Source: Interfolio F180
Andrew Ward
Research Focus
Investigating membrane proteins and viruses using integrative structural biology techniques.
Membrane protein transporters mediate the passage of a wide variety of molecules into and out of the cell. The molecular details underlying the function of most transporters are still unknown. Thus, my group is interested in studying novel membrane proteins using x-ray crystallography, electron microscopy, and other biophysical techniques. Membrane proteins expressed on the surface of enveloped viruses mediate viral entry into the cell by recognizing cell surface receptors and initiating endocytosis or membrane fusion. Recently, broadly neutralizing antibodies targeting these surface spikes have been shown to provide protection against viruses such as HIV and influenza. We are trying to better understand how these antibodies bind to and neutralize viruses. Using single particle electron microscopy and electron tomography we are able to visualize these complexes and whole viruses, providing information about the mechanism of inhibition and aiding in the design of better immunogens for eliciting a broadly neutralizing antibody response in humans.
Education
Ph.D., The Scripps Research Institute, 2008B.S., Duke University, 2001
Awards & Professional Activities
2017 Young Investigator in Virology Award, Viruses2014 Anne Palmenberg Junior Investigator Award, American Society for Virology
2013 Ray Thomas Edwards Foundation Fellowship
2006 Norton B. Gilula Graduate Fellowship, The Scripps Research Institute
2003 National Science Foundation EAPSI Fellowship, The Scripps Research Institute
2001 Howard Hughes Undergraduate Research Fellowship, Duke University, Durham, North Carolina
Selected Publications
Pejchal, R.; Doores, K. J.; Walker, L. M.; Khayat, R.; Stanfield, R. L.; Ramos, A.; Crispin, M.; Katpally, U.; Marozsan, A.; Cupo, A.; Liu, Y.; Mcbride, R.; Ito, Y.; Sanders, R. W.; Ogohara, C.; Paulson, J. C.; Feizi, T.; Scanlan, C. N.; Moore, J. P.; Olson, W. C.; Ward, A. B.; Poignard, P.; Schief, W. R.; Burton, D. R.; Wilson, I. A.; Wong, C. H.; Wang, S. K.; Maloveste, S. M.; Julien, J. P.; Huang, P. S.; Depetris, R. S. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.. Science (New York, N.Y.) 2011, 334, 1097-103.
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Julien, J. P.; Lee, J.; Cupo, A.; Murin, C. D.; Derking, R.; Hoffenberg, S.; Caulfield, M. J.; King, C. R.; Marozsan, A. J.; Klasse, P. J.; Sanders, R. W.; Moore, J. P.; Wilson, I. A.; Ward, A. B. Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9. Proceedings of the National Academy of Sciences of the United States of America 2013, 110, 213-218.
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Kong, L.; Giang, E.; Nieusma, T.; Kadam, R. U.; Cogburn, K. E.; Hua, Y.; Dai, X.; Stanfield, R. L.; Burton, D. R.; Ward, A. B.; Wilson, I. A.; Law, M. Hepatitis C virus E2 envelope glycoprotein core structure.. Science (New York, N.Y.) 2013, 342, 1090-4.
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Dreyfus, C.; Laursen, N. S.; Kwaks, T.; Zuijdgeest, D.; Khayat, R.; Ekiert, D. C.; Lee, J. H.; Metlagel, Z.; Bujny, M. V.; Jongeneelen, M.; Lamrani, M.; Korse, H. J.; Geelen, E.; Sahin, O.; Sieuwerts, M.; Brakenhoff, J. P.; Vogels, R.; Li, O. T.; Poon, L. L.; Peiris, M.; Koudstaal, W.; Ward, A. B.; Wilson, I. A.; Goudsmit, J.; Friesen, R. H.; Vlugt, R. V. Highly conserved protective epitopes on influenza B viruses.. Science (New York, N.Y.) 2012, 337, 1343-8.
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Thornburg, N. J.; Nannemann, D. P.; Blum, D. L.; Belser, J. A.; Tumpey, T. M.; Deshpande, S.; Fritz, G. A.; Sapparapu, G.; Krause, J. C.; Lee, J.; Ward, A. B.; Lee, D. E.; Li, S.; Winarski, K. L.; Spiller, B. W.; Meiler, J.; Crowe, J. E. Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses. Journal of Clinical Investigation 2013, 123, 4405-4409.
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Grover, R. K.; Zhu, X.; Nieusma, T.; Boreo, I.; Macleod, A. S.; Mark, A.; Niessen, S.; Kim, H. J.; Kong, L.; Assad-garcia, N.; Kwon, K.; Chesi, M.; Smider, V. V.; Salomon, D. R.; Jelinek, D. F.; Kyle, R. A.; Pyles, R. B.; Glass, J. I.; Ward, A. B.; Wilson, I. A.; Lerner, R. A.; Jones, T. M.; Boero, I. A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union.. Science (New York, N.Y.) 2014, 343, 656-661.
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