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The Mandyam Lab


Galinato MH, Orio L, Mandyam CDMethamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus. Neuroscience. 2015. Pubmed

Cohen A1, Soleiman MT, Talia R, Koob GF, George O, Mandyam CD. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. Psychopharmacology (Berl). 2015. Pubmed

Somkuwar SS, Staples MC, Galinato MH, Fannon MJ, Mandyam CD. Role of NG2 expressing cells in addiction: a new approach for an old problem. Front. Pharmacol. 2014. Pubmed

Sobieraj JC, Kim A, Fannon MJ, Mandyam CD. Chronic wheel running-induced reduction of extinction and reinstatement of methamphetamine seeking in methamphetamine dependent rats is associated with reduced number of periaqueductal gray dopamine neurons. Brain Struct Funct. 2014. Pubmed

Kim A, Mandyam CD. Methamphetamine affects cell proliferation in the medial prefrontal cortex: a new niche for toxicity.Pharmacol Biochem Behav. 2014. Pubmed

Kim A, Zamora-Martinez ER, Edwards S, Mandyam CD. Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity. Brain Struct Funct. 2014. Pubmed

Contet C, Kim A, Le D, Iyengar SK, Kotzebue RW, Yuan CJ, Kieffer BL, Mandyam CD. μ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche. Addict Biol. 2014. Pubmed

Engelmann AJ1, Aparicio MB, Kim A, Sobieraj JC, Yuan CJ, Grant Y, Mandyam CD. Chronic wheel running reduces maladaptive patterns of methamphetamine intake: regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase. Brain Struct Funct. 2014. Pubmed

Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF,Mandyam CD. Hippocampal neurogenesis protects against cocaine-primed relapse. Addict Biol. 2014. Pubmed

García-Fuster MJ, Rhodes JS, Mandyam CD. The role of dentate gyrus neurogenesis in neuropsychiatric disorders. Neural Plast. 2013. Pubmed

Mandyam CD. The Interplay between the Hippocampus and Amygdala in Regulating Aberrant Hippocampal Neurogenesis during Protracted Abstinence from Alcohol Dependence. Front Psychiatry. 2013. Pubmed

George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF.  Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proc Natl Acad Sci U S A. 2012. Pubmed

Mandyam CD and Koob GF. The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery. In press, Trends Neurosci. 2012. Pubmed

Recinto P, Samant AR, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam CD. Levels of Neural Progenitors in the Hippocampus Predicts Memory Impairment and Relapse to Drug Seeking as a Function of Excessive Methamphetamine Self-Administration. Neuropsychopharmacology. 2011. Pubmed

Yuan CJ, Quiocho JM, Kim A, Wee S, Mandyam CD. Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle. Pharmacol Biochem Behav. 2011 Pubmed

Taffe, M.A., R.W. Kotzebue, R.D. Crean, E.F. Crawford, S. Edwards, and C.D. Mandyam, Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates. Proc Natl Acad Sci U S A, 2010. Pubmed

Richardson, H.N., S.H. Chan, E.F. Crawford, Y.K. Lee, C.K. Funk, G.F. Koob, and C.D. Mandyam, Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence. Neurobiol Dis, 2009. Pubmed

Wee, S., C.D. Mandyam, D.M. Lekic, and G.F. Koob, Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access. Eur Neuropsychopharmacol, 2008. Pubmed

Mandyam, C.D., S. Wee, E.F. Crawford, A.J. Eisch, H.N. Richardson, and G.F. Koob, Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biol Psychiatry, 2008. Pubmed

Mandyam, C.D., E.F. Crawford, A.J. Eisch, C.L. Rivier, and H.N. Richardson, Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus. Dev Neurobiol, 2008. Pubmed

George, O., C.D. Mandyam, S. Wee, and G.F. Koob, Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology, 2008. Pubmed

Arguello, A.A., G.C. Harburg, J.R. Schonborn, C.D. Mandyam, M. Yamaguchi, and A.J. Eisch, Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons. Neuroscience, 2008. Pubmed

Mandyam, C.D., S. Wee, A.J. Eisch, H.N. Richardson, and G.F. Koob, Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. J Neurosci, 2007. Pubmed

Mandyam, C.D., G.C. Harburg, and A.J. Eisch, Determination of key aspects of precursor cell proliferation, cell cycle length and kinetics in the adult mouse subgranular zone. Neuroscience, 2007. Pubmed

Lagace, D.C., M.C. Whitman, M.A. Noonan, J.L. Ables, N.A. DeCarolis, A.A. Arguello, M.H. Donovan, S.J. Fischer, L.A. Farnbauch, R.D. Beech, R.J. DiLeone, C.A. Greer, C.D. Mandyam, and A.J. Eisch, Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J Neurosci, 2007. Pubmed

Eisch, A.J. and C.D. Mandyam, Adult neurogenesis: can analysis of cell cycle proteins move us "Beyond BrdU"? Curr Pharm Biotechnol, 2007. Pubmed

Bawa-Khalfe, T., G.F. Altememi, C.D. Mandyam, L.A. Schwarz, D.C. Eikenburg, and K.M. Standifer, The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. BMC Pharmacol, 2007. Pubmed

Battiste, J., A.W. Helms, E.J. Kim, T.K. Savage, D.C. Lagace, C.D. Mandyam, A.J. Eisch, G. Miyoshi, and J.E. Johnson, Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development, 2007. Pubmed

Richardson, H.N., E.P. Zorrilla, C.D. Mandyam, and C.L. Rivier, Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood. Endocrinology, 2006. Pubmed

Mandyam, C.D., R.D. Norris, and A.J. Eisch, Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone. Journal of Neuroscience Research, 2004. Pubmed

Eisch, A.J. and C.D. Mandyam, Beyond BrdU: Basic and clinical implications for analysis of endogenous cell cycle proteins. Progress in stem cell research. Nova Science Publishers Inc, 2004

Eisch, A.J. and C.D. Mandyam, Drug dependence and addiction, II: Adult neurogenesis and drug abuse. American Journal of Psychiatry, 2004. Pubmed

Mandyam, C.D., D.R. Thakker, and K.M. Standifer, Mu-opioid-induced desensitization of opioid receptor-like 1 and mu-opioid receptors: differential intracellular signaling determines receptor sensitivity. J Pharmacol Exp Ther, 2003. Pubmed

Mandyam, C.D., D.R. Thakker, J.L. Christensen, and K.M. Standifer, Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk. J Pharmacol Exp Ther, 2002. Pubmed

Mathis, J.P., C.D. Mandyam, G.F. Altememi, G.W. Pasternak, and K.M. Standifer, Orphanin FQ/nociceptin and naloxone benzoylhydrazone activate distinct receptors in BE(2)-C human neuroblastoma cells. Neurosci Lett, 2001. Pubmed

Mandyam, C.D., G.F. Altememi, and K.M. Standifer, beta-Funaltrexamine inactivates ORL1 receptors in BE(2)-C human neuroblastoma cells. Eur J Pharmacol, 2000. Pubmed




Lab Members