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Key Laboratory Publications

Westenskow, P.D., Moreno, S., Krohne, T.U., Kurihara, T., Zhu, S., Ding, S., and Friedlander, M. (2012). RPE cells differentiated from induced pluripotent stem cells phagocytose photoreceptor outer segments with similar kinetics as human fetal RPE cells. Submitted.

Krohne, T.U., Westenskow, P.D., Kurihara, T., Friedlander, Lehmann, M., D.F., Dorsey, A.L., Li, W., Zhu, S., Schultz, A., Wang, J., Siuzdak, G., Ding, S., and Friedlander, M. (2012). Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells. Stem Cells Translational Medicine. 2012 1:96-109.

Kurihara, T., Westenskow, P.D., Krohne,T.U., Aguilar, E., S. Johnson, R.S., and Martin Friedlander. (2011). Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye. J. Cell Biology, 195:689-701. PMCID: PMC3257537.

Marchetti, V., Yanes, O., Aguilar, E., Wang, M., Friedlander, D.F., Moreno, S., Storm, K., Zhan, M., Naccache, S., Nemerow, G., Siuzdak, G., and M. Friedlander, (2011). Differential Macrophage Polarization is Required for Tissue Remodeling and Repair in a Model of Ischemic Retinopathy. Sci Rep. 2011;1:76:1-12. PMCID: PMC3216563.

Parmalee NL, Schubert C, Merriam JE, Allikmets K, Bird AC, Gillies MC, Peto T, Figueroa M, Friedlander M, Fruttiger M, Greenwood J, Moss SE, Smith LE, Toomes C, Inglehearn CF, Allikmets R. (2010). Analysis of candidate genes for macular telangiectasia type 2. Mol Vis. 2010 Dec 14;16:2718-26.

Krohne, T.U., Bird, A. and Friedlander, M. (2010). Unilateral blurred vision associated with simultaneous macular and papillary edema in a 34-year-old male patient. Ophthalmologe. Dec 2010; 107:1160-1163.

Marchetti, V, Krohne, TU, Friedlander, DF, and Friedlander, M. (2010). Stemming vision loss with stem cells. J Clin Invest. Sep 1;120(9):3012-21. PMCID: PMC2929728.

Dorrell, M.I., Aguilar, E.A., Jacobson, R., Trauger, S., Friedlander, J.F., Suizdak, G. and M. Friedlander (2010). Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy. Glia 58(1):43-54. PMCID: PMC2814838.

Dorrell, M.I., Aguilar, E.A., Jacobson, R., Yanes, O., Gariano, R., Heckenlively, J., Eyal Banin, E., Ramirez, E.G., Gasmi, M., Bird, A., Suizdak, G., and Friedlander, M. (2009). Treatment with antioxidants or neurotrophic factors preserves function in neurons damaged by neovascularization-associated oxidative stress. J. Clin. Invest. 119(3):611-623. PMCID: PMC2648679.

Scheppke, L., Aguilar, E., Gariano, R.F., Hood, J., Soll R., Yee, S., Noronha, G., Martin, M., Weis, S., Cheresh, D.A. and Friedlander, M. (2008). Retinal vascular permeability suppression by topical application of a novel VEGFR2/SRC kinase inhibitor in mice and rabbits J. Clin. Invest., 118(6):2337-46. PMCID: PMC2381746.

Dorrell, M., Aguilar, E., Scheppke, L., Barnett, F., and M. Friedlander. (2007). Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis. Proc. Natl. Acad. Sci. 104:967-972.

Ritter, M., Banin, E., Aguilar, E.A., Dorrell, M.I. Moreno S.K. and M. Friedlander (2006). Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy. J. Clin. Invest. 116:3266-3276.

Otani, A., Kinder, K., Ewalt, K., Otero, F., Schimmel, P. and Friedlander, M. (2002). Bone marrow derived stem cells cells target retinal astrocytes and have pro- or anti-angiogenic activity. Nature Medicine 8: 1004-1010

Sahin-Toth, M., Kaback, R., Friedlander, M. (1996). Association between the amino and carboxy terminal halves of lactose permease is specific and mediated by multiple transmembrane domains. Biochemistry, 35:2016-2021.

Otani, A., Slike, B., Dorrell, M. I., Hood, J., Kinder, K., Ewalt, K., Cheresh, D.A., Schimmel, P. and Friedlander, M. (2002). A fragment of human TrpRS as a potent antagonist of ocular angiogenesis. Proceedings National Academy of Sciences, 99:178-183.

Ritter, M., Dorrell, M., Edmonds, J. Friedlander, S., and Friedlander, M. (2002). Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis. Proceedings National Academy of Sciences, 99:7455-7460.

Friedlander, M., Theesfeld, C.L., Sugita, M., Fruttiger, M., Thomas, M.A., Chang, S. and Cheresh, D.A. (1996). Involvement of integrins avβ3 and avβ5 in ocular neovascular diseases. Proc. Natl. Acad. Sci. (U.S.A.) 93:9764-9769.

Friedlander, M., Brooks, P., Shaffer, R., Kincaid, C., Varner, J., Cheresh, D. (1995). Two pathways of angiogenesis defined by homologous av integrins. Science, 270:1500-1502.

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