Kurt Wuthrich, PhD

Cecil H. and Ida M. Green Professor of Structural Biology
Professor
Department of Integrative Structural and Computational Biology
California Campus



Scripps Research Joint Appointments

Department of Chemistry
Department of Integrative Structural and Computati, Cell-Based Screening Core
The Skaggs Institute for Chemical Biology
Faculty, Graduate Program

Research Focus

Structure and function of proteins and nucleic acids, nuclear magnetic resonance (NMR) spectroscopy.


The Wüthrich group specializes in nuclear magnetic resonance (NMR) spectroscopy with biological macromolecules. Contributions include NMR structure determination of biological macromolecules, the extension of solution NMR studies to very large molecular structures with the principles of transverse relaxation-optimized spectroscopy (TROSY), the introduction of automated projection spectroscopy (APSY) for efficient structure determination of small soluble proteins, and the use of 5-, 6- and 7- dimensional APSY-NMR experiments for atomic resolution characterization of denatured proteins and functional non-globular polypeptides (so-called “intrinsically disordered proteins”, IDPs). Practical applications are primarily focused on opioid receptors, other GPCRs, and higher-order complexes containing protein domains and RNAs in the spliceosome.


Selected References

Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, Wiley, New York.

Wüthrich, K. (2003) Angew. Chem. Int. Ed. 42, 3340–3363. NMR studies of structure and function of biological macromolecules (Nobel Lecture).

Liu, J.J., Horst, R., Katritch, V., Stevens, R.C. and Wüthrich, K. (2012) Science 335, 1106–1110.  Biased signaling        pathways in β2-adrenergic receptor characterized by 19F-NMR.



Education

Ph.D. (Biology), University of Basel, 1964

Professional Experience

1957–62

University of Bern, Switzerland: Lizentiat in chemistry, physics and mathematics.

1962–64

University of Basel, Switzerland: Ph.D. in chemistry (Prof. S. Fallab); Eidgenössisches Turn- und Sportlehrerdiplom.

1964–65

University of Basel, Switzerland: Postdoctoral training (Prof. S. Fallab).

1965–67

University of California, Berkeley, CA, USA : Postdoctoral training (Prof. R.E. Connick).

1967–69

Bell Telephone Laboratories, Murray Hill, N.J., USA : Member Technical Staff, Biophysics Department (Dr. R.G. Shulman).

1969–

ETH Zurich, Zurich, Switzerland: Privatdozent (70), Assistant Professor (72), Associate Professor (76), Professor of Biophysics (80); Chairman Biology Department (95–2000).

2001–04

The Scripps Research Institute, La Jolla, CA, USA: Cecil H. and Ida M. Green Visiting Professor of Structural Biology.

2004–

The Scripps Research Institute, La Jolla, CA, USA: Cecil H. and Ida M. Green Professor of Structural Biology.

2000-2012 Professor, Chemistry, Scripps Research
2000-2012 Professor, Molecular Biology, Scripps Research

Awards & Professional Activities

1974

Friedrich-Miescher-Preis, Schweizerische Gesellschaft für Biochemie.

1983

Shield of the Faculty of Medicine, Tokyo University, Japan.

1986

Médaille P. Bruylants, Université Catholique de Louvain, Belgium.

1990

Stein and Moore Award of the Protein Society, USA.

1991

Louisa Gross Horwitz Prize, Columbia University, New York, USA.

1991

Gilbert Newton Lewis Medal, University of California, Berkeley, USA.

1992

Marcel Benoist-Preis, awarded by the Swiss Confederation.

1993

Distinguished Service Award, The Miami Bio/Technology Winter Symposia, USA.

1993

Prix Louis Jeantet de Médecine, Fondation Louis Jeantet, Geneva, Switzerland.

1996

Kaj Linderstrøm-Lang Prize, Carlsberg Foundation, Copenhagen, Denmark.

1997

Eminent Scientist of RIKEN, Tokyo, Japan.

1998

Kyoto Prize in Advanced Technology, Inamori Foundation, Kyoto, Japan.

1999

Günther Laukien Prize, Experimental NMR Conference (ENC), USA.

1999

Otto-Warburg-Medaille, Gesellschaft für Biochemie und Molekularbiologie, Germany.

2001

Médaille d‘Honneur en Argent, Société d‘Encouragement au Progrès, Paris, France.

2002

Nobel Prize in Chemistry.

2002

World ‘Future’ Award, The World Awards, Wien, Austria.

2002

Swiss ‘Society’ Award, The Swiss Awards, Zürich, Switzerland.

2002

Ehrenpreis 2002, City of Wallisellen, Switzerland.

2003

Honorary Citizenship, City of Lyss, Switzerland.

2008

Johannes M. Bijvoet Medal, Utrecht University, Utrecht, The Netherlands.

2008

Paul Walden Medal, Riga Technical University, Riga, Latvia.

2009

Jabir ibn Hyyan (Geber) Medal, Saudi Chemical Society, Saudi Arabia.

2010

Ralph and Helen Oesper Award, University of Cincinnati, Cincinnati, OH, USA.

2012

President’s Gold Medal, Government of India.

2013

Theodor Bücher Medal, Federation of European Biochemical Societies.

2015

IUBMB Medal

2016

Shanghai 1,000 Talents Award.

 

 


Selected References

All Publications

Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, Wiley, New York.

Wüthrich, K. (2003) Angew. Chem. Int. Ed. 42, 3340--3363. NMR studies of structure and function of biological macromolecules (Nobel Lecture).


Links

The Skaggs Institute Scientific Report

Wüthrich Wins 2002 Nobel Prize in Chemistry