps Florida Scientists Develop New Drug Delivery Method for Cancer Therapy
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new drug delivery method that produces strong results in treating cancers in animal models, including some hard-to-treat solid and liquid tumors.
March 08, 2017
Potential Drug Candidates Halt Prostate and Breast Cancer Growth
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have designed two new drug candidates to target prostate and triple negative breast cancers.
March 08, 2017
In Battle for Real Estate, a Disordered Protein Wins Out
To their surprise, TSRI scientists found that in a competition between two apparently equivalent proteins, one protein wins out every time as it swoops in to claim a cellular binding target that could be important in cancer therapies.
March 08, 2017
New Enzyme-Like Tool Lets Chemists Modify Hard-to-Reach Spots on Drug Molecules
Chemists at The Scripps Research Institute (TSRI) have devised a versatile molecule-building tool for creating new drugs and other chemical products.
March 06, 2017
Fighting Blindness: TSRI Scientists Bring a Key Protein into Focus
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have discovered how a protein called α2δ4 establishes proper vision.
February 22, 2017
TSRI Researchers Find Standard Pacemakers and Defibrillators Safe for MRI Using a New Protocol
The researchers observed no patient deaths, device or lead failures, losses of pacing function or ventricular arrhythmias in 1,500 patients who underwent MRI using a specific protocol for device interrogation, device programming, patient monitoring and follow-up.
February 21, 2017
TSRI-Invented Compound Ozanimod Shows Positive Results in Late-Stage Clinical Trial for Relapsing Multiple Sclerosis
Results from a new Phase 3 study conducted by the Celgene Corporation demonstrate that ozanimod, a drug candidate originally discovered and optimized at The Scripps Research Institute (TSRI), can reduce the frequency of multiple sclerosis relapse.
February 21, 2017
The Scripps Research Institute Announces New Board Members and Chairman of the Board
The Scripps Research Institute (TSRI), one of the world's largest, private, non-profit research organizations, today announced the appointment of nine new members to its Board of Directors, including John D. Diekman, who will serve as chairman of the board.
February 15, 2017
Scripps Florida Scientists Take Aim at Obesity-Linked Protein
Is there a way to get metabolism to ramp up—even when it’s not cold out?
February 14, 2017
Scripps Florida Collaboration Awarded $3.3 Million to Develop Next-Generation Breast Cancer Therapies
A pair of scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded up to $3.3 million from the National Cancer Institute of the National Institutes of Health (NIH) to create the next generation of breast cancer treatments.
February 13, 2017
TSRI Researchers Discover How the Brain Turns Chronic Stress into Pathological Anxiety
Researchers at The Scripps Research Institute (TSRI) have described the role of two important molecules in the brain that work together to trigger intense anxiety
February 06, 2017
Scripps Florida Scientists Find Clue to Why Zika, But Not Its Close Relatives, Causes Birth Defects
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered the details behind the virus’s unique ability to cross the placental barrier and expose the fetus to a range of birth defects that often go beyond microcephaly to include eye and joint injury, and even other types of brain damage.
February 02, 2017
TSRI Chemists Unveil Versatile New Method for Making Chiral Drug Molecules
“This method essentially mimics the ability of the enzymes in our cells to turn simple organic molecules into chiral molecules,” said senior author Jin-Quan Yu, Frank and Bertha Hupp Professor in the Department of Chemistry at TSRI.
February 01, 2017
TSRI Scientists Show Deep Brain Stimulation Blocks Heroin Relapse in Rats
Scientists at The Scripps Research Institute (TSRI) have found that deep brain stimulation (DBS) can greatly reduce the compulsion to use heroin in standard rat models of addiction.
January 30, 2017
New TSRI Study Shows Early Brain Changes in Fragile X Syndrome
A new study led by scientists at The Scripps Research Institute (TSRI) is giving researchers a first look at the early stages of brain development in patients with Fragile X syndrome, a disorder that causes mild to severe intellectual disability and is the most common genetic cause of autism spectrum disorder.
January 27, 2017
TSRI Scientists Find Brain Hormone that Triggers Fat Burning
Biologists at The Scripps Research Institute (TSRI) have identified a brain hormone that appears to trigger fat burning in the gut.
January 24, 2017
Scripps Florida Team Awarded $1.8 Million Grant to Develop Drugs for Heart Disease and Rheumatoid Arthritis
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded approximately $1.8 million from the National Institute of General Medical Sciences of the National Institutes of Health to develop a series of drug candidates for a number of diseases, including heart disease, rheumatoid arthritis and several neurodegenerative disorders.
January 23, 2017
TSRI Scientists Create First Stable Semisynthetic Organism
Scientists at The Scripps Research Institute (TSRI) have announced the development of the first stable semisynthetic organism.
January 19, 2017
New TSRI Method Could Turbocharge Drug Discovery, Protein Research
A team led by scientists at The Scripps Research Institute (TSRI) has developed a versatile new method that should enhance the discovery of new drugs and the study of proteins.
January 12, 2017
TSRI Scientists Discover Master Regulator of Cellular Aging
Scientists at The Scripps Research Institute (TSRI) have discovered a protein that fine-tunes the cellular clock involved in aging.
January 10, 2017
The Scripps Research Institute Signs Collaboration Agreement with Pfizer to Advance DNA-Encoded Library Technology
The Scripps Research Institute (TSRI), a leading non-profit biomedical research institute, today announced a research collaboration and license agreement with Pfizer Inc. (NYSE: PFE) to pioneer new DNA-encoded library (DEL) technology, including new synthetic chemistry for the creation of next-generation DELs, a potentially transformative technology for early stage drug discovery research.
January 09, 2017
Intarcia and Calibr Announce Collaboration and In-Licensing Deal Aimed At Delivering a Next Generation Combination Product For Diabetes & Obesity
Calibr News: Calibr, a corporate affiliate of The Scripps Research Institute, has announced a strategic research collaboration with Intarcia Therapeutics, Inc.
January 05, 2017
TSRI Researchers Discover Surprising Process Behind Sense of Touch
Biologists on the Florida campus of The Scripps Research Institute (TSRI) have discovered a new mechanism that likely underlies how we feel force or touch.
January 04, 2017
Scripps Florida Scientists Expand Toolbox to Study Cellular Function
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have developed a new tool for studying the molecular details of protein structure.
January 03, 2017
TSRI Scientists Take Step Toward Mapping How the Brain Stores Memories
The research, published recently in the journal eLife, is the first to demonstrate that the same brain region can both motivate a learned behavior and suppress that same behavior.